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https://www.readbyqxmd.com/read/27854266/using-technology-bioinformatics-and-health-informatics-approaches-to-improve-learning-experiences-in-optometry-education-research-and-practice
#1
REVIEW
Vivek K Gupta, Veer B Gupta
Rapid advances in ocular diagnostic approaches and emerging links of pathological changes in the eye with systemic disorders have widened the scope of optometry as the front line of eye health care. Expanding professional requirements stipulate that optometry students get a meticulous training in relevant information and communication technologies (ICT) and various bioinformatics and health informatics software to meet current and future challenges. Greater incorporation of ICT approaches in optometry education can facilitate increased student engagement in shared learning experiences and improve collaborative learning...
November 15, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27830252/findings-from-the-section-on-bioinformatics-and-translational-informatics
#2
H Dauchel, T Lecroq
OBJECTIVES: To summarize excellent current research and propose a selection of best papers published in 2015 in the field of Bioinformatics and Translational Informatics with application in the health domain and clinical care. METHOD: We provide a synopsis of the articles selected for the IMIA Yearbook 2016, from which we attempt to derive a synthetic overview of current and future activities in the field. As last year, a first step of selection was performed by querying MEDLINE with a list of MeSH descriptors completed by a list of terms adapted to the section...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27830250/all-that-glitters-is-not-gold-consumer-health-informatics-and-education-in-the-era-of-social-media-and-health-apps-findings-from-the-yearbook-2016-section-on-consumer-health-informatics
#3
L Fernandez-Luque, P Staccini
OBJECTIVE: To summarize the state of the art published during the year 2015 in the areas related to consumer health informatics and education with a special emphasis on unintended consequences of applying mobile and social media technologies in that domain. METHODS: We conducted a systematic review of articles published in PubMed with a predefined set of queries, which lead to the selection of over 700 potential relevant articles. Section editors screened those papers on the title, abstract, and finally complete paper basis, taking into account the papers' relevance for the section topic...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27807748/medical-imaging-informatics
#4
William Hsu, Suzie El-Saden, Ricky K Taira
Imaging is one of the most important sources of clinically observable evidence that provides broad coverage, can provide insight on low-level scale properties, is noninvasive, has few side effects, and can be performed frequently. Thus, imaging data provides a viable observable that can facilitate the instantiation of a theoretical understanding of a disease for a particular patient context by connecting imaging findings to other biologic parameters in the model (e.g., genetic, molecular, symptoms, and patient survival)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27772824/informatics-standards-for-better-safer-pathology-reporting-and-requesting
#5
M Legg, D Moore
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27769829/graphical-display-of-histopathology-data-from-toxicology-studies-for-drug-discovery-and-development-an-industry-perspective
#6
Alan P Brown, Philip Drew, Brian Knight, Philippe Marc, Sean Troth, Kuno Wuersch, Joyce Zandee
Histopathology data comprise a critical component of pharmaceutical toxicology studies and are typically presented as finding incidence counts and severity scores per organ, tabulated on multiple pages which can be challenging for review and aggregation of results. However, the SEND (Standard for Exchange of Nonclinical Data) standard provides a means for collecting and managing histopathology data in a uniform fashion which can allow informatics systems to archive, display and analyze data in novel ways. Various software applications have become available to convert histopathology data into graphical displays for analyses...
October 18, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27642271/metabolomics-enables-precision-medicine-a-white-paper-community-perspective
#7
Richard D Beger, Warwick Dunn, Michael A Schmidt, Steven S Gross, Jennifer A Kirwan, Marta Cascante, Lorraine Brennan, David S Wishart, Matej Oresic, Thomas Hankemeier, David I Broadhurst, Andrew N Lane, Karsten Suhre, Gabi Kastenmüller, Susan J Sumner, Ines Thiele, Oliver Fiehn, Rima Kaddurah-Daouk
INTRODUCTION BACKGROUND TO METABOLOMICS: Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or "-omics" level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person's metabolic state provides a close representation of that individual's overall health status...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27638921/periodontal-tissue-regeneration-using-syngeneic-adipose-derived-stromal-cells-in-a-mouse-model
#8
Mathieu Lemaitre, Paul Monsarrat, Vincent Blasco-Baque, Pascale Loubières, Rémy Burcelin, Louis Casteilla, Valérie Planat-Bénard, Philippe Kémoun
: : Current treatment of periodontitis is still associated with a high degree of variability in clinical outcomes. Recent advances in regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little is known about the biological processes involved. Here, we aimed to use syngeneic ASCs for periodontal regeneration in a new, relevant, bacteria-induced periodontitis model in mice. Periodontal defects were induced in female C57BL6/J mice by oral gavage with periodontal pathogens...
September 16, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27619529/recent-advances-in-cytochrome-c-biosensing-technologies
#9
Pandiaraj Manickam, Ajeet Kaushik, Chandran Karunakaran, Shekhar Bhansali
This review is an attempt, for the first time, to describe advancements in sensing technology for cytochrome c (cyt c) detection, at point-of-care (POC) application. Cyt c, a heme containing metalloprotein is located in the intermembrane space of mitochondria and released into bloodstream during pathological conditions. The release of cyt c from mitochondria is a key initiative step in the activation of cell death pathways. Circulating cyt c levels represents a novel in-vivo marker of mitochondrial injury after resuscitation from heart failure and chemotherapy...
September 4, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27613300/-annual-report-of-the-working-group-on-informatics-innovative-imaging-and-biobanking-of-the-german-society-for-pathology
#10
G Kayser, G Haroske
No abstract text is available yet for this article.
September 9, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27563486/pathology-informatics-essentials-for-residents-a-flexible-informatics-curriculum-linked-to-accreditation-council-for-graduate-medical-education-milestones
#11
Walter H Henricks, Donald S Karcher, James H Harrison, John H Sinard, Michael W Riben, Philip J Boyer, Sue Plath, Arlene Thompson, Liron Pantanowitz
CONTEXT: Recognition of the importance of informatics to the practice of pathology has surged. Training residents in pathology informatics have been a daunting task for most residency programs in the United States because faculty often lacks experience and training resources. Nevertheless, developing resident competence in informatics is essential for the future of pathology as a specialty. OBJECTIVE: The objective of the study is to develop and deliver a pathology informatics curriculum and instructional framework that guides pathology residency programs in training residents in critical pathology informatics knowledge and skills and meets Accreditation Council for Graduate Medical Education Informatics Milestones...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27540600/highlights-from-the-52nd-annual-meeting-of-the-american-society-of-clinical-oncology-asco-june-3-7-2016-chicago-illinois-usa
#12
A Kibble, A Al-Shamahi, K Kuennemann, F Marqués, L Tremosa, P Cole
The theme of the 52nd Annual American Society of Clinical Oncology (ASCO) meeting, 'Collective Wisdom', was intended to represent the importance of consolidating clinical advances with expertise in areas such as health informatics, pathology and economics in order to improve the role of practice providers in delivering cancer patients every component of quality care. As expected, immunotherapy and precision medicine featured heavily in the 2016 program. Gathering 30,000 oncology professionals in Chicago, educational and science sessions gave the attendees the opportunity to discuss and view ground-breaking research...
July 2016: Drugs of Today
https://www.readbyqxmd.com/read/27423928/the-ana-reflex-test-as-a-model-for-improving-clinical-appropriateness-in-autoimmune-diagnostics
#13
Elio Tonutti, Nicola Bizzaro, Gabriella Morozzi, Antonella Radice, Luigi Cinquanta, Danilo Villalta, Renato Tozzoli, Marilina Tampoia, Brunetta Porcelli, Martina Fabris, Ignazio Brusca, Maria Grazia Alessio, Giuseppina Barberio, Maria Concetta Sorrentino, Antonio Antico, Danila Bassetti, Desré Ethel Fontana, Tiziana Imbastaro, Daniela Visentini, Giampaola Pesce, Marcello Bagnasco
Reflex tests are widely used in clinical laboratories, for example, to diagnose thyroid disorders or in the follow-up of prostate cancer. Reflex tests for antinuclear antibodies (ANA) have recently gained attention as a way to improve appropriateness in the immunological diagnosis of autoimmune rheumatic diseases and avoid waste of resources. However, the ANA-reflex test is not as simple as other consolidated reflex tests (the TSH-reflex tests or the PSA-reflex tests) because of the intrinsic complexity of the ANA test performed by the indirect immunofluorescence method on cellular substrates...
December 2016: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27420575/emerging-themes-in-image-informatics-and-molecular-analysis-for-digital-pathology
#14
Rohit Bhargava, Anant Madabhushi
Pathology is essential for research in disease and development, as well as for clinical decision making. For more than 100 years, pathology practice has involved analyzing images of stained, thin tissue sections by a trained human using an optical microscope. Technological advances are now driving major changes in this paradigm toward digital pathology (DP). The digital transformation of pathology goes beyond recording, archiving, and retrieving images, providing new computational tools to inform better decision making for precision medicine...
July 11, 2016: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/27383543/pathology-informatics-essentials-for-residents-a-flexible-informatics-curriculum-linked-to-accreditation-council-for-graduate-medical-education-milestones
#15
Walter H Henricks, Donald S Karcher, James H Harrison, John H Sinard, Michael W Riben, Philip J Boyer, Sue Plath, Arlene Thompson, Liron Pantanowitz
CONTEXT: -Recognition of the importance of informatics to the practice of pathology has surged. Training residents in pathology informatics has been a daunting task for most residency programs in the United States because faculty often lacks experience and training resources. Nevertheless, developing resident competence in informatics is essential for the future of pathology as a specialty. OBJECTIVE: -To develop and deliver a pathology informatics curriculum and instructional framework that guides pathology residency programs in training residents in critical pathology informatics knowledge and skills, and meets Accreditation Council for Graduate Medical Education Informatics Milestones...
July 6, 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27354690/differences-in-the-prevalence-of-ankylosing-spondylitis-in-primary-and-secondary-care-only-one-third-of-patients-are-managed-in-rheumatology
#16
Linda E Dean, Gary J Macfarlane, Gareth T Jones
OBJECTIVE: Knowing not only the prevalence of SpA, but also the proportion managed in rheumatology, has implications for health care planning. The aims of this study were to determine the prevalence of SpA and the proportion managed in rheumatology and to examine differences in group characteristics. METHODS: For the primary care population, we used the Primary Care Clinical Informatics Unit Research (PCCIUR) electronic primary care database, covering one-third of the Scottish population...
October 2016: Rheumatology
https://www.readbyqxmd.com/read/27338352/spatial-partitioning-of-mirnas-is-related-to-sequence-similarity-in-overall-transcriptome
#17
William Seffens, Fisseha Abebe, Chad Evans, Xiao-Qian Wang
RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27222732/future-perspectives-toward-the-early-definition-of-a-multivariate-decision-support-scheme-employed-in-clinical-decision-making-for-senior-citizens
#18
Christos A Frantzidis, Sotiria Gilou, Antonis Billis, Maria Karagianni, Charalampos D Bratsas, Panagiotis Bamidis
Recent neuroscientific studies focused on the identification of pathological neurophysiological patterns (emotions, geriatric depression, memory impairment and sleep disturbances) through computerised clinical decision-support systems. Almost all these research attempts employed either resting-state condition (e.g. eyes-closed) or event-related potentials extracted during a cognitive task known to be affected by the disease under consideration. This Letter reviews existing data mining techniques and aims to enhance their robustness by proposing a holistic decision framework dealing with comorbidities and early symptoms' identification, while it could be applied in realistic occasions...
March 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/27207365/image-informatics-strategies-for-deciphering-neuronal-network-connectivity
#19
REVIEW
Jan R Detrez, Peter Verstraelen, Titia Gebuis, Marlies Verschuuren, Jacobine Kuijlaars, Xavier Langlois, Rony Nuydens, Jean-Pierre Timmermans, Winnok H De Vos
Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions. Amongst the neuronal structures that show morphological plasticity are neurites, synapses, dendritic spines and even nuclei. This structural remodelling is directly connected with functional changes such as intercellular communication and the associated calcium bursting behaviour. In vitro cultured neuronal networks are valuable models for studying these morpho-functional changes...
2016: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/27150344/no-benefit-after-tha-performed-with-computer-assisted-cup-placement-10-year-results-of-a-randomized-controlled-study
#20
Sebastien Parratte, Matthieu Ollivier, Alexandre Lunebourg, Xavier Flecher, Jean-Noel A Argenson
BACKGROUND: Computer-assisted surgery (CAS) for cup placement has been developed to improve the functional results and to reduce the dislocation rate and wear after total hip arthroplasty (THA). Previously published studies demonstrated radiographic benefits of CAS in terms of implant position, but whether these improvements result in clinically important differences that patients might perceive remains largely unknown. QUESTIONS/PURPOSES: We hypothesized that THA performed with CAS would improve 10-year patient-reported outcomes measured by validated scoring tools, reduce acetabular polyethylene wear as measured using a validated radiological method, and increase survivorship...
October 2016: Clinical Orthopaedics and related Research
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