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https://www.readbyqxmd.com/read/29792754/loss-of-chromosome-18q11-2-q12-1-is-predictive-for-survival-in-patients-with-metastatic-colorectal-cancer-treated-with-bevacizumab
#1
Erik van Dijk, Hedde D Biesma, Martijn Cordes, Dominiek Smeets, Maarten Neerincx, Sudipto Das, Paul P Eijk, Verena Murphy, Anna Barat, Orna Bacon, Jochen H M Prehn, Johannes Betge, Timo Gaiser, Bozena Fender, Gerrit A Meijer, Deborah A McNamara, Rut Klinger, Miriam Koopman, Matthias P A Ebert, Elaine W Kay, Bryan T Hennessey, Henk M W Verheul, William M Gallagher, Darran P O'Connor, Cornelis J A Punt, Fotios Loupakis, Diether Lambrechts, Annette T Byrne, Nicole C T van Grieken, Bauke Ylstra
Purpose Patients with metastatic colorectal cancer (mCRC) have limited benefit from the addition of bevacizumab to standard chemotherapy. However, a subset probably benefits substantially, highlighting an unmet clinical need for a biomarker of response to bevacizumab. Previously, we demonstrated that losses of chromosomes 5q34, 17q12, and 18q11.2-q12.1 had a significant correlation with progression-free survival (PFS) in patients with mCRC treated with bevacizumab in the CAIRO2 clinical trial but not in patients who did not receive bevacizumab in the CAIRO trial...
May 24, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29791806/seasonal-dynamics-of-bacterioplankton-community-in-a-large-shallow-highly-dynamic-freshwater-lake
#2
Zhaoyu Kong, Wenbo Kou, Yantian Ma, Haotian Yu, Gang Ge, Lan Wu
The spatio-temporal shifts of bacterioplankton community can mirror their transition of functional traits in aquatic ecosystem. However, our understanding of spatio-temporal variation of bacterioplankton community composition structure (BCCs) within large, shallow and highly dynamic freshwater lake is still elusive. Here we examined the seasonal and spatial variability of BCCs in the Poyang Lake by 16S rRNA gene amplicon sequencing to explore how hydrological changes affect the BCCs. Principal coordinate analysis showed that the BCCs varied significantly among four sampling seasons, but not spatially...
May 23, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29791564/morphology-and-morphometry-of-upland-lakes-over-lateritic-crust-serra-dos-caraj%C3%A3-s-southeastern-amazon-region
#3
Marcio S DA Silva, José T F Guimarães, Pedro W M Souza Filho, Wilson Nascimento Júnior, Prafulla K Sahoo, Francisco R DA Costa, Renato O Silva Júnior, Tarcísio M Rodrigues, Marlene F DA Costa
High-resolution satellite images, digital elevation models, bathymetric and sedimentological surveys coupled with statistical analysis were used to understand the physical environment and discuss their influence on water quality of the five upland lakes of Serra Sul dos Carajás, southeast Amazonia. The lakes have mid-altitude ranges (elevation), very small (catchment) and shallow to very shallow (central basins). Based on the length, area and volume, Violão and TI (Três Irmãs)-3 lakes may present large vertical movements of the water due to wind action and weakly stratified waters...
May 17, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29791328/silicon-microsphere-whispering-gallery-modes-excited-by-femtosecond-laser-inscribed-glass-waveguides
#4
Hüseyin Ozan Çirkinoğlu, Mustafa Mert Bayer, Ulaş Sabahattin Gökay, Ali Serpengüzel, Belén Sotillo, Vibhav Bharadwaj, Roberta Ramponi, Shane Michael Eaton
We report on the coupling of whispering gallery modes in a 500-μm-radius silicon microsphere to a femtosecond-laser-inscribed glass optical waveguide. The shallow glass waveguide with a large mode field diameter in the near-infrared is written at a depth of 25 μm below the glass surface, resulting in a high excitation impact parameter of 525 μm for the microsphere. The excited whispering gallery modes of the silicon microsphere have quality factors of approximately 105 in the 90° elastic scattering and 0° transmission...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791129/formation-of-deep-electron-trap-by-yb-3-codoping-leads-into-super-long-persistent-luminescence-in-ce-3-doped-yttrium-aluminum-gallium-garnet-phosphors
#5
Jumpei Ueda, Shun Miyano, Setsuhisa Tanabe
The Y3 Al2 Ga3 O12 :Ce3+ -Cr3+ compound is one of the brightest persistent phosphors, but its persistent luminescence (PersL) duration is not so long due to the relatively shallow Cr3+ electron trap. Comparing the vacuum referred binding energy of the electron trapping state by Cr3+ and those by lanthanide ions, we selected Yb3+ as a deeper electron trapping center. The Y3 Al2 Ga3 O12 :Ce3+ -Yb3+ phosphors show Ce3+ :5d→4f green persistent luminescence after ceasing blue light excitation. The formation of Yb2+ was confirmed by the increased intensity of absorption at 585 nm during the charging process...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29791035/uncovering-cryptic-diversity-of-lyngbya-the-new-tropical-marine-cyanobacterial-genus-dapis-oscillatoriales
#6
Niclas Engene, Ana Tronholm, Valerie J Paul
Cyanobacteria comprise an extraordinarily diverse group of microorganisms and, as revealed by increasing molecular information, this biodiversity is even more extensive than previously estimated. In this sense, the cyanobacterial genus Lyngbya is a highly polyphyletic group composed of many unrelated taxa with morphological similarities. In this study, the new genus Dapis was erected from the genus Lyngbya, based on a combined molecular, chemical, and morphological approach. Herein, two new species of cyanobacteria are described: D...
May 23, 2018: Journal of Phycology
https://www.readbyqxmd.com/read/29790914/females-engage-in-stronger-relationships-positive-and-negative-effects-of-shrubs-are-more-intense-for-poa-ligularis-females-than-for-males
#7
Pamela Graff, Martin R Aguiar, Rocio J Almeida
Background and Aims: Dioecious plants are of particular concern in view of global environmental changes because reproductive females are more sensitive to abiotic stresses, thus compromising population viability. Positive interactions with other plants may counteract the direct effects of any abiotic environmental stress, allowing them to thrive and maintain a viable population in suboptimal habitats, although this process has not been tested for dioecious species. Furthermore, almost no data are available on the outcome of such species interactions and their link with local spatial patterns and sex ratios...
May 22, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29789042/phytoplankton-functional-groups-variation-and-influencing-factors-in-a-shallow-temperate-lake
#8
Chang Tian, Daping Hao, Haiyan Pei, Martina A Doblin, Ying Ren, Jielin Wei, Yawei Feng
  The present study was carried out in Luoma Lake, a shallow lake in temperate eastern China. Based on a two-year study, the dynamics of phytoplankton functional groups and influencing factors were analyzed. A total of 178 taxa were identified and sorted into 20 codons, according to the phytoplankton functional group classification. In order to find the environmental factors driving phytoplankton variations, fifteen groups were analyzed in detail using redundancy analysis. Groups P (Fragilaria crotonensis), X2 (Chlamydomonas globosa, C...
June 1, 2018: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/29785350/the-effect-of-climate-change-on-the-distribution-of-a-tropical-zoanthid-palythoa-caribaeorum-and-its-ecological-implications
#9
Leonardo M Durante, Igor C S Cruz, Tito M C Lotufo
Palythoa caribaeorum is a zoanthid often dominant in shallow rocky environments along the west coast of the Atlantic Ocean, from the tropics to the subtropics. This species has high environmental tolerance and is a good space competitor in reef environments. Considering current and future scenarios in the global climate regime, this study aimed to model and analyze the distribution of P. caribaeorum , generating maps of potential distribution for the present and the year 2100. The distribution was modeled using maximum entropy (Maxent) based on 327 occurrence sites retrieved from the literature...
2018: PeerJ
https://www.readbyqxmd.com/read/29783177/evaluating-long-term-patterns-of-decreasing-groundwater-discharge-through-a-lake-bottom-permeable-reactive-barrier
#10
Timothy D McCobb, Martin A Briggs, Denis R LeBlanc, Frederick D Day-Lewis, Carole D Johnson
Identifying and quantifying groundwater exchange is critical when considering contaminant fate and transport at the groundwater/surface-water interface. In this paper, areally distributed temperature and point seepage measurements are used to efficiently assess spatial and temporal groundwater discharge patterns through a glacial-kettle lakebed area containing a zero-valent iron permeable reactive barrier (PRB). Concern was that the PRB was becoming less permeable with time owing to biogeochemical processes within the PRB...
May 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29782141/in-situ-assembly-of-well-dispersed-ag-nanoparticles-throughout-electrospun-alginate-nanofibers-for-monitoring-human-breath-smart-fabrics
#11
Jun Zhang, Xiao-Xiong Wang, Bin Zhang, Seeram Ramakrishna, Miao Yu, Jian-Wei Ma, Yun-Ze Long
Alginate nanofibers assembled with sliver nanoparticles throughout the whole nanofiber were fabricated by three steps including electrospinning of Na-alginate nanofibers, ion exchange between the sodium and silver ions, and in situ reduction of silver nanoparticles. The content, distribution and size of the nanoparticles are controllable by tuning reaction conditions. Ag/alginate nanofibers exhibit good humidity sensitivity in a wide humidity range from ambient RH (20%) to 85% RH. Interestingly, these humidity sensors can be attached to a 3M-9001V mask for monitoring human breath during exercise and emotion changes, and this smart exhibits accurate and continuous human-breath tracking no matter how fast or slow as well as how deep or shallow...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29781155/human-impacts-decouple-a-fundamental-ecological-relationship-the-positive-association-between-host-diversity-and-parasite-diversity
#12
Chelsea L Wood, Brian J Zgliczynski, Alison J Haupt, Ana Sofía Guerra, Fiorenza Micheli, Stuart A Sandin
Human impacts on ecosystems can decouple the fundamental ecological relationships that create patterns of diversity in free-living species. Despite the abundance, ubiquity, and ecological importance of parasites, it is unknown whether the same decoupling effects occur for parasitic species. We investigated the influence of fishing on the relationship between host diversity and parasite diversity for parasites of coral reef fishes on three fished and three unfished islands in the central equatorial Pacific. Fishing was associated with a shallowing of the positive host-diversity-parasite-diversity relationship...
May 20, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29781096/weight-loss-interventions-for-adults-with-overweight-obesity-and-chronic-musculoskeletal-pain-a-mixed-methods-systematic-review
#13
REVIEW
L Cooper, C G Ryan, L J Ells, S Hamilton, G Atkinson, K Cooper, M I Johnson, J P Kirwan, D Martin
Worldwide prevalence of adult overweight and obesity is a growing public health issue. Adults with overweight/obesity often have chronic musculoskeletal pain. Using a mixed-methods review, we aimed to quantify the effectiveness and explore the appropriateness of weight loss interventions for this population. Electronic databases were searched for studies published between 01/01/90 and 01/07/16. The review included 14 randomized controlled trials that reported weight and pain outcomes and three qualitative studies that explored perceptions of adults with co-existing overweight/obesity and chronic musculoskeletal pain...
May 20, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29780613/schwann-cell-durotaxis-can-be-guided-by-physiologically-relevant-stiffness-gradients
#14
Elisabeth B Evans, Samantha W Brady, Anubhav Tripathi, Diane Hoffman-Kim
Background: Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect. Although several groups have studied directed migration of Schwann cells in response to chemical or topographic cues, the current understanding of how the mechanical environment influences migration remains largely understudied and incomplete. Therefore, the focus of this study was to evaluate Schwann cell migration and morphodynamics in the presence of stiffness gradients, which revealed that Schwann cells can follow extracellular gradients of increasing stiffness, in a form of directed migration termed durotaxis...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29780442/an-extended-eddy-diffusivity-mass-flux-scheme-for-unified-representation-of-subgrid-scale-turbulence-and-convection
#15
Zhihong Tan, Colleen M Kaul, Kyle G Pressel, Yair Cohen, Tapio Schneider, João Teixeira
Large-scale weather forecasting and climate models are beginning to reach horizontal resolutions of kilometers, at which common assumptions made in existing parameterization schemes of subgrid-scale turbulence and convection-such as that they adjust instantaneously to changes in resolved-scale dynamics-cease to be justifiable. Additionally, the common practice of representing boundary-layer turbulence, shallow convection, and deep convection by discontinuously different parameterizations schemes, each with its own set of parameters, has contributed to the proliferation of adjustable parameters in large-scale models...
March 2018: Journal of Advances in Modeling Earth Systems
https://www.readbyqxmd.com/read/29778723/paleocene-eocene-and-plio-pleistocene-sea-level-changes-as-species-pumps-in-southeast-asia-evidence-from-althepus-spiders
#16
Fengyuan Li, Shuqiang Li
Sea-level change has been viewed as a primary driver in the formation of biodiversity. Early studies confirmed that Plio-Pleistocene sea-level changes led to the isolation and subsequent genetic differentiation of Southeast (SE) Asian organisms over short geological timescales. However, long-time consequences of sea-level fluctuations remain unclear. Herein, we analyze the evolutionary history of Althepus (spiders) whose distribution encompasses Indo-Burma and the Sunda shelf islands to understand how sea-level changes over shallow and deep timescales effected their history...
May 17, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29778227/what-are-the-main-environmental-factors-driving-the-development-of-the-neurotoxic-dinoflagellate-vulcanodinium-rugosum-in-a-mediterranean-ecosystem-ingril-lagoon-france
#17
Eric Abadie, Claude Chiantella, Anaïs Crottier, Lesley Rhodes, Estelle Masseret, Tom Berteaux, Mohamed Laabir
Vulcanodinium rugosum, a dinoflagellate developing in Ingril Lagoon (Mediterranean, France) is responsible for shellfish intoxications due to the neurotoxin pinnatoxin G. A one year survey (March 2012-April 2013) was conducted in this oligotrophic shallow lagoon and key environmental parameters were recorded (temperature, salinity and nutrients). The spatio-temporal distribution of V. rugosum in water column and on macrophytes was also determined. Planktonic cells of V. rugosum were observed at all sampling stations, but in relatively low concentrations (maximum of 1000 cell/L)...
May 2018: Harmful Algae
https://www.readbyqxmd.com/read/29778174/development-of-methods-for-establishing-nutrient-criteria-in-lakes-and-reservoirs-a-review
#18
REVIEW
Shouliang Huo, Chunzi Ma, Beidou Xi, Yali Zhang, Fengchang Wu, Hongliang Liu
Nutrient criteria provide a scientific foundation for the comprehensive evaluation, prevention, control and management of water eutrophication. In this review, the literature was examined to systematically evaluate the benefits, drawbacks, and applications of statistical analysis, paleolimnological reconstruction, stressor-response model, and model inference approaches for nutrient criteria determination. The developments and challenges in the determination of nutrient criteria in lakes and reservoirs are presented...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29777243/comparison-of-formulae-for-orotracheal-intubation-depth-in-the-paediatric-population
#19
Jen Heng Pek, Elizabeth Mj Tan, Ying Hao, Gene Yk Ong
INTRODUCTION: Multiple formulae have been proposed for calculating orotracheal depth for paediatric intubation. However, literature on the validation of these formulae in the emergency department setting is limited. Three methods described in the local Advanced Paediatric Life Support curriculum include the Broselow tape, endotracheal tube (ETT) size x 3, and the age-based formula of age divided by 2, add 12. We aimed to determine their accuracy. MATERIALS AND METHODS: Patients with intubation performed in the Children's Emergency from 1 January 2009 to 31 December 2013 were included in this retrospective observational study...
April 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29777045/ten-year-incidence-of-primary-angle-closure-in-elderly-chinese-the-liwan-eye-study
#20
Lanhua Wang, Wenyong Huang, Shengsong Huang, Jian Zhang, Xinxing Guo, David S Friedman, Paul J Foster, Mingguang He
PURPOSE: To determine the 10-year incidence of all forms of primary angle closure (PAC) in phakic eyes and its risk factors in an urban Chinese population aged 50 years and older. METHODS: Survivors of 1405 baseline participants were invited to attend the 10-year follow-up visit in the Liwan Eye Study. Participants with established baseline angle closure, including primary angle closure suspects (PACS), PAC and primary angle closure glaucoma (PACG), or those who underwent bilateral cataract surgery during the 10-year period, as well as those who did not tolerate gonioscopic examinations, were excluded from this analysis...
May 18, 2018: British Journal of Ophthalmology
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