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https://www.readbyqxmd.com/read/28926638/the-earliest-ossicone-and-post-cranial-record-of-giraffa
#1
Melinda Danowitz, John C Barry, Nikos Solounias
The oldest Giraffa material presently known consists of dental specimens. The oldest post-cranial Giraffa material belongs to the Plio-Pleistocene taxon Giraffa sivalensis, where the holotype is a third cervical vertebra. We describe three non-dental specimens from the Early Late Miocene of the Potwar Plateau, including an 8.1 million year old ossicone, 9.4 million year old astragalus, and 8.9 million year old metatarsal and refer them to Giraffa. The described ossicone exhibits remarkable similarities with the ossicones of a juvenile modern giraffe, including the distribution of secondary bone growth, posterior curvature, and concave pitted undersurface where the ossicone would attach to the skull...
2017: PloS One
https://www.readbyqxmd.com/read/28926095/model-based-assessment-using-conventional-bioequivalence-limits-to-ensure-safety-and-efficacy-of-rivaroxaban-in-patients-undergoing-hip-or-knee-replacement
#2
Mario González-Sales, Lanyan Fang, Myong-Jin Kim, Liang Zhao
We evaluated whether the current bioequivalence limit is adequate to ensure safety and efficacy of rivaroxaban in patients under total hip arthroplasty and total knee arthroplasty based on its model informed benefit/risk profile. Clinical data from a total of 7145 patients from 3 phase 2 and 4 phase 3 clinical trials were included in the current model-based exposure-response analysis. The relationships between rivaroxaban exposure measurements (ie, minimum or trough, maximum, average concentration, and area under the concentration-time curve [AUC] at steady state) and clinical outcomes (ie, the probabilities of major bleeding [MB] and venous thromboembolism [VTE]) were modeled using NONMEM 7...
September 19, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28925687/film-confinement-induced-jump-percolation-wetting-transition-in-amphiphilic-block-copolymer-films
#3
Namrata Salunke, Asritha Nallapaneni, Guangcui Yuan, Christopher M Stafford, Hui Niu, Matthew D Shawkey, Robert A Weiss, Alamgir Karim
We report a first-order like sharp surface wettability transition with varying film thickness dependent morphology in cast films of an amphiphilic triblock copolymer. Films comprised of poly(2-(N-ethylperfluotooctanesulfonamido) ethyl methylacrylate), poly(FOSM), and poly(N,N'-dimethyl acrylamide), poly(DMA), with thickness (h) in the transition-range, 200 < h < 300 nm, exhibited an abrupt hydrophobic to hydrophilic dynamic water contact angle transition. After an induction time, ti ≈ 40 to 180 s, water contact angle varied as θc ≈ 116° to 40° with an ultra-fast contact angle decay time constant, dθc/dt ≈ -18 °/s...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925550/contemporary-concepts-in-carious-tissue-removal-a-review
#4
REVIEW
Falk Schwendicke
OBJECTIVES: Based on a changed understanding of the disease caries and its pathogenesis, strategies for carious tissue removal have changed, too. This review aims to summarize these changes and to provide clinical recommendations. OVERVIEW: Removing all carious dentin from a cavity is not needed any longer to manage caries or the carious lesion. Instead, the carious lesion should be treated in a way allowing to arrest its activity, while preserving sound tooth tissue and pulp vitality...
September 19, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28924144/south-atlantic-paleobathymetry-since-early-cretaceous
#5
Lucía Pérez-Díaz, Graeme Eagles
We present early Cretaceous to present paleobathymetric reconstructions and quantitative uncertainty estimates for the South Atlantic, offering a strong basis for studies of paleocirculation, paleoclimate and paleobiogeography. Circulation in an initially salty and anoxic ocean, restricted by the topography of the Falkland Plateau, Rio Grande Ridge and Walvis Rise, favoured deposition of thick evaporites in shallow water of the Brazilian-Angolan margins. This ceased as seafloor spreading propagated northwards, opening an equatorial gateway to shallow and intermediate circulation...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923940/defective-decidualization-during-and-after-severe-preeclampsia-reveals-a-possible-maternal-contribution-to-the-etiology
#6
Tamara Garrido-Gomez, Francisco Dominguez, Alicia Quiñonero, Patricia Diaz-Gimeno, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Pablo Padilla-Iserte, Michael McMaster, Olga Genbacev, Alfredo Perales, Susan J Fisher, Carlos Simón
In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant of the placental phenotype. We isolated human endometrial stromal cells from nonpregnant donors with a previous pregnancy that was complicated by severe PE (sPE). Compared with control cells, they failed to decidualize in vitro as demonstrated by morphological criteria and the analysis of stage-specific antigens (i...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923923/hydrologic-regulation-of-plant-rooting-depth
#7
Ying Fan, Gonzalo Miguez-Macho, Esteban G Jobbágy, Robert B Jackson, Carlos Otero-Casal
Plant rooting depth affects ecosystem resilience to environmental stress such as drought. Deep roots connect deep soil/groundwater to the atmosphere, thus influencing the hydrologic cycle and climate. Deep roots enhance bedrock weathering, thus regulating the long-term carbon cycle. However, we know little about how deep roots go and why. Here, we present a global synthesis of 2,200 root observations of >1,000 species along biotic (life form, genus) and abiotic (precipitation, soil, drainage) gradients. Results reveal strong sensitivities of rooting depth to local soil water profiles determined by precipitation infiltration depth from the top (reflecting climate and soil), and groundwater table depth from below (reflecting topography-driven land drainage)...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28921912/fate-of-worn-out-functional-teeth-in-the-upper-jaw-dentition-of-sicyopterus-japonicus-gobioidei-sicydiinae-during-tooth-replacement
#8
Noriyuki Sahara, Keita Moriyama, Midori Iida, Shun Watanabe
Mochizuki and Fukui (1983) studied the development and replacement of the upper jaw teeth in a Japanese fish species, Sicyopterus japonicus (Gobioidei: Sicydiinae), and they reported that worn-out functional teeth in the upper jaw were not shed outside the skin but were taken into the soft tissue of the upper jaw and completely resorbed there. To date, however, this phenomenon appears poorly documented. Furthermore, the mechanism for the resorption of these teeth remains to be determined. In the present study, we examined this phenomenon by using 3D micro-computed tomography (m-CT), scanning electron microscopy (SEM), and various techniques of light (LM) and electron (EM) microcopy...
September 16, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28921906/outcomes-of-severe-uveitic-glaucoma-treated-with-baerveldt-implant-can-blindness-be-prevented
#9
Annelie N Tan, Michiel F Cornelissen, Carroll A B Webers, Roel J Erckens, Tos T J M Berendschot, Henny J M Beckers
PURPOSE: To evaluate long-term outcomes on efficacy and safety of severe uveitic glaucoma treated with a Baerveldt glaucoma implant (BGI). METHODS: A retrospective study of 47 eyes of 47 patients with uveitic glaucoma treated by a BGI between September 2002 and September 2015. Main outcome measures were intraocular pressure (IOP), number of glaucoma medications, course of the uveitis, visual acuity (VA) and complications. RESULTS: Mean IOP dropped from 30...
September 18, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28921396/determination-of-dominant-sources-of-nitrate-contamination-in-transboundary-russian-federation-ukraine-catchment-with-heterogeneous-land-use
#10
Y Vystavna, D Diadin, V Grynenko, V Yakovlev, Y Vergeles, F Huneau, P M Rossi, J Hejzlar, K Knöller
Nitrate contamination of surface water and shallow groundwater was studied in transboundary (Russia/Ukraine) catchment with heterogeneous land use. Dominant sources of nitrate contamination were determined by applying a dual δ (15)N-NO3 and δ (18)O-NO3 isotope approach, multivariate statistics, and land use analysis. Nitrate concentration was highly variable from 0.25 to 22 mg L(-1) in surface water and from 0.5 to 100 mg L(-1) in groundwater. The applied method indicated that sewage to surface water and sewage and manure to groundwater were dominant sources of nitrate contamination...
September 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28920487/unilateral-dislocation-of-the-posterior-tibialis-tendon-ptt-and-flexor-digitorum-longus-tendon-with-contralateral-ptt-subluxation-in-a-patient-with-congenitally-shallow-flexor-groove
#11
Jacob E Waldron, Andrew S Bernhardson, Todd A Fellars
INTRODUCTION: Flexor tendon dislocation from the flexor tendon groove posterior of the medial malleolus has been previously described, and may be difficult to diagnose initially, but is amendable to surgical treatment with good outcomes. We present a unique case of unilateral dislocation of the posterior tibialis and flexor digitorum longus tendons with contralateral flexor digitorum longus subluxation that was treated surgically with a good outcome. CASE PRESENTATION: A 37-year-old active duty male sustained a dislocation and subluxation of the flexor tendons bilaterally after a forced dorsiflexion injury...
October 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28920138/study-on-the-sediment-characteristics-of-the-snow-in-a-typical-residential-community-and-its-integrated-biological-treatment-pattern-in-harbin
#12
Bin-Xia Xue, Tong-Yu Li, Chun-Ying Li, Li Wei, Xiao-He Hou
Winter cities have severe shortages of water resources. The effective classification and recycling of urban water resources that are available here are therefore significant for the sustainable utilization of water in winter cities, and snow is a potential water resource. In this research, the water quality of the snow and the pollutant composition in the vehicle roads of a typical residential community of Harbin are analyzed. It is concluded that there is a large amount of suspended substances, including chemical oxygen demand (COD), salt, ammonia, and oil in this snow...
September 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28919827/is-a-mechanical-assist-device-better-than-manual-chest-compression-a-randomized-controlled-trial
#13
Chaiyaporn Yuksen, Thidathit Prachanukool, Kasamon Aramvanitch, Nuttamon Thongwichit, Kittisak Sawanyawisuth, Yuwares Sittichanbuncha
BACKGROUND: Chest compression quality is a determinant of survival from sudden cardiac arrest. The CPR RsQ Assist Device (CPR RAD) is a new cardiopulmonary resuscitation device for chest compression. It is operated manually but it does not pull up on the chest on the up stroke. The aim of this study was to compare the CPR RAD with standard manual compression in terms of chest compression quality in a manikin model. METHODS: Participants were randomly assigned to either the device or manual chest compression group...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/28919151/the-combined-effects-of-ocean-warming-and-acidification-on-shallow-water-meiofaunal-assemblages
#14
Matthew R Lee, Rodrigo Torres, Patricio H Manríquez
Climate change due to increased anthropogenic CO2 in the atmosphere is causing an increase in seawater temperatures referred to as ocean warming and a decrease in seawater pH, referred to as ocean acidification. The meiofauna play an important role in the ecology of marine ecosystems and the functions they provide. Using microcosms, meiofaunal assemblages were exposed to two temperatures (15 and 19 °C) and two pHs (pCO2 of 400 and 1000 ppm), both individually and in combination, for a period of 90 days. The hypothesis that increased temperature will increase meiofaunal abundance was not supported...
September 8, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28916480/factors-associated-with-zonular-instability-during-cataract-surgery-in-eyes-with-acute-angle-closure-attack
#15
Junki Kwon, Kyung Rim Sung
PURPOSE: To compare the demographics and ocular characteristics, including anterior segment optical coherence tomography images and zonular instability in eyes with a history of acute angle closure (AAC) attack and subsequent cataract surgery. DESIGN: Retrospective, case-control study METHODS: Total 68 eyes of 56 patients with a history of AAC attack who underwent cataract surgery were enrolled. Fourteen eyes were assigned to the zonular instability (+) group and 54 were assigned to the zonular instability (-) group based on the presence of zonular instability during cataract surgery...
September 12, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28916352/baseline-evaluation-of-sediment-contamination-in-the-shallow-coastal-areas-of-saudi-arabian-red-sea
#16
Pedro Ruiz-Compean, Joanne Ellis, João Cúrdia, Richard Payumo, Ute Langner, Burton Jones, Susana Carvalho
Despite the growing recognition of the importance of water and sediment quality there is still limited information on contamination levels in many regions globally including the Red Sea. This study provides a comprehensive assessment of three classes of contaminants (Polycyclic Aromatic Hydrocarbons - PAH; metals; plastics) in coastal sediments along the Saudi Arabian Red Sea mainly collected using grabs. Background concentrations are provided for metals in the region. Concentrations of metals and PAH were generally low in comparison to international guidelines...
September 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28916282/chlorate-origin-and-fate-in-shallow-groundwater-below-agricultural-landscapes
#17
Micòl Mastrocicco, Dario Di Giuseppe, Fabio Vincenzi, Nicolò Colombani, Giuseppe Castaldelli
In agricultural lowland landscapes, intensive agricultural is accompanied by a wide use of agrochemical application, like pesticides and fertilizers. The latter often causes serious environmental threats such as N compounds leaching and surface water eutrophication; additionally, since perchlorate can be present as impurities in many fertilizers, the potential presence of perchlorates and their by-products like chlorates and chlorites in shallow groundwater could be a reason of concern. In this light, the present manuscript reports the first temporal and spatial variation of chlorates, chlorites and major anions concentrations in the shallow unconfined aquifer belonging to Ferrara province (in the Po River plain)...
September 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28915544/mobilisation-of-toxic-trace-elements-under-various-beach-nourishments
#18
Iris R Pit, Stefan C Dekker, Tobias J Kanters, Martin J Wassen, Jasper Griffioen
To enhance protection and maintain wide beaches for recreation, beaches are replenished with sand: so-called beach nourishments. We compared four sites: two traditional beach nourishments, a mega beach nourishment and a reference without beach nourishment. Two sites contain calcareous-rich sand, whereas the other two sites have calcareous-poor sand. We aimed to understand hydrogeochemical processes to indicate factors critical for the mobility of trace elements at nourishments. We therefore analysed the chemical characteristics of sediment and pore water to ascertain the main drivers that mobilise toxic trace elements...
September 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28915493/in-situ-spectral-response-of-the-arabian-gulf-and-sea-of-oman-coastal-waters-to-bio-optical-properties
#19
Maryam R Al Shehhi, Imen Gherboudj, Hosni Ghedira
Mapping of Chlorophyll-a (Chl-a) over the coastal waters of the Arabian Gulf and the Sea of Oman using the satellite-based observations, such as MODIS (Moderate Resolution Imaging Spectro-radiometer), has shown inferior performance (Chl-a overestimation) than that of deep waters. Studies in the region have shown that this poor performance is due to three reasons: (i) water turbidity (sediments re-suspension), and the presence of colored dissolved organic matter (CDOM), (ii) bottom reflectance and (iii) incapability of the existing atmospheric correction models to reduce the effect of the aerosols from the water leaving radiance...
September 6, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28915123/placental-examination-in-nonmacerated-stillbirth-versus-neonatal-mortality
#20
Jerzy Stanek
AIM: To retrospectively statistically compare clinical and placental phenotypes of nonmacerated fetuses and live-born perinatal deaths in 3rd trimester pregnancies. METHODS: Twenty-five clinical and 47 placental phenotypes were statistically compared among 93 cases of nonmacerated (intrapartum, or recent antepartum death) 3rd trimester fetal deaths (Group 1), 118 3rd trimester neonatal deaths (Group 2) and 4285 cases without perinatal mortality (Group 3). RESULTS: Sixteen clinical and placental phenotypes were statistically significantly different between Group 3 and the two groups of perinatal deaths, which included eight placental phenotypes of fetal vascular malperfusion and eight other placental phenotypes of various etiology (amnion nodosum, 2-vessel umbilical cord, villous edema, increased extracellular matrix of chorionic villi, erythroblasts in fetal blood and trophoblastic lesions of shallow placentation)...
September 18, 2017: Journal of Perinatal Medicine
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