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https://www.readbyqxmd.com/read/29149791/the-dementia-care-coordination-program-engaging-health-systems-in-caregiver-supports
#1
Pamela Nadash, Nina M Silverstein, Frank Porell
This paper reports on a process evaluation using mixed methods to assess a Dementia Care Coordination Program, which is distinctive in using the medical system, rather than direct outreach, to identify and refer families to supports provided by an Alzheimer's Association chapter via dedicated care consultants. One care consultant received referrals from individual physicians, while the other, employed by a health plan, received referrals from health plan case managers. Through key informant interviews, focus groups, and physician and caregiver surveys, we identified key issues, finding high rates of stakeholder satisfaction, but some practical issues around information sharing and data tracking...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29122515/xer1-independent-mechanisms-of-vpma-phase-variation-in-mycoplasma-agalactiae-are-triggered-by-vpma-specific-antibodies
#2
Stefan Czurda, Shivanand Manjunath Hegde, Renate Rosengarten, Rohini Chopra-Dewasthaly
Despite their small genomes mycoplasmas maintain large multigene families devoted to surface antigenic variation. Although implicated as important factors for mycoplasma pathogenicity and persistence, the role of these antigenic switches in host immune evasion has never been unequivocally proven in these minimalist microbes. Mycoplasma agalactiae exhibits antigenic variation due to Xer1-mediated site-specific DNA inversions of vpma genes encoding abundant multiple surface lipoproteins. To evaluate the biological significance of Vpma oscillations the xer1 recombinase gene has been disrupted in earlier studies to abolish Vpma switching and to generate stable phase-locked mutants (PLMs) steadily expressing a single Vpma product...
November 6, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29121509/modifications-in-lower-leg-muscle-activation-when-walking-barefoot-or-in-minimalist-shoes-across-different-age-groups
#3
Simon Franklin, François-Xavier Li, Michael J Grey
Ageing is associated with a decline in muscle strength and impaired sensory mechanisms which contribute to an increased risk of falls. Walking barefooted has been suggested to promote increased muscle strength and improved proprioceptive sensibility through better activation of foot and ankle musculature. Minimalist footwear has been marketed as a method of reaping the suggested benefits of barefoot walking whilst still providing a protective surface. The aim of this study was to investigate if walking barefoot or in minimalist footwear provokes increased muscle activation compared to walking in conventional footwear...
October 28, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29099743/local-positioning-system-using-flickering-infrared-leds
#4
Thibaut Raharijaona, Rodolphe Mawonou, Thanh Vu Nguyen, Fabien Colonnier, Marc Boyron, Julien Diperi, Stéphane Viollet
A minimalistic optical sensing device for the indoor localization is proposed to estimate the relative position between the sensor and active markers using amplitude modulated infrared light. The innovative insect-based sensor can measure azimuth and elevation angles with respect to two small and cheap active infrared light emitting diodes (LEDs) flickering at two different frequencies. In comparison to a previous lensless visual sensor that we proposed for proximal localization (less than 30 cm), we implemented: (i) a minimalistic sensor in terms of small size (10 cm 3 ), light weight (6 g) and low power consumption (0...
November 3, 2017: Sensors
https://www.readbyqxmd.com/read/29096029/safety-and-efficacy-of-minimalist-approach-in-transfemoral-transcatheter-aortic-valve-replacement-insights-from-the-optimized-transcatheter-valvular-intervention-transcatheter-aortic-valve-implantation-ocean-tavi-registry
#5
Soh Hosoba, Masanori Yamamoto, Kayoko Shioda, Mitsuru Sago, Yutaka Koyama, Tetsuro Shimura, Ai Kagase, Norio Tada, Toru Naganuma, Motoharu Araki, Futoshi Yamanaka, Shinichi Shirai, Yusuke Watanabe, Kentaro Hayashida
OBJECTIVES: Favourable results have been reported for monitored anaesthesia care that includes local anaesthesia and conscious sedation [minimalist approach (MA)] for transfemoral transcatheter aortic valve replacement (TAVR). However, the efficacy of MA is still controversial in Japan. We describe our experience from a Japanese multicentre registry. METHODS: Between October 2013 and April 2016, 1215 consecutive Japanese patients with symptomatic, severe aortic stenosis undergoing TAVR with self-expandable or balloon-expandable valves were prospectively included in the Optimized transCathEter vAlvular intervention-Transcatheter Aortic Valve Implantation (OCEAN-TAVI) registry...
October 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29094938/rational-synthesis-of-2-bromoporphyrins-and-2-12-dibromoporphyrins
#6
Anna-Bea Bornhof, Ruisheng Xiong, Katalin Eszter Borbas
Bromoporphyrins were prepared by the metal-mediated self-condensation of brominated 1-formyldipyrromethanes. Depending on the conditions, Mg(II)-2,12-dibromoporphyrin and Mg(II)-2-bromoporphyrin could be obtained in up to 11% and 17% isolated yield, respectively. Zn(II) was also a viable templating metal. The positions of the bromine substituents were confirmed by 2D-NMR spectroscopic analysis and the X-ray crystal structure of a derivative. Suzuki and Sonogashira reactions of the bromoporphyrins yielded 2-substituted or 2,12-disubstituted porphyrins with red-shifted absorption and emission spectra...
November 2, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29083911/comics-cartoon-visualization-of-omics-data-in-spatial-context-using-anatomical-ontologies
#7
Dmitrii Travin, Iaroslav Popov, Arzu Tugce Guler, Dmitry Medvedev, Suzanne van der Plas-Duivesteijn, Monica Varela, Iris C R M Kolder, Annemarie H Meijer, Herman P Spaink, Magnus Palmblad
COMICS is an interactive and open-access Web platform for integration and visualization of molecular expression data in anatomograms of zebrafish, carp and mouse model systems. Anatomical ontologies are used to map omics data across experiments and between an experiment and a particular visualization in a data dependent manner. COMICS is built on top of several existing resources. Zebrafish and mouse anatomical ontologies with their controlled vocabulary (CV) and defined hierarchy are used with the ontoCAT R package to aggregate data for comparison and visualization...
October 30, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29079775/a-minimalist-approach-to-stereoselective-glycosylation-with-unprotected-donors
#8
Kim Le Mai Hoang, Jing-Xi He, Gábor Báti, Mary B Chan-Park, Xue-Wei Liu
Mechanistic study of carbohydrate interactions in biological systems calls for the chemical synthesis of these complex structures. Owing to the specific stereo-configuration at each anomeric linkage and diversity in branching, significant breakthroughs in recent years have focused on either stereoselective glycosylation methods or facile assembly of glycan chains. Here, we introduce the unification approach that offers both stereoselective glycosidic bond formation and removal of protection/deprotection steps required for further elongation...
October 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29064073/genuine-participation-in-participant-centred-research-initiatives-the-rhetoric-and-the-potential-reality
#9
Oliver Feeney, Pascal Borry, Heike Felzmann, Lucia Galvagni, Ari Haukkala, Michele Loi, Salvör Nordal, Vojin Rakic, Brígida Riso, Sigrid Sterckx, Danya Vears
The introduction of Web 2.0 technology, along with a population increasingly proficient in Information and Communications Technology (ICT), coupled with the rapid advancements in genetic testing methods, has seen an increase in the presence of participant-centred research initiatives. Such initiatives, aided by the centrality of ICT interconnections, and the ethos they propound seem to further embody the ideal of increasing the participatory nature of research, beyond what might be possible in non-ICT contexts alone...
October 24, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/29062749/transcatheter-aortic-valve-implantation-in-nonagenarians-selectively-feasible-or-extravagantly-futile
#10
Antonis S Manolis, Antonis A Manolis
A growing number of nonagenarians is recorded as life expectancy increases. Unfortunately, this extreme-aged group is plagued by increased prevalence of aortic stenosis amidst a higher occurrence of comorbidities that pose dilemmas to cardiologists and cardiac surgeons when having to choose a conservative or interventional treatment modality, and a surgical or transcatheter aortic valve implantation (TAVI) approach. TAVI is an expensive procedure, which also confers a higher mortality and morbidity risk in nonagenarians, compared to younger patients...
September 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29057965/a-minimalistic-and-optimized-conveyor-belt-for-neutral-atoms
#11
Ritayan Roy, Paul C Condylis, Vindhiya Prakash, Daniel Sahagun, Björn Hessmo
Here we report of a design and the performance of an optimized micro-fabricated conveyor belt for precise and adiabatic transportation of cold atoms. A theoretical model is presented to determine optimal currents in conductors used for the transportation. We experimentally demonstrate a fast adiabatic transportation of Rubidium ((87)Rb) cold atoms with minimal loss and heating with as few as three conveyor belt conductors. This novel design of a multilayered conveyor belt structure is fabricated in aluminium nitride (AlN) because of its outstanding thermal and electrical properties...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29055967/reductive-evolution-in-outer-membrane-protein-biogenesis-has-not-compromised-cell-surface-complexity-in-helicobacter-pylori
#12
Chaille T Webb, Dilini Chandrapala, Siti Nurbaya Oslan, Rebecca S Bamert, Rhys D Grinter, Rhys A Dunstan, Rebecca J Gorrell, Jiangning Song, Richard A Strugnell, Trevor Lithgow, Terry Kwok
Helicobacter pylori is a gram-negative bacterial pathogen that chronically inhabits the human stomach. To survive and maintain advantage, it has evolved unique host-pathogen interactions mediated by Helicobacter-specific proteins in the bacterial outer membrane. These outer membrane proteins (OMPs) are anchored to the cell surface via a C-terminal β-barrel domain, which requires their assembly by the β-barrel assembly machinery (BAM). Here we have assessed the complexity of the OMP C-terminal β-barrel domains employed by H...
October 21, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29054746/the-influence-of-cadence-and-shoes-on-patellofemoral-joint-kinetics-in-runners-with-patellofemoral-pain
#13
Jason Bonacci, Michelle Hall, Aaron Fox, Natalie Saunders, Tristan Shipsides, Bill Vicenzino
OBJECTIVES: To determine the effect of a combination of a minimalist shoe and increased cadence on measures of patellofemoral joint loading during running in individuals with patellofemoral pain. DESIGN: Within-participant repeated measures with four conditions presented in random order: (1) control shoe at preferred cadence; (2) control shoe with +10% cadence; (3) minimalist shoe at preferred cadence; (4) minimalist shoe with +10% cadence. METHODS: Fifteen recreational runners with patellofemoral pain ran on an instrumented treadmill while three-dimensional motion capture data were acquired...
October 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29031271/two-dimensional-mixture-of-amphiphilic-dimers-and-spheres-self-assembly-behaviour
#14
Santi Prestipino, Gianmarco Munaò, Dino Costa, Giuseppe Pellicane, Carlo Caccamo
The emergence of supramolecular aggregates from simple microscopic interaction rules is a fascinating feature of complex fluids which, besides its fundamental interest, has potential applications in many areas, from biological self-assembly to smart material design. We here investigate by Monte Carlo simulation the equilibrium structure of a two-dimensional mixture of asymmetric dimers and spheres (disks). Dimers and disks are hard particles, with an additional short-range attraction between a disk and the smaller monomer of a dimer...
October 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29020108/influence-of-sports-flooring-and-shoes-on-impact-forces-and-performance-during-jump-tasks
#15
Laurent Malisoux, Paul Gette, Axel Urhausen, Joao Bomfim, Daniel Theisen
We aim to determine the influence of sports floorings and sports shoes on impact mechanics and performance during standardised jump tasks. Twenty-one male volunteers performed ankle jumps (four consecutive maximal bounds with very dynamic ankle movements) and multi-jumps (two consecutive maximal counter-movement jumps) on force plates using minimalist and cushioned shoes under 5 sports flooring (SF) conditions. The shock absorption properties of the SF, defined as the proportion of peak impact force absorbed by the tested flooring when compared with a concrete hard surface, were: SF0 = 0% (no flooring), SF1 = 19%, SF2 = 26%, SF3 = 37% and SF4 = 45%...
2017: PloS One
https://www.readbyqxmd.com/read/28993130/gait-retraining-versus-foot-orthoses-for-patellofemoral-pain-a-pilot-randomised-clinical-trial
#16
Jason Bonacci, Michelle Hall, Natalie Saunders, Bill Vicenzino
OBJECTIVES: To determine the feasibility of a clinical trial that compares a 6-week, physiotherapist-guided gait retraining program with a foot orthoses intervention in runners with patellofemoral pain. DESIGN: Pilot randomised controlled trial. METHODS: Runners aged 18-40 years with clinically diagnosed patellofemoral pain were randomly allocated to either a 6-week gait retraining intervention of increasing cadence and use of a minimalist shoe or prefabricated foot orthoses...
October 2, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28987031/using-minimalist-self-assembling-peptides-as-hierarchical-scaffolds-to-stabilize-growth-factors-and-promote-stem-cell-integration-in-the-injured-brain
#17
A L Rodriguez, K F Bruggeman, Y Wang, T Y Wang, R J Williams, C L Parish, D R Nisbet
Neurotrophic growth factors are effective in slowing progressive degeneration and/or promoting neural repair through the support of residual host and/or transplanted neurons. However, limitations including short half-life and enzyme susceptibility of growth factors highlight the need for alternative strategies to prolong localised delivery at a site of injury. Here, we establish the utility of minimalist N-fluorenylmethyloxycarbonyl (Fmoc) self-assembling peptides (SAPs) as growth factor delivery vehicle, targeted at supporting neural transplants in an animal model of Parkinson's disease...
October 7, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28942382/transcatheter-aortic-valve-implantation-in-2017-state-of-the-art
#18
Marco Barbanti, John G Webb, Martine Gilard, Davide Capodanno, Corrado Tamburino
In the last 15 years, transcatheter aortic valve implantation (TAVI) technology has met with rapid uptake, with >350,000 procedures performed in >70 countries. Over the same period, this technique has evolved from a challenging intervention to a standardised, simple, and streamlined procedure. The purpose of this review article is to provide an overview on the rapidly changing field of TAVI therapy, exploring past achievements, current issues and future perspectives. The discussion has been subdivided into three sections: 1) the evolution of clinical and anatomical indications for TAVI, 2) the description of procedural advances and complication rate trends over time, and 3) the progressive adoption of a minimalist approach...
September 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28934499/co-produced-natural-ketolides-methymycin-and-pikromycin-inhibit-bacterial-growth-by-preventing-synthesis-of-a-limited-number-of-proteins
#19
Mashal M Almutairi, Maxim S Svetlov, Douglas A Hansen, Nelli F Khabibullina, Dorota Klepacki, Han-Young Kang, David H Sherman, Nora Vázquez-Laslop, Yury S Polikanov, Alexander S Mankin
Antibiotics methymycin (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae, represent minimalist macrolide protein synthesis inhibitors. Unlike other macrolides, which carry several side chains, a single desosamine sugar is attached to the macrolactone ring of MTM and PKM. In addition, the macrolactone scaffold of MTM is smaller than in other macrolides. The unusual structure of MTM and PKM and their simultaneous secretion by S. venezuelae bring about the possibility that two compounds would bind to distinct ribosomal sites...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28932856/on-the-apparent-yield-stress-in-non-brownian-magnetorheological-fluids
#20
Daniel Vågberg, Brian P Tighe
We use simulations to probe the flow properties of dense two-dimensional magnetorheological fluids. Prior results from both experiments and simulations report that the shear stress σ scales with strain rate [small gamma, Greek, dot above] as σ ∼ [small gamma, Greek, dot above](1-Δ), with values of the exponent ranging between 2/3 < Δ ≤ 1. However it remains unclear what properties of the system select the value of Δ, and in particular under what conditions the system displays a yield stress (Δ = 1)...
October 11, 2017: Soft Matter
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