keyword
MENU ▼
Read by QxMD icon Read
search

minimalist

keyword
https://www.readbyqxmd.com/read/28641120/the-cognitive-bases-of-the-development-of-past-and-future-episodic-cognition-in-preschoolers
#1
Gülten Ünal, Annette Hohenberger
The aim of this study was to use a minimalist framework to examine the joint development of past and future episodic cognition and their underlying cognitive abilities in 3- to 5-year-old Turkish preschoolers. Participants engaged in two main tasks, a what-where-when (www) task to measure episodic memory and a future prediction task to measure episodic future thinking. Three additional tasks were used for predicting children's performance in the two main tasks: a temporal language task, an executive function task, and a spatial working memory task...
June 19, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28641058/acute-kinematics-changes-in-marathon-runners-using-different-footwear
#2
Tania Socorro Amorim Soares, Camila Fonseca de Oliveira, Federico Pizzuto, Rui Manuel Garganta, João Paulo Vila-Boas, Mario Casimiro da Anunciação Paiva
The effects of running with or without shoes on injury prevention have been extensively studied, and several investigations have assessed biomechanical differences between them. However, findings are not consensual and further insights on biomechanical load associated with differently shod or barefoot conditions may be needed. This study aimed to observe if habitually shod marathon runners show acute alterations when running barefoot or with minimalist shoes, and to determine whether the running kinematical adaptations of wearing minimalist shoes were similar to barefoot running...
June 22, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28637918/direct-enzymatic-bioelectrocatalysis-differentiating-between-myth-and-reality
#3
REVIEW
Ross D Milton, Shelley D Minteer
Enzymatic bioelectrocatalysis is being increasingly exploited to better understand oxidoreductase enzymes, to develop minimalistic yet specific biosensor platforms, and to develop alternative energy conversion devices and bioelectrosynthetic devices for the production of energy and/or important chemical commodities. In some cases, these enzymes are able to electronically communicate with an appropriately designed electrode surface without the requirement of an electron mediator to shuttle electrons between the enzyme and electrode...
June 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28630961/a-biocatalytic-and-thermoreversible-hydrogel-from-a-histidine-containing-tripeptide
#4
A M Garcia, M Kurbasic, S Kralj, M Melchionna, S Marchesan
We report the first histidine-containing self-assembling tripeptide devoid of capping groups that forms a thermoreversible hydrogel under physiological conditions and catalyses hydrolysis of an ester, providing a minimalist building block for functional soft materials.
June 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28630154/design-of-self-assembling-transmembrane-helical-bundles-to-elucidate-principles-required-for-membrane-protein-folding-and-ion-transport
#5
REVIEW
Nathan H Joh, Gevorg Grigoryan, Yibing Wu, William F DeGrado
Ion transporters and channels are able to identify and act on specific substrates among myriads of ions and molecules critical to cellular processes, such as homeostasis, cell signalling, nutrient influx and drug efflux. Recently, we designed Rocker, a minimalist model for Zn(2+)/H(+) co-transport. The success of this effort suggests that de novo membrane protein design has now come of age so as to serve a key approach towards probing the determinants of membrane protein folding, assembly and function. Here, we review general principles that can be used to design membrane proteins, with particular reference to helical assemblies with transport function...
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28600550/permeability-driven-selection-in-a-semi-empirical-protocell-model-the-roots-of-prebiotic-systems-evolution
#6
Gabriel Piedrafita, Pierre-Alain Monnard, Fabio Mavelli, Kepa Ruiz-Mirazo
The origin-of-life problem has been traditionally conceived as the chemical challenge to find the type of molecule and free-solution reaction dynamics that could have started Darwinian evolution. Different autocatalytic and 'self-replicative' molecular species have been extensively investigated, together with plausible synthetic pathways that might have led, abiotically, to such a minimalist scenario. However, in addition to molecular kinetics or molecular evolutionary dynamics, other physical and chemical constraints (like compartmentalization, differential diffusion, selective transport, osmotic forces, energetic couplings) could have been crucial for the cohesion, functional integration, and intrinsic stability/robustness of intermediate systems between chemistry and biology...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521711/mini-heme-proteins-designability-of-structure-and-diversity-of-functions
#7
Jagdish Rai
Natural heme proteins may have heme bound to poly-peptide chain as a cofactor via non-covalent forces or heme as a prosthetic group may be covalently bound to the proteins. Nature has used porphyrins in diverse functions like electron transfer, oxidation, reduction, ligand binding, photosynthesis, signaling, etc. by modulating its properties through diverse protein matrices. Synthetic chemists have tried to utilize these molecules in equally diverse industrial and medical applications due to their versatile electro-chemical and optical properties...
May 15, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28516104/minimalist-trans-aneurysmal-approach-to-coronary-button-pseudoaneurysm
#8
EDITORIAL
John A Elefteriades, Gary S Kopf, Bulat A Ziganshin
No abstract text is available yet for this article.
December 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28513898/synthesis-of-bodipy-labelled-cholesterylated-glycopeptides-by-tandem-click-chemistry-for-glycocalyxification-of-giant-unilamellar-vesicles-guvs
#9
Nicolai Stuhr-Hansen, Charikleia-Despoina Vagianou, Ola Blixt
The glycocalyx cover membrane surfaces of all living cells. These complex archtechtures render their interaction mechanisms on the membrane surface difficult to study. Artificial cell-sized membranes with selected and defined glycosylation patterns may serve as a minimalistic approach to systematically study cell surface glycan interactions. Here we developed a facile general synthetic procedure for the synthesis of BODIPY-labelled cholesterylated glycopeptides, which can coat cell-size giant unilamellar vesicles (GUVs)...
May 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28513558/from-cell-to-beak-in-vitro-and-in-vivo-characterization-of-chicken-bitter-taste-thresholds
#10
Shira Cheled-Shoval, Maik Behrens, Ayelet Korb, Antonella Di Pizio, Wolfgang Meyerhof, Zehava Uni, Masha Y Niv
Bitter taste elicits an aversive reaction, and is believed to protect against consuming poisons. Bitter molecules are detected by the Tas2r family of G-protein-coupled receptors, with a species-dependent number of subtypes. Chickens demonstrate bitter taste sensitivity despite having only three bitter taste receptors-ggTas2r1, ggTas2r2 and ggTas2r7. This minimalistic bitter taste system in chickens was used to determine relationships between in-vitro (measured in heterologous systems) and in-vivo (behavioral) detection thresholds...
May 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28487073/a-minimalistic-tetrapeptide-amphiphile-scaffold-for-transmembrane-pores-with-a-preference-for-sodium
#11
Debajyoti Basak, Sucheta Sridhar, Amal K Bera, Nandita Madhavan
Synthetic channels or pores that are easy to synthesize, stable and cation-selective are extremely attractive for the development of therapeutics and materials. Herein, we report a pore developed from a small tetrapeptide scaffold that shows a preference for sodium over lithium/potassium. The sodium selectivity is attributed to the appended oligoether tail at the C-terminus. A peptide dimer is proposed as the predominant cation-transporting pore. Such pyridine containing stable pores can be potentially utilized for the pH modulated ion transport...
April 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28483557/six-week-transition-to-minimalist-shoes-improves-running-economy-and-time-trial-performance
#12
Joel T Fuller, Dominic Thewlis, Margarita D Tsiros, Nicholas A T Brown, Jonathan D Buckley
OBJECTIVES: This study investigated if gradually introducing runners to minimalist shoes during training improved running economy and time-trial performance compared to training in conventional shoes. Changes in stride rate, stride length, footfall pattern and ankle plantar-flexor strength were also investigated. DESIGN: Randomised parallel intervention trial. METHODS: 61 trained runners gradually increased the amount of running performed in either minimalist (n=31) or conventional (n=30) shoes during a six-week standardised training program...
April 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28481275/porcine-circovirus-type-2-pcv2-vaccines-in-the-context-of-current-molecular-epidemiology
#13
REVIEW
Anbu K Karuppannan, Tanja Opriessnig
Porcine circovirus type 2 (PCV2) is an economically important swine pathogen and, although small, it has the highest evolution rate among DNA viruses. Since the discovery of PCV2 in the late 1990s, this minimalistic virus with a 1.7 kb single-stranded DNA genome and two indispensable genes has become one of the most important porcine pathogens, and presently is subjected to the highest volume of prophylactic intervention in the form of vaccines in global swine production. PCV2 can currently be divided into five different genotypes, PCV2a through PCV2e...
May 6, 2017: Viruses
https://www.readbyqxmd.com/read/28476622/green-fluorescence-protein-based-content-mixing-assay-of-snare-driven-membrane-fusion
#14
Paul Heo, Byoungjae Kong, Young-Hun Jung, Joon-Bum Park, Jonghyeok Shin, Myungseo Park, Dae-Hyuk Kweon
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins mediate intracellular membrane fusion by forming a ternary SNARE complex. A minimalist approach utilizing proteoliposomes with reconstituted SNARE proteins yielded a wealth of information pinpointing the molecular mechanism of SNARE-mediated fusion and its regulation by accessory proteins. Two important attributes of a membrane fusion are lipid-mixing and the formation of an aqueous passage between apposing membranes. These two attributes are typically observed by using various fluorescent dyes...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28456166/modular-topology-emerges-from-plasticity-in-a-minimalistic-excitable-network-model
#15
Fabrizio Damicelli, Claus C Hilgetag, Marc-Thorsten Hütt, Arnaud Messé
Topological features play a major role in the emergence of complex brain network dynamics underlying brain function. Specific topological properties of brain networks, such as their modular organization, have been widely studied in recent years and shown to be ubiquitous across spatial scales and species. However, the mechanisms underlying the generation and maintenance of such features are still unclear. Using a minimalistic network model with excitable nodes and discrete deterministic dynamics, we studied the effects of a local Hebbian plasticity rule on global network topology...
April 2017: Chaos
https://www.readbyqxmd.com/read/28445034/dual-in-tether-chiral-centers-modulate-peptide-helicity
#16
Kuan Hu, Chengjie Sun, Mengying Yu, Wenjun Li, Huacan Lin, Jialin Guo, Yixiang Jiang, Chengxiang Lei, Zigang Li
The facile chemical modification on the peptide cross-linking moiety is an important strategy for improving the physicochemical properties of a peptide. Herein, peptides were constrained into helical conformations via the synergistic effects of dual in-tether chiral centers. A pentapeptide minimalistic model was used to determine the correlation between the absolute configurations of the dual in-tether chiral centers and the secondary structures of the peptides. This strategy provides an on-tether modification site that does not interrupt the secondary structure of the peptide...
May 4, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28438724/toward-a-more-usable-home-based-video-telemedicine-system-a-heuristic-evaluation-of-the-clinician-user-interfaces-of-home-based-video-telemedicine-systems
#17
Sruthy Agnisarman, Shraddhaa Narasimha, Kapil Chalil Madathil, Brandon Welch, Fnu Brinda, Aparna Ashok, James McElligott
BACKGROUND: Telemedicine is the use of technology to provide and support health care when distance separates the clinical service and the patient. Home-based telemedicine systems involve the use of such technology for medical support and care connecting the patient from the comfort of their homes with the clinician. In order for such a system to be used extensively, it is necessary to understand not only the issues faced by the patients in using them but also the clinician. OBJECTIVES: The aim of this study was to conduct a heuristic evaluation of 4 telemedicine software platforms-Doxy...
April 24, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28436963/a-sting-activating-nanovaccine-for-cancer-immunotherapy
#18
Min Luo, Hua Wang, Zhaohui Wang, Haocheng Cai, Zhigang Lu, Yang Li, Mingjian Du, Gang Huang, Chensu Wang, Xiang Chen, Matthew R Porembka, Jayanthi Lea, Arthur E Frankel, Yang-Xin Fu, Zhijian J Chen, Jinming Gao
The generation of tumour-specific T cells is critically important for cancer immunotherapy. A major challenge in achieving a robust T-cell response is the spatiotemporal orchestration of antigen cross-presentation in antigen-presenting cells with innate stimulation. Here, we report a minimalist nanovaccine, comprising a simple physical mixture of an antigen and a synthetic polymeric nanoparticle, PC7A NP, which generates a strong cytotoxic T-cell response with low systemic cytokine expression. Mechanistically, the PC7A NP achieves efficient cytosolic delivery of tumour antigens to antigen-presenting cells in draining lymph nodes, leading to increased surface presentation while simultaneously activating type I interferon-stimulated genes...
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28417667/immediate-and-short-term-biomechanical-adaptation-of-habitual-barefoot-runners-who-start-shod-running
#19
Ivan P H Au, Fannie O Y Lau, Winko W An, Janet H Zhang, Tony L Chen, Roy T H Cheung
This study investigated the immediate and short-term effects of minimalist shoes (MS) and traditional running shoes (TRS) on vertical loading rates, foot strike pattern and lower limb kinematics in a group of habitual barefoot runners. Twelve habitual barefoot runners were randomly given a pair of MS or TRS and were asked to run with the prescribed shoes for 1 month. Outcome variables were obtained before, immediate after and 1 month after shoe prescription. Average and instantaneous vertical loading rates at the 1-month follow-up were significantly higher than that at the pre-shod session (P < 0...
April 18, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28376250/supramolecular-hydrogels-based-on-minimalist-amphiphilic-squaramide-squaramates-for-controlled-release-of-zwitterionic-biomolecules
#20
Carlos López, Marta Ximenis, Francisca Orvay, Carmen Rotger, Antonio Costa
Supramolecular hydrogels with tunable properties have innovative applications in biomedicine, catalysis, and materials chemistry. Minimalist low-molecular-weight hydrogelators based on squaramide and squaramic acid motifs have been designed. This approach benefits from the high acidity of squaramic acids and the aromaticity of squaramides. Moreover, substituents on the aryl ring tune the π density of the arylsquaramide motif. Thus, materials featuring distinct thermal and mechanical properties have been successfully prepared...
April 4, 2017: Chemistry: a European Journal
keyword
keyword
82375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"