keyword
MENU ▼
Read by QxMD icon Read
search

minimalist

keyword
https://www.readbyqxmd.com/read/28923694/outcomes-of-transcatheter-aortic-valve-replacement-using-a-minimalist-approach
#1
Sergey Gurevich, Brett Oestreich, Rosemary F Kelly, Mackenzie Mbai, Stefan Bertog, Karen Ringsred, Annette Lawton, Brenda Thooft, Julie Wagner, Santiago Garcia
BACKGROUND: Transcatheter Aortic Valve Replacement (TAVR) is increasingly performed using a minimalist approach under monitored anesthesia care (MAC). The safety of this approach remains controversial and adoption has been low in the US. METHODS: The study cohort was comprised of 130 patients (98% male) who underwent TAVR between 4/2015 and 4/2017 at the Minneapolis VA. We compared the outcomes of 81 patients who underwent TAVR using a standard approach (standard TAVR) and 49 who underwent TAVR using a minimalist approach (minimalist TAVR)...
August 12, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28922990/streamlined-system-for-conducting-in-vitro-studies-using-decellularized-kidney-scaffolds
#2
Andrew Reyes Padalhin, Chanmi Park, Byong-Taek Lee
Kidney regeneration is a complex process that can only be studied in vitro at a limited capacity due to the inherent structural and functional complexity of its tissues. Thus, a suitable platform for conducting cellular response and development should be established from decellularized tissues with intact microarchitecture. In this study, a modular streamlined system was developed to allow manageable handling and set-up of in vitro studies using decellularized rat kidneys. The system is composed of commercially available parts that can be reused, interchanged, and re-configured based on the desired experimental stage and process...
September 19, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28916956/transitioning-to-minimal-footwear-a-systematic-review-of-methods-and-future-clinical-recommendations
#3
REVIEW
Joe P Warne, Allison H Gruber
BACKGROUND: Recent interest in barefoot running has led to the development of minimalist running shoes that are popular in distance runners. A careful transition to these shoes has been suggested and examined in the literature. However, no guidelines based on systematic evidence have been presented. The purpose of this review is to systematically examine the methods employed in the literature to transition to minimal footwear (MFW), as well as the outcomes to these studies in distance runners...
September 15, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28887110/percutaneous-decommissioning-of-left-ventricular-assist-device
#4
Jia-Lin Soon, Ju-Le Tan, Choon-Pin Lim, Teing-Ee Tan, Swee-Yaw Tan, Ka-Lee Kerk, Kheng-Leng David Sim, Cumaraswamy Sivathasan
BACKGROUND: The Left Ventricular Assist Device (LVAD) has revolutionised our treatment of advanced stage heart failure, giving debilitated patients a new lease on life. A small proportion of these LVAD patients can be bridged-to-recovery. The identification of these patients and decision to wean, however, can be challenging. METHODS: The need to fully explant the device upon recovery has evolved to a minimalist approach aiming to avoid injury to the 'recovered' heart...
August 19, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28882205/de-novo-design-of-iron-sulfur-proteins
#5
Zahra B Dizicheh, Nicholas Halloran, William Asma, Giovanna Ghirlanda
Iron-sulfur proteins are one of the most abundant and functionally pliable redox proteins found in all living organisms. Because of their crucial role in mediating electron transfer processes, minimalist model systems have been developed as a proxy to study natural Fe-S redox proteins and to dissect rules to enable tuning of their redox and electron transfer activities. This goal has been pursued through computational design, mutagenesis in the first and second coordination sphere, metal substitution, cofactor replacement, and the use of unnatural amino acids to stabilize a given cluster...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28876928/md-simulations-of-viruslike-particles-with-supra-cg-solvation-affordable-to-desktop-computers
#6
Matı As R Machado, Humberto C González, Sergio Pantano
Viruses are tremendously efficient molecular devices that optimize the packing of genetic material using a minimalistic number of proteins to form a capsid or envelope that protects them from external threats, being also part of cell recognition, fusion, and budding machineries. Progress in experimental techniques has provided a large number of high-resolution structures of viruses and viruslike particles (VLP), while molecular dynamics simulations may furnish lively and complementary insights on the fundamental forces ruling viral assembly, stability, and dynamics...
September 20, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28861382/minimalist-breast-conserving-surgical-approaches-for-inferiorly-sited-cancers
#7
Mona P Tan
Contemporary data suggests that breast conservation treatment (BCT) may confer a survival advantage when compared to mastectomy. Hence, it would be logical to adopt strategies which increase eligibility of successful BCT without compromising oncologic principles or cosmetic outcome. With respect to achieving good aesthetics, inferiorly sited breast cancers pose a particular technical challenge. A vast array of techniques, collectively referred to as oncoplastic breast surgery (OBS) have been developed to minimise post treatment distortion...
August 2017: Gland Surgery
https://www.readbyqxmd.com/read/28859722/validation-of-a-new-system-using-tracheal-body-sound-and-movement-data-for-automated-apnea-hypopnea-index-estimation
#8
Christoph Kalkbrenner, Manuel Eichenlaub, Stefan Rüdiger, Cornelia Kropf-Sanchen, Rainer Brucher, Wolfgang Rottbauer
STUDY OBJECTIVES: The current gold standard for assessment of obstructive sleep apnea is the in-laboratory polysomnography. This approach has high costs and inconveniences the patient, whereas alternative ambulatory systems are limited by reduced diagnostic abilities (type 4 monitors, 1 or 2 channels) or extensive setup (type 3 monitors, at least 4 channels). The current study therefore aims to validate a simplified automated type 4 monitoring system using tracheal body sound and movement data...
August 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28856890/cyclic-dipeptide-based-ambidextrous-supergelators-minimalistic-rational-design-structure-gelation-studies-and-in-situ-hydrogelation
#9
Shivaprasad Manchineella, N Arul Murugan, Thimmaiah Govindaraju
Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic properties. Intermolecular hydrogen bonding, the major driving force for gelation was evaluated using temperature-dependent nuclear magnetic resonance (NMR) spectroscopy. The contribution of attractive van der Waals interaction of tBoc group in driving CDP gelation was ascertained using β-cyclodextrin (β-CD)-adamantane carboxylic acid (AC)-based host-guest gelation and (1)H NMR studies...
September 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28853317/shoe-drop-reduction-influences-the-lower-limb-biomechanics-of-children-tennis-players-during-an-open-stance-forehand-a-longitudinal-study
#10
Alexis Herbaut, Emilie Simoneau-Buessinger, Franck Barbier, Christophe Gillet, Maxime Roux, Nils GuéGuen, Pascale Chavet
Compared to traditional tennis shoes, using 0-drop shoes was shown to induce an immediate switch from rear- to forefoot strike pattern to perform an open stance tennis forehand for 30% of children tennis players. The purpose of the study was to examine the long-term effects of a gradual reduction in the shoe drop on the biomechanics of children tennis players performing open stance forehands. Thirty children tennis players participated in 2 laboratory biomechanical test sessions (intermediate: +4 months and final: +8 months) after an inclusion visit where they were randomly assigned to control (CON) or experimental (EXP) group...
August 30, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28836345/safety-of-shorter-length-of-hospital-stay-for-patients-undergoing-minimalist-transcatheter-aortic-valve-replacement
#11
Ahmad Alkhalil, Harveen Lamba, Salil Deo, Hiram G Bezerra, Sandeep M Patel, Alan Markowitz, Daniel I Simon, Marco A Costa, Angela C Davis, Guilherme F Attizzani
OBJECTIVE: Determine the feasibility and predictors of early discharge after minimalist transcatheter aortic valve replacement (TAVR). BACKGROUND: Duration of hospitalization has a direct impact on overall cost of care, but the clinical impact of length of stay (LOS) in patients undergoing minimalist TAVR remains unclear. METHODS: We studied 268 patients who underwent minimalist TAVR. Short LOS (sLOS) was defined as post-procedural LOS ≤ 3 days and observed in 163 patients...
August 24, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28828046/modern-use-of-echocardiography-in-transcatheter-aortic-valve-replacement-an-up-date
#12
Cristina Caldararu, Serban Balanescu
Echocardiography is the cornerstone in the diagnosis of any valvular heart disease. The accurate diagnosis of aortic stenosis, the left ventricle function and the other heart valves evaluation are currently done by ultrasound alone. Prosthetic valve choice and dimensions prior to implantation can be done solely by proper use of echocardiography. The emergence of new methods to cure aortic stenosis such as trans-catheter aortic valve replacement (TAVR) emphasized the diagnostic value of cardiac ultrasound. The usefulness of echocardiography in TAVR can be divided in the baseline assessment (common to patients treated by conventional surgery), intra-procedural guidance of valve deployment and post-procedural follow-up...
December 2016: Mædica
https://www.readbyqxmd.com/read/28820605/body-sovereignty-and-body-liability-in-the-wake-of-an-obesity-epidemic-a-poststructural-analysis-of-the-soda-ban
#13
Sonia R Ivancic
Public discourse about the 2012 soda ban proposal and its eventual dissolution offers a useful context for interrogating how discursive processes constitute and regulate normality, risk, and obesity. Using poststructural sensibilities, I critique the soda ban and public discourse about it. Although architects of the soda ban and its proponents challenged the neoliberal narrative of free choice by self-governing citizens, their efforts were stymied by (1) arguments that offered a minimalist role for the state in regulating health, and (2) contemporary anxieties about losing the ability to self-determine what to let into the body...
August 18, 2017: Health Communication
https://www.readbyqxmd.com/read/28814172/novel-endovascular-management-of-proximal-type-a-debakey-ii-aortic-dissection-with-a-patent-foramen-ovale-occluder
#14
Xun Yuan, Andreas Mitsis, David Mozalbat, Christoph A Nienaber
PURPOSE: To present a novel endovascular management option that avoids open surgery in selected patients with subacute type A aortic dissection (DeBakey II). CASE REPORT: A 75-year-old woman with previous infrarenal abdominal aortic aneurysm repaired in 2006 and multiple comorbidities (EURO score II 20.5%) was admitted with chest pain; computed tomography angiography (CTA) showed a new dissection in the ascending aorta just above the right coronary ostium. As the patient was considered unfit to undergo surgery, an endovascular solution was suggested after multidisciplinary team discussion...
August 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28813995/a-novel-human-effort-estimation-method-for-knee-assistive-exoskeletons
#15
Lorenzo Saccares, Anais Brygo, Ioannis Sarakoglou, Nikos G Tsagarakis
In this work we present a novel method to estimate online the torques at the knee joints with the goal to generate reference signals for knee assistive devices. One of the main advantages of the proposed approach is its reduced sensing requirements, which leads to an ergonomic setup with minimal instrumentation, especially above the knee and of the upper body. Indeed, only the measurement of the forces and torques exchanged between the ground and the user's feet, the posture of the shanks, and the model of the user's shank itself are needed for the estimation of the knee torque...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28811548/ligand-binding-modes-from-low-resolution-gpcr-models-and-mutagenesis-chicken-bitter-taste-receptor-as-a-test-case
#16
Antonella Di Pizio, Louisa-Marie Kruetzfeldt, Shira Cheled-Shoval, Wolfgang Meyerhof, Maik Behrens, Masha Y Niv
Bitter taste is one of the basic taste modalities, warning against consuming potential poisons. Bitter compounds activate members of the bitter taste receptor (Tas2r) subfamily of G protein-coupled receptors (GPCRs). The number of functional Tas2rs is species-dependent. Chickens represent an intriguing minimalistic model, because they detect the bitter taste of structurally different molecules with merely three bitter taste receptor subtypes. We investigated the binding modes of several known agonists of a representative chicken bitter taste receptor, ggTas2r1...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28809973/competitive-affinity-based-proteome-profiling-and-imaging-to-reveal-potential-cellular-targets-of-betulinic-acid
#17
Haijun Guo, Jiaqian Xu, Piliang Hao, Ke Ding, Zhengqiu Li
Betulinic acid (BA), a pentacyclic triterpenoid natural product, has received considerable attention owing to the broad spectrum of biological activities such as anti-HIV, anti-inflammatory, and especially, antitumor. Despite numerous studies on the antitumor mechanisms over the past decade, the cellular targets in cancer cells remain obscure. Here, we developed two photoprobes, BA-1/BA-2, by attaching terminal alkyne-containing "minimalist" tetrazole/diazirine photo-crosslinkers (L3 and L7) at the C-3 and C-28 positions of BA, respectively, based on well-established structure-activity relationships...
August 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28806396/inhibiting-myc-binding-to-the-e-box-dna-motif-by-me47-decreases-tumour-xenograft-growth
#18
L C Lustig, D Dingar, W B Tu, C Lourenco, M Kalkat, I Inamoto, R Ponzielli, W C W Chan, J A Shin, L Z Penn
Developing therapeutics to effectively inhibit the MYC oncoprotein would mark a key advance towards cancer patient care as MYC is deregulated in over 50% of human cancers. MYC deregulation is correlated with aggressive disease and poor patient outcome. Despite strong evidence in mouse models that inhibiting MYC would significantly impact tumour cell growth and patient survival, traditional approaches have not yet yielded the urgently needed therapeutic agents that directly target MYC. MYC functions through its interaction with MAX to regulate gene transcription by binding to E-box DNA response elements of MYC target genes...
August 14, 2017: Oncogene
https://www.readbyqxmd.com/read/28783236/a-suite-of-minimalist-photo-crosslinkers-for-live-cell-imaging-and-chemical-proteomics-case-study-with-brd4-inhibitors
#19
Sijun Pan, Se-Young Jang, Danyang Wang, Si Si Liew, Zhengqiu Li, Jun-Seok Lee, Shao Q Yao
Affinity-based probes (AfBPs) provide a powerful tool for large-scale chemoproteomic studies of drug-target interactions. The development of high-quality probes capable of recapitulating genuine drug-target engagement, however, could be challenging. "Minimalist" photo-crosslinkers, which contain an alkyl diazirine group and a chemically tractable tag, could alleviate such challenges, but few are currently available. Herein, we have developed new alkyl diazirine-containing photo-crosslinkers with different bioorthogonal tags...
August 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28768339/habitual-minimalist-shod-running-biomechanics-and-the-acute-response-to-running-barefoot
#20
Nicholas Tam, Ian A J Darragh, Nikhil V Divekar, Robert P Lamberts
The aim of the study was to determine whether habitual minimalist shoe runners present with purported favorable running biomechanithat reduce running injury risk such as initial loading rate. Eighteen minimalist and 16 traditionally cushioned shod runners were assessed when running both in their preferred training shoe and barefoot. Ankle and knee joint kinetics and kinematics, initial rate of loading, and footstrike angle were measured. Sagittal ankle and knee joint stiffness were also calculated. Results of a two-factor ANOVA presented no group difference in initial rate of loading when participants were running either shod or barefoot; however, initial loading rate increased for both groups when running barefoot (p=0...
September 2017: International Journal of Sports Medicine
keyword
keyword
82375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"