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https://www.readbyqxmd.com/read/28735373/systematic-heuristic-evaluation-of-computerized-consultation-order-templates-clinicians-and-human-factors-engineers-perspectives
#1
April Savoy, Himalaya Patel, Mindy E Flanagan, Michael Weiner, Alissa L Russ
We assessed the usability of consultation order templates and identified problems to prioritize in design efforts for improving referral communication. With a sample of 26 consultation order templates, three evaluators performed a usability heuristic evaluation. The evaluation used 14 domain-independent heuristics and the following three supplemental references: 1 new domain-specific heuristic, 6 usability goals, and coded clinicians' statements regarding ease of use for 10 sampled templates. Evaluators found 201 violations, a mean of 7...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28727767/exploring-the-binding-pathways-of-the-14-3-3%C3%AE-protein-structural-and-free-energy-profiles-revealed-by-hamiltonian-replica-exchange-molecular-dynamics-with-distancefield-distance-restraints
#2
Gabor Nagy, Chris Oostenbrink, Jozef Hritz
The 14-3-3 protein family performs regulatory functions in eukaryotic organisms by binding to a large number of phosphorylated protein partners. Whilst the binding mode of the phosphopeptides within the primary 14-3-3 binding site is well established based on the crystal structures of their complexes, little is known about the binding process itself. We present a computational study of the process by which phosphopeptides bind to the 14-3-3ζ protein. Applying a novel scheme combining Hamiltonian replica exchange molecular dynamics and distancefield restraints allowed us to map and compare the most likely phosphopeptide-binding pathways to the 14-3-3ζ protein...
2017: PloS One
https://www.readbyqxmd.com/read/28725208/aldo-van-eyck-s-playgrounds-aesthetics-affordances-and-creativity
#3
Rob Withagen, Simone R Caljouw
After World War II, the Dutch architect Aldo van Eyck developed hundreds of playgrounds in the city of Amsterdam. These public playgrounds were located in parks, squares, and derelict sites, and consisted of minimalistic aesthetic play equipment that was supposed to stimulate the creativity of children. Over the last decades, these playgrounds have been studied by sociologists, theorists of art and architecture, and psychologists. Adopting an ecological approach to the human environment, it is argued that the abstract forms of van Eyck's play sculptures indeed stimulate the creativity of the child...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28709312/minimal-motor-for-powering-particle-motion-from-spin-imbalance
#4
Ulf Bissbort, Colin Teo, Chu Guo, Giulio Casati, Giuliano Benenti, Dario Poletti
We introduce a minimalistic quantum motor for coupled energy and particle transport. The system is composed of two spins, each coupled to a different bath and to a particle which can move on a ring consisting of three sites. We show that the energy flowing from the baths to the system can be partially converted to perform work against an external driving, even in the presence of moderate dissipation. We also analytically demonstrate the necessity of coupling between the spins. We suggest an experimental realization of our model using trapped ions or quantum dots...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28707124/examining-the-functional-category-in-chinese-english-code-switching-evidence-from-the-eye-movements
#5
Rui Li, Zhiyi Zhang, Chuanbin Ni, Wei Xiao, Junyan Wei, Haoyun Dai
To investigate the grammatical constraints of code-switching (CS hereafter) under the disputes of the constraint-based account versus the constraint-free account, the effects of functional category on CS have long been investigated in the existing studies. Thus, the present study, by asking 47 participants to take part in an eye-movement experiment, examined the potential effects of functional category on Chinese-English CS. We found that differential switch costs at varying code-switched conditions as well as robust switch effects that last from the early to the late stage...
July 13, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28697898/fusion-domains-guide-the-oriented-insertion-of-light-driven-proton-pumps-into-liposomes
#6
Noah Ritzmann, Johannes Thoma, Stephan Hirschi, David Kalbermatter, Dimitrios Fotiadis, Daniel J Müller
One major objective of synthetic biology is the bottom-up assembly of minimalistic nanocells consisting of lipid or polymer vesicles as architectural scaffolds and of membrane and soluble proteins as functional elements. However, there is no reliable method to orient membrane proteins reconstituted into vesicles. Here, we introduce a simple approach to orient the insertion of the light-driven proton pump proteorhodopsin (PR) into liposomes. To this end, we engineered red or green fluorescent proteins to the N- or C-terminus of PR, respectively...
July 8, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28696706/large-differences-in-the-optical-spectrum-associated-with-the-same-complex-the-effect-of-the-anisotropy-of-the-embedding-lattice
#7
José Antonio Aramburu, Pablo García-Fernández, Juan María García-Lastra, Miguel Moreno
Transition-metal complexes with a well-defined geometry are usually considered to display almost the same properties independently of the system where they are embedded. Here we show that the above statement is not true depending on the anisotropy of the host lattice, which is revealed in the form of the electric field created by the rest of lattice ions over the complex. To illustrate this concept we analyze the origin of the surprisingly large differences in the d-d optical transitions of two systems containing square-planar CuF4(2-) complexes, CaCuF4, and center II in Cu(2+)-doped Ba2ZnF6, even though the Cu(2+)-F(-)distance difference is just found to be 1%...
July 11, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28691911/a-novel-synchronized-diastolic-injection-method-to-reduce-contrast-volume-during-aortography-for-aortic-regurgitation-assessment-in-vitro-experiment-of-a-transcatheter-heart-valve-model
#8
Yosuke Miyazaki, Mohammad Abdelghani, Ellen S de Boer, Jean-Paul Aben, Math van Sloun, Todd Suchecki, Marcel van 't Veer, Carlos Collet, Taku Asano, Yuki Katagiri, Erhan Tenekecioglu, Osama I I Soliman, Yoshinobu Onuma, Robbert de Winter, Pim Tonino, Frans N van de Vosse, Marcel C M Rutten, Patrick W Serruys
AIMS: In the minimalist transcatheter aortic valve implantation (TAVI) era, the usage of transesophageal echocardiography becomes restricted. Conversely, aortography gains clinical ground in quantifying prosthetic valve regurgitation (PVR) during the procedure. In a mock circulation system, we sought to compare the contrast volume required and the accuracy of aortographic videodensitometric PVR assessment using a synchronized diastolic and standard (non-synchronized) injection aortography...
July 11, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28690018/adaptations-of-lumbar-biomechanics-after-four-weeks-of-running-training-with-minimalist-footwear-and-technique-guidance-implications-for-running-related-lower-back-pain
#9
Szu-Ping Lee, Joshua P Bailey, Jo Armour Smith, Stephanie Barton, David Brown, Talia Joyce
OBJECTIVES: To investigate the changes in lumbar kinematic and paraspinal muscle activation before, during, and after a 4-week minimalist running training. DESIGN: Prospective cohort study. SETTING: University research laboratory. PARTICIPANTS: Seventeen habitually shod recreational runners who run 10-50 km per week. MAIN OUTCOME MEASURES: During stance phases of running, sagittal lumbar kinematics was recorded using an electrogoniometer, and activities of the lumbar paraspinal muscles were assessed by electromyography...
December 2, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28686085/conceptualizing-minimalist-footwear-an-objective-definition
#10
Devon R Coetzee, Yumna Albertus, Nicholas Tam, Ross Tucker
Running has been plagued with an alarmingly high incidence of injury, which has resulted in the exploration of interventions aimed at reducing the risk of running-related injury. One such intervention is the introduction of footwear that mimics barefoot running. These have been termed minimalist shoes. Minimalist footwear aims to reduce the risk of injury by promoting adaptations in running biomechanics that have been linked to a reduction in both impact and joint forces. However, some studies have found that minimalist footwear may be beneficial to the runner as they promote favourable biomechanical adaptations, whilst other studies have found the opposite to be true...
July 7, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28684767/facile-control-over-the-supramolecular-ordering-of-self-assembled-peptide-scaffolds-by-simultaneous-assembly-with-a-polysacharride
#11
Rui Li, Mitchell Boyd-Moss, Benjamin Long, Anne Martel, Andrew Parnell, Andrew J C Dennison, Colin J Barrow, David R Nisbet, Richard J Williams
Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28684384/a-bit-of-fit-minimalist-intervention-in-adolescents-based-on-a-physical-activity-tracker
#12
Jeffrey Gaudet, François Gallant, Mathieu Bélanger
BACKGROUND: Only 5% of Canadian youth meet the recommended 60 minutes of moderate to vigorous physical activity (MVPA) per day, with leisure time being increasingly allocated to technology usage. Direct-to-consumer mHealth devices that promote physical activity, such as wrist-worn physical activity trackers, have features with potential appeal to youth. OBJECTIVE: The primary purpose of this study was to determine whether a minimalist physical activity tracker-based intervention would lead to an increase in physical activity in young adolescents...
July 6, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28669114/sure-enough-efficient-bayesian-learning-and-choice
#13
Brad R Foley, Paul Marjoram
Probabilistic decision-making is a general phenomenon in animal behavior, and has often been interpreted to reflect the relative certainty of animals' beliefs. Extensive neurological and behavioral results increasingly suggest that animal beliefs may be represented as probability distributions, with explicit accounting of uncertainty. Accordingly, we develop a model that describes decision-making in a manner consistent with this understanding of neuronal function in learning and conditioning. This first-order Markov, recursive Bayesian algorithm is as parsimonious as its minimalist point-estimate, Rescorla-Wagner analogue...
July 1, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28668499/the-difficulty-with-correlations-energy-expenditure-and-brain-mass-in-bats
#14
Brian K McNab, Meike Köhler
Brain mass has been suggested to determine a mammal's energy expenditure. This potential dependence is examined in 48 species of bats. A correlation between characters may be direct or derived from shared correlations with intervening factors without a direct interaction. Basal rate of metabolism in these bats increases with brain mass: large brains are more expensive than small brains, and both brain mass and basal rate increase with body mass. Basal rate and brain mass also correlate with food habits in bats...
June 29, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28665539/minimalistic-liquid-assisted-route-to-highly-crystalline-%C3%AE-zirconium-phosphate
#15
Yu Cheng, Xiaodong Tony Wang, Stephan Jaenicke, Gaik-Khuan Chuah
Zirconium phosphates have potential applications in areas of ion-exchange, catalysis, photochemistry, and biotechnology. However, synthesis methodologies to form crystalline α-zirconium phosphate (Zr(HPO₄)₂·H₂O) typically involve the use of excess phosphoric acid, addition of HF or oxalic acid and long reflux times or hydrothermal conditions. Herein we report on a minimalistic sustainable route using only zirconium oxychloride and concentrated phosphoric acid to form highly crystalline α-zirconium phosphate within hours...
June 30, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28659308/estimation-of-distance-and-electric-impedance-of-capacitive-objects-in-the-weakly-electric-fish-gnathonemus-petersii
#16
Martin Gottwald, Raya A Bott, Gerhard von der Emde
During active electrolocation the weakly electric fish Gnathonemus petersii judges distance and impedance of nearby objects. Capacitive objects, which modulate local amplitude and waveform of the fish's electric probing signals, cast amplitude- and waveform images onto the fish's electroreceptive skin. For an unambiguous estimation of the impedance and distance of an object, the animal has to deal with multiple dependencies of object- and image parameters. Based on experimentally recorded amplitude and waveform images we investigated possible strategies of the fish to unequivocally determine both the distance and the impedance of capacitive objects...
June 28, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28649851/avoidance-of-urinary-catheterization-to-minimize-in-hospital-complications-after-transcatheter-aortic-valve-implantation-an-observational-study
#17
Sandra B Lauck, Jae-Yung Kwon, David A Wood, Jennifer Baumbusch, Tone M Norekvål, Nay Htun, Leo Stephenson, John G Webb
BACKGROUND: Contemporary transcatheter aortic valve implantation (TAVI) devices and approach present opportunities to review historical practices initially informed by early treatment development and cardiac surgery. The avoidance of urinary catheterization in the older TAVI population is a strategy to minimize in-hospital complications. The purpose of the study was to explore elimination-related complications following the phased implementation of a default strategy of avoiding urinary catheterization in patients undergoing transfemoral (TF) TAVI...
June 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28648335/minimalist-thoracoscopic-resection-of-thymoma-associated-with-myasthenia-gravis
#18
Eugenio Pompeo, Mario Dauri, Roberto Massa, Michael Peer
No abstract text is available yet for this article.
June 22, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28641120/the-cognitive-bases-of-the-development-of-past-and-future-episodic-cognition-in-preschoolers
#19
Gülten Ünal, Annette Hohenberger
The aim of this study was to use a minimalist framework to examine the joint development of past and future episodic cognition and their underlying cognitive abilities in 3- to 5-year-old Turkish preschoolers. Participants engaged in two main tasks, a what-where-when (www) task to measure episodic memory and a future prediction task to measure episodic future thinking. Three additional tasks were used for predicting children's performance in the two main tasks: a temporal language task, an executive function task, and a spatial working memory task...
June 19, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28641058/acute-kinematics-changes-in-marathon-runners-using-different-footwear
#20
Tania Socorro Amorim Soares, Camila Fonseca de Oliveira, Federico Pizzuto, Rui Manuel Garganta, João Paulo Vila-Boas, Mario Casimiro da Anunciação Paiva
The effects of running with or without shoes on injury prevention have been extensively studied, and several investigations have assessed biomechanical differences between them. However, findings are not consensual and further insights on biomechanical load associated with differently shod or barefoot conditions may be needed. This study aimed to observe if habitually shod marathon runners show acute alterations when running barefoot or with minimalist shoes, and to determine whether the running kinematical adaptations of wearing minimalist shoes were similar to barefoot running...
June 22, 2017: Journal of Sports Sciences
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