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https://www.readbyqxmd.com/read/29790722/minimally-invasive-endoscopic-assisted-approaches-to-the-posterior-fossa
#1
Alexander Yang, Zach Folzenlogen, A Samy Youssef
Modern surgical approaches are becoming more minimalistic, associated with the term 'minimally invasive'. The endoscope provides a more panoramic anatomical view in addition to the ability to access narrow deep corners with decent illumination and clear visualization. Endoscopic assisted microsurgery through a tailored small craniotomy is the foundation of keyhole surgery. The endoscope can be advanced deeper into the field, thus enhancing an exposure and allowing bimanual dissection, thus prompting smaller craniotomies and tailored key exposures...
May 22, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29789168/quantlc-an-online-open-source-solution-for-videodensitometric-quantification
#2
Dimitri Fichou, Gertrud E Morlock
The image is the key feature of planar chromatography. Videodensitometry by digital image conversion is the fastest way of its evaluation. Instead of scanning single sample tracks one after the other, only few clicks are needed to convert all tracks at one go. A minimalistic software was newly developed, termed quanTLC, that allowed the quantitative evaluation of samples in few minutes. quanTLC includes important assets such as open-source, online, free of charge, intuitive to use and tailored to planar chromatography, as none of the nine existent software for image evaluation covered these aspects altogether...
May 19, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29775183/improving-the-mesoscopic-modeling-of-dna-denaturation-dynamics
#3
Marta Marty-Roda, Oda Dahlen, Titus Sebastiaan van Erp, Santiago Cuesta-López
Although previously developed mesoscopic DNA models have successfully
 reproduced thermodynamic denaturation data, recent studies show that these
 overestimate the rate of denaturation by orders of magnitude. Using adapted PeyrardBishop-Dauxois (PBD) models, we calculated the denaturation rates of several DNA
 hairpins and made comparison with experimental data. We show that the addition of
 a barrier at the onsite potential of the PBD model gives a more accurate description
 of the unzipping dynamics of short DNA sequences...
May 18, 2018: Physical Biology
https://www.readbyqxmd.com/read/29758683/markovian-robots-minimal-navigation-strategies-for-active-particles
#4
Luis Gómez Nava, Robert Großmann, Fernando Peruani
We explore minimal navigation strategies for active particles in complex, dynamical, external fields, introducing a class of autonomous, self-propelled particles which we call Markovian robots (MR). These machines are equipped with a navigation control system (NCS) that triggers random changes in the direction of self-propulsion of the robots. The internal state of the NCS is described by a Boolean variable that adopts two values. The temporal dynamics of this Boolean variable is dictated by a closed Markov chain-ensuring the absence of fixed points in the dynamics-with transition rates that may depend exclusively on the instantaneous, local value of the external field...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29754103/the-ascent-of-man-made-oxidoreductases
#5
REVIEW
Katie J Grayson, Jl Ross Anderson
Though established 40 years ago, the field of de novo protein design has recently come of age, with new designs exhibiting an unprecedented level of sophistication in structure and function. With respect to catalysis, de novo enzymes promise to revolutionise the industrial production of useful chemicals and materials, while providing new biomolecules as plug-and-play components in the metabolic pathways of living cells. To this end, there are now de novo metalloenzymes that are assembled in vivo, including the recently reported C45 maquette, which can catalyse a variety of substrate oxidations with efficiencies rivalling those of closely related natural enzymes...
May 10, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29742893/synthesis-liposomal-formulation-and-immunological-evaluation-of-a-minimalistic-carbohydrate-%C3%AE-galcer-vaccine-candidate
#6
Felix Broecker, Sebastian Götze, Jonathan Hudon, Dominea C K Rathwell, Claney L Pereira, Pierre Stallforth, Anish Chakkumkal, Peter H Seeberger
Fully synthetic glycan-based vaccines hold great potential as preventive and therapeutic vaccines against infectious diseases as well as cancer. Here, we present a two-component platform based on the facile conjugation of carbohydrate antigens to α-galactosylceramide (α-GalCer) to yield fully synthetic vaccine candidates. Formulation of a cancer-associated Tn antigen glycolipid model vaccine candidate into liposomes of different sizes and subsequent immunization of mice generated specific, high-affinity antibodies against the carbohydrate antigen with characteristics of T cell-dependent immunity...
May 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29742756/applying-user-centered-design-methods-to-the-development-of-an-mhealth-application-for-use-in-the-hospital-setting-by-patients-and-care-partners
#7
Brittany Couture, Elizabeth Lilley, Frank Chang, Ann DeBord Smith, Jessica Cleveland, Awatef Ergai, Zachary Katsulis, James Benneyan, Esteban Gershanik, David W Bates, Sarah A Collins
INTRODUCTION:  Developing an optimized and user-friendly mHealth application for patients and family members in the hospital environment presents unique challenges given the diverse patient population and patients' various states of well-being. OBJECTIVE:  This article describes user-centered design methods and results for developing the patient and family facing user interface and functionality of MySafeCare, a safety reporting tool for hospitalized patients and their family members...
April 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29729078/archaeal-dna-on-the-histone-merry-go-round
#8
Sudipta Bhattacharyya, Francesca Mattiroli, Karolin Luger
How did the nucleosome, the fundamental building block of all eukaryotic chromatin, evolve? This central question has been impossible to address because the four core histones that make up the protein core of the nucleosome are so highly conserved in all eukaryotes. With the discovery of small, minimalist histone-like proteins in most known archaea, the likely origin of histones was identified. We recently determined the structure of an archaeal histone-DNA complex, revealing that archaeal DNA topology and protein-DNA interactions are astonishingly similar compared to the eukaryotic nucleosome...
May 4, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29707050/buckling-down-on-torus-fractures-has-evolving-evidence-affected-practice
#9
B A Williams, C A Alvarado, D C Montoya-Williams, R C Matthias, L C Blakemore
Purpose: The purpose of this study was to evaluate the management of paediatric torus fractures of the distal forearm in current practice in light of growing evidence supporting a 'minimalist' approach with splint immobilization and limited follow-up. We hypothesized that 'traditional' cast-based management has persisted despite alternative evidence. Methods: A retrospective review was performed of a consecutive series of paediatric patients diagnosed with torus fractures of the distal forearm between 2011 and 2014...
April 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29694872/dynamics-of-a-protein-chain-motor-driving-helical-bacteria-under-stress
#10
Julian Roth, Matthias D Koch, Alexander Rohrbach
The wall-less, helical bacterial genus Spiroplasma has a unique propulsion system; it is not driven by propeller-like flagella but by a membrane-bound, cytoplasmic, linear motor that consists of a contractile chain of identical proteins spanning the entire cell length. By a coordinated spread of conformational changes of the proteins, kinks propagate in pairs along the cell body. However, the mechanisms for the initiation or delay of kinks and their coordinated spread remain unclear. Here, we show how we manipulate the initiation of kinks, their propagation velocities, and the time between two kinks for a single cell trapped in an optical line potential...
April 24, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29682454/awake-transcatheter-aortic-valve-replacement-an-anesthesiologist-s-perspective
#11
Jiapeng Huang, Sheng Wang, Jiakai Lu
Transcatheter aortic replacement has become the standard of care for patients with severe aortic valve stenosis. With advancement of technologies, this technique has become much safer and simpler. Both general anesthesia (GA) and monitored anesthesia care (MAC) have been provided for transcatheter aortic valve replacement (TAVR). MAC or awake transcatheter valve replacement was shown to carry similar clinical outcomes with significantly reduced length of stay. We reviewed the literature and presented our practical minimalist anesthesia approach to awake TAVR...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29681079/abortion-law-reform-why-ethical-intractability-and-maternal-morbidity-are-grounds-for-decriminalisation
#12
Andrew McGee, Melanie Jansen, Sally Sheldon
In this paper, we present two grounds for arguing that abortion should be decriminalised. First, we consider the implications of the fact that the long-standing ethical debate concerning the morality of abortion has to date proven intractable. We maintain that because the philosophical literature has failed to demonstrate conclusively that views either for or against abortion's moral acceptability are false, the matter remains at a stalemate in terms of rational debate, contributing to the ongoing absence of political and popular consensus about the issue in our society...
April 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29660237/multiplexed-isobaric-tag-based-profiling-of-seven-murine-tissues-following-in-vivo-nicotine-treatment-using-a-minimalistic-proteomics-strategy
#13
Joao A Paulo, Mark P Jedrychowski, Edward T Chouchani, Lawrence Kazak, Steven P Gygi
Nicotine is a major addictive compound in tobacco and a component of smoking-related products, such as e-cigarettes. Once internalized, nicotine can perturb many cellular pathways and can induce alterations in proteins across different cell types, however the mechanisms thereof remain undetermined. We hypothesize that both tissue-specific and global protein abundance alterations result from nicotine exposure. As such, we present the first proteome analysis of multiple tissues from nicotine-exposed mice. We treat mice via oral administration of nicotine at 200μg/mL in drinking water for 21 days...
April 16, 2018: Proteomics
https://www.readbyqxmd.com/read/29660055/accuracy-assessment-of-pedicle-and-lateral-mass-screw-insertion-assisted-by-customized-3d-printed-drill-guides-a-human-cadaver-study
#14
Peter A J Pijpker, Joep Kraeima, Max J H Witjes, D L Marinus Oterdoom, Maarten H Coppes, Rob J M Groen, Jos M A Kuijlen
BACKGROUND: Accurate cervical screw insertion is of paramount importance considering the risk of damage to adjacent vital structures. Recent research in 3-dimensional (3D) technology describes the advantage of patient-specific drill guides for accurate screw positioning, but consensus about the optimal guide design and the accuracy is lacking. OBJECTIVE: To find the optimal design and to evaluate the accuracy of individualized 3D-printed drill guides for lateral mass and pedicle screw placement in the cervical and upper thoracic spine...
April 5, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29614862/nanomaterial-interactions-with-biomembranes-bridging-the-gap-between-soft-matter-models-and-biological-context
#15
Marco Werner, Thorsten Auth, Paul A Beales, Jean Baptiste Fleury, Fredrik Höök, Holger Kress, Reid C Van Lehn, Marcus Müller, Eugene P Petrov, Lev Sarkisov, Jens-Uwe Sommer, Vladimir A Baulin
Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and the alteration of biological function. Nature and humans use different design strategies to create nanomaterials: biological objects have emerged from billions of years of evolution and from adaptation to their environment resulting in high levels of structural complexity; in contrast, synthetic nanomaterials result from minimalistic but controlled design options limited by the authors' current understanding of the biological world...
April 3, 2018: Biointerphases
https://www.readbyqxmd.com/read/29606578/bacterial-alkaloid-biosynthesis-structural-diversity-via-a-minimalistic-nonribosomal-peptide-synthetase
#16
Martin Klapper, Daniel Braga, Gerald Lackner, Rosa Herbst, Pierre Stallforth
Chemical and biochemical analyses of one of the most basic nonribosomal peptide synthetases (NRPS) from a Pseudomonas fluorescens strain revealed its striking plasticity. Determination of the potential substrate scope enabled us to anticipate novel secondary metabolites that could subsequently be isolated and tested for their bioactivities. Detailed analyses of the monomodular pyreudione synthetase showed that the biosynthesis of the bacterial pyreudione alkaloids does not require additional biosynthetic enzymes...
March 13, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29600867/minimally-invasive-ceramic-restorations-a-step-by-step-clinical-approach
#17
Carlos Marcelo Archangelo, José Carlos Romanini, Karen Cristina Archangelo, Isis Almela Endo Hoshino, Rodolfo Bruniera Anchieta
Minimally invasive treatments are a dominant trend in dentistry. Due to the evolution of adhesive materials and ceramics, minimalistic ceramic restorations have been proposed as alternative treatment options to avoid unnecessary tooth reduction. The aim of this article is to show a clinical protocol for the correct diagnosis, treatment planning, and execution of minimally invasive ceramic veneers. Requiring only slight tooth preparation, this conservative technique is well-suited for restoration of teeth that need color and shape modification...
April 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29597146/electromyography-comparison-of-the-effects-of-various-footwear-in-the-activity-patterns-of-the-peroneus-longus-and-brevis-muscles
#18
Andrea Roca-Dols, Marta Elena Losa-Iglesias, Rubén Sánchez-Gómez, Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, César Calvo-Lobo
BACKGROUND: Peroneus longus and brevis (PLB) disorders are commonly in people with lateral ligamentous instability, ankle pain, lateral hindfoot pain and structures of the proximal compartment of the lower legs and their muscle activity is believed to be influenced by different footwear types. The proposal of this research is to evaluate the effects of five types of footwear with respect to the barefoot condition and analyze the activity patterns of PLB muscles in healthy subjects during the gait cycle...
March 13, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29589679/axillary-surgery-in-breast-cancer-the-beginning-of-the-end
#19
Dorin Dumitru, Ayesha Khan, Giuseppe Catanuto, Nicola Rocco, Maurizio B Nava, John R Benson
Axillary surgery in breast cancer patients has shifted from more extensive to minimalist approaches with re-evaluation of the risks versus benefits of available treatment options which are increasingly tailored to individual patient characteristics.A radical axillary node dissection is rarely indicated nowadays due to several factors including screening with detection of small node negative cancers, introduction of targeted node sampling, less reliance on information from nodal staging for adjuvant therapy decision making and evidence that non-surgical treatments such as systemic therapies (chemotherapy, hormonal therapy, biological therapy) together with radiotherapy can safely treat low burden axillary disease...
March 28, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29574812/the-teaching-of-oral-maxillofacial-surgery-to-dental-students-in-australia-new-zealand
#20
A N Goss
The teaching of OMS to dental students in Australia & New Zealand was surveyed. Generally the established schools had well developed curricula with good didactic and clinical experience conducted by specialist OMS educators. There was a much greater array of teaching in some of the newer schools with some appearing to barely meet the current minimalist professional competencies of the ADC. The critical element was whether or not the school was associated with a speciality OMS Unit at a Teaching Hospital...
March 2018: Australian Dental Journal
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