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https://www.readbyqxmd.com/read/28054630/disaggregation-of-amylin-aggregate-by-novel-conformationally-restricted-aminobenzoic-acid-containing-%C3%AE-%C3%AE-and-%C3%AE-%C3%AE-hybrid-peptidomimetics
#1
Ashim Paul, Sourav Kalita, Sujan Kalita, Piruthivi Sukumar, Bhubaneswar Mandal
Diabetes has emerged as a threat to the current world. More than ninety five per cent of all the diabetic population has type 2 diabetes mellitus (T2DM). Aggregates of Amylin hormone, which is co-secreted with insulin from the pancreatic β-cells, inhibit the activities of insulin and glucagon and cause T2DM. Importance of the conformationally restricted peptides for drug design against T2DM has been invigorated by recent FDA approval of Symlin, which is a large conformationally restricted peptide. However, Symlin still has some issues including solubility, oral bioavailability and cost of preparation...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28051921/tube-thoracostomy-at-the-time-of-congenital-diaphragmatic-hernia-repair-reassessing-the-risks-and-benefits
#2
Avraham Schlager, Kelly Arps, Ragavan Siddharthan, Matthew S Clifton
PURPOSE: Postoperative pneumothorax and effusion remain a concern following congenital diaphragmatic hernia (CDH) repair. Despite a recent trend away from intraoperative thoracostomy, few studies have actually compared outcomes with and without a chest tube. Rationale commonly cited for the more minimalistic approach include the presumed low likelihood of postoperative complications, potential risk of patch infection, and prolonged intubation. We evaluate these theories, as well as the implications of intraoperative chest tube (IOCT) placement...
January 4, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28046434/su-f-t-458-tracking-trends-of-tg-142-parameters-via-analysis-of-data-recorded-by-2d-chamber-array
#3
A Alexandrian, C Kabat, D Defoor, D Saenz, K Rasmussen, N Kirby, A Gutierrez, N Papanikolaou, S Stathakis
PURPOSE: With increasing QA demands of medical physicists in clinical radiation oncology, the need for an effective method of tracking clinical data has become paramount. A tool was produced which scans through data automatically recorded by a 2D chamber array and extracts relevant information recommended by TG-142. Using this extracted information a timely and comprehensive analysis of QA parameters can be easily performed enabling efficient monthly checks on multiple linear accelerators simultaneously...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28025343/reefgenomics-org-a-repository-for-marine-genomics-data
#4
Yi Jin Liew, Manuel Aranda, Christian R Voolstra
Over the last decade, technological advancements have substantially decreased the cost and time of obtaining large amounts of sequencing data. Paired with the exponentially increased computing power, individual labs are now able to sequence genomes or transcriptomes to investigate biological questions of interest. This has led to a significant increase in available sequence data. Although the bulk of data published in articles are stored in public sequence databases, very often, only raw sequencing data are available; miscellaneous data such as assembled transcriptomes, genome annotations etc...
2016: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/27998549/patient-hand-off-initiation-and-evaluation-phone-study-a-randomized-trial-of-patient-handoff-methods
#5
Jesse Clanton, Aimee Gardner, Michael Subichin, Patrick McAlvanah, William Hardy, Amar Shah, Joel Porter
BACKGROUND: As residency work hour restrictions have tightened, transitions of care have become more frequent. Many institutions dedicate significant time and resources to patient handoffs despite the fact that the ideal method is relatively unknown. We sought to compare the effect of a rigorous formal handoff approach to a minimized but focused handoff process on patient outcomes. METHODS: A randomized prospective trial was conducted at a large teaching hospital over ten months...
November 23, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27991496/nonequilibrium-description-of-de-novo-biogenesis-and-transport-through-golgi-like-cisternae
#6
Himani Sachdeva, Mustansir Barma, Madan Rao
A central issue in cell biology is the physico-chemical basis of organelle biogenesis in intracellular trafficking pathways, its most impressive manifestation being the biogenesis of Golgi cisternae. At a basic level, such morphologically and chemically distinct compartments should arise from an interplay between the molecular transport and chemical maturation. Here, we formulate analytically tractable, minimalist models, that incorporate this interplay between transport and chemical progression in physical space, and explore the conditions for de novo biogenesis of distinct cisternae...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27970139/tct-753-fascia-iliaca-compartment-block-ficb-and-none-to-light-sedation-as-an-alternative-minimalist-approach-to-sedation-for-patients-undergoing-transffemoral-transcatheter-aortic-valve-replacement-tf-tavr-a%C3%A2-single-center-30-day-outcome-experience
#7
Wei Lau, George Hanzel, Robert Safian, Amr Abbas, Marc Sakwa, Francis Shannon
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970118/tct-738-optimizing-cost-savings-in-minimalist-transfemoral-tavr-closing-the-gap
#8
Marcus Burns, Mario Goessl, Lynelle Schneider, Tjorvi Perry, Andrea Sweeney, Craig Strauss, Pam Rush, Kenneth Lamb, Saeid Farivar, Paul Sorajja
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27959811/indoor-scene-reconstruction-using-near-light-photometric-stereo
#9
Jingtang Liao, Bert Buchholz, Jean-Marc Thiery, Pablo Bauszat, Elmar Eisemann
We propose a novel framework for photometric stereo (PS) under low-light conditions using uncalibrated nearlight illumination. It operates on free-form video sequences captured with a minimalistic and affordable setup. We address issues such as albedo variations, shadowing, perspective projections and camera noise. Our method uses specular spheres detected with a perspective-correcting Hough transform to robustly triangulate light positions in the presence of outliers via a least-squares approach. Furthermore, we propose an iterative reweighting scheme in combination with an `p-norm minimizer to robustly solve the calibrated near-light PS problem...
December 7, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27926854/structural-characterization-and-statistical-mechanical-model-of-epidermal-patterns
#10
Duyu Chen, Wen Yih Aw, Danelle Devenport, Salvatore Torquato
In proliferating epithelia of mammalian skin, cells of irregular polygon-like shapes pack into complex, nearly flat two-dimensional structures that are pliable to deformations. In this work, we employ various sensitive correlation functions to quantitatively characterize structural features of evolving packings of epithelial cells across length scales in mouse skin. We find that the pair statistics in direct space (correlation function) and Fourier space (structure factor) of the cell centroids in the early stages of embryonic development show structural directional dependence (statistical anisotropy), which is a reflection of the fact that cells are stretched, which promotes uniaxial growth along the epithelial plane...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27910301/minimalist-immediate-mechanical-intervention-approach-in-the-management-of-an-acute-proximal-left-anterior-descending-artery-occlusion-with-extensive-thrombus-burden-in-the-left-main-coronary-artery
#11
Laura Cetran, Frédéric Casassus, Guillermo J Tearney, Benjamin Seguy, Pierre Poustis, Pierre Coste, Edouard Gerbaud
No abstract text is available yet for this article.
February 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/27862901/does-minimalist-transfemoral-transcatheter-aortic-valve-replacement-produce-better-survival-in-patients-with-severe-chronic-obstructive-pulmonary-disease
#12
Jose F Condado, Moosa N Haider, Stamatios Lerakis, Patricia Keegan, Hope Caughron, Vinod H Thourani, Chandan Devireddy, Bradley Leshnower, Kreton Mavromatis, Eric L Sarin, James Stewart, Robert Guyton, Jessica Forcillo, Ateet Patel, Amy Simone, Peter C Block, Vasilis Babaliaros
OBJECTIVES: To compare outcomes after minimalist and standard transfemoral transcatheter aortic valve replacement (TF-TAVR) in patients with severe chronic obstructive pulmonary disease (COPD). BACKGROUND: TF-TAVR is increasingly performed with conscious sedation and transthoracic echocardiography guidance (minimalist). The safety/efficacy of this technique in patients with severe COPD is unknown. METHODS: We compared demographics, 30-day outcomes and 1-year survival of patients with severe COPD (FEV1% ≤50) who underwent minimalist vs...
November 12, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27859571/my-heart-made-me-do-it-children-s-essentialist-beliefs-about-heart-transplants
#13
Meredith Meyer, Susan A Gelman, Steven O Roberts, Sarah-Jane Leslie
Psychological essentialism is a folk theory characterized by the belief that a causal internal essence or force gives rise to the common outward behaviors or attributes of a category's members. In two studies, we investigated whether 4- to 7-year-old children evidenced essentialist reasoning about heart transplants by asking them to predict whether trading hearts with an individual would cause them to take on the donor's attributes. Control conditions asked children to consider the effects of trading money with an individual...
November 17, 2016: Cognitive Science
https://www.readbyqxmd.com/read/27853136/formation-of-bacterial-pilus-like-nanofibres-by-designed-minimalistic-self-assembling-peptides
#14
Tom Guterman, Micha Kornreich, Avigail Stern, Lihi Adler-Abramovich, Danny Porath, Roy Beck, Linda J W Shimon, Ehud Gazit
Mimicking the multifunctional bacterial type IV pili (T4Ps) nanofibres provides an important avenue towards the development of new functional nanostructured biomaterials. Yet, the development of T4Ps-based applications is limited by the inability to form these nanofibres in vitro from their pilin monomers. Here, to overcome this limitation, we followed a reductionist approach and designed a self-assembling pilin-based 20-mer peptide, derived from the presumably bioelectronic pilin of Geobacter sulfurreducens...
November 17, 2016: Nature Communications
https://www.readbyqxmd.com/read/27834504/redistribution-of-mechanical-work-at-the-knee-and-ankle-joints-during-fast-running-in-minimalist-shoes
#15
Joel T Fuller, Jonathan D Buckley, Margarita D Tsiros, Nicholas A T Brown, Dominic Thewlis
CONTEXT: Minimalist shoes have been suggested as a way to alter running biomechanics to improve running performance and reduce injuries. However, to date, researchers have only considered the effect of minimalist shoes at slow running speeds. OBJECTIVE: To determine if runners change foot-strike pattern and alter the distribution of mechanical work at the knee and ankle joints when running at a fast speed in minimalist shoes compared with conventional running shoes...
October 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27831937/minimalistic-optic-flow-sensors-applied-to-indoor-and-outdoor-visual-guidance-and-odometry-on-a-car-like-robot
#16
Stefano Mafrica, Alain Servel, Franck Ruffier
Here we present a novel bio-inspired optic flow (OF) sensor and its application to visual  guidance and odometry on a low-cost car-like robot called BioCarBot. The minimalistic OF sensor was robust to high-dynamic-range lighting conditions and to various visual patterns encountered thanks to its M(2)APIX auto-adaptive pixels and the new cross-correlation OF algorithm implemented. The low-cost car-like robot estimated its velocity and steering angle, and therefore its position and orientation, via an extended Kalman filter (EKF) using only two downward-facing OF sensors and the Ackerman steering model...
November 10, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27816175/-transfemoral-tavi-procedure-in-women-minimally-invasive-technique
#17
H Benamer, B Chevalier, A Roy, M A Bouzid, C Perdrix, P Garot, T Hovasse, T Unterseeh, S Champagne, T Lefèvre
Demographic data point to a substantial proportion of women in the population of elderly patients with an increasing prevalence of aortic stenosis. Implantation of an aortic bioprosthesis via an endovascular approach known as Transcatheter aortic valve implantation (TAVI) in patients presenting with a symptomatic tight aortic stenosis (severe aortic stenosis) (AS) is an alternative therapeutic option to surgical aortic valve replacement in patients at high surgical risk or ineligible for surgery. The literature has shown that this technique seems to be particularly beneficial in female patients...
December 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27804212/international-estimated-fetal-weight-standards-of-the-intergrowth-21-st-project
#18
J Stirnemann, J Villar, L J Salomon, E Ohuma, P Ruyan, D G Altman, F Nosten, R Craik, S Munim, L Cheikh Ismail, F C Barros, A Lambert, S Norris, M Carvalho, Y A Jaffer, J A Noble, E Bertino, M G Gravett, M Purwar, C Victora, R Uauy, Z Bhutta, S Kennedy, A T Papageorghiou
BACKGROUND: Estimated fetal weight (EFW) and fetal biometry are complementary measures to screen for fetal growth disturbances. Our aim was to provide international EFW standards to complement the INTERGROWTH-21(st) Fetal Growth Standards that are available for use worldwide. METHODS: Women with an accurate gestational age assessment, who were enrolled in the prospective, international, multicentre, population-based, Fetal Growth Longitudinal Growth Study (FGLS) and INTERBIO-21(st) Fetal Study (FS), two of the components of the INTERGROWTH-21(st) Project, had ultrasound scans every 5 weeks from 9-14 weeks until 40 weeks' gestation...
November 2, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27804156/transfemoral-transcatheter-aortic-valve-implantation-how-minimalistic-can-we-become
#19
Fadi J Sawaya, Thierry Lefèvre, Marco Spaziano, Andrew Roy, Leticia Fernandez, Phillipe Garot, Bernard Chevalier, Thomas Hovasse
Transcatheter aortic valve implantation (TAVI) has become a well-established intervention with reproducible and excellent early and mid-term outcomes. A minimalist approach to TAVI is already the standard of care in many experienced centers. In this report, we share our experience and opinions on how we can further simplify the TAVI procedure in hope to establish the best possible outcomes.
December 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27779182/dynamic-microfluidic-control-of-supramolecular-peptide-self-assembly
#20
Zohar A Arnon, Andreas Vitalis, Aviad Levin, Thomas C T Michaels, Amedeo Caflisch, Tuomas P J Knowles, Lihi Adler-Abramovich, Ehud Gazit
The dynamic nature of supramolecular polymers has a key role in their organization. Yet, the manipulation of their dimensions and polarity remains a challenge. Here, the minimalistic diphenylalanine building block was applied to demonstrate control of nano-assemblies growth and shrinkage using microfluidics. To fine-tune differential local environments, peptide nanotubes were confined by micron-scale pillars and subjected to monomer flows of various saturation levels to control assembly and disassembly. The small-volume device allows the rapid adjustment of conditions within the system...
October 25, 2016: Nature Communications
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