keyword
MENU ▼
Read by QxMD icon Read
search

minimalist

keyword
https://www.readbyqxmd.com/read/28521711/mini-heme-proteins-designability-of-structure-and-diversity-of-functions
#1
Jagdish Rai
Natural heme proteins may have heme bound to poly-peptide chain as a cofactor via non-covalent forces or heme as a prosthetic group may be covalently bound to the proteins. Nature has used porphyrins in diverse functions like electron transfer, oxidation, reduction, ligand binding, photosynthesis, signaling, etc. by modulating its properties through diverse protein matrices. Synthetic chemists have tried to utilize these molecules in equally diverse industrial and medical applications due to their versatile electro-chemical and optical properties...
May 15, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28516104/minimalist-trans-aneurysmal-approach-to-coronary-button-pseudoaneurysm
#2
EDITORIAL
John A Elefteriades, Gary S Kopf, Bulat A Ziganshin
No abstract text is available yet for this article.
December 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28513898/synthesis-of-bodipy-labelled-cholesterylated-glycopeptides-by-tandem-click-chemistry-for-glycocalyxification-of-giant-unilamellar-vesicles-guvs
#3
Nicolai Stuhr-Hansen, Charikleia-Despoina Vagianou, Ola Blixt
The glycocalyx cover membrane surfaces of all living cells. These complex archtechtures render their interaction mechanisms on the membrane surface difficult to study. Artificial cell-sized membranes with selected and defined glycosylation patterns may serve as a minimalistic approach to systematically study cell surface glycan interactions. Here we developed a facile general synthetic procedure for the synthesis of BODIPY-labelled cholesterylated glycopeptides, which can coat cell-size giant unilamellar vesicles (GUVs)...
May 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28513558/from-cell-to-beak-in-vitro-and-in-vivo-characterization-of-chicken-bitter-taste-thresholds
#4
Shira Cheled-Shoval, Maik Behrens, Ayelet Korb, Antonella Di Pizio, Wolfgang Meyerhof, Zehava Uni, Masha Y Niv
Bitter taste elicits an aversive reaction, and is believed to protect against consuming poisons. Bitter molecules are detected by the Tas2r family of G-protein-coupled receptors, with a species-dependent number of subtypes. Chickens demonstrate bitter taste sensitivity despite having only three bitter taste receptors-ggTas2r1, ggTas2r2 and ggTas2r7. This minimalistic bitter taste system in chickens was used to determine relationships between in-vitro (measured in heterologous systems) and in-vivo (behavioral) detection thresholds...
May 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28487073/a-minimalistic-tetrapeptide-amphiphile-scaffold-for-transmembrane-pores-with-a-preference-for-sodium
#5
Debajyoti Basak, Sucheta Sridhar, Amal K Bera, Nandita Madhavan
Synthetic channels or pores that are easy to synthesize, stable and cation-selective are extremely attractive for the development of therapeutics and materials. Herein, we report a pore developed from a small tetrapeptide scaffold that shows a preference for sodium over lithium/potassium. The sodium selectivity is attributed to the appended oligoether tail at the C-terminus. A peptide dimer is proposed as the predominant cation-transporting pore. Such pyridine containing stable pores can be potentially utilized for the pH modulated ion transport...
April 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28483557/six-week-transition-to-minimalist-shoes-improves-running-economy-and-time-trial-performance
#6
Joel T Fuller, Dominic Thewlis, Margarita D Tsiros, Nicholas A T Brown, Jonathan D Buckley
OBJECTIVES: This study investigated if gradually introducing runners to minimalist shoes during training improved running economy and time-trial performance compared to training in conventional shoes. Changes in stride rate, stride length, footfall pattern and ankle plantar-flexor strength were also investigated. DESIGN: Randomised parallel intervention trial. METHODS: 61 trained runners gradually increased the amount of running performed in either minimalist (n=31) or conventional (n=30) shoes during a six-week standardised training program...
April 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28481275/porcine-circovirus-type-2-pcv2-vaccines-in-the-context-of-current-molecular-epidemiology
#7
REVIEW
Anbu K Karuppannan, Tanja Opriessnig
Porcine circovirus type 2 (PCV2) is an economically important swine pathogen and, although small, it has the highest evolution rate among DNA viruses. Since the discovery of PCV2 in the late 1990s, this minimalistic virus with a 1.7 kb single-stranded DNA genome and two indispensable genes has become one of the most important porcine pathogens, and presently is subjected to the highest volume of prophylactic intervention in the form of vaccines in global swine production. PCV2 can currently be divided into five different genotypes, PCV2a through PCV2e...
May 6, 2017: Viruses
https://www.readbyqxmd.com/read/28476622/green-fluorescence-protein-based-content-mixing-assay-of-snare-driven-membrane-fusion
#8
Paul Heo, Byoungjae Kong, Young-Hun Jung, Joon-Bum Park, Jonghyeok Shin, Myungseo Park, Dae-Hyuk Kweon
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins mediate intracellular membrane fusion by forming a ternary SNARE complex. A minimalist approach utilizing proteoliposomes with reconstituted SNARE proteins yielded a wealth of information pinpointing the molecular mechanism of SNARE-mediated fusion and its regulation by accessory proteins. Two important attributes of a membrane fusion are lipid-mixing and the formation of an aqueous passage between apposing membranes. These two attributes are typically observed by using various fluorescent dyes...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28456166/modular-topology-emerges-from-plasticity-in-a-minimalistic-excitable-network-model
#9
Fabrizio Damicelli, Claus C Hilgetag, Marc-Thorsten Hütt, Arnaud Messé
Topological features play a major role in the emergence of complex brain network dynamics underlying brain function. Specific topological properties of brain networks, such as their modular organization, have been widely studied in recent years and shown to be ubiquitous across spatial scales and species. However, the mechanisms underlying the generation and maintenance of such features are still unclear. Using a minimalistic network model with excitable nodes and discrete deterministic dynamics, we studied the effects of a local Hebbian plasticity rule on global network topology...
April 2017: Chaos
https://www.readbyqxmd.com/read/28445034/dual-in-tether-chiral-centers-modulate-peptide-helicity
#10
Kuan Hu, Chengjie Sun, Mengying Yu, Wenjun Li, Huacan Lin, Jialin Guo, Yixiang Jiang, Chengxiang Lei, Zigang Li
The facile chemical modification on the peptide cross-linking moiety is an important strategy for improving the physicochemical properties of a peptide. Herein, peptides were constrained into helical conformations via the synergistic effects of dual in-tether chiral centers. A pentapeptide minimalistic model was used to determine the correlation between the absolute configurations of the dual in-tether chiral centers and the secondary structures of the peptides. This strategy provides an on-tether modification site that does not interrupt the secondary structure of the peptide...
May 4, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28438724/toward-a-more-usable-home-based-video-telemedicine-system-a-heuristic-evaluation-of-the-clinician-user-interfaces-of-home-based-video-telemedicine-systems
#11
Sruthy Agnisarman, Shraddhaa Narasimha, Kapil Chalil Madathil, Brandon Welch, Fnu Brinda, Aparna Ashok, James McElligott
BACKGROUND: Telemedicine is the use of technology to provide and support health care when distance separates the clinical service and the patient. Home-based telemedicine systems involve the use of such technology for medical support and care connecting the patient from the comfort of their homes with the clinician. In order for such a system to be used extensively, it is necessary to understand not only the issues faced by the patients in using them but also the clinician. OBJECTIVES: The aim of this study was to conduct a heuristic evaluation of 4 telemedicine software platforms-Doxy...
April 24, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28436963/a-sting-activating-nanovaccine-for-cancer-immunotherapy
#12
Min Luo, Hua Wang, Zhaohui Wang, Haocheng Cai, Zhigang Lu, Yang Li, Mingjian Du, Gang Huang, Chensu Wang, Xiang Chen, Matthew R Porembka, Jayanthi Lea, Arthur E Frankel, Yang-Xin Fu, Zhijian J Chen, Jinming Gao
The generation of tumour-specific T cells is critically important for cancer immunotherapy. A major challenge in achieving a robust T-cell response is the spatiotemporal orchestration of antigen cross-presentation in antigen-presenting cells with innate stimulation. Here, we report a minimalist nanovaccine, comprising a simple physical mixture of an antigen and a synthetic polymeric nanoparticle, PC7A NP, which generates a strong cytotoxic T-cell response with low systemic cytokine expression. Mechanistically, the PC7A NP achieves efficient cytosolic delivery of tumour antigens to antigen-presenting cells in draining lymph nodes, leading to increased surface presentation while simultaneously activating type I interferon-stimulated genes...
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28417667/immediate-and-short-term-biomechanical-adaptation-of-habitual-barefoot-runners-who-start-shod-running
#13
Ivan P H Au, Fannie O Y Lau, Winko W An, Janet H Zhang, Tony L Chen, Roy T H Cheung
This study investigated the immediate and short-term effects of minimalist shoes (MS) and traditional running shoes (TRS) on vertical loading rates, foot strike pattern and lower limb kinematics in a group of habitual barefoot runners. Twelve habitual barefoot runners were randomly given a pair of MS or TRS and were asked to run with the prescribed shoes for 1 month. Outcome variables were obtained before, immediate after and 1 month after shoe prescription. Average and instantaneous vertical loading rates at the 1-month follow-up were significantly higher than that at the pre-shod session (P < 0...
April 18, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28376250/supramolecular-hydrogels-based-on-minimalist-amphiphilic-squaramide-squaramates-for-controlled-release-of-zwitterionic-biomolecules
#14
Antonio Costa, Carlos López, Marta Ximenis, Francisca Orvay, Carmen Rotger
Supramolecular hydrogels with tunable properties have innovative applications in biomedicine, catalysis and materials chemistry. Herein, we have designed minimalist low molecular weight hydrogelators based on squaramide and squaramic acid motifs. Our approach benefits from the high acidity of squaramic acids and the aromaticity of squaramides. Moreover, the substituents on the aryl ring tune the π density of the aryl-squaramide motif. Thus, we successfully prepared materials featuring distinct thermal and mechanical properties...
April 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28364023/rna-activation-independent-dna-targeting-of-the-type-iii-crispr-cas-system-by-a-csm-complex
#15
Kwang-Hyun Park, Yan An, Tae-Yang Jung, In-Young Baek, Haemin Noh, Woo-Chan Ahn, Hans Hebert, Ji-Joon Song, Jeong-Hoon Kim, Byung-Ha Oh, Eui-Jeon Woo
The CRISPR-Cas system is an adaptive and heritable immune response that destroys invading foreign nucleic acids. The effector complex of the Type III CRISPR-Cas system targets RNA and DNA in a transcription-coupled manner, but the exact mechanism of DNA targeting by this complex remains elusive. In this study, an effector Csm holocomplex derived from Thermococcus onnurineus is reconstituted with a minimalistic combination of Csm1121334151, and shows RNA targeting and RNA-activated single-stranded DNA (ssDNA) targeting activities...
May 2017: EMBO Reports
https://www.readbyqxmd.com/read/28342257/transcatheter-aortic-valve-replacement-by-a-minimalist-approach-a-breath-of-fresh-air-for-patients-with-chronic-obstructive-pulmonary-disease
#16
EDITORIAL
Adriano Caixeta, Pedro A Lemos
No abstract text is available yet for this article.
March 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28338079/dissecting-mirna-gene-repression-on-single-cell-level-with-an-advanced-fluorescent-reporter-system
#17
Nicolas Lemus-Diaz, Kai O Böker, Ignacio Rodriguez-Polo, Michael Mitter, Jasmin Preis, Maximilian Arlt, Jens Gruber
Despite major advances on miRNA profiling and target predictions, functional readouts for endogenous miRNAs are limited and frequently lead to contradicting conclusions. Numerous approaches including functional high-throughput and miRISC complex evaluations suggest that the functional miRNAome differs from the predictions based on quantitative sRNA profiling. To resolve the apparent contradiction of expression versus function, we generated and applied a fluorescence reporter gene assay enabling single cell analysis...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28316235/evaluation-of-nanobody-conjugates-and-protein-fusions-as-bioanalytical-reagents
#18
Virginia J Bruce, Brian R McNaughton
Enzyme-linked immunosorbent assay (ELISA), flow cytometry, and Western blot are common bioanalytical techniques. Successful execution traditionally requires the use of one or more commercially available antibody-small-molecule dye, or antibody-reporter protein conjugates that recognize relatively short peptide tags (<15 amino acids). However, the size of antibodies, and their molecular complexity (by virtue of post-translational disulfide formation and glycosylation) typically requires either expression in mammalian cells or purification from immunized mammals...
March 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28292715/footwear-characteristics-are-related-to-running-mechanics-in-runners-with-patellofemoral-pain
#19
Jean-Francois Esculier, Blaise Dubois, Laurent J Bouyer, Bradford J McFadyen, Jean-Sébastien Roy
Running footwear is known to influence step rate, foot inclination at foot strike, average vertical loading rate (VLR) and peak patellofemoral joint (PFJ) force. However, the association between the level of minimalism of running shoes and running mechanics, especially with regards to these relevant variables for runners with patellofemoral pain (PFP), has yet to be investigated. The objective of this study was to explore the relationship between the level of minimalism of running shoes and habitual running kinematics and kinetics in runners with PFP...
March 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28265506/immediate-effects-of-eva-midsole-resilience-and-upper-shoe-structure-on-running-biomechanics-a-machine-learning-approach
#20
Andrea N Onodera, Wilson P Gavião Neto, Maria Isabel Roveri, Wagner R Oliveira, Isabel Cn Sacco
BACKGROUND: Resilience of midsole material and the upper structure of the shoe are conceptual characteristics that can interfere in running biomechanics patterns. Artificial intelligence techniques can capture features from the entire waveform, adding new perspective for biomechanical analysis. This study tested the influence of shoe midsole resilience and upper structure on running kinematics and kinetics of non-professional runners by using feature selection, information gain, and artificial neural network analysis...
2017: PeerJ
keyword
keyword
82375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"