Jiamin Zeng, Sida Liao, Zhu Liang, Caiping Li, Yuewen Luo, Kexin Wang, Dapeng Zhang, Lan Lan, Suzhen Hu, Wanyan Li, Ran Lin, Zichen Jie, Yuanlong Hu, Shiting Dai, Zhimin Zhang
Chronic obstructive pulmonary disease (COPD) is a serious chronic lung disease. Schisandrin A (SchA) is one of the most important active ingredients in Schisandra chinensis and has been used to treat various lung diseases in several countries. Here, we studied the pharmacological effect of SchA on airway inflammation induced by cigarette smoke (CS) and explored the therapeutic mechanism of SchA in COPD model mice. Our results showed that SchA treatment significantly improved the lung function of CS-induced COPD model mice and reduced the recruitment of leukocytes and hypersecretion of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α) in bronchoalveolar lavage fluid (BALF)...
July 3, 2023: European Journal of Medical Research