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Dexamethasone and chronic lung disease

Anna Pomerenke, Simon R Lea, Sarah Herrick, Mark A Lindsay, Dave Singh
PURPOSE: Viruses are a common cause of exacerbations in chronic obstructive pulmonary disease (COPD). They activate toll-like receptors (TLRs) 3, 7, and 8, leading to a pro-inflammatory response. We have characterized the responses of TLR3 and TLR7/8 in lung tissue explants from COPD patients and control smokers. METHODS: We prepared lung whole tissue explants (WTEs) from patients undergoing surgery for confirmed or suspected lung cancer. In order to mimic the conditions of viral infection, we used poly(I:C) for TLR3 stimulation and R848 for TLR7/8 stimulation...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Xia Yang, Jian-Ning Lv, Hui Li, Bo Jiao, Qiu-Hong Zhang, Yong Zhang, Jie Zhang, Yan-Qin Liu, Ming Zhang, Hu Shan, Jin-Zhao Zhang, Run-Miao Wu, Ya-Li Li
OBJECTIVES: Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Curcumin has been found to have anti-inflammatory and antifibrosis effects. Researchers reported that curcumin regulated Wnt/b-catenin signaling in lots of cells. However, whether curcumin regulates the levels of Wnt/ b-Catenin signaling in lung tissues and DCs (dendritic cells) remains unclear. In this study, we assessed the effects of curcumin on DCs and asthma. METHODS: C57BL/6 mice immunized with OVA (ovalbumin) were challenged thrice with an aerosol of OVA every second day for 8 days...
August 15, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Yu-Chieh Chen, Ying-Hua Huang, Jiunn-Ming Sheen, You-Lin Tain, Hong-Ren Yu, Chih-Cheng Chen, Miao-Meng Tiao, Ho-Chang Kuo, Li-Tung Huang
BACKGROUND: There is increasing epidemiological evidence indicating that many chronic diseases originate during early life, even before birth, through what are termed fetal programming effects. Prenatal glucocorticoid is frequently used clinically to accelerate the maturation of the lung, but its long-term effects remain unclear. METHODS: We gave pregnant Sprague-Dawley rats either intraperitoneal dexamethasone (0.1 mg/kg body weight) or vehicle at Gestational Days 14-20 and assessed the effects to pancreas at Postnatal Days 7 and 120...
June 18, 2016: Pediatrics and Neonatology
You-Lin Tain, Meng-Shan Wu, Yu-Ju Lin
Glucocorticoids, predominantly dexamethasone (DEX), are widely used to reduce the risk of prematurity-related chronic lung disease. However, prenatal DEX treatment links to adverse effects in later life, including hypertension. Given that sex differences exist in the blood pressure (BP) control, and that renal transcriptome is sex-specific, thus we intended to elucidate whether prenatal DEX-induced programmed hypertension is in a sex-specific manner and identify candidate genes and pathways using the whole-genome RNA next-generation sequencing (NGS) approach...
November 2016: Steroids
Md Mostafizur Rahman, Pavan Prabhala, Nowshin N Rumzhum, Brijeshkumar S Patel, Thomas Wickop, Philip M Hansbro, Nicole M Verrills, Alaina J Ammit
Corticosteroids are effective anti-inflammatory therapies widely utilized in chronic respiratory diseases. But these medicines can lose their efficacy during respiratory infection resulting in disease exacerbation. Further in vitro research is required to understand how infection worsens lung function control in order to advance therapeutic options to treat infectious exacerbation in the future. In this study, we utilize a cellular model of bacterial exacerbation where we pretreat A549 lung epithelial cells with the synthetic bacterial lipoprotein Pam3CSK4 (a TLR2 ligand) to mimic bacterial infection and tumor necrosis factor α (TNFα) to simulate inflammation...
September 2016: International Journal of Biochemistry & Cell Biology
Camila Pivari Pedroso Sakoda, Alessandra Choqueta de Toledo, Adenir Perini, Nathalia Montouro Pinheiro, Meire Ioshie Hiyane, Simone Dos Santos Grecco, Iolanda de Fátima Lopes Calvo Tibério, Niels Olsen Saraiva Câmara, Milton de Arruda Martins, João Henrique Ghilardi Lago, Renato Fraga Righetti, Carla Máximo Prado
BACKGROUND AND PURPOSE: Asthma is a disease of high prevalence and morbidity that generates high costs in hospitalization and treatment. Although the airway is involved in the physiopathology of asthma, there is also evidence of the importance of vascular and lung parenchyma inflammation and remodeling, which can contribute to the functional pulmonary alterations observed in asthmatic patients. Our aim was to evaluate treatment using sakuranetin, a flavone isolated from the twigs of Baccharis retusa (Asteraceae), on vascular and lung parenchyma alterations in an experimental murine model of asthma...
July 2016: Acta Histochemica
Anne Marie Barrette, Jessica K Roberts, Cheryl Chapin, Edmund A Egan, Mark R Segal, Juan A Oses-Prieto, Shreya Chand, Alma L Burlingame, Philip L Ballard
RATIONALE: Lung inflammation in premature infants contributes to development of bronchopulmonary dysplasia (BPD), a chronic lung disease with long-term sequelae. Pilot studies administering budesonide suspended in surfactant have found reduced BPD without apparent adverse effects as occur with systemic dexamethasone therapy. OBJECTIVES: To determine budesonide potency, stability and anti-inflammatory effects in human fetal lung. METHODS: We cultured explants of second trimester fetal lung with budesonide or dexamethasone and used microscopy, immunoassays, RNAseq, liquid chromatography/tandem mass spectrometry and pulsating bubble surfactometry...
June 9, 2016: American Journal of Respiratory Cell and Molecular Biology
Satoshi Ohnishi, Hiroyuki Ichiba, Mika Saito, Takashi Hamazaki, Hisako Matsumura, Haruo Shintaku
BACKGROUND: We investigated the effects of glucocorticoids, erythropoietin (EPO) and spironolactone (SPL) on human fetal lung fibroblasts and human alveolar epithelial cells exposed to tracheal aspirate fluid (TAF) from extremely premature infants with chronic lung disease (CLD), which is characterized by fibrosis and changes in the alveolar epithelium. METHODS: Fibroblasts and epithelial cells (FHs 738Lu and A549, respectively) were treated with different concentrations of hydrocortisone (HDC), dexamethasone (DEX), betamethasone (BET), SPL, and EPO in the absence or presence of TAF from infants with CLD (gestational age, 25...
April 14, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Jiunn-Ming Sheen, Chih-Sung Hsieh, You-Lin Tain, Shih-Wen Li, Hong-Ren Yu, Chih-Cheng Chen, Miao-Meng Tiao, Yu-Chieh Chen, Li-Tung Huang
Increasing evidence has shown that many chronic diseases originate from early life, even before birth, through what are termed as fetal programming effects. Glucocorticoids are frequently used prenatally to accelerate the maturation of the lungs of premature infants. High-fat diets are associated with insulin resistance, but the effects of prenatal glucocorticoid exposure plus a postnatal high-fat diet in diabetes mellitus remain unclear. We administered pregnant Sprague-Dawley rats' intraperitoneal dexamethasone (0...
2016: International Journal of Molecular Sciences
K P Patel, A S Giraud, C S Samuel, S G Royce
No abstract text is available yet for this article.
June 2016: British Journal of Pharmacology
Yuan Ma, Ai Ge, Wen Zhu, Ya-Nan Liu, Ning-Fei Ji, Wang-Jian Zha, Jia-Xiang Zhang, Xiao-Ning Zeng, Mao Huang
Asthma is one of the most common inflammatory diseases characterized by airway hyperresponsiveness, inflammation, and remodeling. Morin, an active ingredient obtained from Moraceae plants, has been demonstrated to have promising anti-inflammatory activities in a range of disorders. However, its impacts on pulmonary diseases, particularly on asthma, have not been clarified. This study was designed to investigate whether morin alleviates airway inflammation in chronic asthma with an emphasis on oxidative stress modulation...
2016: Oxidative Medicine and Cellular Longevity
Rabih Halwani, Asma Sultana, Roua Al-Kufaidy, Amer Jamhawi, Alejandro Vazquez-Tello, Saleh Al-Muhsen
BACKGROUND: Although corticosteroid is a powerful anti-inflammatory drug that is used widely to control asthma, still severe asthmatics can develop steroid resistance. Airway fibroblasts are quite resistant to steroids during Idiopathic pulmonary fibrosis (IPF) and fibrosis in asthmatic lungs is not always controlled. Th-17 regulatory cytokine which are elevated in lung tissues of asthmatics were shown to enhance the survival of various types of cells. STAT factors are central to this anti-apoptotic function...
2016: Respiratory Research
Yun-Li Zhao, Jian-Hua Shang, Shi-Biao Pu, Heng-Shan Wang, Bei Wang, Lu Liu, Ya-Ping Liu, Hong-Mei Shen, Xiao-Dong Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Alstonia scholaris (Apocynaceae) have been traditionally used for treatment of respiratory diseases in "dai" ethnopharmacy for hundreds years, especially for cough, asthma, phlegm, chronic obstructive pulmonary disease and so on. The formulas including the leaf extract have also been prescribed in hospitals and sold over the retail pharmacies. AIM OF THE STUDY: A. scholaris is used as a traditional herbal medicine for the treatment of respiratory tract inflammation...
February 3, 2016: Journal of Ethnopharmacology
Ling-Bo Li, Donald Y M Leung, Elena Goleva
Steroid resistance is a significant problem in management of chronic inflammatory diseases, including asthma. Accessible biomarkers are needed to identify steroid resistant patients to optimize their treatment. This study examined corticosteroid resistance in severe asthma. 24 asthmatics with forced expiratory volume in one second of less then 80% predicted were classified as steroid resistant or steroid sensitive based on changes in their lung function following a week of treatment with oral prednisone. Heparinised blood was collected from patients prior to oral prednisone administration...
2015: PloS One
Xinxin Ci, Weiting Zhong, Hua Ren, Zhongmei Wen, Dan Li, Liping Peng
BACKGROUND: The role of airway inflammation and inflammation-induced oxidative stress in the pathogenesis and progression of chronic inflammatory airway diseases has received increasing attention in recent years. We investigated the potential anti-inflammatory and antioxidative effects of esculentoside A (EsA), a saponin isolated from the Chinese herb Phytolacca esculenta, in comparison to dexamethasone, a potent corticosteroid, in a murine model of allergic asthma. METHODS: EsA was added to cultures of A549 cells at different concentrations or for different lengths of time, and nuclear factor erythroid 2-related factor 2 (Nrf-2) translocation and heme oxygenase 1 expression were monitored...
2015: International Archives of Allergy and Immunology
Yun Sun, Keyi Wang, Min-Xia Li, Wei He, Jin-Rui Chang, Cheng-Cheng Liao, Fan Lin, Yong-Fen Qi, Rui Wang, Ya-Hong Chen
Oxidative stress and inflammation play crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Most patients with COPD show a poor response to corticosteroids. Hydrogen sulfide (H2S ) has been implicated in the pathogenesis of COPD, but its expression and effects in lung tissue from COPD patients are not clear. In peripheral lung tissue samples from 24 patients, we found that compared with nonsmokers, the protein level of cystathionine-γ-lyase (CSE) was decreased in smokers and COPD patients...
2015: Scientific Reports
Jessica K Roberts, Chris Stockmann, Mar Janna Dahl, Kurt H Albertine, Edmund Egan, Zhenjian Lin, Christopher A Reilly, Philip L Ballard, Roberta A Ballard, Robert M Ward
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of premature human infants, which may persist through adulthood. Airway inflammation has been firmly established in the pathogenesis of BPD. Previous studies to reduce airway inflammation with high-dose dexamethasone demonstrated adverse neurological outcomes, despite lower incidences of BPD. Instillation of budesonide and surfactant can facilitate early extubation and reduce the incidence of BPD and death among very low birth weight infants. However, the pharmacokinetics of budesonide and its distribution into the lung and brain are unknown...
2016: Current Clinical Pharmacology
Lingling Li, Yujie Wang, Wei Gao, Cheng Yuan, Sini Zhang, Hong Zhou, Mao Huang, Xin Yao
Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Klotho, an anti-aging protein, has an anti-inflammatory function. However, the role of Klotho has never been investigated in COPD. The aim of this study is to investigate the possible role of Klotho by alveolar macrophages in airway inflammation in COPD. Klotho levels were assessed in the lung samples and peripheral blood mononuclear cells of non-smokers, smokers, and patients with COPD...
November 13, 2015: Journal of Biological Chemistry
Bhakti N Sadarani, Anuradha S Majumdar
Cigarette smoking is considered to be the main etiological factor in Chronic Obstructive Pulmonary Disease (COPD). In this study, we explored the potential of resveratrol, to reinstate the effectiveness of dexamethasone when administered as an adjunct in acute lung inflammation induced by cigarette smoke (CS) and lipopolysaccharide (LPS). CS and LPS instillation produced acute inflammatory response exhibited by increased leukocyte count, particularly neutrophils, total protein, MMP-9 activity, cytokines like TNF-α, IL-8 in bronchoalveolar lavage fluid (BALF) as well as elevated myeloperoxidase activity, and lipid peroxidation in lung...
September 2015: International Immunopharmacology
Carmen F Mendoza, Patricia Ontiveros, Daniel X Xibillé, Heriberto Manuel Rivera, Manuel H Rivera
BACKGROUND: The association between mesotheliomas and ectopic ACTH secretion has been rarely reported; we present the first case of ectopic ACTH secretion (EAS) associated with a well-differentiated peritoneal mesothelioma in whom the high dose dexamethasone suppression test (HDDST) results and plasmatic ACTH levels were similar to those found in Cushing's disease (CD). CASE PRESENTATION: A 43-year-old hispanic woman with a 20 year history of treatment resistant diabetes mellitus and arterial hypertension...
2015: BMC Endocrine Disorders
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