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https://www.readbyqxmd.com/read/27908391/prevalence-profile-and-prognosis-of-severe-obesity-in-contemporary-hospitalized-heart-failure-trial-populations
#1
Emer Joyce, Anuradha Lala, Susanna R Stevens, Lauren B Cooper, Omar F AbouEzzeddine, John D Groarke, Justin L Grodin, Eugene Braunwald, Kevin J Anstrom, Margaret M Redfield, Lynne W Stevenson
OBJECTIVES: This study evaluated the prevalence, profile, and prognosis of severe obesity in a large contemporary acute heart failure (AHF) population. BACKGROUND: Better prognosis has been reported for obese heart failure (HF) patients than nonobese HF patients, but in other cardiovascular populations, this effect has not been demonstrated for severely obese patients. METHODS: A cohort of 795 participants with body mass index (BMI) measured at time of admission and complete follow-up were identified from enrollment in 3 contemporary AHF trials (DOSE [Diuretic Strategies Optimization Evaluation], CARRESS-HF [Cardiorenal Rescue Study in Acute Decompensated Heart Failure], and ROSE [Renal Optimization Strategies Evaluation in Acute Heart Failure])...
December 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27873227/the-relationship-between-aortic-root-size-and-hypertension-an-unsolved-conundrum
#2
Giuseppe Mulè, Emilio Nardi, Massimiliano Morreale, Antonella Castiglia, Giulio Geraci, Dario Altieri, Valentina Cacciatore, Margherita Schillaci, Francesco Vaccaro, Santina Cottone
Thoracic aortic aneurysms rupture and dissection are among the most devastating vascular diseases, being characterized by elevated mortality, despite improvements in diagnostic imaging and surgical techniques.An increased aortic root diameter (ARD) represents the main risk factor for thoracic aortic dissection and rupture and for aortic valve regurgitation.Even though arterial hypertension is commonly regarded as a predisposing condition for the development of thoracic aorta aneurysms, the role of blood pressure (BP) as determinant of aortic root enlargement is still controversial...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27832460/investigating-the-differences-of-body-mass-index-and-waist-circumference-in-the-follow-up-assessment-of-patients-to-cardiac-rehabilitation-with-acute-coronary-syndrome
#3
Hui Zhao, Jun Ma, Qiru Zhou, Wei Chen, Wei Zhu, Zekun Cai, Hongqiang Lei, Yu Deng, Lin Xu, Jian Qiu
Obesity management is a key point during cardiac rehabilitation. The effect of new index, waist circumference (WC), in the obesity management of cardiac rehabilitation is not clear yet. Therefore, our study compared the WC index to the body mass index (BMI) in the evaluation of obesity management for the patients with acute coronary syndrome (ACS) in a well-designed cardiac rehabilitation program (CRP). Totally 61 patients were enrolled into our study between October 2013 and January 2014 in our hospital. All these patients were requested to participate in the CRP actively for 6 months...
November 10, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27754006/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#4
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27714717/annual-prognostic-factors-in-chronic-heart-failure-in-patients-over-80-years-old
#5
Anna Cichocka-Radwan, Małgorzata Lelonek
BACKGROUND: In the elderly the most common cause of hospitalization and the leading cause of death is heart failure. AIM: The purpose was to determine prognostic factors in chronic heart failure (CHF) in octogenarians and nonagenarians. METHODS: The analysis included 197 consecutive patients older than 80 years old (mean age 83.63+3.01 years; 46.19% of men) hospitalized in 2010-2013 in the Department of Cardiology due to CHF. Sixty two parameters were investigated such as: age, gender, NYHA functional class, body mass index, blood pressure, other comorbidities, the parameters of the 12-lead resting ECG and the echocardiography, the results of basic laboratory tests and selected biomarkers, including N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitive troponin T (hs-TnT), high-sensitive C-reactive protein (hs-CRP)...
October 7, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/27642917/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#6
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27627559/the-relationship-of-carotid-arterial-stiffness-and-left-ventricular-concentric-hypertrophy-in-hypertension
#7
Joanna Jaroch, Krystyna Łoboz-Grudzień, Stefania Magda, Maria Florescu, Zbigniew Bociąga, Andrea O Ciobanu, Ewa Kruszyńska, Krzysztof Dudek, Dragos Vinereanu
BACKGROUND: Left ventricular hypertrophy (LVH) and geometry patterns vary in different hemodynamic profiles The concentric hypertrophy (CH) pattern has been proved to have the worst prognosis. OBJECTIVES: The aim of the study was to test the hypothesis that carotid artery stiffness, as a marker of vascular damage, is associated with CH, independently of other potential determinants such as demographic factors (age, sex, BMI), clinical parameters (smoking, diabetes, creatinine level) and hemodynamic variables (blood pressure, pulse pressure [PP])...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27614542/cumulative-burden-of-myocardial-dysfunction-in-cardiac-amyloidosis-assessed-using-four-chamber-cardiac-strain
#8
Yuichiro Kado, Masaru Obokata, Yasufumi Nagata, Tomoko Ishizu, Karima Addetia, Kazutaka Aonuma, Masahiko Kurabayashi, Roberto M Lang, Masaaki Takeuchi, Yutaka Otsuji
BACKGROUND: The aim of this study was to test the hypothesis that prognosis in patients with cardiac amyloidosis is closely coupled with amyloid burden in all four cardiac chambers. The goal was to evaluate longitudinal strain (LS) in each cardiac chamber and to determine whether LS in specific cardiac chambers is preferentially associated with prognosis over conventional two-dimensional echocardiographic parameters in patients with cardiac amyloidosis. METHODS: Patients with two phenotypes of left ventricular (LV) hypertrophy (cardiac amyloidosis in 55 patients and nonobstructive hypertrophic cardiomyopathy in 40 patients) and 55 healthy subjects were retrospectively enrolled for the simultaneous assessment of LS of all four cardiac chambers in the apical four-chamber view...
September 7, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27553872/late-gadolinium-enhancement-and-adverse-outcomes-in-a-contemporary-cohort-of-adult-survivors-of-tetralogy-of-fallot
#9
Richard J Dobson, Ify Mordi, Mark H Danton, Niki L Walker, Hamish A Walker, Nikolaos Tzemos
OBJECTIVE: Myocardial fibrosis has been associated with poorer outcomes in tetralogy of Fallot, however only a handful of studies have assessed its significance in the current era. Our aim was to quantify the amount of late gadolinium enhancement in both the LV and RV in a contemporary cohort of adults with surgically repaired tetralogy of Fallot, and assess the relationship with adverse clinical outcomes. DESIGN: Single centre cohort study SETTING: National tertiary referral center Patients: One hundred fourteen patients with surgically repaired tetralogy of Fallot with median age 29...
August 24, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27508754/-op-5c-07-do-combined-electrocardiographic-and-echocardiographic-markers-of-left-ventricular-hypertrophy-improve-cardiovascular-risk-estimation
#10
C Cuspidi, G L Seravalle, A Re, F Zanchettin, F Bonomi, F Quarti Trevano, R Facchetti, C Sala, M Bombelli, M Tadjc, G Mancia, G Grassi
OBJECTIVE: We estimated the risk of cardiovascular mortality associated with echocardiographic (ECHO) sub-types of left ventricular hypertrophy (LVH), as defined by an up-dated classification, in subjects with and without electrocardiographic (ECG) LVH. To this purpose 1,691 representatives of the general population of Monza, enrolled in the Pressioni Monitorate e Loro Associazioni (PAMELA) study, were included in the present analysis. DESIGN AND METHOD: Cut-points for ECHO-LVH and abnormal LV geometry were derived from reference values of the healthy fraction of the PAMELA population by combining LV mass index, LV diameter and relative wall thickness, ECG-LVH was defined according to Cornell voltage index...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508688/-op-4a-03-is-white-coat-effect-protective-for-the-prognosis-of-cardiovascular-events
#11
J Bastos, A Araújo, J Pires, J Pinto, P Almeida, J Polonia
OBJECTIVE: HASH(0x50ea190) AIM: It is not well known if systolic white coat effect (WCE), the difference between casual systolic blood pressure (SBPc) and daytime systolic blood pressure determined by ambulatory blood pressure (ABPM), is a marker or not of worst cardiovascular events (CV).The aim of the study was to evaluate the prognostic value of white coat effect in relation to cardiovascular events (CV) stroke (AVC) and coronary events (DC). DESIGN AND METHOD: Casual and ABP were obtained in 1200 hypertensive patients (645 female) age 51 ± 12 years, BMI 27 ± 5 Kg/m2, SBPc 154...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508558/-op-1c-10-benefits-of-ambulatory-blood-pressure-measurement-in-post-acute-aortic-syndrome-predictors-for-blood-pressure-control-and-importance-of-nocturnal-blood-pressure-influence
#12
P Delsart, G Ledieu, P Devos, J Sobocinski, R Clough, S Haulon, C Mounier-Vehier
OBJECTIVE: Ambulatory blood pressure measurement (ABPM) is recommended to assess optimal blood pressure (BP) control, the most important factor in management post acute aortic syndrome (AAS). Data in this case are lacking. ABPM has previously been shown to be more closely associated with prognosis than clinical values. We assessed these advantages in post AAS.(Figure is included in full-text article.) DESIGN AND METHOD: : We retrospectively collected data from 111 patients with Type B AAS from January 2004 to September 2014...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27490427/prevalence-of-sleep-disordered-breathing-and-patient-characteristics-in-a-coronary-artery-disease-cohort-undergoing-cardiovascular-rehabilitation
#13
Henrik Fox, Hans-Christian Purucker, Isabelle Holzhacker, Ulrich Tebtmann, Thomas Bitter, Dieter Horstkotte, Andrea Graml, Holger Woehrle, Olaf Oldenburg
PURPOSE: Coronary artery disease (CAD) is a leading cause of death and identification of risk factors for CAD is crucial. One such potential risk factor is sleep-disordered breathing (SDB). This prospective cohort study investigated the prevalence of SDB and determined risk factors for the presence of SDB in a large CAD cohort undergoing cardiac rehabilitation. METHODS: A total of 1425 patients with confirmed CAD starting rehabilitation were screened for SDB using cardiorespiratory polygraphy (n = 921) or polygraphy plus pulse oximetry (n = 484)...
August 3, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27468488/-progressive-risks-of-latent-keshan-disease-a-long-term-follow-up-study
#14
Xin Liu, Guang Yang, Li-xin Wang, Jin Wei, Wu-hong Tan, Yan-he Zhu
OBJECTIVE: To observe ten-year prognosis of patients with latent Keshan disease (KD) and to determine its associated risk factors. METHODS: A total of 448 patients with newly diagnosed latent KD were monitored and followed up for 10 years. Their ECG abnormalities were classified as major or minor using the Minnesota Code. COX proportional hazards regression models were established to identify risk factors associated with the development of chronic KD. RESULTS: A final sample of 414 cases was included in analyses, with an average of (112...
May 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/27458659/prevalence-clinical-and-echocardiographic-characteristics-of-various-flow-and-gradient-patterns-in-mild-or-moderate-aortic-stenosis-with-normal-left-ventricular-ejection-fraction
#15
Yong-Qiang Benjamin Tan, Jinghao Nicholas Ngiam, William K F Kong, Tiong-Cheng Yeo, Kian-Keong Poh
BACKGROUND/OBJECTIVES: Paradoxical low-flow aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) has only been described in severe AS. Controversy surrounds prognosis and management but no studies have reported this phenomenon in mild or moderate AS. We investigated the prevalence of flow and gradient patterns in this population, characterising their clinical and echocardiographic profile. METHODS: Consecutive subjects (n=1362) with isolated AS: mild (n=462, aortic valve area≥1...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27452432/carbohydrate-and-fatty-acid-perturbations-in-the-amniotic-fluid-of-the-recipient-twin-of-pregnancies-complicated-by-twin-twin-transfusion-syndrome-in-relation-to-treatment-and-fetal-cardiovascular-risk
#16
Warwick B Dunn, J William Allwood, Tim Van Mieghem, R Katie Morris, Fiona L Mackie, Caroline E Fox, Mark D Kilby
INTRODUCTION: Twin-twin transfusion syndrome (TTTS) complicates 15% of monochorionic twin pregnancies, often being associated with recipient cardiac dysfunction. Untreated, it has a fetal mortality rate of at least 90%; although treatment by fetoscopic laser coagulation significantly improves prognosis. Measurement of recipient amniotic fluid metabolites, such as cardiac Troponin T and atrial natriuretic polypeptide, correlate with cardiac function in this fetus. The aim of this study is to describe the amniotic fluid metabolomic profile in TTTS, relate this to fetal recipient cardiac function and assess the metabolomic changes induced by fetoscopic laser coagulation...
August 2016: Placenta
https://www.readbyqxmd.com/read/27440307/association-of-thoracic-aorta-calcium-score-with-left-ventricular-hypertrophy-and-clinical-outcomes-in-patients-with-severe-aortic-stenosis-after-aortic-valve-replacement
#17
In-Jeong Cho, Hyuk-Jae Chang, Ran Heo, In-Cheol Kim, Ji Min Sung, Byung-Chul Chang, Chi Young Shim, Geu-Ru Hong, Namsik Chung
BACKGROUND: Substantial aortic calcification is known to be associated with aortic stiffening and subsequent left ventricular (LV) hypertrophy. This study examined whether the thoracic aorta calcium score (TACS) is related to LV hypertrophy and whether it leads to an adverse prognosis in patients with severe aortic stenosis (AS) after aortic valve replacement (AVR). METHODS: We retrospectively reviewed 47 patients (mean age, 64 ± 11 years) with isolated severe AS who underwent noncontrast computed tomography of the entire thoracic aorta and who received AVR...
July 17, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27423871/non-alcoholic-fatty-liver-disease-with-and-without-metabolic-syndrome-different-long-term-outcomes
#18
Aki Juhani Käräjämäki, Risto Bloigu, Heikki Kauma, Y Antero Kesäniemi, Olli-Pekka Koivurova, Juha Perkiömäki, Heikki Huikuri, Olavi Ukkola
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are both shown to increase the risk of cardiovascular diseases and type 2 diabetes. However, there is a great overlap between these two diseases. The present study was aimed to examine the cardiovascular and metabolic prognosis of non-alcoholic fatty liver disease with and without metabolic syndrome. METHODS: Middle-aged subjects (n=958) were divided into four subgroups, those with NAFLD and MetS, those with NAFLD or MetS, and healthy controls...
July 1, 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27374035/red-cell-distribution-width-and-chronic-heart-failure-prognostic-role-beyond-echocardiographic-parameters
#19
Enrico Vizzardi, Edoardo Sciatti, Ivano Bonadei, Natalia L Pezzali, Carlo M Lombardi, Marco Metra
AIM: Red cell distribution width (RDW) is a measure of anisocytosis. Higher values are robustly associated to adverse outcome in several conditions, including chronic heart failure (HF). The present study aimed to compared its prognostic role with that of echocardiographic parameters in this kind of patients. METHODS: 32 stable and optimally treated chronic HF patients were enrolled. We excluded subjects suffering from valvular diseases or atrial fibrillation. They underwent blood sampling and echocardiographic examination...
June 22, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/27334442/ecg-strain-pattern-in-hypertension-is-associated-with-myocardial-cellular-expansion-and-diffuse-interstitial-fibrosis-a-multi-parametric-cardiac-magnetic-resonance-study
#20
Jonathan C L Rodrigues, Antonio Matteo Amadu, Amardeep Ghosh Dastidar, Bethannie McIntyre, Gergley V Szantho, Stephen Lyen, Cattleya Godsave, Laura E K Ratcliffe, Amy E Burchell, Emma C Hart, Mark C K Hamilton, Angus K Nightingale, Julian F R Paton, Nathan E Manghat, Chiara Bucciarelli-Ducci
AIMS: In hypertension, the presence of left ventricular (LV) strain pattern on 12-lead electrocardiogram (ECG) carries adverse cardiovascular prognosis. The underlying mechanisms are poorly understood. We investigated whether hypertensive ECG strain is associated with myocardial interstitial fibrosis and impaired myocardial strain, assessed by multi-parametric cardiac magnetic resonance (CMR). METHODS AND RESULTS: A total of 100 hypertensive patients [50 ± 14 years, male: 58%, office systolic blood pressure (SBP): 170 ± 30 mmHg, office diastolic blood pressure (DBP): 97 ± 14 mmHg) underwent ECG and 1...
June 22, 2016: European Heart Journal Cardiovascular Imaging
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