Margo B Heston, Kendra L Hanslik, Katie R Zarbock, Sandra J Harding, Nancy J Davenport-Sis, Robert L Kerby, Nathaniel Chin, Yi Sun, Ana Hoeft, Yuetiva Deming, Nicholas M Vogt, Tobey J Betthauser, Sterling C Johnson, Sanjay Asthana, Gwendlyn Kollmorgen, Ivonne Suridjan, Norbert Wild, Henrik Zetterberg, Kaj Blennow, Federico E Rey, Barbara B Bendlin, Tyler K Ulland
Age-related disease may be mediated by low levels of chronic inflammation ("inflammaging"). Recent work suggests that gut microbes can contribute to inflammation via degradation of the intestinal barrier. While aging and age-related diseases including Alzheimer's disease (AD) are linked to altered microbiome composition and higher levels of gut microbial components in systemic circulation, the role of intestinal inflammation remains unclear. To investigate whether greater gut inflammation is associated with advanced age and AD pathology, we assessed fecal samples from older adults to measure calprotectin, an established marker of intestinal inflammation which is elevated in diseases of gut barrier integrity...
November 14, 2023: Scientific Reports