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https://www.readbyqxmd.com/read/29142297/5-aminolevulinic-acid-guided-sampling-of-glioblastoma-microenvironments-identifies-pro-survival-signaling-at-infiltrative-margins
#1
James L Ross, Lee A D Cooper, Jun Kong, David Gutman, Merete Williams, Carol Tucker-Burden, Myles R McCrary, Alexandros Bouras, Milota Kaluzova, William D Dunn, Duc Duong, Constantinos G Hadjipanayis, Daniel J Brat
Glioblastoma (GBM) contains diverse microenvironments with uneven distributions of oncogenic alterations and signaling networks. The diffusely infiltrative properties of GBM result in residual tumor at neurosurgical resection margins, representing the source of relapse in nearly all cases and suggesting that therapeutic efforts should be focused there. To identify signaling networks and potential druggable targets across tumor microenvironments (TMEs), we utilized 5-ALA fluorescence-guided neurosurgical resection and sampling, followed by proteomic analysis of specific TMEs...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29139095/local-alkylating-chemotherapy-applied-immediately-after-5-ala-guided-resection-of-glioblastoma-does-not-provide-additional-benefit
#2
William Sage, Mathew Guilfoyle, Catriona Luney, Adam Young, Rohitashwa Sinha, Donatella Sgubin, Joseph H McAbee, Ruichong Ma, Sarah Jefferies, Rajesh Jena, Fiona Harris, Kieren Allinson, Tomasz Matys, Wendi Qian, Thomas Santarius, Stephen Price, Colin Watts
Grade IV glioma is the most common and aggressive primary brain tumour. Gross total resection with 5-aminolevulinic acid (5-ALA) guided surgery combined with local chemotherapy (carmustine wafers) is an attractive treatment strategy in these patients. No previous studies have examined the benefit carmustine wafers in a treatment programme of 5-ALA guided resection followed by a temozolomide-based chemoradiotherapy protocol. The objective of this study was to examine the benefit of carmustine wafers on survival in patients undergoing 5-ALA guided resection...
November 14, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29129543/idiopathic-elastosis-perforans-serpiginosa-with-satisfactory-response-after-5-ala-photodynamic-therapy
#3
S Alique-García, J Company-Quiroga, C Horcajada-Reales, B Echeverría-García, J C Tardío-Dovao, J Borbujo
Photodynamic therapy (PDT) involves the use of photochemical reactions mediated through the interaction of photosensitizing agents, light, and oxygen for the treatment of malignant or benign diseases. Topical photosensitizers employed in dermatology are 5-aminolevulinic acid (5 ALA) and methyl aminolevulinate, classically used for the treatment of superficial non-melanoma skin cancer and their precursors. Recently the efficacy of PDT has been introduced in other benign diseases. Elastosis perforans serpiginosa (EPS) is a rare skin disorder characterized by transepidermal elimination of abnormal elastic fibers...
November 9, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29101863/contemporary-use-of-intraoperative-imaging-in-glioma-surgery-a-survey-among-eans-members
#4
Jan Coburger, Arya Nabavi, Ralph König, Christian Rainer Wirtz, Andrej Pala
OBJECTIVES: In glioma surgery, intraoperative imaging is regarded highly valuable to improve extent of resection. Current distribution of intraoperative imaging techniques is largely unknown. Further, controversy exists which method might be most beneficial. PATIENTS AND METHODS: We performed a web-based survey among members of the European Association of Neurological Surgeons(EANS) from April to May 2017. Our questionnaire included intraoperative MRI(iMRI), 5-aminolevulinic acid(5-ALA), intraoperative ultrasound(iUS),Na-Fluorescein and intraoperative CT(iCT)...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29076783/systematic-histopathological-analysis-of-different-5-aminolevulinic-acid-induced-fluorescence-levels-in-newly-diagnosed-glioblastomas
#5
Barbara Kiesel, Mario Mischkulnig, Adelheid Woehrer, Mauricio Martinez-Moreno, Matthias Millesi, Ammar Mallouhi, Thomas Czech, Matthias Preusser, Johannes A Hainfellner, Stefan Wolfsberger, Engelbert Knosp, Georg Widhalm
OBJECTIVE Glioblastoma (GBM) is characterized by distinct intratumoral histopathological heterogeneity with regard to variable tumor morphology, cell proliferation, and microvascularity. Maximum resection of a GBM results in an improved prognosis and thus represents the aim of surgery in the majority of cases. Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is currently widely applied for improved intraoperative tumor visualization in patients with a GBM. Three intratumoral fluorescence levels (i...
October 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29066318/5-ala-induced-fluorescence-in-leptomeningeal-dissemination-of-spinal-malignant-glioma
#6
Zarela Krause Molle, Kristin Gierga, Bernd Turowski, Hans-Jakob Steiger, Jan Frederick Cornelius, Marion Rapp, Michael Sabel, Marcel A Kamp
No abstract text is available yet for this article.
October 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29038905/recent-advances-in-production-of-5-aminolevulinic-acid-using-biological-strategies
#7
REVIEW
Zhen Kang, Wenwen Ding, Xu Gong, Qingtao Liu, Guocheng Du, Jian Chen
5-Aminolevulinic acid (5-ALA) is the precursor for the biosynthesis of tetrapyrrole compounds and has broad applications in the medical and agricultural fields. Because of the disadvantages of chemical synthesis methods, microbial production of 5-ALA has drawn intensive attention and has been regarded as an alternative in the last years, especially with the rapid development of metabolic engineering and synthetic biology. In this mini-review, recent advances on the application and microbial production of 5-ALA using novel biological approaches (such as whole-cell enzymatic-transformation, metabolic pathway engineering and cell-free process) are described and discussed in detail...
October 16, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29033402/5-aminolevulinic-acid-5-ala-fluorescence-guided-mohs-surgery-resection-of-penile-scrotal-extramammary-paget-s-disease
#8
Xiaoqiong Peng, Wei Qian, Jiangang Hou
This report aims to evaluate the usefulness of 5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease for achieving maximum tumor resection. Between January 2014 and December 2015, 5 patients underwent surgical resection of a penile-scrotal extramammary Paget's disease in department of urology, Huashan hospital, Fudan University. All patients were coated with 5-ALA (concentration of 20%) throughout the scrotum and the visible range of the lesion plus a 2cm margin 3 hours before the induction of anesthesia...
October 16, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/29023876/mri-assessment-of-treatment-delivery-for-interstitial-photodynamic-therapy-of-high-grade-glioma-in-a-preclinical-model
#9
Henri-Arthur Leroy, Maximilien Vermandel, Bertrand Leroux, Alain Duhamel, Jean-Paul Lejeune, Serge Mordon, Nicolas Reyns
BACKGROUND: High-grade gliomas are primary brain tumors that have shown increasing incidence and unfavorable outcomes. Local control is crucial to the management of this pathology. Photodynamic therapy (PDT), based on the light-induced activation of a photosensitizer (PS), achieves local treatment by inducing selective lesions in tumor tissue. OBJECTIVES: Previous studies have reported the outcomes of PDT for glioblastoma via immunohistological data. Our study aimed to evaluate MRI findings, including diffusion, and perfusion sequences, compared with immunohistological data from the same population to address the efficiency of light fractionation...
October 11, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28964889/modulating-mitochondrial-morphology-enhances-antitumor-effect-of-5-ala-mediated-photodynamic-therapy-both-in-vitro-and-in-vivo
#10
Hongyou Zhao, Rong Yin, Ying Wang, Yuan-Hao Lee, Ting Luo, Jiaying Zhang, Haixia Qiu, Stephen Ambrose, Lijie Wang, Jie Ren, Jie Yao, Defu Chen, Yucheng Wang, Zhipin Liang, Jie Zhen, Sumin Wu, Zulin Ye, Jing Zeng, Naiyan Huang, Ying Gu
5-aminolevulinic acid mediated PDT (5-ALA-PDT) is an approved therapeutic procedure for treating carcinomas of the cervix. However, when employed as a monotherapy, 5-ALA-PDT could not produce satisfactory results toward large and deep tumors. Therefore, developing a method to improve the efficacy of 5-ALA-PDT becomes important. In this study, we demonstrate an enhanced antitumor effect of 5-ALA-PDT by the modulation of mitochondrial morphology. The mitochondria in the cells were regulated into tubular mitochondria or fragmented mitochondria through over expression of Drp1 or Mfn2...
September 20, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28962578/intraoperative-5-aminolevulinic-acid-induced-photodynamic-diagnosis-of-metastatic-brain-tumors-with-histopathological-analysis
#11
R Yagi, S Kawabata, N Ikeda, N Nonoguchi, M Furuse, Y Katayama, Y Kajimoto, T Kuroiwa
BACKGROUND: Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is a promising real-time navigation method in the surgical resection of malignant gliomas. In order to determine whether this method is applicable to metastatic brain tumors, we evaluated the usefulness of intraoperative fluorescence patterns and histopathological features in patients with metastatic brain tumors. METHODS: We retrospectively reviewed the cases of 16 patients with metastatic brain tumors who underwent intraoperative 5-ALA fluorescence-guided resection...
September 29, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28955092/role-of-5-ala-in-improving-extent-of-tumour-resection-in-patients-with-glioblastoma-multiforme
#12
Muhammad Waqas, Inamullah Khan, Muhammad Shahzad Shamim
Goal of surgery for patients with Glioblastoma Multiforme (GBM) is gross total resection with no new neurological deficits. Surgical resection is often restricted due the difficulty in differentiating the tumour from surrounding normal brain using either naked eye, or standard intra-operative white light microscopy. GBM uptakes orally administered 5-ALA becomes fluorescent when viewed by a special light, and this property has been used to improve intra-operative tumour identification. This technique should therefore allow better extent of tumour resection...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28951177/5-aminolevulinic-acid-based-photodynamic-therapy-of-chordoma-in-vitro-experiments-on-a-human-tumor-cell-line
#13
Jan F Cornelius, Lennert Eismann, Lara Ebbert, Brigitte Senger, Athanasios K Petridis, Marcel Alexander Kamp, Rüdiger V Sorg, Hans Jakob Steiger
BACKGROUND: Chordomas are very rare tumors of the skull base and the sacrum. They show infiltrating and destructive growth and are known to be chemo- and radio-resistant. After surgical resection, the recurrence rate is high and overall survival limited. As current adjuvant treatments are ineffective, new treatment concepts are urgently needed. 5-aminolevulinic acid-based photodynamic therapy (5-ALA based PDT) showed promising results for malignant gliomas. However, it is unknown so far, whether chordomas accumulate protoporphyrin IX (PPIX) after application of 5-ALA and whether they are sensitive to subsequent 5-ALA based PDT...
September 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28939850/glutaminase-2-expression-is-associated-with-regional-heterogeneity-of-5-aminolevulinic-acid-fluorescence-in-glioblastoma
#14
Sojin Kim, Ja Eun Kim, Yong Hwy Kim, Taeyoung Hwang, Sung Kwon Kim, Wen Jun Xu, Jong-Yeon Shin, Jong-Il Kim, Hyoungseon Choi, Hee Chan Kim, Hye Rim Cho, Anna Choi, Tamrin Chowdhury, Youngbeom Seo, Yun-Sik Dho, Jin Wook Kim, Dong Gyu Kim, Sung-Hye Park, Hyeonjin Kim, Seung Hong Choi, Sunghyouk Park, Se-Hoon Lee, Chul-Kee Park
Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment. However, intratumoral heterogeneity of fluorescence intensity may reflect different onco-metabolic programs. Here, we investigated the metabolic mechanism underlying the heterogeneity of 5-ALA fluorescence in GBM. Using an in-house developed fluorescence quantification system for tumor tissues, we collected 3 types of GBM tissues on the basis of their fluorescence intensity, which was characterized as strong, weak, and none...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28933502/synthesis-and-evaluation-of-new-5-aminolevulinic-acid-derivatives-as-prodrugs-of-protoporphyrin-for-photodynamic-therapy
#15
Wei Zhu, Ying-Hua Gao, Chun-Hong Song, Zhi-Bin Lu, Tabbisa Namulinda, Yi-Ping Han, Yi-Jia Yan, Lai-Xing Wang, Zhi-Long Chen
Protoporphyrin IX (PpIX) is used as a photosensitizer in the photodynamic diagnosis (PDD) and photodynamic therapy (PDT) of cancer and is synthesized intracellularly from 5-aminolevulinic acid (5-ALA) precursors. Thirteen novel 5-ALA derivatives were designed and synthesized appropriately with tailored hydrophilicity and lipophilicity. The generation of PpIX was detected and their antitumor activity in vitro and in vivo was also investigated. It was shown that compounds 9b-c, 11b-c and 13a displayed a characteristic long wavelength absorption peak at 593 nm after 5 h incubation in mice fibrosarcoma S180 cells...
November 8, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28929305/auditory-display-for-fluorescence-guided-open-brain-tumor-surgery
#16
David Black, Horst K Hahn, Ron Kikinis, Karin Wårdell, Neda Haj-Hosseini
PURPOSE: Protoporphyrin (PpIX) fluorescence allows discrimination of tumor and normal brain tissue during neurosurgery. A handheld fluorescence (HHF) probe can be used for spectroscopic measurement of 5-ALA-induced PpIX to enable objective detection compared to visual evaluation of fluorescence. However, current technology requires that the surgeon either views the measured values on a screen or employs an assistant to verbally relay the values. An auditory feedback system was developed and evaluated for communicating measured fluorescence intensity values directly to the surgeon...
September 19, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28921173/maximizing-safe-resections-the-roles-of-5-aminolevulinic-acid-and-intraoperative-mr-imaging-in-glioma-surgery-review-of-the-literature
#17
REVIEW
Eric Suero Molina, S Schipmann, W Stummer
Malignant glioma surgery involves the challenge of preserving the neurological status of patients harboring these lesions while pursuing a maximal tumor resection, which is correlated with overall and progression-free survival. Presently, several tools exist for assisting neurosurgeons in visualizing malignant tissue. Fluorescence-guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) has increasingly been used during the last decade for identifying malignant glioma. Intraoperative magnetic resonance imaging (iMRI), first introduced in the mid-1990s, is being evaluated as a further tool to maximize the extent of resection...
September 18, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28918177/photodynamic-therapy-in-oral-potentially-malignant-disorders-critical-literature-review-of-existing-protocols
#18
REVIEW
Jéssica Araújo Figueira, Vanessa Cristina Veltrini
INTRODUCTION: Oral cancer is a serious public health issue. Apart from its high rate of prevalence, incidence and mortality, it can often result in more complex and expensive treatment when diagnosed late. Potentially malignant disorders (PMDs) can precede oral cancer, and are usually treated by surgical excision. However, in many cases patients are elderly and multiple interventions may be required. Photodynamic therapy (PDT) is a simple alternative, which has been successfully used in the treatment of oral PMDs...
September 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28894407/fluorescence-guided-versus-conventional-surgical-resection-of-high-grade-glioma-a-single-centre-7-year-comparative-effectiveness-study
#19
Wei Ping Ng, Boon Seng Liew, Zamzuri Idris, Azmin Kass Rosman
BACKGROUND: High grade gliomas (HGGs) are locally invasive brain tumours that carry a dismal prognosis. Although complete resection increases median survival, the difficulty in reliably demonstrating the tumour border intraoperatively is a norm. The Department of Neurosurgery, Hospital Sungai Buloh is the first public hospital in Malaysia to overcome this problem by adopting fluorescence-guided (FG) surgery using 5-aminolevulinic acid (5-ALA). METHODS: A total of 74 patients with histologically proven HGGs treated between January 2008 and December 2014, who fulfilled the inclusion criteria, were enrolled...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28882957/5-aminolevulinic-acid-mediated-photodynamic-diagnosis-enhances-the-detection-of-peritoneal-metastases-in-biliary-tract-cancer-in-mice
#20
Toshihiro Kushibiki, Takehiro Noji, Yuma Ebihara, Koji Hontani, Masato Ono, Shota Kuwabara, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Masahiro Ishizuka, Satoshi Hirano
BACKGROUND/AIM: Previous studies on the accuracy of 5-aminolevulinic-acid-mediated photodynamic diagnosis (5-ALA PDD) have been reported for various cancers and brain surgery. However, biliary tract cancer is rare. Therefore, 5-ALA PDD has not been fully evaluated in biliary tract cancers. Small biliary tract cancer lesions such as peritoneal dissemination, liver metastases, and lymph node metastases are negative prognosticators in patients with biliary cancer. The purpose of this exploratory study was to determine if 5-ALA PDD could detect small biliary tract cancer lesions in murine models of biliary cancers...
September 2017: In Vivo
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