keyword
MENU ▼
Read by QxMD icon Read
search

5-ALA

keyword
https://www.readbyqxmd.com/read/28048774/su-f-j-215-non-thermal-pulsed-high-intensity-focused-ultrasound-therapy-combined-with-5-aminolevulinic-acid-an-in-vivo-pilot-study
#1
B Wang, W He, D Cvetkovic, L Chen, C Ma
PURPOSE: It has recently been shown that non-thermal pulsed high intensity focused ultrasound (pHIFU) has a cell-killing effect. The purpose of the study is to investigate the sonosensitizing effect of 5-Aminolevulinic Acid (5-ALA) in non-thermal pHIFU cancer therapy. METHODS: FaDu human head and neck squamous cell carcinoma cells were injected subcutaneously in the flanks of nude mice. After one to two weeks, the tumors reached the volume of 112 ± 8 mm3 and were assigned randomly into a non-thermal pHIFU group (n=9) and a non-thermal sonodynamic therapy (pHIFU after 5-ALA administration) group (n=7)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048178/su-f-t-674-in-vitro-study-of-5-aminolevulinic-acid-mediated-photo-dynamic-therapy-in-human-cancer-cell-lines
#2
D Cvetkovic, B Wang, R Gupta, C Ma
PURPOSE: Photodynamic therapy (PTD) is a promising cancer treatment modality. 5-sminolevulinic acid (ALA) is a clinically approved photosensitizer. Here we studied the effect of 5-ALA administration with irradiation on several cell lines in vitro. METHODS: Human head and neck (FaDu), lung (A549) and prostate (LNCaP) cancer cells (104/well) were seeded overnight in 96-well plates (Figure 1). 5-ALA at a range from 0.1 to 30.0mg/ml was added to confluent cells 3h before irradiation in 100ul of culture medium...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038959/minispectrometer-with-handheld-probe-for-5-ala-based-fluorescence-guided-surgery-of-brain-tumors-preliminary-study-for-clinical-applications
#3
J F Cornelius, J M Placke, J Knipps, I Fischer, M Kamp, H J Steiger
INTRODUCTION: Recently a mini-spectrometer with a handheld probe quantifying 5-aminolevulinic acid (5-ALA) based fluorescence intensity of brain tumors was developped by Kim and co-workers to improve fluorescence-guided neurosurgery. OBJECTIVE: To evaluate if this new tool is capable to discriminate nuances of fluorescence intensity of strongly fluorescing tumors (glioblastomas (GBM) and meningiomas (MM)). To study different modes of measurement (touch/no-touch)...
December 27, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28035368/5-aminolevulinic-acid-enhances-mitochondrial-stress-upon-ionizing-irradiation-exposure-and-increases-delayed-production-of-reactive-oxygen-species-and-cell-death-in-glioma-cells
#4
Kunihiro Ueta, Junkoh Yamamoto, Tohru Tanaka, Yoshiteru Nakano, Takehiro Kitagawa, Shigeru Nishizawa
5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker. Previously, we and other authors demonstrated that 5-ALA has a radiosensitizing effect for tumours. In the present study, we aimed to investigate the mechanism underlying the radiosensitizing effect of 5-ALA by focusing on glioma cell mitochondria. Using an enhancer (ciprofloxacin) of 5-ALA-induced PpIX accumulation, we evaluated the influence of ionizing irradiation (IR) and delayed reactive oxygen species (ROS) production 12 h after IR by colony-forming assay and flow cytometry (FCM) with different amounts of PpIX accumulation...
December 28, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28012197/interstitial-photodynamic-therapy-and-glioblastoma-light-fractionation-in-a-preclinical-model
#5
Henri-Arthur Leroy, Maximilien Vermandel, Anne-Sophie Vignion-Dewalle, Bertrand Leroux, Claude-Alain Maurage, Alain Duhamel, Serge Mordon, Nicolas Reyns
BACKGROUND: Glioblastoma is a high-grade cerebral tumor with local recurrence and poor outcome. Photodynamic therapy (PDT) is a localized treatment based on the light activation of a photosensitizer (PS) in the presence of oxygen, which results in the formation of cytotoxic species. The delivery of fractionated light may enhance treatment efficacy by reoxygenating tissues. OBJECTIVE: To evaluate the efficiency of two light-fractionation schemes using immunohistological data...
December 24, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28004205/vascular-alterations-after-photodynamic-therapy-mediated-by-5-aminolevulinic-acid-in-oral-leukoplakia
#6
Flávia Cristina Perillo Rosin, Ana Rita Ribeiro Barcessat, Giuliana Gadoni Giovanni Borges, Luciana Gonçalves Valente Ferreira, Luciana Corrêa
Impairment of vascular functions after photodynamic therapy (PDT) is frequently associated with tumor remission and is considered one of the main antineoplastic PDT effects. Vascular alterations in oral leukoplakia (OL) treated with PDT have not yet been described. The aim of this study was to evaluate the effect of topical 5-ALA-mediated PDT on the vascular network of 4NQO-induced OL in rats. After applying 4NQO topically on the tongue during 16 weeks, there was induction of dysplastic lesions, which were treated with two PDT sessions (with an interval of 72 h between them), using topical application of 5-ALA and posterior irradiation with a laser (90 J/cm(2) fluency)...
December 21, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27984090/rip3-antagonizes-a-tsc2-mediated-pro-survival-pathway-in-glioblastoma-cell-death
#7
Gregory Fettweis, Emmanuel Di Valentin, Laurent L'homme, Cédric Lassence, Franck Dequiedt, Marianne Fillet, Isabelle Coupienne, Jacques Piette
Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and radio-therapy. Photodynamic therapy (PDT) is a treatment well known to induce mainly necrotic and apoptotic cell death in solid tumors. 5-Aminolevulinic acid (5-ALA)-based PDT was recently shown to sensitize human glioblastoma cells (LN-18) to a RIP3 (Receptor Interacting Protein 3)-dependent cell death which is counter-acted by activation of autophagy...
October 27, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27919664/photodynamic-therapy-with-green-light-for-the-treatment-of-vulvar-lichen-sclerosus-preliminary-results
#8
B J Osiecka, K Jurczyszyn, P Nockowski, M Murawski, P Ziółkowski
INTRODUCTION: The standard treatment for lichen sclerosus (LS) is symptomatic and is primarily based on the chronic use of corticosteroids, sometimes resulting in unsatisfactory effects. Therefore, other non-pharmacological methods are being sought, which are less aggravating for the patient. LS can be treated topically by using photodynamic therapy (PDT) based on 5-aminolevulinic acid (5-ALA). Unfortunately, therapy with the red light is often connected with severe local pain during the illumination...
December 2, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27886396/5-ala-mediated-photodynamic-therapy-reduces-the-parasite-load-in-mice-infected-with-leishmania-braziliensis
#9
Danila Malheiros Souza, Polyanna Miranda Alves, Mona Lisa Fabiana Silva, Tony Paiva Paulino, Henrique Ovidio Coraspe, Mônica Miguel Sawan Mendonça, Betânia Maria Ribeiro, Marcos Vinicius da Silva, Virmondes Rodrigues Júnior, Denise Bertulucci Rocha Rodrigues
INTRODUCTION: Photodynamic therapy (PDT) has proven to be an effective alternative for the treatment of cutaneous leishmaniasis. Skin lesions consist of ulcers with well-defined raised edges, and granular floor. Th1 immune response is the protective profile in patients infected with Leishmania. In the present study, the photodynamic therapy with 5-aminolevulinic acid, the parasitic load, and the modulation of the immune response were evaluated in mice infected with Leishmania braziliensis...
November 25, 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27878374/agents-for-fluorescence-guided-glioma-surgery-a-systematic-review-of-preclinical-and-clinical-results
#10
REVIEW
Joeky T Senders, Ivo S Muskens, Rosalie Schnoor, Aditya V Karhade, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery. In this paper, we systematically review all clinically tested fluorescent agents for application in FGS for glioma and all preclinically tested agents with the potential for FGS for glioma. METHODS: We searched the PubMed and Embase databases for all potentially relevant studies through March 2016...
January 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27871684/the-utility-of-5-aminolevulinic-acid-mediated-photodynamic-diagnosis-in-the-detection-of-intraoperative-bile-leakage
#11
Yoshihiro Inoue, Yoshiro Imai, Kensuke Fujii, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
PURPOSE: The purpose of this retrospective study was to evaluate the utility of the new intraoperative bile leakage test as a preventive measure of postoperative bile leakage. METHOD: 737 patients were retrospectively analyzed with respect to the management of intra- and post-operative bile leakage. RESULTS: Nine (8.3%) of 109 patients evaluated using conventional white light fluorescent imaging were recognized as having intra-operative bile leakage...
October 8, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27837434/prediction-of-genetic-subgroups-in-adult-supra-tentorial-gliomas-by-pre-and-intraoperative-parameters
#12
Shunsuke Nakae, Kazuhiro Murayama, Hikaru Sasaki, Masanobu Kumon, Yuya Nishiyama, Shigeo Ohba, Kazuhide Adachi, Shinya Nagahisa, Takuro Hayashi, Joji Inamasu, Masato Abe, Mitsuhiro Hasegawa, Yuichi Hirose
Recent progress in neuro-oncology has validated the significance of genetic diagnosis in gliomas. We previously investigated IDH1/2 and TP53 mutations via Sanger sequencing for adult supratentorial gliomas and reported that PCR-based sequence analysis classified gliomas into three genetic subgroups that have a strong association with patient prognosis: IDH mutant gliomas without TP53 mutations, IDH and TP53 mutant gliomas, and IDH wild-type gliomas. Furthermore, this analysis had a strong association with patient prognosis...
November 11, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27832337/evaluation-of-the-risk-of-liver-damage-from-the-use-of-5-aminolevulinic-acid-for-intra-operative-identification-and-resection-in-patients-with-malignant-gliomas
#13
Cecilie Mørck Offersen, Jane Skjoeth-Rasmussen
BACKGROUND: The clinical efficacy of 5-aminolevulinic acid (5-ALA) for fluorescence-guided surgery of malignant gliomas is evident from several studies; however, as post-operative elevations of liver enzymes have been seen, there is a potential risk of liver damage upon administration. The aim of the present study was to assess the potential risk of liver damage and investigate liver enzyme reactions of patients going through 5-ALA-guided operations to improve the monitoring of their operations...
January 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27780784/comparative-effectiveness-of-fluorescent-versus-white-light-cystoscopy-for-initial-diagnosis-or-surveillance-of-bladder-cancer-on-clinical-outcomes-systematic-review-and-meta-analysis
#14
REVIEW
Roger Chou, Shelley Selph, David I Buckley, Rongwei Fu, Jessica C Griffin, Sara Grusing, John L Gore
PURPOSE: We systematically reviewed the comparative effectiveness of fluorescent vs white light cystoscopy in bladder cancer clinical outcomes. MATERIALS AND METHODS: Systematic literature searches of Ovid MEDLINE® (January 1990 through September 2015), Cochrane databases and reference lists were performed. A total of 14 randomized trials of fluorescent cystoscopy using 5-amimolevulinic acid or hexaminolevulinic acid vs white light cystoscopy for the diagnosis of initial or recurrent bladder cancer that reported bladder cancer recurrence, progression, mortality and harms were selected for review...
October 22, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27774388/a-nanosystem-capable-of-releasing-a-photosensitizer-bioprecursor-under-two-photon-irradiation-for-photodynamic-therapy
#15
Hao Wu, Fang Zeng, Hang Zhang, Jiangsheng Xu, Jianrong Qiu, Shuizhu Wu
The applications of photodynamic therapy (PDT) are usually limited by photosensitizers' side effects and singlet oxygen's short half-life. Herein, a mitochondria-targeted nanosystem is demonstrated to enhance the PDT efficacy by releasing a bio-precursor of photosensitizer under two-photon irradiation. A phototriggerable coumarin derivative is first synthesized by linking 5-aminolevulinic acid (5-ALA, the bio-precursor) to coumarin; and the nanosystem (CD-ALA-TPP) is then fabricated by covalently incorporating this coumarin derivative and a mitochondria-targeting compound triphenylphosphonium (TPP) onto carbon dots (CDs)...
February 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27757721/outcome-of-patients-affected-by-newly-diagnosed-glioblastoma-undergoing-surgery-assisted-by-5-aminolevulinic-acid-guided-resection-followed-by-bcnu-wafers-implantation-a-3-year-follow-up
#16
Alessandro Della Puppa, Giuseppe Lombardi, Marta Rossetto, Oriela Rustemi, Franco Berti, Diego Cecchin, Marina Paola Gardiman, Giuseppe Rolma, Luca Persano, Vittorina Zagonel, Renato Scienza
The purpose of the study was to evaluate the clinical outcome of the association of BCNU wafers implantation and 5-aminolevulinic acid (5-ALA) fluorescence in the treatment of patients with newly diagnosed glioblastoma (ndGBM). Clinical and surgical data from patients who underwent 5-ALA surgery followed by BCNU wafers implantation were retrospectively evaluated (20 patients, Group I) and compared with data of patients undergoing surgery with BCNU wafers alone (42 patients, Group II) and 5-ALA alone (59 patients, Group III)...
October 18, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27757708/feasibility-of-photodynamic-therapy-for-secondary-hyperparathyroidism-in-chronic-renal-failure-rats
#17
Takayo Miyakogawa, Genta Kanai, Ryoko Tatsumi, Hiroo Takahashi, Kaichiro Sawada, Takatoshi Kakuta, Masafumi Fukagawa
BACKGROUND: Feasibility of photodynamic therapy (PDT) for secondary hyperparathyroidism (SHPT) was examined in a rat model of SHPT. METHODS: A photosensitizer, 5-aminolevulinic acid (5-ALA), was injected intraperitoneally, and the parathyroid glands were irradiated either after surgical exposure with 385-nm light or transdermally with 630-nm light from a light-emitting diode (LED) lamp. RESULTS: PDT with high 5-ALA and irradiation doses caused severe hypoparathyroidism in SHPT rats within two days...
October 18, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27748558/multispectral-autofluorescence-imaging-for-detection-of-cervical-lesions-a-preclinical-study
#18
Soo-Jin Bae, Dae-Sic Lee, Vladimir Berezin, Uk Kang, Keun-Ho Lee
AIM: The aim of this study was to develop a novel optical imaging system for detecting protoporphyrin IX (PpIX) autofluorescence, to prove that PpIX autofluorescence is as useful as 5-aminolevulinic acid (5-ALA)-induced fluorescence for detecting and localizing cervical cancer, and to monitor the change in PpIX autofluorescence or induced PpIX fluorescence before, during, and after photodynamic therapy (PDT). METHODS: TC-1 cells - highly tumorigenic cells immortalized using human papillomavirus type 16 proteins E6 and E7 - were subcutaneously grafted into the thighs of nude mice...
December 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27741220/intraoperative-near-infrared-optical-imaging-can-localize-gadolinium-enhancing-gliomas-during-surgery
#19
John Y K Lee, Jayesh P Thawani, John Pierce, Ryan Zeh, Maria Martinez-Lage, Michelle Chanin, Ollin Venegas, Sarah Nims, Kim Learned, Jane Keating, Sunil Singhal
BACKGROUND: Although real-time localization of gliomas has improved with intraoperative image guidance systems, these tools are limited by brain shift, surgical cavity deformation, and expense. OBJECTIVE: To propose a novel method to perform near-infrared (NIR) imaging during glioma resections based on preclinical and clinical investigations, in order to localize tumors and to potentially identify residual disease. METHODS: Fifteen patients were identified and administered a Food and Drug Administration-approved, NIR contrast agent (Second Window indocyanine green [ICG], 5 mg/kg) before surgical resection...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27738640/the-safety-and-tolerability-of-5-aminolevulinic-acid-phosphate-with-sodium-ferrous-citrate-in-patients-with-type-2-diabetes-mellitus-in-bahrain
#20
Feryal Al-Saber, Waleed Aldosari, Mariam Alselaiti, Hesham Khalfan, Ahmed Kaladari, Ghulam Khan, George Harb, Riyadh Rehani, Sizuka Kudo, Aya Koda, Tohru Tanaka, Motowo Nakajima, Abdulla Darwish
Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC). This prospective, randomized, single-blind, placebo-controlled, dose escalating pilot clinical trial assessed the safety of 5-ALA with SFC at doses up to 200 mg 5-ALA/229.42 mg SFC per day in patients living in Bahrain with type 2 diabetes mellitus that was uncontrolled despite the use of one or more antidiabetic drugs...
2016: Journal of Diabetes Research
keyword
keyword
8236
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"