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https://www.readbyqxmd.com/read/28647678/methyl-jasmonate-attenuated-lipopolysaccharide-induced-depressive-like-behaviour-in-mice
#1
Adaeze Adebesin, Olusegun A Adeoluwa, Anthony T Eduviere, Solomon Umukoro
Depression is a recurrent neuropsychiatric disorder that affects millions of individuals worldwide and impact negatively on the patients' social functions and quality of life. Studies have shown that i.p injection of lipopolysaccharide (LPS) induces depressive-like behavior in rodents via induction of oxidative stress and neuroinflammation. Methyl jasmonate (MJ), an isolated compound from jasmine plant has gained reputation in aromatherapy for treatment of depression, nervousness and memory deficits. This study was designed to evaluate the effects of MJ on LPS-induced depressive-like behavior in mice...
June 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28647593/features-of-emotional-and-social-behavioral-phenotypes-of-calsyntenin2-knockout-mice
#2
S V Ranneva, K S Pavlov, A V Gromova, T G Amstislavskaya, T V Lipina
Calsyntenin-2 (Clstn2) is the synaptic protein that belongs to the super family of cadherins, playing an important role in learning and memory. We recently reported that Clstn2 knockout mice (Clstn2-KO) have a deficit of GABAergic interneurons coupled with hyperactivity and deficient spatial memory. Given, that impaired functioning of GABA receptors is linked to several psychopathologies, including anxiety and autism, we sought to further characterize Clstn2-KO mice with respect to emotional and social behavior...
June 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28646400/a-brief-assessment-tool-for-investigating-facets-of-moral-judgment-from-realistic-vignettes
#3
Michael Kruepke, Erin K Molloy, Konrad Bresin, Aron K Barbey, Edelyn Verona
Humans make moral judgments every day, and research demonstrates that these evaluations are based on a host of related event features (e.g., harm, legality). In order to acquire systematic data on how moral judgments are made, our assessments need to be expanded to include real-life, ecologically valid stimuli that take into account the numerous event features that are known to influence moral judgment. To facilitate this, Knutson et al. (in Social Cognitive and Affective Neuroscience, 5(4), 378-384, 2010) developed vignettes based on real-life episodic memories rated concurrently on key moral features; however, the method is time intensive (~1...
June 23, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28642696/how-accumulated-real-life-stress-experience-and-cognitive-speed-interact-on-decision-making-processes
#4
Eva Friedel, Miriam Sebold, Sören Kuitunen-Paul, Stephan Nebe, Ilya M Veer, Ulrich S Zimmermann, Florian Schlagenhauf, Michael N Smolka, Michael Rapp, Henrik Walter, Andreas Heinz
Rationale: Advances in neurocomputational modeling suggest that valuation systems for goal-directed (deliberative) on one side, and habitual (automatic) decision-making on the other side may rely on distinct computational strategies for reinforcement learning, namely model-free vs. model-based learning. As a key theoretical difference, the model-based system strongly demands cognitive functions to plan actions prospectively based on an internal cognitive model of the environment, whereas valuation in the model-free system relies on rather simple learning rules from operant conditioning to retrospectively associate actions with their outcomes and is thus cognitively less demanding...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28642080/impact-of-juvenile-chronic-stress-on-adult-cortico-accumbal-function-implications-for-cognition-and-addiction
#5
REVIEW
Michael J Watt, Matthew A Weber, Shaydel R Davies, Gina L Forster
Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One possible explanation lies in stress-induced disruption to the development of specific brain regions associated with executive function and reward processing, deficits in which are common to the disorders promoted by childhood stress...
June 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28641817/-preventing-violence-in-schizophrenia-with-cognitive-remediation
#6
C Darmedru, C Demily, N Franck
OBJECTIVES: The association between schizophrenia and violence represents an important issue in psychiatry. Often highly publicized, violent acts raise the question of their detection, prevention, management and treatment. There is no single, direct and exclusive link between aggressiveness and the underlying psychiatric disorder. On the contrary, the processes underlying this violence are multiple and interlinked. In addition to static and dynamic risk factors, cognitive deficits play an important role in the genesis and maintenance of violent and aggressive behavior...
June 19, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28641585/cancer-bereaved-siblings-positive-and-negative-memories-and-experiences-of-illness-and-death-a-nationwide-follow-up
#7
Mary-Elizabeth Bradley Eilertsen, Malin Lövgren, Alexandra Eilegård Wallin, Ulrika Kreicbergs
OBJECTIVE: Our aim was to explore bereaved siblings' positive and negative memories and experiences of their brother's or sister's illness and death. METHOD: In our nationwide Swedish study, 174 of 240 (73%) bereaved siblings participated, and 70% responded to two open-ended statements, which focused on siblings' positive and negative memories and experiences of illness and death. The data were analyzed using systematic text condensation. RESULTS: The bereaved siblings' responses were categorized into four different themes: (1) endurance versus vulnerability, (2) family cohesion versus family conflicts, (3) growth versus stagnation, and (4) professional support versus lack of professional support...
June 23, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28639564/effect-of-an-ecological-executive-skill-training-program-for-school-aged-children-with-attention-deficit-hyperactivity-disorder-a-randomized-controlled-clinical-trial
#8
Ying Qian, Min Chen, Lan Shuai, Qing-Jiu Cao, Li Yang, Yu-Feng Wang
BACKGROUND: As medication does not normalize outcomes of children with attention deficit hyperactivity disorder (ADHD), especially in real-life functioning, nonpharmacological methods are important to target this field. This randomized controlled clinical trial was designed to evaluate the effects of a comprehensive executive skill training program for school-aged children with ADHD in a relatively large sample. METHODS: The children (aged 6-12 years) with ADHD were randomized to the intervention or waitlist groups...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28639175/valence-and-origin-of-emotional-words-influence-on-subsequent-perception-of-ambiguous-stimuli-in-terms-of-competence-versus-warmth
#9
Kamil K Imbir
The aim of this study was to examine whether the valence and origin of emotional words can alter perception of ambiguous objects in terms of warmth versus competence, fundamental dimensions of social cognition. 60 individuals were invited into the study focusing on the limits of intuition. They were asked to try to guess the meaning of Japanese pictorial signs in terms of their warmth versus competence connotations. Before each trial a subsequent memory load task was applied. Participants were supposed to read and remember words creating a factorial manipulation of valence (three levels) and origins (three levels: automatic, neutral and reflective) of affective connotations presenting to them for 500 ms...
June 21, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28638591/replicable-in-vivo-physiological-and-behavioral-phenotypes-of-the-shank3b-null-mutant-mouse-model-of-autism
#10
Sameer C Dhamne, Jill L Silverman, Chloe E Super, Stephen H T Lammers, Mustafa Q Hameed, Meera E Modi, Nycole A Copping, Michael C Pride, Daniel G Smith, Alexander Rotenberg, Jacqueline N Crawley, Mustafa Sahin
BACKGROUND: Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral abnormalities. No treatments are approved for the core diagnostic symptoms of ASD. To enable the earliest stages of therapeutic discovery and development for ASD, robust and reproducible behavioral phenotypes and biological markers are essential to establish in preclinical animal models. The goal of this study was to identify electroencephalographic (EEG) and behavioral phenotypes that are replicable between independent cohorts in a mouse model of ASD...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28636751/using-experimentation-to-understand-the-10-year-snowshoe-hare-cycle-in-the-boreal-forest-of-north-america
#11
C J Krebs, R Boonstra, S Boutin
Population cycles have long fascinated ecologists from the time of Charles Elton in the 1920s. The discovery of large population fluctuations in undisturbed ecosystems challenged the idea that pristine nature was in a state of balance. The 10-year cycle of snowshoe hares (Lepus americanus Erxleben) across the boreal forests of Canada and Alaska is a classic cycle, recognized by fur traders for more than 300 years. Since the 1930s ecologists have investigated the mechanisms that might cause these cycles. Proposed causal mechanisms have varied from sunspots to food supplies, parasites, diseases, predation, and social behaviour...
June 21, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28634464/anti-inflammatory-and-neuroprotective-effects-of-co-ultrapealut-in-a-mouse-model-of-vascular-dementia
#12
Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Rosalia Crupi, Emanuela Esposito, Stefania Petrosino, Salvatore Cuzzocrea
Vascular dementia (VaD), the second most common cause of cognitive impairment in the population, is a disease that results from reduction in regional cerebral blood flow and involves oxidative stress and inflammation. Co-ultramicronized PEALut (co-ultra PEALut) is a new compound with beneficial effects, which include anti-inflammatory and antioxidant properties. Recently, co-ultraPEALut has been shown to exhibit neuroprotective effects in models of Parkinson's disease, cerebral ischemia and Alzheimer's disease...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28631721/disc1-in-astrocytes-influences-adult-neurogenesis-and-hippocampus-dependent-behaviors-in-mice
#13
Chantelle E Terrillion, Bagrat Abazyan, Zhongxi Yang, Joshua Crawford, Alexey V Shevelkin, Yan Jouroukhin, Ki Hyun Yoo, Chang Hoon Cho, Robin Roychaudhuri, Solomon H Snyder, Mi-Hyeon Jang, Mikhail V Pletnikov
The functional role of genetic variants in glia in the pathogenesis of psychiatric disorders remains poorly studied. Disrupted-In-Schizophrenia 1 (DISC1), a genetic risk factor implicated in major mental disorders, has been implicated in regulation of astrocyte functions. As both astrocytes and DISC1 influence adult neurogenesis in the dentate gyrus (DG) of the hippocampus, we hypothesized that selective expression of dominant-negative C-terminus truncated human DISC1 (mutant DISC1) in astrocytes would affect adult hippocampal neurogenesis and hippocampus-dependent behaviors...
June 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28630290/childhood-social-class-and-cognitive-aging-in-the-swedish-adoption-twin-study-of-aging
#14
Malin Ericsson, Cecilia Lundholm, Stefan Fors, Anna K Dahl Aslan, Catalina Zavala, Chandra A Reynolds, Nancy L Pedersen
In this report we analyzed genetically informative data to investigate within-person change and between-person differences in late-life cognitive abilities as a function of childhood social class. We used data from nine testing occasions spanning 28 y in the Swedish Adoption/Twin Study of Aging and parental social class based on the Swedish socioeconomic index. Cognitive ability included a general factor and the four domains of verbal, fluid, memory, and perceptual speed. Latent growth curve models of the longitudinal data tested whether level and change in cognitive performance differed as a function of childhood social class...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28627117/the-cognitive-features-of-idiopathic-and-dyt1-dystonia
#15
REVIEW
Marjan Jahanshahi, Mariam Torkamani
Dystonia is a common movement disorder. In this paper, we review the literature on cognitive function in idiopathic and DYT1 dystonia. In idiopathic or DYT1 dystonia, cognition is largely intact with only isolated executive dysfunction. Dystonia patients also have increased temporal and spatial discrimination thresholds, considered endophenotypes of the disorder because deficits are also shown by unaffected relatives and nonmanifesting carriers of the DYT1 mutation. Anticholinergic medication in high doses can be associated with memory impairment in dystonia...
June 19, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28626971/genetics-and-developmental-biology-of-cooperation
#16
Claudia Kasper, Maddalena Vierbuchen, Ulrich Ernst, Stefan Fischer, Reinder Radersma, Aura Raulo, Filipa Cunha-Saraiva, Min Wu, Kenyon Mobley, Barbara Taborsky
Despite essential progress towards understanding the evolution of cooperative behaviour, we still lack detailed knowledge about its underlying molecular mechanisms, genetic basis, evolutionary dynamics and ontogeny. An international workshop 'Genetics and Development of Cooperation', organized by the University of Bern (Switzerland), aimed at discussing the current progress in this research field and suggesting avenues for future research. This review uses the major themes of the meeting as a springboard to synthesize the concepts of genetic and non-genetic inheritance of cooperation, and to review a quantitative genetic framework that allows for the inclusion of indirect genetic effects...
June 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28625494/acute-stress-shifts-the-balance-between-controlled-and-automatic-processes-in-prospective-memory
#17
Marcus Möschl, Moritz Walser, Franziska Plessow, Thomas Goschke, Rico Fischer
In everyday life we frequently rely on our abilities to postpone intentions until later occasions (prospective memory; PM) and to deactivate completed intentions even in stressful situations. Yet, little is known about the effects of acute stress on these abilities. In the present work we investigated the impact of acute stress on PM functioning under high task demands. 1) Different from previous studies, in which intention deactivation required mostly low processing demands, we used salient focal PM cues to induce high processing demands during intention-deactivation phases...
June 15, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28625354/foraging-cognition-reviving-the-ecological-intelligence-hypothesis
#18
REVIEW
Alexandra G Rosati
What are the origins of intelligent behavior? The demands associated with living in complex social groups have been the favored explanation for the evolution of primate cognition in general and human cognition in particular. However, recent comparative research indicates that ecological variation can also shape cognitive abilities. I synthesize the emerging evidence that 'foraging cognition' - skills used to exploit food resources, including spatial memory, decision-making, and inhibitory control - varies adaptively across primates...
June 15, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28624821/on-the-social-life-and-motivational-changes-of-aging-monkeys
#19
Julia Fischer
Although nonhuman primates have been used in biomedical research to develop a better understanding of physiological aging processes, their value as models for studying age-related differences in motivation, cognition, and decision-making has only recently been appreciated. This paper reviews the state of the art, with a focus on a recent study on Barbary macaques. A number of studies reported that with increasing age, Old World monkeys spend more time resting, have fewer social partners, and/or spend less time in social interactions, though other studies found no such effects...
June 17, 2017: Gerontology
https://www.readbyqxmd.com/read/28623167/the-ketogenic-diet-affects-the-social-behavior-of-young-male-rats
#20
Daniela Kasprowska-Liśkiewicz, Arkadiusz D Liśkiewicz, Marta M Nowacka-Chmielewska, Joanna Nowicka, Andrzej Małecki, Jarosław J Barski
The positive effects of the ketogenic diet (KD) on social behavior have been recently reported in patients and rodent models of autism spectrum disorder (ASD). Given the beneficial effects of the KD on epilepsy, mitochondrial function, carbohydrate metabolism, and inflammation, treatment based on the KD has the potential to reduce some of the ASD-associated symptoms, including abnormal social interactions. It is not known whether the KD influences sociability by reducing the pathological processes underlying ASD or through some independent mechanism...
June 13, 2017: Physiology & Behavior
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