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https://www.readbyqxmd.com/read/28811259/should-i-trust-you-learning-and-memory-of-social-interactions-in-dementia
#1
Stephanie Wong, Muireann Irish, Claire O'Callaghan, Fiona Kumfor, Greg Savage, John R Hodges, Olivier Piguet, Michael Hornberger
Social relevance has an enhancing effect on learning and subsequent memory retrieval. The ability to learn from and remember social interactions may impact on susceptibility to financial exploitation, which is elevated in individuals with dementia. The current study aimed to investigate learning and memory of social interactions, the relationship between performance and financial vulnerability and the neural substrates underpinning performance in 14 Alzheimer's disease (AD) and 20 behavioural-variant frontotemporal dementia (bvFTD) patients and 20 age-matched healthy controls...
August 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28810487/the-aging-population-in-china-subjective-well-being-of-empty-nesters-in-rural-eastern-china
#2
Ying Liang, Xueting Niu, Peiyi Lu
In this article, we explore the subjective well-being of empty nesters who lived in rural eastern China ( N = 967). The Memorial University of Newfoundland Scale of Happiness is used to measure subjective well-being. The results indicate that Memorial University of Newfoundland Scale of Happiness is appropriate for empty nesters in rural China due to its reliability and validity. Generally, male empty nesters report greater subjective well-being scores than females. Negative factors include low levels of education, being a widow or widower, or being unmarried...
July 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28808356/the-gist-of-delay-of-gratification-understanding-and-predicting-problem-behaviors
#3
Valerie F Reyna, Evan A Wilhelms
Delay of gratification captures elements of temptation and self-denial that characterize real-life problems with money and other problem behaviors such as unhealthy risk taking. According to fuzzy-trace theory, decision makers mentally represent social values such as delay of gratification in a coarse but meaningful form of memory called "gist." Applying this theory, we developed a gist measure of delay of gratification that does not involve quantitative trade-offs (as delay discounting does) and hypothesize that this construct explains unique variance beyond sensation seeking and inhibition in accounting for problem behaviors...
April 2017: Journal of Behavioral Decision Making
https://www.readbyqxmd.com/read/28801311/ethical-issues-when-modelling-brain-disorders-in-non-human-primates
#4
Carolyn P Neuhaus
Non-human animal models of human diseases advance our knowledge of the genetic underpinnings of disease and lead to the development of novel therapies for humans. While mice are the most common model organisms, their usefulness is limited. Larger animals may provide more accurate and valuable disease models, but it has, until recently, been challenging to create large animal disease models. Genome editors, such as Clustered Randomised Interspersed Palindromic Repeat (CRISPR), meet some of these challenges and bring routine genome engineering of larger animals and non-human primates (NHPs) well within reach...
August 11, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28798977/risperidone-and-aripiprazole-alleviate-prenatal-valproic-acid-induced-abnormalities-in-behaviors-and-dendritic-spine-density-in-mice
#5
Yuta Hara, Yukio Ago, Atsuki Taruta, Shigeru Hasebe, Haruki Kawase, Wataru Tanabe, Shinji Tsukada, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma
RATIONALE: Rodents exposed prenatally to valproic acid (VPA) exhibit autism spectrum disorder (ASD)-like behavioral abnormalities. We recently found that prenatal VPA exposure causes hypofunction of the prefrontal dopaminergic system in mice. This suggests that the dopaminergic system may be a potential pharmacological target for treatment of behavioral abnormalities in ASD patients. OBJECTIVES: In the present study, we examined the effects of antipsychotic drugs, which affect the dopaminergic system, on the social interaction deficits, recognition memory impairment, and reduction in dendritic spine density in the VPA mouse model of ASD...
August 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28794901/a-randomized-controlled-trial-to-test-the-efficacy-of-the-sci-get-fit-toolkit-on-leisure-time-physical-activity-behaviour-and-social-cognitive-processes-in-adults-with-spinal-cord-injury
#6
Kelly P Arbour-Nicitopoulos, Shane N Sweet, Marie-Eve Lamontagne, Kathleen A Martin Ginis, Samantha Jeske, François Routhier, Amy E Latimer-Cheung
STUDY DESIGN: Single blind, two-group randomized controlled trial. OBJECTIVES: To evaluate the efficacy of the SCI Get Fit Toolkit delivered online on theoretical constructs and moderate-to-vigorous physical activity (MVPA) among adults with SCI. SETTING: Ontario and Quebec, Canada. ELIGIBILITY: Inactive, English- and French-speaking Canadian adults with traumatic SCI with Internet access, and no self-reported cognitive or memory impairments...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28793933/can-cognitive-assessment-really-discriminate-early-stages-of-alzheimer-s-and-behavioural-variant-frontotemporal-dementia-at-initial-clinical-presentation
#7
Sophia Reul, Hubertus Lohmann, Heinz Wiendl, Thomas Duning, Andreas Johnen
BACKGROUND: Neuropsychological testing is considered crucial for differential diagnosis of Alzheimer's disease (AD) and behavioural variant frontotemporal dementia (bvFTD). In-depth neuropsychological assessment revealed specific dysfunctions in the two dementia syndromes. However, a significant overlap of cognitive impairments exists in early disease stages. We questioned whether a standard neuropsychological assessment at initial clinical presentation can delineate patients with AD versus bvFTD...
August 9, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28793136/an-exploration-of-the-associations-among-hearing-loss-physical-health-and-visual-memory-in-adults-from-west-central-alabama
#8
Marcia J Hay-McCutcheon, Adriana Hyams, Xin Yang, Jason Parton, Brianna Panasiuk, Sarah Ondocsin, Mary Margaret James, Forrest Scogin
Purpose: The purpose of this preliminary study was to explore the associations among hearing loss, physical health, and visual memory in adults living in rural areas, urban clusters, and an urban city in west Central Alabama. Method: Two hundred ninety-seven adults (182 women, 115 men) from rural areas, urban clusters, and an urban city of west Central Alabama completed a hearing assessment, a physical health questionnaire, a hearing handicap measure, and a visual memory test...
August 9, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28792672/constitutive-loss-and-acute-pharmacological-manipulation-of-erbb4-signaling-do-not-affect-attention-and-inhibitory-control-in-mice
#9
Elena Marchisella, Ruud Wijnands, Bastijn Koopmans, Sabine Spijker, Maarten Loos
The receptor tyrosine kinase ErbB4 and its ligand trophic factors of the neuregulin (NRG) family have been associated with schizophrenia and other mental disorders in human genetic studies. In vivo studies in mice have shown how abnormal Nrg-ErbB4 signaling leads to deviant behaviors relevant to distinct aspects of schizophrenia, including hyperactivity, sensory gating deficits, working and spatial memory deficits and impaired social behavior. However, so far little is known on the role of ErbB4 in attention and inhibitory control, two aspects of executive functions that are impaired in schizophrenia...
August 9, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28790912/associations-of-childhood-and-adulthood-cognition-with-bone-mineral-density-in-later-adulthood-a-population-based-longitudinal-study
#10
Rebecca Bendayan, Diana Kuh, Rachel Cooper, Stella Muthuri, Graciela Muniz-Terrera, Judith Adams, Kate Ward, Marcus Richards
This study explores the association between cognitive ability in childhood and midlife and bone health outcomes in early old age; and the relationships of these bone measures with contemporaneous and subsequent cognitive ability in the MRC National Survey of Health and Development (NSHD). This British birth cohort assessed areal and volumetric bone mineral density (aBMD and vBMD) at age 60-64, derived from peripheral quantitative computed tomography and dual-energy X-ray absorptiometry, and cognitive performance from childhood to age 69, among 866 women and 792 men...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28790425/minimal-long-term-neurobehavioral-impairments-after-endovascular-perforation-subarachnoid-hemorrhage-in-mice
#11
Claudia Fanizzi, Andrew D Sauerbeck, Mihika Gangolli, Gregory J Zipfel, David L Brody, Terrance T Kummer
Cognitive deficits are among the most severe and pervasive consequences of aneurysmal subarachnoid hemorrhage (SAH). A critical step in developing therapies targeting such outcomes is the characterization of experimentally-tractable pre-clinical models that exhibit multi-domain neurobehavioral deficits similar to those afflicting humans. We therefore searched for neurobehavioral abnormalities following endovascular perforation induction of SAH in mice, a heavily-utilized model. We instituted a functional screen to manage variability in injury severity, then assessed acute functional deficits, as well as activity, anxiety-related behavior, learning and memory, socialization, and depressive-like behavior at sub-acute and chronic time points (up to 1 month post-injury)...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28778056/cognitive-predictors-of-adaptive-functioning-in-children-with-symptomatic-epilepsy
#12
Elizabeth N Kerr, Nora Fayed
The current study sought to understand the contribution of the attention and working memory challenges experienced by children with active epilepsy without an intellectual disability to adaptive functioning (AF) while taking into account intellectual ability, co-occurring brain-based psychosocial diagnoses, and epilepsy-related variables. METHODS: The relationship of attention and working memory with AF was examined in 76 children with active epilepsy with intellectual ability above the 2nd percentile recruited from a tertiary care center...
July 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28776897/relationship-between-cortisol-reactivity-to-psychosocial-stress-and-declarative-memory-decline-during-aging-impact-of-age-and-sex
#13
Aline Talita Dos Santos, Dayse Maria D Leyendecker, Ana Lucia Siqueira Costa, Juliana Nery de Souza-Talarico
AIM: To analyze the relationship between memory performance and the neuroendocrine and cardiovascular response to acute psychosocial stress in healthy older people, and the sex and age impact in this relationship. METHODS: We randomly selected 100 literate older adults, without cognitive or functional impairment. The neuroendocrine stress response was evaluated by measuring the concentration of salivary cortisol, whereas cardiovascular reactions were determined based on blood pressure and heart rate measures taken before, during and after participant exposure to an acute psychosocial stressor ( the Trier social stress test [TSST])...
August 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28774220/prospective-memory-impairment-in-multiple-sclerosis-a-review
#14
Isabelle Rouleau, Emmanuelle Dagenais, Alexandra Tremblay, Mélanie Demers, Élaine Roger, Céline Jobin, Pierre Duquette
OBJECTIVE: Multiple sclerosis (MS) is a progressive disease of the central nervous system affecting information processing speed, episodic memory, attention, and executive functions. MS patients also often report prospective memory (PM) failures that directly impact their functional autonomy, including professional and social life. The purpose of this paper was to review the literature concerning the assessment and remediation of PM deficits in MS. METHOD: The literature pertaining to PM impairment in MS was carefully reviewed using PubMed, PsyINFO, and Google Scholar, as well as cross-references from the articles published on this topic...
August 4, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28770540/collaborative-remembering-revisited-study-context-access-modulates-collaborative-inhibition-and-later-benefits-for-individual-memory
#15
Magdalena Abel, Karl-Heinz T Bäuml
Collaborating groups typically show reduced recall relative to nominal groups, i.e., to the cumulated non-redundant recall of the same number of people remembering in isolation-a finding termed collaborative inhibition. Motivated by the results of several previous studies, this study examined in two experiments whether access to study context at test influences the effects of collaboration. In both experiments, subjects collaborated in triads or recalled previously studied material in isolation. Experiment 1 applied short versus prolonged retention intervals to vary access to study context at test, whereas Experiment 2 used the list-method directed forgetting task and applied remember versus forget instructions to modulate context access...
August 2, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28766816/improving-adherence-to-multiple-medications-in-older-people-in-primary-care-selecting-intervention-components-to-address-patient-reported-barriers-and-facilitators
#16
Deborah E Patton, Cathal A Cadogan, Cristín Ryan, Jill J Francis, Gerard J Gormley, Peter Passmore, Ngaire Kerse, Carmel M Hughes
BACKGROUND: Medication adherence is vital to ensuring optimal patient outcomes, particularly amongst multimorbid older people prescribed multiple medications. Interventions targeting adherence often lack a theoretical underpinning and this may impact on effectiveness. The theoretical domains framework (TDF) of behaviour can aid intervention development by systematically identifying key determinants of medication adherence. OBJECTIVES: This study aimed to (i) identify determinants (barriers, facilitators) of adherence to multiple medications from older people's perspectives; (ii) identify key domains to target for behaviour change; and (iii) map key domains to intervention components [behaviour change techniques (BCTs)] that could be delivered in an intervention by community pharmacists...
August 1, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28761413/curcuma-longa-l-extract-improves-the-cortical-neural-connectivity-during-the-aging-process
#17
REVIEW
Gonzalo Flores
Turmeric or Curcuma is a natural product that has anti-inflammatory, antioxidant and anti-apoptotic pharmacological properties. It can be used in the control of the aging process that involves oxidative stress, inflammation, and apoptosis. Aging is a physiological process that affects higher cortical and cognitive functions with a reduction in learning and memory, limited judgment and deficits in emotional control and social behavior. Moreover, aging is a major risk factor for the appearance of several disorders such as cerebrovascular disease, diabetes mellitus, and hypertension...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28760699/modulation-of-the-storage-of-social-recognition-memory-by-neurotransmitter-systems-in-the-insular-cortex
#18
Lorena E S Cavalcante, Carolina G Zinn, Scheila D Schmidt, Bruna F Saenger, Flávia F Ferreira, Cristiane R G Furini, Jociane C Myskiw, Ivan Izquierdo
The insular cortex (IC) receives projections from prefrontal, entorhinal and cingulate cortex, olfactory bulb and basal nuclei and has reciprocal connections with the amygdala and entorhinal cortex. These connections suggest a possible involvement in memory processes; this has been borne out by data on several behaviors. Social recognition memory (SRM) is essential to form social groups and to establish hierarchies and social and affective ties. Despite its importance, knowledge about the brain structures and the neurotransmitter mechanisms involved in its processing is still scarce...
July 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28759780/neural-correlates-of-evaluating-self-and-close-other-in-physical-academic-and-prosocial-domains
#19
R van der Cruijsen, S Peters, E A Crone
Behavioral studies showed that self-concept can be distinguished into different domains, but few neuroimaging studies have investigated either domain-specific or valence-specific activity. Here, we investigated whether evaluating self- and mother-traits in three domains (physical, academic, prosocial) relies on similar or distinct brain regions. Additionally, we explored the topical discussion in the literature on whether vmPFC activity during self-evaluations is induced by valence or importance of traits. Participants evaluated themselves and their mothers on positive and negative traits in three domains...
July 28, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28758690/rearing-environment-dependent-hippocampal-local-field-potential-differences-in-wildtype-and-inositol-trisphosphate-receptor-type-2-knockout-mice
#20
Mika Tanaka, Xiaowen Wang, Katsuhiko Mikoshiba, Hajime Hirase, Yoshiaki Shinohara
Rearing in an enriched environment (ENR) is known to enhance cognitive and memory abilities in rodents, whereas social isolation (ISO) induces depression-like behaviour. The hippocampus has been documented to undergo morphological and functional changes depending on these rearing environments. For instance, rearing condition during juvenility alters CA1 stratum radiatum gamma oscillation power in rats. In this study, hippocampal CA1 local field potentials (LFP) were recorded from bilateral CA1 in urethane-anesthetized mice that were reared in either ENR or ISO condition...
July 31, 2017: Journal of Physiology
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