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https://www.readbyqxmd.com/read/28445983/transport-stress-induces-weight-loss-and-heart-injury-in-chicks-disruption-of-ionic-homeostasis-via-modulating-ion-transporting-atpases
#1
Zhao-Yang Li, Jia Lin, Feng Sun, Hui Li, Jun Xia, Xue-Nan Li, Jing Ge, Cong Zhang, Jin-Long Li
Transportation is inevitable in the poultry industry, and it can induce stress to chicks in varying degrees, such as mild discomfort, sometimes even death. However, the research about the effects of transport stress on the weight loss and heart injury of chicks is lacking. To elucidate the underlying mechanism of transport stress-induced effects, chicks were transported for 2h, 4h and 8h. The creatinine kinase (CK) activities, the ionic contents, the ATPases activities and the transcription of the ATPase associated subunits in chick heart were detected...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444183/calcium-dysregulation-and-cdk5-atm-pathway-involved-in-a-mouse-model-of-fragile-x-associated-tremor-ataxia-syndrome
#2
Gaëlle Robin, José R López, Glenda M Espinal, Susan Hulsizer, Paul J Hagerman, Isaac N Pessah
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurological disorder that affects premutation carriers with 55-200 CGG-expansion repeats (preCGG) in FMR1, presenting with early alterations in neuronal network formation and function that precede neurodegeneration. Whether intranuclear inclusions containing DNA damage response (DDR) proteins, are causally linked to abnormal synaptic function, neuronal growth and survival are unknown. In a mouse that harbors a premutation CGG expansion (preCGG), cortical and hippocampal FMRP expression is moderately reduced from birth through adulthood, with greater FMRP reductions in the soma than in the neurite, despite several-fold elevation of Fmr1 mRNA levels...
April 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28443506/catestain-a-master-regulator-of-cardiovascular-functions
#3
Sushil K Mahata, Malapaka Kiranmayi, Nitish R Mahapatra
Cardiovascular disease (CVD), the most common cause of death globally, accounts for ~30% of all deaths worldwide. Hypertension is a common contributor to morbidity and mortality from CVD. The plasma concentration of chromogranin A (CgA) is elevated in patients with CVD as well as patients with established human essential hypertension and heart failure (HF). In contrast, the plasma level of the CgA-derived peptide catestatin (CST) is diminished in human essential hypertension. Low conversion of CgA-to-CST has been associated with increased mortality in patients hospitalized with acute HF...
April 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28442726/effects-of-the-continuous-use-of-organic-manure-and-chemical-fertilizer-on-soil-inorganic-phosphorus-fractions-in-calcareous-soil
#4
Ke Song, Yong Xue, Xianqing Zheng, Weiguang Lv, Hongxia Qiao, Qin Qin, Jianjun Yang
A 4-year field trial with three treatments and three types of annually rotated vegetables was conducted in calcareous soil in a greenhouse using a phosphorus (P) fractionation method based on the inorganic P fraction classification system described by Jiang-Gu. With the same nutrient input, vegetable yields and P uptake were more stable under the chemical fertilizer (CF) treatment than under the organic manure (OM) treatment, and the average utilization rate of P fertilizer (URP) values were 5.27% and 11.40% under the OM and CF treatments, respectively, over the 4 years...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440436/annexin%C3%A2-a2-inhibition-suppresses-ovarian-cancer-progression-via-regulating-%C3%AE-catenin-emt
#5
Yan Liu, Hongyu Li, Zhenying Ban, Manman Nai, Li Yang, Yannan Chen, Yiming Xu
Annexin A2 is a member of the Annexin family that acts as a Ca2+-dependent phospholipid and membrane binding protein, which is associated with the survival and spread of multiple neoplasms. However, the function of Annexin A2 in ovarian cancer progression remains unclear. In this study, we aimed to investigate the role and underlying molecular mechanism of Annexin A2 in cell proliferation and invasion in ovarian cancer. We found that the mRNA expression of Annexin A2 was upregulated in ovarian cancer tissues and cell lines...
April 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28440188/trp-channels-as-novel-targets-for-endogenous-ligands-focus-on-endocannabinoids-and-nociceptive-signalling
#6
Maksim V Storozhuk, Alexander V Zholos
The endocannabinoid system is gaining steadily increasing research interest as its important role in the regulation of many fundamental physiological processes becomes more and more evident. One area which received particularly significant attention concerns targeting the endocannabinoid system as a useful strategy in pain control, especially in refractory, difficult to treat cases of chronic pain. Apart from the classical targets of cannabinoids, the CB1 and CB2 receptors, several members of the large TRP family of Ca2+-permeable cation channels have been designated as "ionotropic cannabinoid receptors" to highlight their role in cannabinoid signalling...
April 24, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28440093/turmeric-curcuma-longa-l-extract-may-prevent-the-deterioration-of-spatial-memory-and-the-deficit-of-estimated-total-number-of-hippocampal-pyramidal-cells-of-trimethyltin-exposed-rats
#7
Sapto Yuliani, Mustofa, Ginus Partadiredja
CONTEXT: Protection of neurons from degeneration is an important preventive strategy for dementia. Much of the dementia pathology implicates oxidative stress pathways. Turmeric (Curcuma longa L.) contains curcuminoids which has anti-oxidative and neuro-protective effects. These effects are considered to be similar to those of citicoline which has been regularly used as one of standard medications for dementia. OBJECTIVE: This study aimed at investigating the effects of turmeric rhizome extract on the hippocampus of trimethyltin (TMT)-treated Sprague-Dawley rats...
April 25, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28438779/human-alternative-macrophages-populate-calcified-areas-of-atherosclerotic-lesions-and-display-impaired-rankl-induced-osteoclastic-bone-resorption-activity
#8
Giulia Chinetti-Gbaguidi, Mehdi Daoudi, Mickael Rosa, Manjula Vinod, Loïc Louvet, Corinne Copin, Melanie Fanchon, Jonathan Vanhoutte, Bruno Derudas, Loic Belloy, Stephan Haulon, Christophe Zawadzki, Sophie Susen, Ziad A Massy, Jérôme Eeckhoute, Bart Staels
Rationale: Vascular calcification is a process similar to bone formation leading to an inappropriate deposition of calcium phosphate minerals in advanced atherosclerotic plaques. Monocyte-derived macrophages, located in atherosclerotic lesions and presenting heterogeneous phenotypes, from classical pro-inflammatory M1 to alternative anti-inflammatory M2 macrophages, could potentially display osteoclast-like functions. Objective: To characterize the phenotype of macrophages located in areas surrounding the calcium deposits in human atherosclerotic plaques...
April 24, 2017: Circulation Research
https://www.readbyqxmd.com/read/28438504/agomelatine-protects-against-neuronal-damage-without-preventing-epileptogenesis-in-the-kainate-model-of-temporal-lobe-epilepsy
#9
Jana Tchekalarova, Dimitrinka Atanasova, Zlatina Nenchovska, Milena Atanasova, Lidia Kortenska, Rumyana Gesheva, Nikolai Lazarov
Recent studies about the novel antidepressant agomelatine, which is a mixed MT1 and MT2 melatonin receptor agonist and 5HT2C serotonin receptor antagonist possessing an anticonvulsant and neuroprotective action, suggest that it may have potential to contribute against epileptogenesis and epilepsy-induced memory impairment. In order to ascertain whether protection of some brain structures could suppress epileptogenesis, in the present study, we evaluated the effect of chronic post-status treatment with agomelatine on epileptogenesis, behavioral and neuronal damage induced by kainate acid (KA) status epilepticus (SE)...
April 21, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28437279/npy-impairs-cell-viability-and-mitochondrial-membrane-potential-through-ca2-and-p38-signaling-pathways-in-neonatal-rat-cardiomyocytes
#10
Jun Hu, Xuehua Xu, Yuanyi Zuo, Xiangting Gao, Yun Wang, Cunquan Xiong, Hongcheng Zhou, Shaohua Zhu
NPY is involved in stress cardiomyopathy (SCM). However, the associated mechanism for NPY-induced SCM remains unclear. In this study, we aimed to explore potential cell signaling pathways that are related to NPY-mediated cell viability in neonatal rat cardiomyocytes. We found that NPY induced cell viability suppression in cultured cardiomyocytes in a dose-dependent manner. After NPY treatment, the expression of CaN and p-CAMKII was increased significantly, and the phosphorylation of p38 but not ERK and JNK was detected...
April 18, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28437073/inter-motif-communication-induces-hierarchical-ca2-filling-of-caldendrin
#11
Uday Kiran, Phanindranath Regur, Michael R Kreutz, Yogendra Sharma, Asima Chakraborty
A crucial event in calcium signalling is the transition of a calcium sensor from the apo (Ca2+ free) to the holo (Ca2+ saturated) state. Caldendrin (CDD) is a neuronal Ca2+-binding protein with two functional (EF3 and EF4) and two atypical (EF1 and EF2), non-Ca2+-binding EF-hand motifs. During the transition from the apo to the holo state, guided by the step-wise filling of Ca2+, the protein passes through distinct states and acquires a stable conformational state when only EF3 is occupied by Ca2+. This state is characterized by a Ca2+-derived structural gain in EF3 with destabilization of the EF4 motif...
April 24, 2017: Biochemistry
https://www.readbyqxmd.com/read/28436920/hybrid-3d-printing-and-electrodeposition-approach-for-controllable-3d-alginate-hydrogel-formation
#12
Wanfeng Shang, Yanting Liu, Wenfeng Wan, Chengzhi Hu, Zeyang Liu, Chin To Wong, Toshio Fukuda, Yajing Shen
Calcium alginate hydrogel is one of the most widely used biocompatible materials in biomedical and tissue engineering. This paper reports a hybrid 3D printing and electrodeposition approach to form the 3D calcium alginate hydrogel in a controllable manner. Firstly, a specific 3D printing system is developed by combining a 3D printer and a customized ejection syringe. Then, the mixed solution (1% w/v sodium alginate and 0.25% w/v CaCO3 nano particles) is filled in the syringe and ejected out from the nozzle to the substrate continuously...
April 24, 2017: Biofabrication
https://www.readbyqxmd.com/read/28436224/multi-functional-hydrogels-prepared-by-dual-ion-crosslinking-for-chronic-wound-healing
#13
Yonghui Li, Yan Han, Xiaoya Wang, Jinliang Peng, Yuhong Xu, Jiang Chang
The creation of moist environment and promotion of blood vessel formation are critical for wound healing. Sodium alginate (SA) hydrogel, which has good biocompatibility and is able to provide moist environment, has been widely used as wound dressing. However, it lacks antibacterial and bio-activities, which would facilitate chronic wound healing. On the basis of gelation characteristics of SA and the bioactive hardystonite (HS) bioceramic, we designed a unique bioactive injectable composite hydrogel through double ion-crosslinking, in which divalent ions such as Ca2+ and Zn2+ function as crosslinkers, Zn2+ also functions as antibacterial component and nutrition for wound healing, and Si ions play the key role in determining the bioactivity of the hydrogel...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28432256/global-sensitivity-analysis-of-onguard-models-identifies-key-hubs-for-transport-interaction-in-stomatal-dynamics
#14
Silvere Rm Vialet-Chabrand, Adrian Hills, Yizhou Wang, Howard Griffiths, Virgilio Lew, Tracy Lawson, Mike R Blatt, Simon Rogers
The physical requirement for charge to balance across biological membranes means that transmembrane transport of each ionic species is inter-related, and manipulating solute flux through any one transporter will affect other transporters at the same membrane, often with unforeseen consequences. The OnGuard systems modelling platform has helped to resolve the mechanics of stomatal movements, uncovering previously unexpected behaviors of stomata. To date, however, the manual approach to exploring model parameter space has captured little formal information about the emergent connections between parameters that define the most interesting properties of the system as a whole...
April 21, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28430879/role-of-phosphatase-and-tensin-homolog-pten-in-hypoxic-pulmonary-vasoconstriction
#15
Adrienn Krauszman, Tak Mak, Katalin Szaszi, Wolfgang M Kuebler
AIMS: Hypoxic pulmonary vasoconstriction (HPV) redistributes blood flow from poorly ventilated to better aerated areas in the lung, thereby optimizing ventilation-perfusion ratio (V/Q). Pulmonary artery smooth muscle cell (PASMC) contraction in response to hypoxia is triggered by Ca2+ influx via transient receptor potential canonical 6 (TRPC6) cation channels that have translocated to caveolae in the plasma membrane. Since phosphatase and tensin homolog (PTEN) was suggested to regulate TRPC6 in endothelial cells, we aimed to define its role in the hypoxic response of PASMCs and as a putative mediator of HPV...
April 18, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28430866/maternal-high-sucrose-diets-altered-vascular-large-conductance-ca2-activated-k-channels-via-reactive-oxygen-species-in-offspring-rats%C3%A2
#16
Xueqin Feng, Xiuwen Zhou, Wenna Zhang, Xiang Li, Axin He, Bailin Liu, Ruixiu Shi, Lei Wu, Jue Wu, Di Zhu, Na Li, Miao Sun, Zhice Xu
Overnutrition during pregnancy could increase risks of cardiovascular diseases in late life. This study investigated whether and how reactive oxygen species (ROS) may influence functions of large-conductance Ca2+-activated K+ channels (BKCa) in the offspring exposed to prenatal high-sucrose (HS). We found that prenatal high-sucrose diets significantly increased phenylephrine (PE)-induced vessel contractions in mesenteric arteries of the adult offspring. Pretreatment with iberiotoxin (BKCa blocker, IBTX) significantly increased PE-mediated vascular contractions in the control, not in the HS group...
April 18, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28430609/characterization-of-pressure-mediated-vascular-tone-in-resistance-arteries-from-bile-duct-ligated-rats
#17
Ravirajsinh N Jadeja, Menaka C Thounaojam, Sandeep Khurana
In cirrhosis, changes in pressure-mediated vascular tone, a key determinant of systemic vascular resistance (SVR), are unknown. To address this gap in knowledge, we assessed ex vivo dynamics of pressurized mesenteric resistance arteries (diameter ~ 260 μm) from bile duct-ligated (BDL) and sham-operated (SHAM) rats and determined the underlying mechanisms. At isobaric intraluminal pressure (70 mmHg) as well as with step-wise increase in pressure (10-110 mmHg), arteries from SHAM-rats constricted more than BDL-rats, and had reduced luminal area...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430606/ketamine-administered-pregnant-rats-impair-learning-and-memory-in-offspring-via-the-creb-pathway
#18
Xinran Li, Cen Guo, Yanan Li, Lina Li, Yuxin Wang, Yiming Zhang, Yue Li, Yu Chen, Wenhan Liu, Li Gao
Ketamine has been reported to impair the capacity for learning and memory. This study examined whether these capacities were also altered in the offspring and investigated the role of the CREB signaling pathway in pregnant rats, subjected to ketamine-induced anesthesia. On the 14th day of gestation (P14), female rats were anesthetized for 3 h via intravenous ketamine injection (200 mg/Kg). Morris water maze task, contextual and cued fear conditioning, and olfactory tasks were executed between the 25th to 30th day after birth (B25-30) on rat pups, and rats were sacrificed on B30...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429338/caffeic-acid-n-butyl-ester-triggered-necrosis-like-cell-death-in-lung-cancer-cell-line-a549-is-prompted-by-ros-mediated-alterations-in-mitochondrial-membrane-potential
#19
Y-X Zhang, P-F Yu, Z-M Gao, J Yuan, Z Zhang
OBJECTIVE: The aim of the present study was to evaluate the anticancer activity of caffeic acid n-butyl ester against lung cancer cell line A549 and to investigate the underlying mechanism. MATERIALS AND METHODS: IC50 was determined by MTT assay. Fluorescent probes DCFH-DA, Indo 1/AM, DiOC6 were used to determine ROS, Ca2+, and mitochondrial membrane potential (ΔΨm). ATP levels were determined by using ATP liteTM kit. DNA damage was investigated by DAPI and comet assays...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28427048/1-25-dihydroxyvitamin-d3-attenuates-the-effects-of-lipopolysaccharide-by-causing-adam10-dependent-ectodomain-shedding-of-toll-like-receptor-4
#20
Won Seok Yang, Jin Ju Kim, Nam Jeong Han, Eun Kyoung Lee, Su-Kil Park
BACKGROUND/AIMS: We investigated how 1,25-dihydroxyvitamin D3 (1,25D3) inhibits the effects of lipopolysaccharide (LPS) in human aortic endothelial cells. METHODS: Cellular signaling was explored by determination of protein abundance with Western blot, measurement of cytosolic Ca2+ concentration and immunofluorescence staining for a disintegrin and metalloprotease 10 (ADAM10). RESULTS: LPS stimulated the expression of intercellular adhesion molecule 1 (ICAM-1) through toll-like receptor 4 (TLR4) and subsequent activation of p38 mitogen-activated protein kinase (p38 MAPK)...
April 17, 2017: Cellular Physiology and Biochemistry
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