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https://www.readbyqxmd.com/read/28095637/gene-therapy-for-achromatopsia
#1
REVIEW
Stylianos Michalakis, Christian Schön, Elvir Becirovic, Martin Biel
AIM: This review summarizes the current status of Achromatopsia (ACHM) gene therapy-related research activities and provides an outlook for their clinical application. DISCUSSION: ACHM is an inherited eye disease characterized by congenital absence of cone photoreceptor function. As a consequence, ACHM is associated with strongly impaired daylight vision, photophobia, nystagmus, and lack of color discrimination. Currently, six genes have been linked to ACHM. Up to 80% of the patients carry mutations in the genes CNGA3 and CNGB3 encoding the two subunits of the cone cyclic nucleotide-gated (CNG) channel...
January 17, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28093604/pretreatment-with-5-fluorouracil-cream-enhances-the-efficacy-of-daylight-mediated-photodynamic-therapy-for-actinic-keratosis
#2
Christoffer V Nissen, Ida Marie Heerfordt, Stine R Wiegell, Carsten S Mikkelsen, Hans C Wulf
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone...
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28091662/self-assembly-optical-thermal-and-electrochemical-properties-of-bis-n-benzyl-perylene-diimide-dye
#3
Devrim Ozdal, Nur P Aydinlik, Jagadeesh B Bodapati, Huriye Icil
Flexible methylene containing N,N'-bis-(benzyl)-3,4,9,10-perylenebis(dicarboximide) (1) was synthesized. Self-assembled microstructures (hollow tubes, average length and width: 7.7 and 0.8 μm) of 1 were also prepared (T-1). Comparative studies of the optical, thermal and electrochemical properties of 1 and T-1 have been extensively carried out. The T-1 hallow tubes have shown extremely broad absorption in the near-infrared (300-800 nm) region (NIR) even in solution and intensified conductivity in the solid-state compared to 1...
January 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28072708/life-threatening-motor-vehicle-crashes-in-bright-sunlight
#4
Donald A Redelmeier, Sheharyar Raza
: Bright sunlight may create visual illusions that lead to driver error, including fallible distance judgment from aerial perspective. We tested whether the risk of a life-threatening motor vehicle crash was increased when driving in bright sunlight.This longitudinal, case-only, paired-comparison analysis evaluated patients hospitalized because of a motor vehicle crash between January 1, 1995 and December 31, 2014. The relative risk of a crash associated with bright sunlight was estimated by evaluating the prevailing weather at the time and place of the crash compared with the weather at the same hour and location on control days a week earlier and a week later...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070301/blood-serum-retinol-levels-in-asinara-white-donkeys-reflect-albinism-induced-metabolic-adaptation-to-photoperiod-at-mediterranean-latitudes
#5
Maria Grazia Cappai, Maria Grazia Antonietta Lunesu, Francesca Accioni, Massimo Liscia, Mauro Pusceddu, Lucia Burrai, Maria Nieddu, Corrado Dimauro, Gianpiero Boatto, Walter Pinna
Previous works on albinism form of Asinara white donkeys (Equus asinus) identified the mutation leading to the peculiar phenotype spread to all specimens of the breed. Inbreeding naturally occurred under geographic isolation, on Asinara Island, in the Mediterranean Sea. Albino individuals can be more susceptible to develop health problems when exposed to natural sun radiation. Alternative metabolic pathways involved in photoprotection were explored in this trial. Nutrition-related metabolites are believed to contribute to the conservation of Asinara donkeys, in which melanin, guaranteeing photoprotection, is lacking...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28063524/switching-from-conventional-photodynamic-therapy-to-daylight-photodynamic-therapy-for-actinic-keratoses-systematic-review-and-meta-analysis
#6
A Tomás-Velázquez, P Redondo
Actinic keratosis is a precursor lesion to the most common nonmelanoma skin cancer. Conventional photodynamic therapy (PDT) has been shown to be effective, but the procedure is time-consuming, can be very painful, and requires infrastructure. These shortcomings led to the emergence of daylight PDT. To obtain a global estimate of efficacy, we undertook a systematic literature review and performed a meta-analysis of the available evidence on the efficacy and safety of daylight PDT as compared to conventional PDT in the treatment of actinic keratosis and/or field cancerization...
January 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28059283/modified-optical-fiber-daylighting-system-with-sunlight-transportation-in-free-space
#7
Ngoc-Hai Vu, Thanh-Tuan Pham, Seoyong Shin
We present the design, optical simulation, and experiment of a modified optical fiber daylighting system (M-OFDS) for indoor lighting. The M-OFDS is comprised of three sub-systems: concentration, collimation, and distribution. The concentration part is formed by coupling a Fresnel lens with a large-core plastic optical fiber. The sunlight collected by the concentration sub-system is propagated in a plastic optical fiber and then collimated by the collimator, which is a combination of a parabolic mirror and a convex lens...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28059247/remote-raman-measurements-of-minerals-organics-and-inorganics-at-430%C3%A2-%C3%A2-m-range
#8
Tayro E Acosta-Maeda, Anupam K Misra, Lloyd G Muzangwa, Genesis Berlanga, Dalton Muchow, John Porter, Shiv K Sharma
Raman spectroscopy is a characterization technique that is able to analyze and detect water or water-bearing minerals, minerals, and organic materials that are of special interest for planetary science. Using a portable pulsed remote Raman system with a commercial 8 in. (203.2 mm) telescope, a frequency doubled Nd-YAG-pulsed laser, and a spectrometer equipped with an intensified CCD camera, we acquired good quality Raman spectra of various materials from a 430 m standoff distance during daylight with detection times of 1-10 s, in a realistic context in which both the exciting source and the detector are part of the same measurement system...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28058998/subjective-assessments-of-floor-slipperiness-before-and-after-walk-under-two-lighting-conditions
#9
Kai Way Li, Caijun Zhao, Lu Peng, Ai-Qun Liu
A gait experiment was performed. The participants were tested under shoes, floors, surface, and lighting conditions. They gave floor slipperiness ratings before and after a gait trial. The perceived sense of slip (PSOS) was collected. It was found that the perceived floor slipperiness (PFS) before walking was affected significantly by the lighting, floor, and surface conditions. Relative low PFS values were recorded under wet and detergent contaminated conditions at normal daylight condition as compared to those in the dimmed condition...
January 6, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28054017/driver-behaviour-data-linked-with-vehicle-weather-road-surface-and-daylight-data
#10
Odd André Hjelkrem, Eirin Olaussen Ryeng
In this data set, vehicle observations have been linked to data containing weather and road surface conditions. A total of 311 908 observations are collected and classified in categories of precipitation type, road status information, and daylight condition. The data is collected for a long period of time, so that several different weather situations are present, ranging from dry summer to adverse winter weather conditions.
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28053207/dynamics-of-weight-change-and-temperature-of-apis-mellifera-hymenoptera-apidae-colonies-in-a-wintering-building-with-controlled-temperature
#11
E Stalidzans, A Zacepins, A Kviesis, V Brusbardis, J Meitalovs, L Paura, N Bulipopa, M Liepniece
Honey bee wintering in a wintering building (indoors) with controlled microclimate is used in some cold regions to minimize colony losses due to the hard weather conditions. The behavior and possible state of bee colonies in a dark room, isolated from natural environment during winter season, was studied by indirect temperature measurements to analyze the expression of their annual rhythm when it is not affected by ambient temperature, rain, snow, wind, and daylight. Thus, the observed behavior in the wintering building is initiated solely by bee colony internal processes...
January 4, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28035767/oxygenic-and-anoxygenic-photosynthesis-in-a-microbial-mat-from-an-anoxic-and-sulfidic-spring
#12
Dirk de Beer, Miriam Weber, Arjun Chennu, Trinity Hamilton, Christian Lott, Jennifer Macalady, Judith Klatt
Oxygenic and anoxygenic photosynthesis were studied with microsensors in microbial mats found at 9-10 m depth in anoxic and sulfidic water in Little Salt Spring (Florida, USA). The lake sediments were covered with a 1-2 mm thick red mat dominated by filamentous Cyanobacteria, below which Green Sulfur Bacteria (GSB, Chlorobiaceae) were highly abundant. Within 4 mm inside the mats, the incident radiation was attenuated to undetectable levels. In situ microsensor data showed both oxygenic photosynthesis in the red surface layer and light-induced sulfide dynamics up to 1 cm depth...
December 30, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/28018660/manta-birostris-predator-of-the-deep-insight-into-the-diet-of-the-giant-manta-ray-through-stable-isotope-analysis
#13
Katherine B Burgess, Lydie I E Couturier, Andrea D Marshall, Anthony J Richardson, Scarla J Weeks, Michael B Bennett
The characterization of diet for the giant manta ray Manta birostris has been problematic given their large-scale movement patterns and the difficulty in obtaining stomach contents from this species. The large majority of existing information is based on observational data limited to feeding events at the sea surface during daylight. Recently discovered aggregation sites for the giant manta ray off mainland Ecuador are some of the most accessible to date and provide a unique opportunity for researchers to gather much needed information on this elusive species...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/28018637/from-resource-to-female-defence-the-impact-of-roosting-ecology-on-a-bat-s-mating-strategy
#14
Linus Günther, Marlena D Lopez, Mirjam Knörnschild, Kyle Reid, Martina Nagy, Frieder Mayer
With their extraordinary species richness and diversity in ecological traits and social systems, bats are a promising taxon for testing socio-ecological hypotheses in order to get new insights into the evolution of animal social systems. Regarding its roosting habits, proboscis bats form an extreme by occupying sites which are usually completely exposed to daylight (e.g. tree trunks, vines or rocks). This is accompanied by morphological and behavioural adaptations to remain cryptic in exposed day roosts. With long-term behavioural observations and genetic parentage analyses of individually marked proboscis bats, we assessed its social dispersion and male mating strategy during day and night...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/28010807/relationships-between-ambient-conditions-thermal-status-and-feed-intake-of-cattle-during-summer-heat-stress-with-access-to-shade
#15
A K Curtis, B Scharf, P A Eichen, D E Spiers
Heat stress in feedlot cattle is known to reduce their performance. The challenge comes in determining reliable predictors of current and near-future changes in thermal status and performance. A 42-d study, using crossbred (Bos taurus) steers was conducted during summer months (July through August) to identify best environmental determinants of rumen temperature (Trumen) and feed intake (FI) in feedlot cattle with access to shade. A further goal was to define the relationship between Trumen and FI. Shade coverage was approximately 50%, and all animals were provided standard feedlot diets and water ad libitum...
January 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28006027/evidence-for-weakened-intercellular-coupling-in-the-mammalian-circadian-clock-under-long-photoperiod
#16
M Renate Buijink, Assaf Almog, Charlotte B Wit, Ori Roethler, Anneke H O Olde Engberink, Johanna H Meijer, Diego Garlaschelli, Jos H T Rohling, Stephan Michel
For animals living in temperate latitudes, seasonal changes in day length are an important cue for adaptations of their physiology and behavior to the altered environmental conditions. The suprachiasmatic nucleus (SCN) is known as the central circadian clock in mammals, but may also play an important role in adaptations to different photoperiods. The SCN receives direct light input from the retina and is able to encode day-length by approximating the waveform of the electrical activity rhythm to the duration of daylight...
2016: PloS One
https://www.readbyqxmd.com/read/28004052/an-au-agbr-ag-heterostructure-plasmonic-photocatalyst-with-enhanced-catalytic-activity-under-visible-light
#17
Rahul Purbia, Santanu Paria
This study reports an easy synthesis protocol of a novel bimetallic silver halide (Au/AgBr-Ag) plasmonic heterostructure as a visible light induced photocatalyst. In this process, first CTAB capped Au NPs were coated with AgBr, and then Ag nanoparticles were formed on the surface of AgBr by photoreduction, while exposing to daylight at room temperature. The presence of Au and Ag improves the visible absorption ability of NPs and avoids charge recombination of the semiconductor AgBr during photoexcitation, which in turn enhances 16 and 8...
December 22, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27998181/perspectives-and-experiences-of-patients-with-type-2-diabetes-observing-the-ramadan-fast
#18
Hadi A Almansour, Betty Chaar, Bandana Saini
INTRODUCTION: Diabetes is a common chronic disease among Australians. Culturally and linguistically diverse groups are observed to have higher prevalence rates of diabetes. Continuing management needs adherence to medication and diet regimens. Religious practices such as fasting can affect diabetes management and medication use. Pharmacists as medication specialists have a significant role in helping people observing religious practices such as the Ramadan fast, which involves month-long absolute abstinence from food during daylight hours, to maintain good control over their condition...
December 21, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27997553/solar-aligned-pictographs-at-the-paleoindian-site-of-painel-do-pil%C3%A3-o-along-the-lower-amazon-river-at-monte-alegre-brazil
#19
Christopher Sean Davis
The archaeological sites near Monte Alegre, along Brazil's lower Amazon River, provide new information on the little-known activities and symbolism of South American Paleoindians toward the end of the Ice Age. While paleoindian sites like Monte Verde in Chile, or Guitarrero Cave in Peru, are located near the pacific coast, Monte Alegre lies much further inland, 680 km upriver from the mouth of the Amazon River and the Atlantic Coast. With excavated wood charcoal radiocarbon dated as early as 13,200 calibrated years ago, the hill-as a source of sandstone and quartz lithics-supplied early pioneers with adequate tools needed for colonizing the interior of the continent...
2016: PloS One
https://www.readbyqxmd.com/read/27990490/long-photoperiods-sustain-high-ph-in-arctic-kelp-forests
#20
Dorte Krause-Jensen, Núria Marbà, Marina Sanz-Martin, Iris E Hendriks, Jakob Thyrring, Jacob Carstensen, Mikael Kristian Sejr, Carlos M Duarte
Concern on the impacts of ocean acidification on calcifiers, such as bivalves, sea urchins, and foraminifers, has led to efforts to understand the controls on pH in their habitats, which include kelp forests and seagrass meadows. The metabolism of these habitats can lead to diel fluctuation in pH with increases during the day and declines at night, suggesting no net effect on pH at time scales longer than daily. We examined the capacity of subarctic and Arctic kelps to up-regulate pH in situ and experimentally tested the role of photoperiod in determining the capacity of Arctic macrophytes to up-regulate pH...
December 2016: Science Advances
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