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https://www.readbyqxmd.com/read/28538172/using-hescs-to-probe-the-interaction-of-the-diabetes-associated-genes-cdkal1-and-mt1e
#1
Min Guo, Tuo Zhang, Xue Dong, Jenny Zhaoying Xiang, Minxiang Lei, Todd Evans, Johannes Graumann, Shuibing Chen
Genome-wide association studies (GWASs) have identified many disease-associated variant alleles, but understanding whether and how different genes/loci interact requires a platform for probing how the variant alleles act mechanistically. Isogenic mutant human embryonic stem cells (hESCs) provide an unlimited resource to derive and study human disease-relevant cells. Here, we focused on CDKAL1, linked by GWASs to diabetes. Through transcript profiling, we find that expression of the metallothionein (MT) gene family, also linked by GWASs to diabetes, is significantly downregulated in CDKAL1(-/-) cells that have been differentiated to insulin-expressing pancreatic beta-like cells...
May 23, 2017: Cell Reports
https://www.readbyqxmd.com/read/28537944/behavioural-responses-of-zebrafish-larvae-to-acute-ethosuximide-exposure
#2
Yongxia Ji, Jia Lin, Xiaolan Peng, Xiuyun Liu, Fei Li, Yinglan Zhang, Ning Guo, Qiang Li
The anticonvulsant drug ethosuximide has shown diverse anxiety-related activity in rodents, but research in zebrafish is limited. To evaluate the effects of acute ethosuximide exposure on locomotor activity and anxiety-related thigmotaxis behaviours of zebrafish larvae, the activity of AB strain zebrafish larvae at 5 and 7 days postfertilization (dpf) was analysed under normal constant illumination and stressful light-dark transitions. Under constant illumination, ethosuximide at concentrations of 2, 5 and 10 mmol/l increased the distances travelled and intensified locomotor responses to a novel environment...
May 19, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28535270/intrinsically-photosensitive-retinal-ganglion-cell-function-sleep-efficiency-and-depression-in-advanced-age-related-macular-degeneration
#3
Michelle L Maynard, Andrew J Zele, Anthony S Kwan, Beatrix Feigl
Purpose: Melanopsin expressing intrinsically photosensitive retinal ganglion cells (ipRGC) input to multiple brain regions including those for pupil control, circadian rhythms, sleep and mood regulation. Here we measured ipRGC function and its relationship to sleep quality and depression in patients with advanced AMD. Methods: The melanopsin-mediated post-illumination pupil response (PIPR) was measured in 53 patients with advanced AMD (age 78.8 ± 8.8 years) and in 20 healthy controls (age 72...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28534823/preparation-and-in-vitro-photodynamic-activity-of-glucosylated-zinc-ii-phthalocyanines-as-underlying-targeting-photosensitizers
#4
Jian-Yong Liu, Chen Wang, Chun-Hui Zhu, Zhi-Hong Zhang, Jin-Ping Xue
Two novel glucosylated zinc(ІІ) phthalocyanines 7a-7b, as well as the acetyl-protected counterparts 6a-6b, have been synthesized by the Cu(I)-catalyzed 1,3-dipolar cycloaddition between the propargylated phthalocyanine and azide-substituted glucoses. All of these phthalocyanines were characterized with various spectroscopic methods and studied for their photo-physical, photo-chemical, and photo-biological properties. With glucose as the targeting unit, phthalocyanines 7a-7b exhibit a specific affinity to MCF-7 breast cancer cells over human embryonic lung fibroblast (HELF) cells, showing higher cellular uptake...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28534767/domain-generalization-and-adaptation-using-low-rank-exemplar-svms
#5
Wen Li, Zheng Xu, Dong Xu, Dengxin Dai, Luc Van Gool
Domain adaptation between diverse source and target domains is a challenging research problem, especially in the real-world visual recognition tasks where the images and videos consist of significant variations in viewpoints, illuminations, qualities, etc. In this paper, we propose a new approach for domain generalization and domain adaptation based on exemplar SVMs. Specifically, we decompose the source domain into many subdomains, each of which contains only one positive training sample and all negative samples...
May 16, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28534665/-i-look-at-my-own-forest-and-fields-in-a-different-way-the-lived-experience-of-nature-based-therapy-in-a-therapy-garden-when-suffering-from-stress-related-illness
#6
Ulrik Sidenius, Ulrika K Stigsdotter, Dorthe Varning Poulsen, Terese Bondas
Evidence confirms that nature-based therapy (NBT) has a positive effect on people with mental illnesses. However, there is a lack of evidence on the meaning of NBT for specific patient groups. The Nacadia® Therapy Garden was designed according to an evidence-based design process, and an NBT programme was developed. The aim of the study was to illuminate the phenomenon of participants' lived experience of the NBT in Nacadia. Fourteen participants took part in semi-structured interviews (SSIs), and by way of reflective lifeworld research, the SSIs were analysed to identify and describe the meanings of the phenomenon...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28534647/considering-built-environment-and-spatial-correlation-in-modelling-pedestrian-injury-severity
#7
Carlo G Prato, Sigal Kaplan, Alexandre Patrier, Thomas K Rasmussen
OBJECTIVE: This study looks at mitigating and aggravating factors that are associated with the injury severity of pedestrians when they have crashes with another road user and overcomes existing limitations in the literature by posing attention on the built environment and considering spatial correlation across crashes. METHOD: Reports for 6539 pedestrian crashes occurred in Denmark between 2006 and 2015 were merged with geographic information system resources containing detailed information about built environment and exposure at the crash locations...
May 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28534395/hyaluronic-acid-templated-ag-nanoparticles-graphene-oxide-composites-for-synergistic-therapy-of-bacteria-infection
#8
Xiang Ran, Ye Du, Zhenzhen Wang, Huan Wang, Fang Pu, Jinsong Ren, Xiaogang Qu
Developing methods of decreasing the harm to cell and increasing the antibacterial efficiency is becoming a potential topic to medical treatments. We demonstrated a hyaluronidase-triggered photothermal platform for killing bacteria based on AgNPs and graphene oxide (GO). The property of the HAase-triggered release provided excellent antibacterial activity against S. aureus. Upon illumination of NIR light, the GO-based nanomaterials locally raised the temperature, resulting in high mortality of bacterial. The HAase-triggered AgNPs releasing approach for antibacterial allows AgNPs to be protected by HA template without affecting mammalian cells...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28534394/sonochemical-synthesis-of-zinc-oxide-core-shell-nanorod-radial-p-n-homojunction-ultraviolet-photodetector
#9
Phani Kiran Vabbina, Raju Sinha, Arash Ahmadivand, Mustafa Karabiyik, Burak Gerislioglu, Osama Awadallah, Nezih Pala
We report for the first time, on the growth of homogeneous radial p-n junction in ZnO core-shell configuration with a p-doped ZnO nanoshell structure grown around a high quality un-intentionally n-doped ZnO nanorods using sonochemistry. The simultaneous decomposition of Phosphorous (P), Zinc (Zn) and Oxygen (O) from their respective precursors during sonication allows for the successful incorporation of P atoms in to the ZnO lattice. The as formed p-n junction shows a rectifying current - voltage characteristic consistent with a p-n junction with a threshold voltage of 1...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28533820/medip-seq-and-ncpg-analyses-illuminate-sexually-dimorphic-methylation-of-gonadal-development-genes-with-high-historic-methylation-in-turtle-hatchlings-with-temperature-dependent-sex-determination
#10
Srihari Radhakrishnan, Robert Literman, Beatriz Mizoguchi, Nicole Valenzuela
BACKGROUND: DNA methylation alters gene expression but not DNA sequence and mediates some cases of phenotypic plasticity. Temperature-dependent sex determination (TSD) epitomizes phenotypic plasticity where environmental temperature drives embryonic sexual fate, as occurs commonly in turtles. Importantly, the temperature-specific transcription of two genes underlying gonadal differentiation is known to be induced by differential methylation in TSD fish, turtle and alligator. Yet, how extensive is the link between DNA methylation and TSD remains unclear...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28533565/ocean-research-priorities-similarities-and-differences-among-scientists-policymakers-and-fishermen-in-the-united-states
#11
Julia G Mason, Murray A Rudd, Larry B Crowder
Understanding and solving complex ocean conservation problems requires cooperation not just among scientific disciplines but also across sectors. A recently published survey that probed research priorities of marine scientists, when provided to ocean stakeholders, revealed some agreement on priorities but also illuminated key differences. Ocean acidification, cumulative impacts, bycatch effects, and restoration effectiveness were in the top 10 priorities for scientists and stakeholder groups. Significant priority differences were that scientists favored research questions about ocean acidification and marine protected areas; policymakers prioritized questions about habitat restoration, bycatch, and precaution; and fisheries sector resource users called for the inclusion of local ecological knowledge in policymaking...
May 1, 2017: Bioscience
https://www.readbyqxmd.com/read/28533523/characterization-of-two-distant-double-slits-by-chaotic-light-second-order-interference
#12
Milena D'Angelo, Aldo Mazzilli, Francesco V Pepe, Augusto Garuccio, Vincenzo Tamma
We present the experimental characterization of two distant double-slit masks illuminated by chaotic light, in the absence of first-order imaging and interference. The scheme exploits second-order interference of light propagating through two indistinguishable pairs of disjoint optical paths passing through the masks of interest. The proposed technique leads to a deeper understanding of biphoton interference and coherence, and opens the way to the development of novel schemes for retrieving information on the relative position and the spatial structure of distant objects, which is of interest in remote sensing, biomedical imaging, as well as monitoring of laser ablation, when first-order imaging and interference are not feasible...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533467/the-current-and-future-state-of-animal-coloration-research
#13
REVIEW
John A Endler, Johanna Mappes
Animal colour patterns are a model system for understanding evolution because they are unusually accessible for study and experimental manipulation. This is possible because their functions are readily identifiable. In this final paper of the symposium we provide a diagram of the processes affecting colour patterns and use this to summarize their functions and put the other papers in a broad context. This allows us to identify significant 'holes' in the field that only become obvious when we see the processes affecting colour patterns, and their interactions, as a whole...
July 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28533273/akt-signaling-is-sustained-by-a-cd44-splice-isoform-mediated-positive-feedback-loop
#14
Sali Liu, Chonghui Cheng
Tumor cells nearly invariably evolve sustained PI3K/Akt signaling as an effective means to circumvent apoptosis and maintain survival. However, for those tumor cells that do not acquire PI3K/Akt mutations to achieve this end the underlying mechanisms have remained obscure. Here we describe the discovery of a splice isoform-dependent positive feedback loop that is essential to sustain PI3K/Akt signaling in breast cancer. Splice isoform CD44s promoted expression of the hyaluronan synthase HAS2 by activating the Akt signaling cascade...
May 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28533074/exercise-science-principles-and-the-vocal-warm-up-implications-for-singing-voice-pedagogy
#15
Matthew Hoch, Mary J Sandage
OBJECTIVES/HYPOTHESES: Principles from exercise science literature were applied to singing warm-up pedagogy as a method for examining parallels between athletic and voice training. Analysis of the use of exercise principles in vocal warm-up should illuminate aspects of voice training that may be further developed in the future. METHODS/DESIGN: A selected canon of standard voice pedagogy texts and well-regarded warm-up methods were evaluated for use of exercise science principles for skill acquisition and fatigue resistance...
May 19, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28531352/conformational-complexity-in-the-lh2-antenna-of-the-purple-sulfur-bacterium-allochromatium-vinosum-revealed-by-hole-burning-spectroscopy
#16
Adam Kell, Mahboobe Jassas, Khem Acharya, Kirsty Hacking, Richard J Cogdell, Ryszard J Jankowiak
This work discusses the protein conformational complexity of the B800-850 LH2 complexes from the purple sulfur bacterium Allochromatium vinosum, focusing on the spectral characteristics of the B850 chromophores. Low-temperature B850 absorption and the split B800 band shift blue and red, respectively, at elevated temperatures, revealing isosbestic points. The latter indicates the presence of two (unresolved) conformations of B850 bacteriochlorophylls (BChls), referred to as conformations 1 and 2, and two conformations of B800 BChls, denoted as B800R and B800B...
May 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28530826/high-speed-atomic-force-microscopy-reveals-loss-of-nuclear-pore-resilience-as-a-dying-code-in-colorectal-cancer-cells
#17
Mahmoud Shaaban Mohamed, Akiko Kobayashi, Azuma Taoka, Takahiro Watanabe-Nakayama, Yosuke Kikuchi, Masaharu Hazawa, Toshinari Minamoto, Yoshihiro Fukumori, Noriyuki Kodera, Takayuki Uchihashi, Toshio Ando, Richard W Wong
Nuclear pore complexes (NPCs) are the sole turnstile implanted in the nuclear envelope (NE), acting as a central nano-regulator of transport between the cytosol and the nucleus. NPCs consist of ~30 proteins, termed nucleoporins. About one-third of nucleoporins harbour natively unstructured, intrinsically disordered phenylalanine-glycine strings (FG-Nups), which engage in transport selectivity. Because the barriers insert deeply in the NPC, they are nearly inaccessible. Several in vitro barrier models have been proposed; however, the dynamic FG-Nups protein molecules themselves are imperceptible in vivo...
May 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28530792/phosphonated-pillar-5-arene-valved-mesoporous-silica-drug-deliv-ery-systems
#18
Xuan Huang, Shanshan Wu, Xiaokang Ke, Xueyuan Li, Xuezhong Du
To explore the diversity and promising applications of pillararene-based molecular machines, phosphonated pillar[5]arenes (PPA[5]) were synthesized to construct novel supramolecular nanovalves for the first time, based on mesoporous silica nanoparticles (MSNs) functionalized with choline and pyridinium moieties, respectively. PPA[5] encircled the choline or pyridinium stalks to construct supramolecular nanovalves for encapsulation of drugs within the MSN pores. PPA[5] showed a high binding affinity for the quaternary ammonium stalks through the host-guest interactions primarily via ion pairing between the phosphonate and quaternary ammonium moieties, in comparison to carboxylated pillar[5]arene (CPA[5]), to minimize premature drug release...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28530748/photomultiplication-type-narrowband-organic-photodetectors-working-at-forward-and-reverse-bias
#19
Jianli Miao, Fujun Zhang, Mingde Du, Wenbin Wang, Ying Fang
It is a great challenge to obtain narrowband and photomultiplication (PM) type organic photodetectors (OPDs) without optical filters due to the broad absorption range and large exciton binding energy of organic materials. Narrowband OPDs with the special structure of ITO/PFN-OX/P3HT : PC61BM (100 : 1,wt/wt)/Al were successfully fabricated with different active layer thicknesses, exhibiting a tunable response window and PM phenomenon under bi-directional bias. The OPDs exhibit U-shaped EQE spectra with two narrowband response windows under forward bias and a single narrowband response window under reverse bias...
May 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28530718/resonant-thermoelectric-nanophotonics
#20
Kelly W Mauser, Seyoon Kim, Slobodan Mitrovic, Dagny Fleischman, Ragip Pala, K C Schwab, Harry A Atwater
Photodetectors are typically based either on photocurrent generation from electron-hole pairs in semiconductor structures or on bolometry for wavelengths that are below bandgap absorption. In both cases, resonant plasmonic and nanophotonic structures have been successfully used to enhance performance. Here, we show subwavelength thermoelectric nanostructures designed for resonant spectrally selective absorption, which creates large localized temperature gradients even with unfocused, spatially uniform illumination to generate a thermoelectric voltage...
May 22, 2017: Nature Nanotechnology
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