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https://www.readbyqxmd.com/read/28351053/macular-edema-rationale-for-therapy
#1
Thomas J Wolfensberger
Macular edema represents the end-stage of multiple pathophysiological pathways in a multitude of ocular vascular, inflammatory, and other diseases. The rationale for clinical treatment of macular edema is based on the understanding and the inhibition of these pathophysiological mechanisms. When macular edema is caused by a generalized health problem such as diabetes, high blood pressure, or generalized inflammatory conditions, treatment of these generalized diseases can in many cases cure macular edema directly...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28350958/photo-controlled-sirna-delivery-and-biomarker-triggered-aiegen-emission-by-upconversion-nayf4-yb-3-tm-3-sio2-nanoparticles-for-inducing-and-monitoring-stem-cell-differentiation
#2
Jinming Li, Chris Wai Tung Leung, Dexter Siu Hong Wong, Jianbin Xu, Rui Li, Yueyue Zhao, Chris Yu Yee Yung, Engui Zhao, Benzhong Tang, Liming Bian
Controlling differentiation of stem cell and monitoring the cell differentiation has attracted much research interest since the discovery of stem cells. In this regard, a novel and personalized near-infrared (NIR) light-activated nanoplatform is obtained by encapsulating the photoactivated caged compound (DMNPE/siRNA) and combining a MMP13 cleavaged imaging peptide-tetrapheny-lethene (TPE) unit conjugated with the mesoporous silica coated upconversion nanoparticles (UCNPs) for the remote control of cell differentiation and simultaneously for real-time monitoring of differentiation...
March 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28346338/smartfluo-a-method-and-affordable-adapter-to-measure-chlorophyll-a-fluorescence-with-smartphones
#3
Anna Friedrichs, Julia Anke Busch, Hendrik Jan van der Woerd, Oliver Zielinski
In order to increase the monitoring capabilities of inland and coastal waters, there is a need for new, affordable, sensitive and mobile instruments that could be operated semi-automatically in the field. This paper presents a prototype device to measure chlorophyll a fluorescence: the SmartFluo. The device is a combination of a smartphone offering an intuitive operation interface and an adapter implying a cuvette holder, as well as a suitable illumination source. SmartFluo is based on stimulated fluorescence of water constituents such as chlorophyll a...
March 25, 2017: Sensors
https://www.readbyqxmd.com/read/28346215/enhanced-optoelectronic-quality-of-perovskite-films-with-excess-ch3nh3i-for-high-efficient-solar-cells-in-ambient-air
#4
Yunhai Zhang, Huiru Lv, Can Cui, Lingbo Xu, Peng Wang, Hao Wang, Xuegong Yu, Jiangsheng Xie, Jiabin Huang, Zeguo Tang, Deren Yang
The solution-processed polycrystalline perovskite film contributes critically to the high photovoltaic performance of perovskite based solar cells (PSCs). The inevitable electronic trap states at grain boundaries and the intrinsic defects such as metallic lead (Pb0) and halide vacancies in perovskite film cause serious carrier recombination loss. Furthermore, the film can easily decompose into PbI2 in moisture atmosphere. Here, we introduce a simple strategy through a small increase in methylammonium iodide (CH3NH3I, MAI) molar proportion (5%) for perovskite fabrication in ambient air with a ~50% relative humidity...
March 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28346141/insights-into-electrosensory-organ-development-physiology-and-evolutionfrom-a-lateral-line-enriched-transcriptome
#5
Melinda S Modrell, Mike Lyne, Adrian R Carr, Harold H Zakon, David Buckley, Alexander S Campbell, Marcus C Davis, Gos Micklem, Clare Vh Baker
The anamniote lateral line system, comprising mechanosensory neuromasts and electrosensory ampullary organs, is a useful model for investigating the developmental and evolutionary diversification of different organs and cell types. Zebrafish neuromast development is increasingly well understood, but neither zebrafish nor Xenopus is electroreceptive and our molecular understanding of ampullary organ development is rudimentary. We have used RNA-seq to generate a lateral line-enriched gene-set from late-larval paddlefish (Polyodon spathula)...
March 27, 2017: ELife
https://www.readbyqxmd.com/read/28346104/bioengineered-3d-glial-cell-culture-systems-and-applications-for-neurodegeneration-and-neuroinflammation
#6
P Marc D Watson, Edel Kavanagh, Gary Allenby, Matthew Vassey
Neurodegeneration and neuroinflammation are key features in a range of chronic central nervous system (CNS) diseases such as Alzheimer's and Parkinson's disease, as well as acute conditions like stroke and traumatic brain injury, for which there remains significant unmet clinical need. It is now well recognized that current cell culture methodologies are limited in their ability to recapitulate the cellular environment that is present in vivo, and there is a growing body of evidence to show that three-dimensional (3D) culture systems represent a more physiologically accurate model than traditional two-dimensional (2D) cultures...
February 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28345699/gold-and-iodine-diffusion-in-large-area-perovskite-solar-cells-under-illumination
#7
S Cacovich, L Ciná, F Matteocci, G Divitini, P A Midgley, A Di Carlo, C Ducati
Operational stability is the main issue hindering the commercialisation of perovskite solar cells. Here, a long term light soaking test was performed on large area hybrid halide perovskite solar cells to investigate the morphological and chemical changes associated with the degradation of photovoltaic performance occurring within the devices. Using Scanning Transmission Electron Microscopy (STEM) in conjunction with EDX analysis on device cross sections, we observe the formation of gold clusters in the perovskite active layer as well as in the TiO2 mesoporous layer, and a severe degradation of the perovskite due to iodine migration into the hole transporter...
March 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28345657/multicolor-bioimaging-with-biosynthetic-zinc-nanoparticles-and-their-application-in-tumor-detection
#8
Yanjun Kang, Yi-Zhou Wu, Xianyun Hu, Xueqin Xu, Jie Sun, Rong Geng, Tongxing Huang, Xiaohang Liu, Yichen Ma, Ying Chen, Quan Wan, Xiaobang Qi, Gen Zhang, Xiaohui Zhao, Xin Zeng
Because they generate excellent images, nanoparticles (NPs), especially biosynthesized NPs, provide a new solution for tumor imaging. In this research, we unveil a novel type of biosynthesized NPs featuring multicolor fluorescence. These NPs exhibit little cytotoxicity to cells. The explored NPs, designated Zn-ZFP-GST NPs (Zinc NPs in abbreviation), are generated from leukemia cells treated with a Zn(2+) solution, while zinc-finger protein and glutathione S-transferase (GST) were also identified in the Zinc NPs...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345286/highly-selective-synthesis-of-cis-enediyne-on-a-ag-111-surface
#9
Tao Wang, Haifeng Lv, Qitang Fan, Lin Feng, Xiaojun Wu, Junfa Zhu
Cis-enediyne-type compounds have received much attention as potent antitumor antibiotics. The conventional synthesis of cis-enediynes in solution typically involves multiple steps and various side reactions. For the first time, selective one-step synthesis of cis-enediyne from a single reactant is reported on a Ag(111) surface with a yield up to 90 %. High selectivity for the formation of cis-enediyne originates from the steric effect posed by weak intermolecular interactions, which protect the cis-enediyne from further reaction...
March 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28345084/the-importance-of-solvent-quality-on-the-modification-of-conjugated-polymer-conformation-and-thermodynamics-with-illumination
#10
Brian Morgan, Mark D Dadmun
Device efficiency in key organic electronic devices such as organic photovoltaics, field transistors, and light emitting diodes has long been known to be closely tied to the conformation of the conjugated polymer chains which make up the active layers. Our previous results show that light exposure can have a profound effect on the structure and assembly of these optoelectronic materials in solution. In order to advance our understanding of the role which solvent quality plays in this phenomenon, we have further studied the modulation of these illumination dependent structural changes on the key benchmark conjugated polymers P3HT and MEH-PPV as a function of solvent quality over a wide range of polymer solubilities...
March 27, 2017: Soft Matter
https://www.readbyqxmd.com/read/28345036/abundant-off-fault-seismicity-and-orthogonal-structures-in-the-san-jacinto-fault-zone
#11
Zachary E Ross, Egill Hauksson, Yehuda Ben-Zion
The trifurcation area of the San Jacinto fault zone has produced more than 10% of all earthquakes in southern California since 2000, including the June 2016 Mw (moment magnitude) 5.2 Borrego Springs earthquake. In this area, the fault splits into three subparallel strands and is associated with broad VP /VS anomalies. We synthesize spatiotemporal properties of historical background seismicity and aftershocks of the June 2016 event. A template matching technique is used to detect and locate more than 23,000 aftershocks, which illuminate highly complex active fault structures in conjunction with a high-resolution regional catalog...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28344724/functional-fixedness-in-creative-thinking-tasks-depends-on-stimulus-modality
#12
Evangelia G Chrysikou, Katharine Motyka, Cristina Nigro, Song-I Yang, Sharon L Thompson-Schill
Pictorial examples during creative thinking tasks can lead participants to fixate on these examples and reproduce their elements even when yielding suboptimal creative products. Semantic memory research may illuminate the cognitive processes underlying this effect. Here, we examined whether pictures and words differentially influence access to semantic knowledge for object concepts depending on whether the task is close- or open-ended. Participants viewed either names or pictures of everyday objects, or a combination of the two, and generated common, secondary, or ad hoc uses for them...
November 2016: Psychology of Aesthetics, Creativity, and the Arts
https://www.readbyqxmd.com/read/28344713/exploring-the-experience-of-residents-during-the-first-six-months-of-family-medicine-residency-training
#13
Dawn Martin, Louise Nasmith, Susan Glover Takahashi, Bart J Harvey
BACKGROUND: The shift from undergraduate to postgraduate education signals a new phase in a doctor's training. This study explored the resident's perspective of how the transition from undergraduate to postgraduate (PGME) training is experienced in a Family Medicine program as they first meet the reality of feeling and having the responsibility as a doctor. METHODS: Qualitative methods explored resident experiences using interpretative inquiry through monthly, individual in-depth interviews with five incoming residents during the first six months of training...
February 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28344699/curricular-initiatives-that-enhance-student-knowledge-and-perceptions-of-sexual-and-gender-minority-groups-a-critical-interpretive-synthesis
#14
REVIEW
Jennifer Desrosiers, Tim Wilkinson, Gillian Abel, Suzanne Pitama
BACKGROUND: There is no accepted best practice for optimizing tertiary student knowledge, perceptions, and skills to care for sexual and gender diverse groups. The objective of this research was to synthesize the relevant literature regarding effective curricular initiatives designed to enhance tertiary level student knowledge, perceptions, and skills to care for sexual and gender diverse populations. METHODS: A modified Critical Interpretive Synthesis using a systematic search strategy was conducted in 2015...
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28344634/an-image-analysis-pipeline-for-automated-classification-of-imaging-light-conditions-and-for-quantification-of-wheat-canopy-cover-time-series-in-field-phenotyping
#15
Kang Yu, Norbert Kirchgessner, Christoph Grieder, Achim Walter, Andreas Hund
BACKGROUND: Robust segmentation of canopy cover (CC) from large amounts of images taken under different illumination/light conditions in the field is essential for high throughput field phenotyping (HTFP). We attempted to address this challenge by evaluating different vegetation indices and segmentation methods for analyzing images taken at varying illuminations throughout the early growth phase of wheat in the field. 40,000 images taken on 350 wheat genotypes in two consecutive years were assessed for this purpose...
2017: Plant Methods
https://www.readbyqxmd.com/read/28344107/molecular-phylogenetics-and-historical-biogeography-of-sorbus-sensu-stricto-rosaceae
#16
Meng Li, Ohi-Toma Tetsuo, Yun-Dong Gao, Bo Xu, Zhang-Ming Zhu, Wen-Bin Ju, Xin-Fen Gao
Explaining how plants from eastern Asia migrated to other Northern Hemisphere regions is still challenging. The genus Sorbus sensu stricto (including c. 88 species) is considered as a good example to illuminate this scenario, due to the wide distribution in the temperate zone and high diversity in the Himalayas and Hengduan Mountains. Based on four nuclear markers (LEAFY-2, GBSSI-1, SBEI and WD) and one chloroplast marker (rps16-trnK), we reconstructed the phylogenetic relationship of Sorbus using 54 taxa (60% of the genus representing all subgenera, sections, or series and geographical areas in the previous classifications), and estimated divergence time and historical biogeography of the genus...
March 23, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28342424/end-of-life-care-in-a-community-garden-findings-from-a-participatory-action-research-project-in-regional-australia
#17
Pauline Marsh, Gabrielle Gartrell, Gwen Egg, Andrew Nolan, Merylin Cross
This article presents findings from research that explored how a community garden might function as a place of end-of-life and bereavement support. Adopting Participatory Action Research (PAR) methods, and informed by Third Place theory and notions of therapeutic landscape, creative consultations were held in the Garden and people's homes. The findings provide insights into the nature of informal care as it is played out in the liminal garden space, between home and institution. The results illuminate the therapeutic landscape of community gardens, and contribute new understandings to the fields of PAR, health geography and end-of-life care...
March 22, 2017: Health & Place
https://www.readbyqxmd.com/read/28341063/the-personnel-s-experiences-with-the-implementation-of-an-activity-program-for-men-in-municipal-health-services
#18
Vigdis Abrahamsen Grøndahl, Eli-Anne Skaug, Marit Skaflestad Hornnes, Ann Karin Helgesen
The aim of this study was to explore the personnel's experiences with the implementation of an activity program for male residents in municipal care services. The design was inspired by a grounded theory approach. The data were collected by means of two focus group interviews with 11 participants in total. The findings showed that the personnel experienced that continuity was a prerequisite to being and remaining motivated when taking part in the activity program. Therefore, a lack of continuity was an obstacle...
March 22, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28340762/reference-free-spectroscopic-determination-of-fat-and-protein-in-milk-in-the-visible-and-near-infrared-region-below-1000nm-using-spatially-resolved-diffuse-reflectance-fiber-probe
#19
Andrey Bogomolov, Valeria Belikova, Vladislav Galyanin, Anastasiia Melenteva, Hans Meyer
New technique of diffuse reflectance spectroscopic analysis of milk fat and total protein content in the visible (Vis) and adjacent near infrared (NIR) region (400-995nm) has been developed and tested. Sample analysis was performed through a probe having eight 200-µm fiber channels forming a linear array. One of the end fibers was used for the illumination and other seven - for the spectroscopic detection of diffusely reflected light. One of the detection channels was used as a reference to normalize the spectra and to convert them into absorbance-equivalent units...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340703/a-ratiometric-two-photon-fluorescent-probe-for-imaging-hydrogen-sulfide-in-lysosomes
#20
Wenqi Feng, Zhiqiang Mao, Lingzhi Liu, Zhihong Liu
Hydrogen sulfide (H2S) is a kind of gaseous signalling molecule that plays pivotal role in various biological processes. So far, it is still a challenge to develop convenient and reliable methods for H2S detection in lysosomes. Herein, we developed a novel ratiometric two-photon fluorescent probe LR-H2S for imaging H2S in lysosomes. Upon the addition of H2S (using Na2S as a donor) to LR-H2S in buffer solution, the azide group is reduced to amino group and subsequently the carbamate ester is cleaved by 1,6-elimination, resulting in a fluorescence emission increase at 541nm and a concomitant emission decrease at 475nm...
May 15, 2017: Talanta
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