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https://www.readbyqxmd.com/read/28654700/both-absolute-and-relative-quantification-of-urinary-mrna-are-useful-for-non-invasive-diagnosis-of-acute-kidney-allograft-rejection
#1
Jung-Woo Seo, Haena Moon, Se-Yun Kim, Ju-Young Moon, Kyung Hwan Jeong, Yu-Ho Lee, Yang-Gyun Kim, Tae-Won Lee, Chun-Gyoo Ihm, Chan-Duck Kim, Byung Ha Chung, Yeong Hoon Kim, Sang Ho Lee
Urinary mRNA analysis with three-gene set (18S rRNA, CD3ε, and IP-10) has been suggested as a non-invasive biomarker of acute rejection (AR) in kidney transplant recipients using quantitative real-time PCR (qPCR). Application of droplet digital PCR (ddPCR), which has been suggested to provide higher sensitivity, accuracy, and absolute quantification without standard curves, could be a useful method for the quantifying low concentration of urinary mRNA. We investigated the urinary expression of these three genes in Korean patients with kidney transplantation and also evaluated the usefulness of ddPCR...
2017: PloS One
https://www.readbyqxmd.com/read/28653113/association-of-soluble-st2-with-functional-capacity-in-outpatients-with-heart-failure
#2
O Yucel, I Gul, A Zararsiz, O Demirpence, H Yucel, Z Cinar, A Zorlu, M B Yilmaz
BACKGROUND: Biomarkers play an important role in the risk stratification of patients with heart failure (HF). Recent studies have shown that soluble suppression of tumorigenicity 2 (sST2), a member of the interleukin 1 receptor family, is associated with disease prognosis in acute and chronic HF. In this study we aimed to investigate the relation between sST2 level and functional capacity in outpatients with systolic HF. PATIENTS AND METHODS: This study included 120 HF patients with reduced ejection fraction (HFrEF; EF ≤ 40%)...
June 26, 2017: Herz
https://www.readbyqxmd.com/read/28651886/investigation-of-uch-l1-levels-in-ischemic-stroke-intracranial-hemorrhage-and-metabolic-disorder-induced-impaired-consciousness
#3
Ihsan Yigit, Metin Atescelik, Mustafa Yilmaz, Mehmet Cagri Goktekin, Mehtap Gurger, Nevin Ilhan
OBJECTIVE: We aimed to determine the levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in patients admitted to the emergency department with impaired consciousness due to metabolic or neurological reasons. MATERIALS - METHODS: The study included 80 patients with ischemic stroke (IS), 40 patients with intracranial hemorrhage (ICH), 80 patients with metabolic disorder induced impaired consciousness (MDIC) and 40 healthy controls. RESULTS: The levels of UCH-L1 [median (IQR)] were as follows: 5...
June 21, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28650775/urine-interleukin-18-il-18-as-a-biomarker-of-total-body-irradiation-a-preliminary-study-in-nonhuman-primates
#4
Mang Xiao, David L Bolduc, XiangHong Li, Wanchang Cui, Kevin P Hieber, Rolf Bünger, Natalia I Ossetrova
We have reported that circulating IL-18 can be used as a radiation biomarker in mice, minipigs and nonhuman primates (NHPs, Macaca mulatta). Here, we report the levels of IL-18 in individual NHP's urine before and at 6 h-7 days after 5.0, 6.5 and 8.5 Gy (60)Co total-body irradiation (TBI) using enzyme linked immunosorbent assay (ELISA). Six animals (3.5-5.5 kg, 3-4 years old) per radiation dose were investigated. Correlation values between urine IL-18 and blood cell counts and serum chemistry parameters including lactate dehydrogenase (LDH), lipase, and serum total protein (TP), as well as between urine IL-18 and 60-day survival, were analyzed...
June 26, 2017: Radiation Research
https://www.readbyqxmd.com/read/28650254/proteomics-to-predict-the-response-to-tumour-necrosis-factor-%C3%AE-inhibitors-in-rheumatoid-arthritis-using-a-supervised-cluster-analysis-based-protein-score
#5
Bvj Cuppen, Rde Fritsch-Stork, I Eekhout, W de Jager, A C Marijnissen, Jwj Bijlsma, M Custers, J M van Laar, Fpjg Lafeber, Pmj Welsing
OBJECTIVE: In rheumatoid arthritis (RA), it is of major importance to identify non-responders to tumour necrosis factor-α inhibitors (TNFi) before starting treatment, to prevent a delay in effective treatment. We developed a protein score for the response to TNFi treatment in RA and investigated its predictive value. METHOD: In RA patients eligible for biological treatment included in the BiOCURA registry, 53 inflammatory proteins were measured using xMAP® technology...
June 26, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28648903/social-frailty-and-functional-disability-findings-from-the-singapore-longitudinal-ageing-studies
#6
Nigel Teo, Qi Gao, Ma Shwe Zin Nyunt, Shiou Liang Wee, Tze-Pin Ng
BACKGROUND/OBJECTIVE: To examine the association between the social frailty (SF) phenotype and functional disability, independently of the physical frailty (PF) phenotype, and compare the abilities of the PF, SF, and combined social and physical (PSF) indexes for predicting functional disability. METHOD: Cross-sectional and longitudinal analyses of a population-based cohort (Singapore Longitudinal Ageing Study, SLAS-1) of 2406 community-dwelling older adults with 3 years of follow-up (N = 1254 and N = 1557 for instrumental activity of daily living (IADL) disability and severe disability (≥3 basic ADL) respectively)...
July 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28648123/value-of-intravoxel-incoherent-motion-in-assessment-of-pathological-grade-of-clear-cell-renal-cell-carcinoma
#7
Qingqiang Zhu, Jing Ye, Wenrong Zhu, Jingtao Wu, Wenxin Chen
Background Intravoxel incoherent motion (IVIM) can provide a unique view of tissue perfusion without the use of exogenous contrast agents. Purpose To investigate the value of IVIM in assessing grades of clear cell renal cell carcinoma (CRCC). Material and Methods A total of 107 patients with pathologically proven CRCC were included, 26 with grade I, 27 with grade II, 25 with grade III, and 29 with grade IV. These tumors were divided into low (I + II) and high grades (III + IV). Nine b values (0, 30, 50, 80, 150, 300, 500, 800, and 1500 s/mm(2)) were used in diffusion-weighted imaging (DWI)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28647999/-relationship-between-the-ratio-of-neutrophil-lymphocyte-and-risk-stratification-prognosis-in-patients-with-non-st-elevation-acute-coronary-syndrome
#8
Y Wang, S J Jia, Z Chi
Objective: To investigate the value of neutrophil to lymphocyte ratio (NLR) in predicting risk stratification and prognosis in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: A total of 227 NSTE-ACS patients after percutaneous coronary intervention (PCI) were collected from September 2012 to September 2014 in Beijing Anzhen Hospital.Groups: (1)According to NLR, the patients were divided into 3 groups: NLR<2.20 group; 2.2≤NLR<3.33 group; NLR≥3.33 group.(2)According to the global registry of acute coronary events (GRACE) score, the patients were divided into 3 groups: Low-risk group, Medium-risk group and High-risk group...
June 20, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28647971/-association-between-body-fat-percentage-visceral-fat-index-and-cardiometabolic-risk-factor-clustering-among-population-aged-35-year-old-or-over-in-tibet-autonomous-region-and-xinjiang-uygur-autonomous-region
#9
J L Wang, Z Chen, L F Zhang, X Wang, Y Dong, J Y Nie, C Y Zheng, L Shao, Y Tian, Z W Wang
Objective: To investigate the association between body fat percentage (BFP), visceral fat index (VFI) and Cardiometabolic Risk Factor Clustering (CRFC), among population aged 35 or older in Tibet and Xinjiang areas. Methods: Using the stratified multi-stage random sampling method, 7 571 residents aged 35 or above were examined with international standardized examination between 2015 and 2016. Of the eligible 5 643 participants, association of BFP and VFI with CRFC was defined as having two or more of the four risk factors: hypertension, diabetes mellitus, high TG and low HDL-C, at the same time...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28646855/the-neutrophil-to-lymphocyte-ratio-on-admission-is-a-good-predictor-for-all-cause-mortality-in-hypertensive-patients-over-80%C3%A2-years-of-age
#10
Xiaonan Sun, Leiming Luo, Xiaoqian Zhao, Ping Ye, Ruixue Du
BACKGROUND: Immuno-inflammation plays a major role in the process of hypertension. We aimed to evaluate the association between inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW) and all-cause mortality in elderly patients with hypertension. METHODS: A total of 341 hypertensive patients over 80 years of age were included to this study. The NLR and RDW were measured on admission and all the selected patients were followed up for up to 90 days...
June 24, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28646700/increased-serum-mir-7-is-a-promising-biomarker-for-type-2-diabetes-mellitus-and-its-microvascular-complications
#11
Shujun Wan, Jun Wang, Jing Wang, Jia Wu, Jiaxi Song, Chen-Yu Zhang, Chunni Zhang, Cheng Wang, Jun-Jun Wang
AIMS: To investigate the alteration pattern and physiologic state of islet-specific miR-7 in the serum of patients with type 2 diabetes mellitus (T2DM) and T2DM-associated microvascular complications (T2DMC) and to evaluate its clinical significance. METHODS: The levels of serum miR-7 were firstly examined and compared in 76 T2DM patients, 76 T2DMC patients and 74 age-gender matched controls using RT-qPCR. Subsequently, the physiologic state of serum miR-7 was characterized by determining its concentrations in isolated exosomes and corresponding exosome-free samples from the same three cohorts' samples...
June 11, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28645324/bmi-and-recommended-levels-of-physical-activity-in-school-children
#12
Phillipp Schwarzfischer, Martina Weber, Dariusz Gruszfeld, Piotr Socha, Veronica Luque, Joaquin Escribano, Annick Xhonneux, Elvira Verduci, Benedetta Mariani, Berthold Koletzko, Veit Grote
BACKGROUND: Physical activity (PA) and its health benefits are a continuous point of discussion. Recommendations for children's daily PA vary between guidelines. To better define the amount of PA necessary to prevent overweight and obesity in children, further research is needed. The present study investigates children's compliance to physical activity guidelines (PAGs) and the association between objectively measured PA and body mass index (BMI). METHODS: Participating children were 11 years old (n = 419) and part of the European CHOP trial, which was conducted in Germany, Belgium, Poland, Spain, Italy...
June 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28644873/circular-rna-expression-profiling-of-human-granulosa-cells-during-maternal-aging-reveals-novel-transcripts-associated-with-assisted-reproductive-technology-outcomes
#13
Jing Cheng, Jia Huang, Suzhen Yuan, Su Zhou, Wei Yan, Wei Shen, Yun Chen, Xi Xia, Aiyue Luo, Da Zhu, Shixuan Wang
Circular RNAs (circRNAs) are a unique class of endogenous RNAs which could be used as potential diagnostic and prognostic biomarkers of many diseases. Our study aimed to investigate circRNA profiles in human granulosa cells (GCs) during maternal aging and to uncover age-related circRNA variations that potentially reflect decreased oocyte competence. CircRNAs in GCs from in vitro fertilization (IVF) patients with young age (YA, ≤ 30 years) and advanced age (AA, ≥ 38 years) were profiled by microarray, and validated in 20 paired samples...
2017: PloS One
https://www.readbyqxmd.com/read/28641643/-change-of-plasma-interleukin-16-level-in-patients-with-multiple-myeloma-and-its-clinical-significance
#14
Yue-Li Gu, Xi-Chun Xiao, Shuo Yang
OBJECTIVE: To investigate the change of plasma IL-16 level in patients with multiple myeloma(MM) and its clinical significance. METHODS: Sixty-two patients with multiple myeloma were admitted in our hospital from June 2008 to June 2015. Forty healthy volunteers were selected as control group. The peripheral blood of all the patients and healthy volunteers were collected before the treatment of patients. The levels of IL-16, Cys-C, LDH and β2-MG were measured. ROC curve was used to analyze the optimal IL-16 thresholds in MM patients...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28641629/-ratio-of-primary-bone-marrow-cells-after-induction-chemothrapy-for-two-weeks-in-the-patients-with-ph-all-and-its-influence-on-complete-remission-and-overall-progrosis
#15
Xi-Feng Wu, Ling Sun, Tan-Tan Li, Xiang-Cong Yin, Xue-Hong Ran
OBJECTIVE: To investigate the influence of bone marrow blasts ratio after induction chemotherapy for 2 weeks in patients with Ph(-) ALL, and it's influence on complete remission (CR) and overall prognosis. METHODS: A total of 172 patients with Ph(-) ALL in our hospital from March 2012 to February 2016 were selected. The bone marrow blast ratio was analyzed by the receiver-operating characteristic curve (ROC) in patients after induction chemotherapy for 2 weeks, at same time its influence on CR and overall prognosis of Ph(-) ALL patients was evaluated...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28641624/-relationship-between-peripheral-blood-white-blood-cell-count-and-early-death-rate-in-patients-with-acute-promyelocytic-leukemia
#16
Huai-Yu Wang, Xin-Xin Zhang, Hui-Yun Zhang, Jing Wang, Li-Mei Chen, Meng-Chang Wang, Jie-Ying Xi, Ming Xie, Ting Fan
OBJECTIVE: To investigate the relationship between peripheral white blood cell count and early death rate of the patients with acute promyelocytic leukemia (APL). METHODS: Through retrospective study, the relationship of early death rate in 116 cases newly diagnosed APL patients with maximum of peripheral blood white blood cell count should be analyzed before and after induction therapy as well as in the whole course of disease during the past 8 years. RESULTS: There was a close relationship between the peripheral white blood cell count and the early death rate in APL patients...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28640854/maternal-bmi-and-diabetes-in-pregnancy-investigating-variations-between-ethnic-groups-using-routine-maternity-data-from-london-uk
#17
Erin Nishikawa, Laura Oakley, Paul T Seed, Pat Doyle, Eugene Oteng-Ntim
OBJECTIVE: To investigate the ethnicity-specific association between body mass index (BMI) and diabetes in pregnancy, with a focus on the appropriateness of using BMI cut-offs to identify pregnant women at risk of diabetes. STUDY DESIGN: Analysis of routinely-collected data from a maternity unit in London, UK. Data were available on 53 264 women delivering between 2004 and 2012. Logistic regression was used to explore the association between diabetes in pregnancy and BMI among women of different ethnicities, and adjusted probability estimates were used to derive risk equivalent cut-offs...
2017: PloS One
https://www.readbyqxmd.com/read/28640531/apparent-diffusion-coefficient-in-estrogen-receptor-positive-and-lymph-node-negative-invasive-breast-cancers-at-3-0t-dw-mri-a-potential-predictor-for-an-oncotype-dx-test-recurrence-score
#18
Sunitha B Thakur, Manuela Durando, Soledad Milans, Gene Y Cho, Lucas Gennaro, Elizabeth J Sutton, Dilip Giri, Elizabeth A Morris
PURPOSE: To measure the apparent diffusion coefficient (ADC) values in estrogen receptor-positive (ER+) and axillary lymph node-negative (LN-) invasive breast cancer and investigate the correlation of ADC with Oncotype Dx test recurrence scores (ODxRS). MATERIALS AND METHODS: This was a Health Insurance Portability and Accountability Act (HIPAA)-compliant single-site retrospective study. Patients underwent preoperative 3.0T MRI scans with additional diffusion-weighted imaging sequential scans (b = 0, 600 and b = 0, 1000 s/mm(2) ) from January 2011 to 2013...
June 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28639049/multiparametric-voxel-based-analyses-of-standardized-uptake-values-and-apparent-diffusion-coefficients-of-soft-tissue-tumours-with-a-positron-emission-tomography-magnetic-resonance-system-preliminary-results
#19
Koji Sagiyama, Yuji Watanabe, Ryotaro Kamei, Sungtak Hong, Satoshi Kawanami, Yoshihiro Matsumoto, Hiroshi Honda
OBJECTIVES: To investigate the usefulness of voxel-based analysis of standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) for evaluating soft-tissue tumour malignancy with a PET/MR system. METHODS: Thirty-five subjects with either ten low/intermediate-grade tumours or 25 high-grade tumours were prospectively enrolled. Zoomed diffusion-weighted and fluorodeoxyglucose ((18)FDG)-PET images were acquired along with fat-suppressed T2-weighted images (FST2WIs)...
June 20, 2017: European Radiology
https://www.readbyqxmd.com/read/28638465/prediction-of-lymph-node-metastases-in-gastric-cancer-by-serum-ape1-expression
#20
Xi Wei, Yi-Bo Li, Ying Li, Ben-Cheng Lin, Xiao-Min Shen, Ran-Liang Cui, Ya-Jun Gu, Ming Gao, Yue-Guo Li, Sheng Zhang
Aims: To investigate the functional role of serum Human apurinic/apyrimidinic endonuclease 1 (APE1) in prediction of lymph node metastasis in gastric cancer patients. Materials and methods: Serum samples were pre-operational collected from 86 patients with gastric cancer from Tianjin Medical University Cancer Institute and Hospital from March 2016 to August 2016. The serum of APE1 was measured by ELISA development kit and other CA242, CA724, CA199 and CEA levels by electrochemiluminescence assay. Results: The total of 86 patients with gastric cancer was classified into two groups (lymph node positive and negative groups)...
2017: Journal of Cancer
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