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Stefan Rampp, Leonhard Rensch, Sebastian Simmermacher, Torsten Rahne, Christian Strauss, Julian Prell
OBJECTIVE Brainstem auditory evoked potentials (BAEPs) have been used for intraoperative monitoring of the auditory nerve for many years. However, BAEPs yield limited information about the expected postoperative hearing quality and speech perception. The auditory steady-state response (ASSR) enables objective audiograms to be obtained in patients under anesthesia. These ASSRs could be used for intraoperative estimation of hearing classes to improve the postoperative outcome and quality of life. Studies investigating the clinical use of ASSRs during total intravenous anesthesia are currently lacking...
October 14, 2016: Journal of Neurosurgery
Hanna Thuné, Marc Recasens, Peter J Uhlhaas
Importance: The neurobiological mechanisms underlying circuit dysfunctions in schizophrenia remain poorly understood. The 40-Hz auditory steady-state response (ASSR) has been suggested as a potential biomarker for schizophrenia. Objectives: To provide a meta-analytical insight into the presence of 40-Hz ASSR impairments in patients with schizophrenia and to examine the effects of the participant group, stimulus parameters, and analysis and recording techniques. Data Sources: Searches were conducted in PubMed and reference lists of appropriate publications to identify relevant studies published from November 1999 to March 2016...
October 12, 2016: JAMA Psychiatry
Franck Michel, Kristoffer Foldager Jørgensen
OBJECTIVE: The objective of this study is to compare air-conduction thresholds obtained with ASSR evoked by narrow band (NB) CE-chirps and ABR evoked by tone pips (tpABR) in infants with various degrees of hearing loss. DESIGN: Thresholds were measured at 500, 1000, 2000 and 4000 Hz. Data on each participant were collected at the same day. STUDY SAMPLE: Sixty-seven infants aged 4 d to 22 months (median age = 96 days), resulting in 57, 52, 87 and 56 ears for 500, 1000, 2000 and 4000 Hz, respectively...
October 7, 2016: International Journal of Audiology
Magdalena Lachowska, Jorge Bohórquez, Özcan Özdamar, Kazimierz Niemczyk
OBJECTIVES: To evaluate the accuracy with which the innovative QASSR method predicts behavioral thresholds in adult patients with sensorineural hearing loss. DESIGN: Subjects were tested at four carrier frequencies (500, 1000, 2000, and 4000 Hz).The resulting QASSR recordings were analyzed for thresholds and magnitude/phase characteristics. Tone-burst ABR was recovered from QASSR signal using CLAD method and analyzed in the time domain. The electrophysiological estimates were compared to hearing thresholds determined behaviorally...
December 2016: International Journal of Audiology
Hironori Kuga, Toshiaki Onitsuka, Yoji Hirano, Itta Nakamura, Naoya Oribe, Hiroaki Mizuhara, Ryota Kanai, Shigenobu Kanba, Takefumi Ueno
Recent MRI studies have shown that schizophrenia is characterized by reductions in brain gray matter, which progress in the acute state of the disease. Cortical circuitry abnormalities in gamma oscillations, such as deficits in the auditory steady state response (ASSR) to gamma frequency (>30-Hz) stimulation, have also been reported in schizophrenia patients. In the current study, we investigated neural responses during click stimulation by BOLD signals. We acquired BOLD responses elicited by click trains of 20, 30, 40 and 80-Hz frequencies from 15 patients with acute episode schizophrenia (AESZ), 14 symptom-severity-matched patients with non-acute episode schizophrenia (NASZ), and 24 healthy controls (HC), assessed via a standard general linear-model-based analysis...
September 13, 2016: EBioMedicine
Jingjing Chen, Qin Gong, Fei Wu
The auditory steady-state response (ASSR) is an auditory evoked potential that occurs in response to periodically presented auditory stimuli. The ASSR has drawn attention as a biomarker of psychiatric disorders owing to its connection with neural oscillations as well as its easy and noninvasive recording. Abnormalities in the γ band ASSR have been found consistently in patients with schizophrenia and bipolar disorder. However, although major depressive disorder (MDD) is also part of the common psychiatric diseases, the relationship between the ASSR and MDD has not been characterized sufficiently...
October 19, 2016: Neuroreport
Alexandre Villeneuve, Caroline Hommet, Charles Aussedat, Emmanuel Lescanne, Kevin Reffet, David Bakhos
The objective of this study is to assess the validity of ASSR as a complementary diagnostic test for peripheral hearing loss by proving a significant correlation between behavioral thresholds and ASSR. The design used in this study is monocentric prospective study from November 2014 to April 2015. The setting used in this study is the ENT-Head and Neck Surgery Department and Geriatrics Department in a French Regional and University Hospital. The participants are patients over 75 years with cognitive impairment (Alzheimer's disease or mild-cognitive impairment) with a Mini-Mental State Examination score under 27/30 and without hearing aids...
August 23, 2016: European Archives of Oto-rhino-laryngology
W Shehata-Dieler, W Großmann
The primary diagnostic aim prior to cochlear implantation is establishment of a comprehensive and multidisciplinary diagnosis, in order to subsequently begin therapy as early as possible. Audiological evaluation prior to implantation employs a test battery-approach, including subjective and objective procedures. Objective measures show high reliability and therefore play a major role in the diagnosis of difficult-to-test subjects such as infants and young children. During postoperative follow-up, objective measures offer a valid method for analyzing the effects of different stimuli on the auditory system...
August 10, 2016: HNO
M François, E Dehan, M Carlevan, H Dumont
OBJECTIVE: In patients who cannot or will not cooperate in behavioral hearing assessment, electrophysiological examinations are used, but are time-consuming because the subject has to remain immobile. The aim of this study was to assess whether auditory steady-state responses (ASSR) are sufficiently reliable, compared to auditory brainstem responses (ABR) and free-field audiometry, for assessment to begin with ASSR instead of ABR. MATERIAL AND METHODS: A retrospective study was performed between January 2012 and April 2013, including children less than 6 years of age who could not be tested via headphones...
August 5, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
James J Finneran, Roxanne Echon, Jason Mulsow, Dorian S Houser
Biosonar gain control mechanisms in a bottlenose dolphin were investigated by measuring the auditory steady-state response (ASSR) to an external tone while the animal echolocated. The dolphin performed an echo change-detection task that utilized electronically synthesized echoes with echo delays corresponding to 25- and 50-m target range. During the task, amplitude modulated tones with carrier frequencies from 25 to 125 kHz were continuously presented and the instantaneous electroencephalogram stored for later analysis...
July 2016: Journal of the Acoustical Society of America
Carolina Sánchez-Rodríguez, Eduardo Martín-Sanz, Esperanza Cuadrado, Juan José Granizo, Ricardo Sanz-Fernández
UNLABELLED: Age-related hearing loss (AHL) -presbycusis- is the number one neurodegenerative disorder and top communication deficit of our aged population. Experimental evidence suggests that mitochondrial dysfunction associated with reactive oxygen species (ROS) plays a central role in the aging process of cochlear cells. Dietary antioxidants, in particular polyphenols, have been found to be beneficial in protecting against the generation of ROS in various diseases associated with oxidative stress, such as cancer, neurodegenerative diseases and aging...
October 2016: Experimental Gerontology
Aleksandras Voicikas, Ieva Niciute, Osvaldas Ruksenas, Inga Griskova-Bulanova
Auditory steady-state responses (ASSRs) are used to test the ability of local cortical networks to generate gamma frequency activity in patients with psychiatric disorders. For the effective use of ASSRs in research and clinical applications, it is necessary to find a comfortable stimulation type and to know how ASSRs are modulated by the tasks given to the subjects during the recording session. We aimed to evaluate the suitability of flutter amplitude modulated tone (FAM) stimulation for generation of ASSRs: subjective pleasantness of FAMs and attentional effects on FAM-elicited 40Hz ASSRs were assessed...
August 26, 2016: Neuroscience Letters
Tine Goossens, Charlotte Vercammen, Jan Wouters, Astrid van Wieringen
As people age, speech perception problems become highly prevalent, especially in noisy situations. In addition to peripheral hearing and cognition, temporal processing plays a key role in speech perception. Temporal processing of speech features is mediated by synchronized activity of neural oscillations in the central auditory system. Previous studies indicate that both the degree and hemispheric lateralization of synchronized neural activity relate to speech perception performance. Based on these results, we hypothesize that impaired speech perception in older persons may, in part, originate from deviances in neural synchronization...
2016: Frontiers in Aging Neuroscience
T S Santos, J J Silva, O G Lins, D B Melges, C J Tierra-Criollo
AIM: This study aimed to investigate the efficiency of Magnitude Squared Coherence (MSC) and Spectral F test (SFT) for the detection of auditory steady state responses (ASSR) obtained by amplitude-modulated noises. MATERIAL AND METHODS: Twenty individuals (12 women) without any history of neurological or audiological diseases, aged from 18 to 59 years (mean ± standard deviation = 26.45 ± 3.9 years), who provided written informed consent, participated in the study...
September 2016: Hearing Research
Dong-Kee Kim, In Seok Moon, Hye Jin Lim, Shin-Young Yoo, Kyung Wook Heo, Seong-Cheon Bae, Kyung Ray Moon, Jong Joo Lee, Yun-Hoon Choung, Shi-Nae Park
OBJECTIVE: To investigate the time course of tinnitus changes in patients receiving cochlear implantation (CI) in a prospective, multicenter setting and to determine related factors. MATERIALS AND METHODS: A total of 79 adult patients who underwent CI were included in this study. We used the same questionnaires sequentially 5 times. The questionnaires included the Visual Analog Scale (VAS) for tinnitus severity, the Tinnitus Handicap Inventory (THI), Beck's Depression Index (BDI), and the Brief Encounter Psychosocial Instrument (BEPSI) for stress assessment...
2016: Audiology & Neuro-otology
Deepu Singh, B Sinha, V P Rai, M N Singh, D K Singh, R Kumar, A K Singh
Inheritance of resistance to Fusarium wilt (FW) disease caused by Fusarium udum was investigated in pigeonpea using four different long duration FW resistant genotypes viz., BDN-2004-1, BDN-2001-9, BWR-133 and IPA-234. Based on the F2 segregation pattern, FW resistance has been reported to be governed by one dominant gene in BDN-2004-1 and BDN-2001-9, two duplicate dominant genes in BWR-133 and two dominant complimentary genes in resistance source IPA-234. Further, the efficacy of six simple sequence repeat (SSR) markers namely, ASSR-1, ASSR-23, ASSR-148, ASSR-229, ASSR-363 and ASSR-366 reported to be associated with FW resistance were also tested and concluded that markers ASSR-1, ASSR-23, ASSR-148 will be used for screening of parental genotypes in pigeonpea FW resistance breeding programs...
April 2016: Plant Pathology Journal
V F Velho, P Foladori, G Andreottola, R H R Costa
The long-term performances of a full-scale anaerobic side-stream reactor (ASSR) aimed at sludge reduction have been monitored for the first time, in comparison with a conventional activated sludge process (CAS). The plant was integrated with an ASSR treatment of 2293-3293 m(3). Operational parameters in the ASSR were: ORP -250 mV, interchange ratio of 7-10%, hydraulic retention time of 7 d. No worsening of effluent quality was observed in the ASSR configuration and removal efficiency of COD and NH4 was above 95%...
July 15, 2016: Journal of Environmental Management
Bahram Jalaei, Mohd Normani Zakaria
INTRODUCTION: The performance of auditory steady state response (ASSR) in threshold testing when recorded ipsilaterally and contralaterally, as well as at low and high modulation frequencies (MFs), has not been systematically studied. OBJECTIVE: To verify the influences of mode of recording (ipsilateral vs. contralateral) and modulation frequency (40Hz vs. 90Hz) on ASSR thresholds. METHODS: Fifteen female and 14 male subjects (aged 18-30 years) with normal hearing bilaterally were studied...
March 29, 2016: Brazilian Journal of Otorhinolaryngology
M N Zakaria, B Jalaei, D Sidek
OBJECTIVE: Few studies have investigated the auditory steady state response (ASSR) thresholds evoked by ipsilateral and contralateral stimulation. The present study was conducted to compare 40-Hz ASSR thresholds between ipsilateral and contralateral recordings at specific test frequencies. METHODS: Twenty young female subjects with normal hearing bilaterally (hearing level ≤ 20 dB HL across speech frequencies) were included in the study. One-octave-wide narrow band CE-chirp® stimuli centred at 500, 1000, 2000 and 4000 Hz with 40 Hz modulation frequency (MF) were presented ipsilaterally and contralaterally to each subject through insert earphones...
2016: B-ENT
Robert Luke, Jan Wouters
Auditory steady state responses (ASSRs) are brain responses to modulated or repetitive stimuli that can be captured in the EEG recording. ASSRs can be used as an objective measure to clinically determine frequency specific hearing thresholds, to quantify the sensitivity of the auditory system to modulation, and have been related to speech intelligibility. However, the detection of ASSRs is difficult due to the low signal to noise ratio of the responses. Moreover, minimising measurement time is important for clinical applications...
April 6, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
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