Read by QxMD icon Read


Bryony A Caswell, Christopher L J Frid
Global warming during the Early Jurassic, and associated widespread ocean deoxygenation, was comparable in scale with the changes projected for the next century. This study quantifies the impact of severe global environmental change on the biological traits of marine communities that define the ecological roles and functions they deliver. We document centennial-millennial variability in the biological trait composition of Early Jurassic (Toarcian) seafloor communities and examine how this changed during the event using biological traits analysis...
October 18, 2016: Oecologia
Jiangan Xie, Christopher Codd, Kevin Mo, Yongqun He
M. bovis strain Bacillus Calmette-Guérin (BCG) has been the only licensed live attenuated vaccine against tuberculosis (TB) for nearly one century and has also been approved as a therapeutic vaccine for bladder cancer treatment since 1990. During its long time usage, different adverse events (AEs) have been reported. However, the AEs associated with the BCG preventive TB vaccine and therapeutic cancer vaccine have not been systematically compared. In this study, we systematically collected various BCG AE data mined from the US VAERS database and PubMed literature reports, identified statistically significant BCG-associated AEs, and ontologically classified and compared these AEs related to these two types of BCG vaccine...
2016: PloS One
Jiangan Xie, Lili Zhao, Shangbo Zhou, Yongqun He
Vaccinations often induce various adverse events (AEs), and sometimes serious AEs (SAEs). While many vaccines are used in combination, the effects of vaccine-vaccine interactions (VVIs) on vaccine AEs are rarely studied. In this study, AE profiles induced by hepatitis A vaccine (Havrix), hepatitis B vaccine (Engerix-B), and hepatitis A and B combination vaccine (Twinrix) were studied using the VAERS data. From May 2001 to January 2015, VAERS recorded 941, 3,885, and 1,624 AE case reports where patients aged at least 18 years old were vaccinated with only Havrix, Engerix-B, and Twinrix, respectively...
October 3, 2016: Scientific Reports
Ramesh Kaipa, U Ajith Kumar
Functional symmetry of medial olivocochlear bundle (MOCB) as a function of handedness remains to be well investigated. The current study aimed to assess the functional symmetry of MOCB through contralateral inhibition of otoacoustic emissions (OAEs) in right- and left-handed individuals. Thirteen left-handed and 13 right-handed individuals in the age range of 19-25 years participated. Behavioural experiment involved measuring speech perception in noise and vocal reaction time. Physiological experiment involved measuring the contralateral inhibition of OAEs in both the ears of participants...
August 9, 2016: Laterality
James B Dewey, Sumitrajit Dhar
The characteristics of human otoacoustic emissions (OAEs) have not been thoroughly examined above the standard audiometric frequency range (>8 kHz). This is despite the fact that deterioration of cochlear function often starts at the basal, high-frequency end of the cochlea before progressing apically. Here, stimulus-frequency OAEs (SFOAEs) were obtained from 0.5 to 20 kHz in 23 young, audiometrically normal female adults and three individuals with abnormal audiograms, using a low-to-moderate probe level of 36 dB forward pressure level (FPL)...
September 28, 2016: Journal of the Association for Research in Otolaryngology: JARO
Shvetank Bhatt, Radhakrishnan Mahesh, Ankur Jindal, Thangaraj Devadoss
BACKGROUND: Several preclinical studies have shown that serotonergic 5-HT3 receptor antagonists play an important role in the management of neuropsychiatric disorders, such as depression and anxiety. In the present study the compound "6n" (N-n-propyl-3-ethoxyquinoxaline-2-carboxamide), a novel 5-HT3 receptor antagonist with an optimal log P (2.52) and pA2 (7.6) value was screened for its neuro-pharmacological potential in chronic rodent models of depression and anxiety named traumatic brain injury (TBI)...
September 23, 2016: Journal of Basic and Clinical Physiology and Pharmacology
Sho Otsuka, Shigeto Furukawa, Shimpei Yamagishi, Koich Hirota, Makio Kashino
This study examined whether the mechanical characteristics of the cochlea could influence individual variation in the ability to use temporal fine structure (TFS) information. Cochlear mechanical functioning was evaluated by swept-tone evoked otoacoustic emissions (OAEs), which are thought to comprise linear reflection by micromechanical impedance perturbations, such as spatial variations in the number or geometry of outer hair cells, on the basilar membrane (BM). Low-rate (2 Hz) frequency modulation detection limens (FMDLs) were measured for carrier frequency of 1000 Hz and interaural phase difference (IPD) thresholds as indices of TFS sensitivity and high-rate (16 Hz) FMDLs and amplitude modulation detection limens (AMDLs) as indices of sensitivity to non-TFS cues...
September 8, 2016: Journal of the Association for Research in Otolaryngology: JARO
W Wiktor Jedrzejczak, Krzysztof Kochanek, Edyta Pilka, Henryk Skarzynski
OBJECTIVE: Spontaneous otoacoustic emissions (SOAEs) are one of the least studied types of otoacoustic emissions (OAEs). The purpose of this study was twofold: first, to determine the prevalence of SOAEs in schoolchildren, and second to test whether there was dependence between the presence or absence of SOAEs in a subject and the corresponding level of their transiently evoked OAEs (TEOAEs). METHODS: Measurements were made on a group of normally hearing children of age 7-13 years...
October 2016: International Journal of Pediatric Otorhinolaryngology
M Riga, A Komis, P Maragkoudakis, G Korres, V Danielides
OBJECTIVE: Normative otoacoustic emission (OAE) suppression values are currently lacking and the role of cochlear efferent innervation in tinnitus is controversial. The aim of this study was to investigate the association between tinnitus and medial olivocochlear bundle (MOCB) malfunction. Potential suppression amplitude cut-off criteria that could differentiate participants with tinnitus from those without were sought. DESIGN: Mean suppression amplitudes of transient evoked OAEs and distortion product OAEs by contralateral white noise (50 dBSL) were recorded...
December 2016: International Journal of Audiology
Edison Ong, Yongqun He
Hundreds of biological and biomedical ontologies have been developed to support data standardization, integration and analysis. Although ontologies are typically developed for community usage, community efforts in ontology development are limited. To support ontology visualization, distribution, and community-based annotation and development, we have developed Ontokiwi, an ontology extension to the MediaWiki software. Ontokiwi displays hierarchical classes and ontological axioms. Ontology classes and axioms can be edited and added using Ontokiwi form or MediaWiki source editor...
2016: AMIA Summits on Translational Science Proceedings
Mark D Fletcher, Katrin Krumbholz, Jessica de Boer
The active cochlear mechanism amplifies responses to low-intensity sounds, compresses the range of input sound intensities to a smaller output range, and increases cochlear frequency selectivity. The gain of the active mechanism can be modulated by the medial olivocochlear (MOC) efferent system, creating the possibility of top-down control at the earliest level of auditory processing. In humans, MOC function has mostly been measured by the suppression of otoacoustic emissions (OAEs), typically as a result of MOC activation by a contralateral elicitor sound...
August 22, 2016: Journal of the Association for Research in Otolaryngology: JARO
Qi Peng, Suran Huang, Yuan Liang, Keze Ma, Siping Li, Lin Yang, Wenrui Li, Qiang Ma, Qian Liu, Baimao Zhong, Xiaomei Lu
OBJECTIVE: The goal of this study was to investigate the use of concurrent genetic screening together with standard newborn hearing screening (NHS) in an effort to provide a scientific basis for the beneficial use of concurrent genetic hearing screening in newborns. Our aim was to improve the neonatal detection rate of hearing impairment and the potential for hearing loss, allowing for increased early intervention and potentially allowing for prevention of later onset hearing loss. This information could also be used to increase the effectiveness of genetic counseling regarding hearing impairment...
October 2016: Genetic Testing and Molecular Biomarkers
Dawn Konrad-Martin, Gayla L Poling, Laura E Dreisbach, Kelly M Reavis, Garnett P McMillan, Judi A Lapsley Miller, Lynne Marshall
The purpose of this report is to provide guidance on the use of otoacoustic emissions (OAEs) as a clinical trial outcome measure for pharmaceutical interventions developed to prevent acquired hearing loss secondary to cochlear insult. OAEs are a rapid, noninvasive measure that can be used to monitor cochlear outer hair cell function. Serial monitoring of OAEs is most clearly established for use in hearing conservation and ototoxicity monitoring programs in which they exhibit more frequent and earlier changes compared with pure-tone audiometry...
September 2016: Otology & Neurotology
Jack Pein Cheong, Siew Shuin Soo, Anura Michelle Manuel
OBJECTIVE: To determine the factors contributing towards hearing impairment in patients with cleft lip/palate. METHOD: A prospective analysis was conducted on 173 patients (346 ears) with cleft lip and palate (CL/P) who presented to the combined cleft clinic at University Malaya Medical Centre (UMMC) over 12 months. The patients' hearing status was determined using otoacoustic emission (OAE), pure tone audiometry (PTA) and auditory brainstem response (ABR). These results were analysed against several parameters, which included age, gender, race, types of cleft pathology, impact and timing of repair surgery...
September 2016: International Journal of Pediatric Otorhinolaryngology
Ozlem Unsal, Gulpembe Bozkurt, Meltem Akpinar, Pinar Akova, Bilge Turk, Berna Uslu Coskun
Importance: Performing an open-approach extracorporeal septoplasty (OAES) without simultaneous rhinoplasty could have adverse effects. We sought to understand the effects of OAES without simultaneous rhinoplasty on nasal tip projection and rotation in patients with severe septal deviation. Objectives: To evaluate the outcomes of OAES without simultaneous rhinoplasty in terms of nasal tip projection and rotation using objective measurements. Design, Setting, and Participants: This retrospective study was conducted at a training and research hospital using medical records of 32 adult patients who underwent OAES without simultaneous rhinoplasty between April 10, 2012 and June 12, 2015...
October 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
Yongqun He
Compared with controlled terminologies (e.g., MedDRA, CTCAE, and WHO-ART), the community-based Ontology of AEs (OAE) has many advantages in adverse event (AE) classifications. The OAE-derived Ontology of Vaccine AEs (OVAE) and Ontology of Drug Neuropathy AEs (ODNAE) serve as AE knowledge bases and support data integration and analysis. The Immune Response Gene Network Theory explains molecular mechanisms of vaccine-related AEs. The OneNet Theory of Life treats the whole process of a life of an organism as a single complex and dynamic network (i...
June 2016: Current Pharmacology Reports
Annick Gilles, Winny Schlee, Sarah Rabau, Kristien Wouters, Erik Fransen, Paul Van de Heyning
OBJECTIVES: Young people are often exposed to high music levels which make them more at risk to develop noise-induced symptoms such as hearing loss, hyperacusis, and tinnitus of which the latter is the symptom perceived the most by young adults. Although, subclinical neural damage was demonstrated in animal experiments, the human correlate remains under debate. Controversy exists on the underlying condition of young adults with normal hearing thresholds and noise-induced tinnitus (NIT) due to leisure noise...
2016: Frontiers in Neuroscience
Francesco Morescalchi, Elena Gambicorti, Sarah Duse, Ciro Costagliola, Francesco Semeraro
INTRODUCTION: Pharmacologic vitreolysis is a strategy used to treat anomalous posterior vitreous detachment, by weakening vitreoretinal adhesion with an intravitreal drug. Pharmacologic vitreolysis facilitates surgery, and abnormalities of the vitreoretinal interface including vitreomacular traction (VMT) and early stage macular hole (MH) could be resolved. Ocriplasmin is a recombinant protease, active against fibronectin and laminin, which are important components of the vitreoretinal interface...
September 2016: Expert Opinion on Drug Safety
Ishika Vashistha, Yogesh Aseri, B K Singh, P C Verma
Hearing impairment is prevalent in the general population, early intervention facilitates proper development. The aim of this study was to establish the prevalence of hearing impairment in high-risk infants born between 2013 and 2014. 100 newborns were evaluated using evoked otoacoustic emissions and distortion produce and auditory behavior. Tests were reported if the results were altered. If altered results persisted, the child was referred for impedance testing and when necessary for medical evaluation. Infants referred for BOA and OAE undergone Brainstem auditory evoked potential testing...
June 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
Yoshinaga Okumura, Masashi Oae, Yusuke Shiraishi, Takeshi Soda, Hiroshi Kanamaru, Nobuyoshi Arima
A 27-year-old man visited our hospital with painless swelling of the left scrotum. Hematologic studies showed the following levels of lactate dehydrogenase, 3,171 IU/l ; alpha-fetoprotein, 2.2 ng/ml ; and β- human chorionic gonadotropin, 0.4 ng/ml, and abdominal computed tomography revealed a mass of 10×8 ×4 cm in the left testis, and that of 3.5×3.0×5.0 cm in the left renal hilar lymph node, without any other metastasis. Left high inguinal orchiectomy was performed, and histopathological examination revealed mixed form with seminoma and teratoma...
May 2016: Hinyokika Kiyo. Acta Urologica Japonica
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"