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https://www.readbyqxmd.com/read/29134475/synchronized-spontaneous-otoacoustic-emissions-provide-a-signal-to-noise-ratio-advantage-in-medial-olivocochlear-reflex-assays
#1
James D Lewis
Detection of medial olivocochlear-induced (MOC) changes to transient-evoked otoacoustic emissions (TEOAE) requires high signal-to-noise ratios (SNR). TEOAEs associated with synchronized spontaneous (SS) OAEs exhibit higher SNRs than TEOAEs in the absence of SSOAEs, potentially making the former well suited for MOC assays. Although SSOAEs may complicate interpretation of MOC-induced changes to TEOAE latency, recent work suggests SSOAEs are not a problem in non-latency-dependent MOC assays. The current work examined the potential benefit of SSOAEs in TEOAE-based assays of the MOC efferents...
November 13, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29118228/do-published-data-in-trials-assessing-cancer-drugs-reflect-the-real-picture-of-efficacy-and-safety
#2
Jia-Wei Lv, Yu-Pei Chen, Guan-Qun Zhou, Xu Liu, Ying Guo, Yan-Ping Mao, Jun Ma, Ying Sun
Background: The reporting quality of publications is of vital importance to ensure accurate evidence dissemination. This study aimed to compare the consistency of results reporting between the ClinicalTrials.gov results database and the respective matching publications. Methods: We identified 323 phase III/IV cancer drug trials with a randomized controlled design and searched PubMed for publications in a 50% random sample (n=160). Data were extracted independently from ClinicalTrials.gov and publications. A scoring system was applied to determine characteristics associated with reporting quality...
November 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29061976/ontology-based-systematical-representation-and-drug-class-effect-analysis-of-package-insert-reported-adverse-events-associated-with-cardiovascular-drugs-used-in-china
#3
Liwei Wang, Mei Li, Jiangan Xie, Yuying Cao, Hongfang Liu, Yongqun He
With increased usage of cardiovascular drugs (CVDs) for treating cardiovascular diseases, it is important to analyze CVD-associated adverse events (AEs). In this study, we systematically collected package insert-reported AEs associated with CVDs used in China, and developed and analyzed an Ontology of Cardiovascular Drug AEs (OCVDAE). Extending the Ontology of AEs (OAE) and NDF-RT, OCVDAE includes 194 CVDs, CVD ingredients, mechanisms of actions (MoAs), and CVD-associated 736 AEs. An AE-specific drug class effect is defined to exist when all the drugs (drug chemical ingredients or drug products) in a drug class are associated with an AE, which is formulated as a new proportional class level ratio ("PCR") = 1...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29058218/ontology-based-vaccine-adverse-event-representation-and-analysis
#4
Jiangan Xie, Yongqun He
Vaccine is the one of the greatest inventions of modern medicine that has contributed most to the relief of human misery and the exciting increase in life expectancy. In 1796, an English country physician, Edward Jenner, discovered that inoculating mankind with cowpox can protect them from smallpox (Riedel S, Edward Jenner and the history of smallpox and vaccination. Proceedings (Baylor University. Medical Center) 18(1):21, 2005). Based on the vaccination worldwide, we finally succeeded in the eradication of smallpox in 1977 (Henderson, Vaccine 29:D7-D9, 2011)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29049619/field-monitoring-of-otoacoustic-emissions-during-noise-exposure-pilot-study-in-controlled-environment
#5
Vincent Nadon, Annelies Bockstael, Dick Botteldooren, Jérémie Voix
Purpose: In spite of all the efforts to implement workplace hearing conservation programs, noise-induced hearing loss remains the leading cause of disability for North American workers. Nonetheless, an individual's susceptibility to noise-induced hearing loss can be estimated by monitoring changes in hearing status in relation to the level of ambient noise exposure. The purpose of this study was to validate an approach that could improve workplace hearing conservation practices. The approach was developed using a portable and robust system designed for noisy environments and consisted of taking continuous measurements with high temporal resolution of the health status of the inner ear using otoacoustic emissions (OAEs)...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28938414/sex-and-tissue-specific-role-of-estrogen-sulfotransferase-in-energy-homeostasis-and-insulin-sensitivity
#6
Wojciech G Garbacz, Mengxi Jiang, Meishu Xu, Jun Yamauchi, H Henry Dong, Wen Xie
Estrogen sulfotransferase catalyzes the sulfoconjugation and deactivation of estrogens. Previously, we showed that loss of Est in male ob/ob mice, but not in female ob/ob mice, exacerbated the diabetic phenotype, but the underlying mechanism was unclear. In this study, we show that transgenic reconstitution of Est in the adipose tissue, but not in the liver, attenuated diabetic phenotype in Est-deficient ob/ob mice (obe mice). Mechanistically, adipose reconstitution of Est in obe mice (oae mice) resulted in reduced local and systemic inflammation, improved insulin sensitivity, and increased energy expenditure...
November 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28929058/universal-hearing-screening-in-newborns-using-otoacoustic-emissions-and-brainstem-evoked-response-in-eastern-uttar-pradesh
#7
Ashwini Kumar, S C Gupta, V R Sinha
The objectives were to determine the incidence of hearing impairment in a standardized population of neonates and to determine the significance of association of epidemiological and risk factors with neonatal hearing loss. A cohort of 600 newborns was selected for study and divided into two groups-525 in 'No Risk' group and remaining 75 in 'At Risk' group. The study protocol was carried out in three steps: (a) Screening of Hearing Loss with TOAE, done from 36 h after birth to 28 days of life, (b) Re-screening of hearing loss in newborns (of 4-12 weeks of age), who were tested positive for hearing loss in the first screening, done with DPOAE, (c) Confirmation of hearing loss with BERA, in those who were tested positive in both the first and second screening...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28863614/towards-a-joint-reflection-distortion-otoacoustic-emission-profile-results-in-normal-and-impaired-ears
#8
Carolina Abdala, Radha Kalluri
Otoacoustic emissions (OAEs) provide salient information about cochlear function and dysfunction. Two broad classes of emissions, linear reflection and nonlinear distortion, arise via distinct cochlear processes and hence, appear to provide independent information about cochlear health and hearing. Considered in combination, these two OAE types may characterize sensory hearing loss most effectively. In this study, the level-dependent growth of stimulus-frequency OAEs (a reflection-type emission) and distortion-product OAEs (a distortion-type emission) were measured in ten normal-hearing ears and eight ears with slight-to-moderate sensorineural hearing loss...
August 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28855148/ivermectin-treatment-in-patients-with-onchocerciasis-associated-epilepsy-protocol-of-a-randomized-clinical-trial
#9
Robert Colebunders, Michel Mandro, Deby Mukendi, Housseini Dolo, Patrick Suykerbuyk, Marieke Van Oijen
BACKGROUND: Many studies have reported an association between epilepsy, nodding syndrome (NS), and onchocerciasis (river blindness). A high prevalence of epilepsy has been noted particularly in onchocerciasis hyperendemic areas where onchocerciasis is not or insufficiently controlled with mass ivermectin distribution. There is evidence that increasing the coverage of ivermectin reduces the incidence of epilepsy, and anecdotal evidence suggests a reduction in seizure frequency in onchocerciasis-associated epilepsy (OAE) patients who receive ivermectin...
August 30, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28816687/hearing-and-otoacoustic-emissions-outcome-of-stapedotomy-does-the-prosthesis-diameter-matter
#10
Nabil Faranesh, Ebrahim Magamseh, Suliman Zaaroura, Reem Zeidan, Avi Shupak
OBJECTIVE: To compare the hearing and otoacoustic emissions (OAE) outcome of stapedotomy employing 0.4 and 0.6 mm diameter prostheses. MATERIALS AND METHODS: In total, 18 patients with otosclerosis participated in a prospective, double-armed, randomized cohort study. All the patients underwent small fenestra drill stapedotomy employing the Causse fluroplastic large loop piston prostheses. The patients were randomly assigned to groups of 0.4 mm (n=9) and 0.6 mm (n=9) diameter prostheses...
August 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28808684/constraining-the-rate-of-oceanic-deoxygenation-leading-up-to-a-cretaceous-oceanic-anoxic-event-oae-2-94-ma
#11
Chadlin M Ostrander, Jeremy D Owens, Sune G Nielsen
The rates of marine deoxygenation leading to Cretaceous Oceanic Anoxic Events are poorly recognized and constrained. If increases in primary productivity are the primary driver of these episodes, progressive oxygen loss from global waters should predate enhanced carbon burial in underlying sediments-the diagnostic Oceanic Anoxic Event relic. Thallium isotope analysis of organic-rich black shales from Demerara Rise across Oceanic Anoxic Event 2 reveals evidence of expanded sediment-water interface deoxygenation ~43 ± 11 thousand years before the globally recognized carbon cycle perturbation...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28791945/comparison-of-various-extraction-techniques-of-medicago-sativa-yield-antioxidant-activity-and-content-of-phytochemical-constituents
#12
Aneta Krakowska, Katarzyna Rafińska, Justyna Walczak, Tomasz Kowalkowski, Bogusław Buszewski
Medicago sativa L. (M. sativa) is a source of many valuable secondary metabolites. Extraction yield and the concentration of phenolics, flavonoids, and saponins, as well as antioxidant potential were determined in extracts from different parts of M. sativa obtained using extraction methods such as maceration, ultrasound-assisted extraction (UAE), accelerated solvent extraction (ASE), and supercritical fluid extraction (SFE). The concentrations of the listed groups of compounds were spectrophotometrically determined and confirmed by HPLC-MS...
July 13, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28764449/intensimetric-detection-of-distortion-product-otoacoustic-emissions-with-ear-canal-calibration
#13
Renata Sisto, Luigi Cerini, Filippo Sanjust, Arturo Moleti
Distortion product otoacoustic emissions (DPOAEs) have been accurately measured with an intensimetric technique, involving simultaneous measure of pressure and velocity in the ear canal, which allows one to correctly calibrate both the input stimuli and the otoacoustic emission (OAE) level. Suitable combinations of standard intensimetric quantities, active intensity and power density [Stanzial, Shiffrer, and Sacchi, J. Acoust. Soc. Am. 131, 269-280 (2012)], are used to equalize the stimuli transmitted to the middle ear, and to estimate the DPOAE level emitted by the eardrum...
July 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28712672/noise-induced-cochlear-synaptopathy-in-rhesus-monkeys-macaca-mulatta
#14
M D Valero, J A Burton, S N Hauser, T A Hackett, R Ramachandran, M C Liberman
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers (ANFs) and inner hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the synaptopathy occurs first in high-threshold ANFs. However, the fiber loss likely impairs temporal processing and hearing-in-noise, a classic complaint of those with sensorineural hearing loss...
September 2017: Hearing Research
https://www.readbyqxmd.com/read/28697607/wideband-acoustic-immittance-for-assessing-middle-ear-functioning-for-preterm-neonates-in-the-neonatal-intensive-care-unit
#15
Nandel Gouws, De Wet Swanepoel, Leigh Biagio De Jager
BACKGROUND: The primary aim of newborn hearing screening is to detect permanent hearing loss. Because otoacoustic emissions (OAEs) and automated auditory brainstem response (AABR) are sensitive to hearing loss, they are often used as screening tools. On the other hand, false-positive results are most often because of transient outer- and middle ear conditions. Wideband acoustic immittance (WAI), which includes physical measures known as reflectance and absorbance, has shown potential for accurate assessment of middle ear function in young infants...
June 28, 2017: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/28694487/evidence-for-rapid-weathering-response-to-climatic-warming-during-the-toarcian-oceanic-anoxic-event
#16
Theodore R Them, Benjamin C Gill, David Selby, Darren R Gröcke, Richard M Friedman, Jeremy D Owens
Chemical weathering consumes atmospheric carbon dioxide through the breakdown of silicate minerals and is thought to stabilize Earth's long-term climate. However, the potential influence of silicate weathering on atmospheric pCO2 levels on geologically short timescales (10(3)-10(5) years) remains poorly constrained. Here we focus on the record of a transient interval of severe climatic warming across the Toarcian Oceanic Anoxic Event or T-OAE from an open ocean sedimentary succession from western North America...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28678080/noise-history-and-auditory-function-in-young-adults-with-and-without-type-1-diabetes-mellitus
#17
Christopher Spankovich, Colleen G Le Prell, Edward Lobarinas, Linda J Hood
OBJECTIVES: The purpose of this study was to examine the relationship between noise exposure history, type 1 diabetes mellitus (DM), and suprathreshold measures of auditory function. DESIGN: A cross-sectional study was conducted; 20 normal-hearing participants without type 1 DM were matched on age and sex to 20 normal-hearing participants with type 1 DM (n=40). Participants, all having normal audiometric thresholds, completed noise history questionnaires and a battery of auditory physiological tests including transient evoked otoacoustic emissions, distortion product otoacoustic emissions, and auditory brainstem responses (ABR) at 80 dB nHL and at 2 different stimulus rates in both ears...
November 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28594958/the-effects-of-different-frequency-treadmill-exercise-on-lipoxin-a4-and-articular-cartilage-degeneration-in-an-experimental-model-of-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#18
Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, Lunhao Bai
The aim was to investigate the effects of different frequencies treadmill exercise with total exercise time being constancy on articular cartilage, lipoxin A4 (LXA4) and the NF-κB pathway in rat model of monosodium iodoacetate-induced osteoarthritis (OA). Fifty male Sprague-Dawley rats were randomly divided into five groups (n = 10): controls (CG), knee OA model (OAG), OA + treadmill exercise once daily (OAE1), OA + treadmill exercise twice daily, rest interval between exercise>4h (OAE2) and OA + treadmill exercise three times daily, rest interval between exercise>4h (OAE3)...
2017: PloS One
https://www.readbyqxmd.com/read/28555601/influence-of-smoking-on-ultra-high-frequency-auditory-sensitivity
#19
Prashanth Prabhu, Gowtham Varma, Kristi Kaveri Dutta, Prajwal Kumar, Swati Goyal
OBJECTIVE: In this study, an attempt was made to determine the effect of smoking on ultra-high-frequency auditory sensitivity. The study also attempted to determine the relationship between the nature of smoking and ultra-high-frequency otoacoustic emissions (OAEs) and thresholds. MATERIALS AND METHODS: The study sample included 25 smokers and 25 non-smokers. A detailed history regarding their smoking habits was collected. High-frequency audiometric thresholds and amplitudes of high-frequency distortion-product OAEs were analyzed for both ears from all participants...
April 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28538833/research-about-suppression-effect-and-auditory-processing-in-individuals-who-stutter
#20
Cláudia Fassin Arcuri, Ana Maria Schiefer, Marisa Frasson de Azevedo
Purpose: To verify the auditory processing abilities and occurrence of the suppression effect of Otoacoustic Emissions (OAE) in individuals who stutter. Methods: The study sample comprised 15 adult individuals who stutter, aged 18-40 years, with stuttering severity ranging from mild to severe, paired according to gender, age, and schooling with individuals without speech complaint or disorder. All participants underwent conventional clinical evaluation, specific stuttering assessment, and basic (audiometry, imitanciometry, and measurement of acoustic reflexes) and specific (auditory processing evaluation and measurement of suppression effect of OAEs) audiological assessments...
May 22, 2017: CoDAS
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