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Anabolic androgen steroid

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https://www.readbyqxmd.com/read/29201444/the-interaction-effects-of-resistance-training-and-sustanon-abuse-on-liver-antioxidant-activities-and-serum-enzymes-in-male-rats
#1
Hamid Arazi, Siavash Rahmati, Hosein Ghafoori
Background: Anabolic-androgenic steroids (AAS) are synthetic drugs derived from testosterone, the uncontrolled usage of which may lead to serious side effects. Previous studies have shown that resistance training (RT) is the main exercise modality practiced by AAS abusers. Thus, this work was carried out to evaluate the hepatotoxic effects of sustanon (Su) as an example of AAS in trained male rats. Methods: Rats were divided into sedentary/non-Su, sedentary/Su, RT/non-Su, and RT/Su...
September 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/29197722/tracking-internet-interest-in-anabolic-androgenic-steroids-using-google-trends
#2
Joseph Tay Wee Teck, Mark McCann
BACKGROUND: There is a perception that the prevalence of anabolic-androgenic steroid (AAS) use is increasing in the UK, with consequent individual and public health risks. Nevertheless, there is a lack of real-time surveillance data to support the development of effective policy. This paper explores the potential of Google Trends to complement existing surveillance methods by analysing user generated search term data. METHODS: The Google Trends web tool was used to identify patterns of UK online interest in 15 AAS from January 2011 to December 2015, with 10 ultimately suitable for further analysis...
November 30, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29185593/behavioral-cross-sensitization-between-testosterone-and-fenproporex-in-adolescent-and-adult-rats
#3
C Q Conceição, S A Engi, F C Cruz, C S Planeta
The abuse of psychoactive drugs is considered a global health problem. During the last years, a relevant number of studies have investigated the relationship between anabolic-androgenic steroids (AAS) and other psychoactive drugs. AAS, such as testosterone, can cause a dependence syndrome that shares many features with the classical dependence to psychoactive substances. Pre-clinical evidence shows that there are interactions between testosterone and psychoactive drugs, such as cocaine. However, few studies have been performed to investigate the effect of repeated testosterone treatment on behavioral effects of amphetamine derivatives, such as fenproporex...
November 17, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29172848/the-role-of-hormones-in-muscle-hypertrophy
#4
Julius Fink, Brad Jon Schoenfeld, Koichi Nakazato
Anabolic-androgenic steroids (AAS) and other hormones such as growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have been shown to increase muscle mass in patients suffering from various diseases related to muscle atrophy. Despite known side-effects associated with supraphysiologic doses of such drugs, their anabolic effects have led to their widespread use and abuse by bodybuilders and athletes such as strength athletes seeking to improve performance and muscle mass. On the other hand, resistance training (RT) has also been shown to induce significant endogenous hormonal (testosterone (T), GH, IGF-1) elevations...
November 25, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29160404/interaction-of-anabolic-androgenic-steroids-and-induced-tooth-movement-in-rats
#5
Lilian Mary Karakida, Cristiano Miranda de Araujo, Aline Cristina Batista Rodrigues Johann, Elisa Souza Camargo, Orlando Motohiro Tanaka, Odilon Guariza Guariza
This study evaluated the interaction between tooth movement and two anabolic androgenic steroids (AAS), Deposteron® and Nebido®. One hundred Wistar rats were divided into 3 groups: control (C) n=30, Nebido experimental (N) n=35 and Deposteron experimental (D) n=35. The control group was subdivided into 6 subgroups: 1, 2, 3, 5, 7 and 14. The experimental groups were subdivided into 7 subgroups: 0, 1, 2, 3, 5, 7 and 14, which corresponded to the day of animal's euthanasia after applying orthodontic force. Orthodontic devices were used to induce tooth movement using 50 cN of reciprocal force between the maxillary right first molar and the maxillary incisors...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29150304/are-the-estrogenic-hormonal-effects-of-environmental-toxins-affecting-small-intestinal-bacterial-and-microfilaria-overgrowth
#6
Edward Lichten
The important role of microfilaria (worms) in human and animal disease remains an area of key disagreement between the naturopathic and allopathic physicians. While microfilaria infections are rampart in undeveloped countries, they rarely rise to identification as a cause of disease in Western countries. New research studies in the diagnosis and treatment of SIBO (Small Intestinal Bacterial Overgrowth) and (IBD) Inflammatory Bowel Diseases of ulcerative colitis, Crohn's Disease and microcytic colitis may make both sides equally correct...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29141576/analysis-of-elevated-levels-of-nandrolone-decanoate-induced-cytochrome-p450-alterations-in-mice
#7
Parmita Chowdhury, Rita Mahantab
BACKGROUND: Frequent non-medicated use of anabolic androgenic steroids (AAS) is an instance of substance abuse which mimics the status of a natural hormone and upon prolonged exposure may lead to adverse drug reactions. These adverse drug reactions proceed in a manner so as to alter the normal metabolism of an enzyme mediated pathway such as the cytochrome P450 (CYP) family of enzymes. OBJECTIVE: The present study was conducted to investigate the impact of overuse of Nandrolone Decanoate (ND), an AAS, upon CYP enzyme activity and a CYP gene, belonging to CYP1 family...
November 14, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29106544/effects-of-adult-female-rat-androgenization-on-brain-morphology-and-metabolomic-profile
#8
Carmen Perez-Laso, Sebastián Cerdan, Carme Junque, Ángel Gómez, Esperanza Ortega, Mireia Mora, Carlos Avendaño, Esther Gómez-Gil, María Cruz Rodríguez Del Cerro, Antonio Guillamon
Androgenization in adult natal women, as in transsexual men (TM), affects brain cortical thickness and the volume of subcortical structures. In order to understand the mechanism underlying these changes we have developed an adult female rat model of androgenization. Magnetic resonance imaging and spectroscopy were used to monitor brain volume changes, white matter microstructure and ex vivo metabolic profiles over 32 days in androgenized and control subjects. Supraphysiological doses of testosterone prevents aging decrease of fractional anisotropy values, decreased general cortical volume and the relative concentrations of glutamine (Gln) and myo-Inositol (mI)...
July 6, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29105125/prevalence-and-correlates-of-tattooing-in-norway-a-large-scale-cross-sectional-study
#9
Dominic Sagoe, Ståle Pallesen, Cecilie Schou Andreassen
To our knowledge, no previous large-scale study has examined the prevalences and correlates of having only easily concealed tattoos, or readily visible tattoos. We conducted an exploratory online survey in Norway asking 15,654 (6,151 females) persons aged 16-91 (m = 33.65 ± 12.27) about various demographic, sports, substance use, mental health, personality, and tattooing questions. The estimated prevalence of tattooing was 20.8% (females: 23.8%, males: 17.9%), of which 13.3% had readily visible tattoos. Results of multivariate logistic regression analysis indicated that females, being older than 19 years, higher body mass index, lifetime anabolic-androgenic steroid use (AAS), and higher scores on extraversion were associated with higher odds of having a tattoo...
December 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29058169/chronic-exercise-reduces-cetp-and-mesterolone-treatment-counteracts-exercise-benefits-on-plasma-lipoproteins-profile-studies-in-transgenic-mice
#10
Andrea Camargo Casquero, Jairo Augusto Berti, Laura Lauand Sampaio Teixeira, Helena Coutinho Franco de Oliveira
Regular exercise and anabolic androgenic steroids have opposing effects on the plasma lipoprotein profile and risk of cardio-metabolic diseases in humans. Studies in humans and animal models show conflicting results. Here, we used a mice model genetically modified to mimic human lipoprotein profile and metabolism. They under-express the endogenous LDL receptor gene (R1) and express a human transgene encoding the cholesteryl ester transfer protein (CETP), normally absent in mice. The present study was designed to evaluate the independent and interactive effects of testosterone supplementation, exercise training and CETP expression on the plasma lipoprotein profile and CETP activity...
October 20, 2017: Lipids
https://www.readbyqxmd.com/read/29055822/anabolic-steroid-use-among-gay-and-bisexual-men-living-in-australia-and-new-zealand-associations-with-demographics-body-dissatisfaction-eating-disorder-psychopathology-and-quality-of-life
#11
Scott Griffiths, Stuart B Murray, Matthew Dunn, Aaron J Blashill
BACKGROUND AND AIMS: Gay and bisexual men may be at heightened risk for using anabolic androgenic steroids (AAS). Few studies, however, have examined AAS use among gay and bisexual men living in countries outside the United States. In addition, few studies have explored the potential associations of AAS use with body image concerns beyond muscularity, including height and genitals, or with eating disorder symptoms and quality of life. Thus, we examined the associations of AAS use, and of thoughts about using AAS, with body image, eating disorder symptoms, and quality of life among gay and bisexual men living in Australia and New Zealand...
October 18, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29040222/neurovascular-response-during-exercise-and-mental-stress-in-anabolic-steroid-users
#12
Rafael Armani Porello, Marcelo Rodrigues Dos Santos, Francis Ribeiro de Souza, Guilherme Wesley Peixoto da Fonseca, Ana Luiza Carrari Sayegh, Tiago Franco de Oliveira, César Abreu Akiho, Maurício Yonamine, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Maria-Janieire de Nazaré Nunes Alves
PURPOSE: Increased resting muscle sympathetic nerve activity (MSNA) and lower forearm blood flow (FBF) were observed in young men who use anabolic androgenic steroids (AAS). However, the response of MSNA and FBF in AAS users triggered by muscle mechanoreflex and central command has never been tested. Additionally, we evaluated the blood pressure (BP) and heart rate (HR) responses during these maneuvers. METHODS: Nineteen AAS users (AASU) aged 31±6 yr and 18 AAS nonusers (AASNU) aged 29±4 yr were recruited...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29020729/diagnosing-and-managing-androgen-deficiency-in-men
#13
REVIEW
Raveen Kaur Sandher, Jonathan Aning
Androgens play a crucial role in bone, muscle and fat metabolism, erythropoiesis and cognitive health. In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is 2.1-5.7%. Decreased libido or reduced frequency and quality of erections, fatigue, irritability, infertility or a diminished feeling of wellbeing may be presenting complaints. However, a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns. Important factors to elicit from the history in addition to the presenting complaint include: a medical history of obesity, type 2 diabetes, systemic diseases or metabolic syndrome which all impact on testosterone physiology...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29019018/long-term-anabolic-steroids-in-male-bodybuilders-induce-cardiovascular-structural-and-autonomic-abnormalities
#14
Octávio Barbosa Neto, Gustavo Ribeiro da Mota, Carla Cristina De Sordi, Elisabete Aparecida M R Resende, Luiz Antônio P R Resende, Marco Antônio Vieira da Silva, Moacir Marocolo, Rafael Silva Côrtes, Lucas Felipe de Oliveira, Valdo José Dias da Silva
OBJECTIVE: The aims of this study were to examine the hypothesis that users of anabolic androgenic steroids (AAS) would have cardiac autonomic disorders and that there is a correlation between sympathetic modulation, high blood pressure (BP) and alterations to cardiac dimensions. METHODS: Forty-five male subjects were enrolled in the study. They were categorized into three groups comprising bodybuilders actively using AAS (AAS users; n = 15), bodybuilders who had never used AAS (nonusers; n = 15) and age-paired healthy sedentary controls (n = 15)...
October 10, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28988314/the-prostate-response-to-prolactin-modulation-in-adult-castrated-rats-subjected-to-testosterone-replacement
#15
Flávia B Constantino, Ana C L Camargo, Sérgio A A Santos, Ketlin T Colombelli, Laura F Martin, Marcia G Silva, Sérgio L Felisbino, Luis A Justulin
Despite the androgenic dependence, other hormones, growth factors, and cytokines are necessary to support prostatic growth and maintain the glandular structure; among them, prolactin is a non-steroidal hormone secreted mainly by the pituitary gland. However, extra-pituitary expression of prolactin, such as in the prostate, has also been demonstrated, highlighting the paracrine and autocrine actions of prolactin within the prostate. Here, we investigated whether prolactin modulation alters ventral prostate (VP) morphophysiology in adult castrated rats...
December 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28971665/androgenic-anabolic-steroids-the-new-insidious-killer-leading-to-heart-failure
#16
Maria V Polito, Santo Dellegrottaglie, Rosanna Matturro, Domenico Bonadies, Roberta DE Rosa, Gennaro Galasso
No abstract text is available yet for this article.
December 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28971285/the-role-of-anabolic-androgenic-steroids-in-disruption-of-the-physiological-function-in-discrete-areas-of-the-central-nervous-system
#17
REVIEW
Giuseppe Bertozzi, Francesco Sessa, Giuseppe Davide Albano, Gabriele Sani, Francesca Maglietta, Mohsin H K Roshan, Giovanni Li Volti, Renato Bernardini, Roberto Avola, Cristoforo Pomara, Monica Salerno
Anabolic-androgenic steroids (AAS) abuse is often associated with a wide spectrum of adverse effects. These drugs are frequently abused by adolescents and athletes for esthetic purposes, as well as for improvement of their endurance and performances. In this literature review, we evaluated the correlation between AAS and anxiety or aggression. Two pathways are thought to be involved in AAS-induced behavioral disorders. Direct pathway via the amygdalo-fugal pathway, which connects the central nucleus of the amygdala to the brainstem, is involved in cognitive-emotive and homeostatic processes...
October 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28959650/use-of-anabolic-androgenic-steroids-produces-greater-oxidative-stress-responses-to-resistance-exercise-in-strength-trained-men
#18
Hamid Arazi, Heidar Mohammadjafari, Abbas Asadi
The aim of this study was to determine the effect of anabolic androgenic steroids (AAS) use on oxidative stress responses to a single session of resistance exercise in strength-trained men. Twenty-three strength trained men, with 11 self-reporting regular AAS use and 12 self-reporting never taking AAS (NAAS) volunteered to participate in this study. Blood draws were obtained pre and post resistance exercise in order to evaluate changes in oxidative stress biomarkers levels (i.e., 8-hydroxy-2-deoxyguanosine [8-OHdG], malondialdehyde [MDA], and nitric oxide [NO]), antioxidant defense systems (i...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28943276/detection-of-anabolic-androgenic-steroid-use-by-elite-athletes-and-by-members-of-the-general-public
#19
REVIEW
Bradley D Anawalt
Because national and international sports competitions are sources of community pride and financial revenue, there have been great efforts to prevent and detect the use of performance-enhancing drugs such as anabolic androgenic steroids by elite athletes. The World Anti-Doping Agency and its national affiliate anti-doping agencies have created sophisticated monitoring systems and advanced testing techniques to detect the use of banned substances including anabolic androgenic steroids by participants in international and national athletic competitions...
September 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28911778/applications-of-isotope-ratio-mass-spectrometry-in-sports-drug-testing-accounting-for-isotope-fractionation-in-analysis-of-biological-samples
#20
Thomas Piper, Mario Thevis
The misuse of anabolic-androgenic steroids (AAS) in sports aiming at enhancing athletic performance has been a challenging matter for doping control laboratories for decades. While the presence of a xenobiotic AAS or its metabolite(s) in human urine immediately represents an antidoping rule violation, the detection of the misuse of endogenous steroids such as testosterone necessitates comparably complex procedures. Concentration thresholds and diagnostic analyte ratios computed from urinary steroid concentrations of, e...
2017: Methods in Enzymology
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