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https://www.readbyqxmd.com/read/28427160/biomarker-analysis-of-the-phase-3-torch-trial-for-first-line-erlotinib-versus-chemotherapy-in-advanced-non-small-cell-lung-cancer-patients
#1
Lucia Kim, Mauro Saieg, Massimo Di Maio, Ciro Gallo, Charles Butts, Fortunato Ciardiello, Ronald Feld, Dengxiao Cheng, Vittorio Gebbia, Marco Angelo Burgio, Yasmin Alam, Simona Signoriello, Antonio Rossi, Natasha Leighl, Paolo Maione, Alessandro Morabito, Geoffrey Liu, Ming-Sound Tsao, Francesco Perrone, Cesare Gridelli
BACKGROUND: The TORCH phase III trial compared the efficacy of first-line erlotinib followed by chemotherapy at progression (experimental arm) with the reverse sequence (standard arm) in unselected advanced non-small cell lung cancer (NSCLC) patients. Here we report biomarker analyses. METHODS: EGFR and KRAS mutation, expression of EGFR family members and of cMET and PTEN and EGFR and ABCG2 germline polymorphisms were tested on tumor tissue or blood samples to either confirm previously proposed predictive role or describe it in an explorative setting...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28373641/influence-of-nitric-oxide-generated-through-microwave-plasma-on-l6-skeletal-muscle-cell-myogenesis-via-oxidative-signaling-pathways
#2
Naresh Kumar, Priyanka Shaw, Han Sup Uhm, Eun Ha Choi, Pankaj Attri
Myogenic precursors are myoblasts that have a potency to differentiate into muscle fibers on injury and maintain the regenerative power of skeletal muscle. However, the roles of exogenous nitric oxide (NO) in muscle development and myoblast differentiation are largely unknown. Therefore, in this study, we examined the effects of exogenous NO generated by a microwave plasma torch on rat myoblastic L6 cell proliferation and differentiation. We observed that the differentiation of L6 myogenic precursor cells into myotubes was significantly enhanced after NO treatment...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28358813/prevalence-and-associated-factors-of-pterygium-among-adults-living-in-gondar-city-northwest-ethiopia
#3
Dereje Hayilu Anbesse, Tsehay Kassa, Biruktayit Kefyalew, Atirsaw Tasew, Abie Atnie, Beredu Desta
PURPOSE: The aim of this study was to assess the prevalence and associated factors of pterygium among adults living in Gondar city, Northwest Ethiopia. METHODS: A cross sectional design study was carried out in 390 participants in Gondar city from April 15 to May 7, 2016. Basic ophthalmic examination was performed using portable slit lamb, 3.5x magnifying loop with torch light and a pretested and structured questionnaire was completed. The raw data has been entered into EPI INFO 3...
2017: PloS One
https://www.readbyqxmd.com/read/28335425/linear-mathematical-model-for-seam-tracking-with-an-arc-sensor-in-p-gmaw-processes
#4
Wenji Liu, Liangyu Li, Ying Hong, Jianfeng Yue
Arc sensors have been used in seam tracking and widely studied since the 80s and commercial arc sensing products for T and V shaped grooves have been developed. However, it is difficult to use these arc sensors in narrow gap welding because the arc stability and sensing accuracy are not satisfactory. Pulse gas melting arc welding (P-GMAW) has been successfully applied in narrow gap welding and all position welding processes, so it is worthwhile to research P-GMAW arc sensing technology. In this paper, we derived a linear mathematical P-GMAW model for arc sensing, and the assumptions for the model are verified through experiments and finite element methods...
March 14, 2017: Sensors
https://www.readbyqxmd.com/read/28335222/effects-of-atomization-injection-on-nanoparticle-processing-in-suspension-plasma-spray
#5
Hong-Bing Xiong, Cheng-Yu Zhang, Kai Zhang, Xue-Ming Shao
Liquid atomization is applied in nanostructure dense coating technology to inject suspended nano-size powder materials into a suspension plasma spray (SPS) torch. This paper presents the effects of the atomization parameters on the nanoparticle processing. A numerical model was developed to simulate the dynamic behaviors of the suspension droplets, the solid nanoparticles or agglomerates, as well as the interactions between them and the plasma gas. The plasma gas was calculated as compressible, multi-component, turbulent jet flow in Eulerian scheme...
May 20, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28296971/retention-and-sustainability-of-community-based-health-volunteers-activities-a-qualitative-study-in-rural-northern-ghana
#6
Samuel Chatio, Patricia Akweongo
BACKGROUND: The shortage of formal health workers has led to the utilization of Community-Based Health Volunteers (CBHV) to provide health care services to people especially in rural and neglected communities. Community-based health volunteers have been effective partners in health care delivery at the community level for many years. The challenge is how to retain these volunteers and also sustain their activities. This study explored factors affecting retention and sustainability of community-based health volunteers' activities in a rural setting in Northern Ghana...
2017: PloS One
https://www.readbyqxmd.com/read/28292484/external-validation-of-health-economic-decision-models-for-chronic-obstructive-pulmonary-disease-copd-report-of-the-third-copd-modeling-meeting
#7
Martine Hoogendoorn, Talitha L Feenstra, Yumi Asukai, Andrew H Briggs, Ryan N Hansen, Reiner Leidl, Nancy Risebrough, Yevgeniy Samyshkin, Margarethe Wacker, Maureen P M H Rutten-van Mölken
OBJECTIVES: To validate outcomes of presently available chronic obstructive pulmonary disease (COPD) cost-effectiveness models against results of two large COPD trials-the 3-year TOwards a Revolution in COPD Health (TORCH) trial and the 4-year Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT) trial. METHODS: Participating COPD modeling groups simulated the outcomes for the placebo-treated groups of the TORCH and UPLIFT trials using baseline characteristics of the trial populations as input...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28278065/ultraviolet-uv-reflective-paint-with-ultraviolet-germicidal-irradiation-uvgi-improves-decontamination-of-nosocomial-bacteria-on-hospital-room-surfaces
#8
Katelyn C Jelden, Shawn G Gibbs, Philip W Smith, Angela L Hewlett, Peter C Iwen, Kendra K Schmid, John J Lowe
An ultraviolet germicidal irradiation (UVGI) generator (the TORCH™, ClorDiSys Solutions, Inc.) was used to compare the disinfection of surface coupons (plastic from a bedrail, stainless steel, and chrome-plated light switch cover) in a hospital room with walls coated with ultraviolet (UV)-reflective paint (Lumacept) or standard paint. Each surface coupon was inoculated with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus faecalis (VRE), placed at 6 different sites within a hospital room coated with UV-reflective paint or standard paint, and treated by 10 minute UVC exposure (UVC dose of 0-688 mJ/cm(2) between sites with standard paint and 0-553 mJ/cm(2) with UV-reflective paint) in 8 total trials...
February 28, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28269986/differentiation-using-microwave-plasma-torch-desorption-mass-spectrometry-of-navel-oranges-cultivated-in-neighboring-habitats
#9
Xinchen Wang, Meiling Yang, Zhiyuan Wang, Hua Zhang, Guofeng Wang, Min Deng, Huanwen Chen, Liping Luo
The molecular fingerprinting of intact fruit samples combined with statistical data analysis can allow the assessment of fruit quality and location of origin. Herein, microwave plasma torch desorption ionization mass spectrometry (MPT-MS) was applied to produce molecular fingerprints for the juice sac and exocarp of navel oranges cultivated in three closely located habitats, and the mass spectrometric fingerprints were differentiated by principal component analysis (PCA). Because of the relatively high temperature and high ionization efficiency of MPT, the volatile aroma compounds and semivolatile chemicals in the navel oranges were sensitively detected and confidently identified by collision induced dissociation (CID)...
March 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28260505/copy-number-variations-with-isolated-fetal-ventriculomegaly
#10
P Hu, Y Wang, R Sun, L Cao, X Chen, C Liu, C Luo, D Ma, W Wang, X Fu, W Shi, S Yi, K Zhang, H Liu, Z Xu
BACKGROUND: Copy Number Variations (CNVs) are an important genetic cause of a number of neurodevelopmental disorders (NDs). However, the association between CNVs and the development and prognosis of isolated fetal ventriculomegaly (IMV) is unclear. OBJECTIVES: To investigate possible associations between CNVs and the development of fetal IMV. METHODS: This retrospective study recruited 154 subjects with ultrasound-confirmed fetal IMV and 190 subjects in a control cohort who underwent a high-risk prenatal serum screening program...
March 3, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28251633/outcome-of-pregnancy-in-women-diagnosed-with-idiopathic-polyhydramnios
#11
Sarwat Khan, Jennifer Donnelly
INTRODUCTION: Polyhydramnios is present in approximately 2% of pregnancies and it has been associated with a variety of adverse pregnancy outcomes. OBJECTIVES: The aim of our study was to evaluate the association between polyhydramnios and adverse pregnancy outcomes. METHODS: This was a retrospective case control study of 288 singleton pregnancies delivered in the Rotunda Hospital, Dublin, between 2013 and 2014. Polyhydramnios was defined as: (i) amniotic fluid index (AFI) ≥ 25 cm; (ii) maximal vertical pocket (MVP) of ≥8 cm; and (iii) a gestational age-specific threshold for AFI...
February 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28243836/early-childhood-caries-and-associated-risk-factors-among-preschool-children-in-ras-al-khaimah-united-arab-emirates
#12
M B Kowash, J O Alkhabuli, S A Dafaalla, A Shah, A H Khamis
AIM: To investigate the prevalence and contributing factors of early childhood caries (ECC) in preschool children of Ras Al-Khaimah (RAK), United Arab Emirates (UAE). STUDY DESIGN: Cross-sectional. METHODS: The sample consisted of 540 healthy preschool children between four and six years of age attending 10 nursery schools in RAK, UAE. A structured questionnaire was distributed to the mothers of children who gave consent for their children to be included in the study...
February 27, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28230344/fully-automatic-in-syringe-magnetic-stirring-assisted-dispersive-liquid-liquid-microextraction-hyphenated-to-high-temperature-torch-integrated-sample-introduction-system-inductively-coupled-plasma-spectrometer-with-direct-injection-of-the-organic-phase
#13
Raquel Sánchez, Burkhard Horstkotte, Kateřina Fikarová, Hana Sklenářová, Salvador Maestre, Manuel Miró, Jose-Luis Todolí
A proof of concept study involving the online coupling of automatic dispersive liquid-liquid microextraction (DLLME) to inductively coupled plasma optical emission spectrometry (ICP OES) with direct introduction and analysis of the organic extract is herein reported for the first time. The flow-based analyzer features a lab-in-syringe (LIS) setup with an integrated stirring system, a Meinhard nebulizer in combination with a heated single-pass spray chamber, and a rotary injection valve, used as an online interface between the microextraction system and the detection instrument...
March 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28223455/acute-fetal-demise-with-first-trimester-maternal-infection-resulting-from-listeria-monocytogenes-in-a-nonhuman-primate-model
#14
Bryce Wolfe, Gregory J Wiepz, Michele Schotzko, Gennadiy I Bondarenko, Maureen Durning, Heather A Simmons, Andres Mejia, Nancy G Faith, Emmanuel Sampene, Marulasiddappa Suresh, Sophia Kathariou, Charles J Czuprynski, Thaddeus G Golos
Infection with Listeria monocytogenes during pregnancy is associated with miscarriage, preterm birth, and neonatal complications, including sepsis and meningitis. While the risk of these conditions is thought to be greatest during the third trimester of pregnancy, the determinants of fetoplacental susceptibility to infection, the contribution of gestational age, and the in vivo progression of disease at the maternal-fetal interface are poorly understood. We developed a nonhuman primate model of listeriosis to better understand antecedents of adverse pregnancy outcomes in early pregnancy...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28146192/-zika-virus-infection-in-pregnancy-fetal-and-neonatal-impact
#15
Wilfrido Coronell-Rodríguez, Cindy Arteta-Acosta, M Alejandra Suárez-Fuentes, M Cecilia Burgos-Rolon, M Teresa Rubio-Sotomayor, Michelle Sarmiento-Gutiérrez, Carlos Corzo-Díaz
Zika virus (ZV) is an arbovirus transmitted by Aedes aegypti and A. albopictus. The neurotropic profile of this virus is known since 1952. The main finding related to ZV in America is microcephaly. Two hypotheses are tested on its involvement in the central nervous system: its neurotropic feature and the direct effect of ZV on the placenta. Malformations and clinical findings on fetal development comprise congenital Zika syndrome. RT-PCR and serology (IgM) are useful for definitive diagnosis. However, we should keep in mind first that the viremia in pregnant women can stay for a longer period of time, and second, a positive IgM for Zika should be properly interpreted in an endemic area to other flavivirus...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28125382/effects-of-weld-damage-on-the-dynamics-of-energy-absorbing-lanyards
#16
David N Katona, Charlie R Bennett, Michael McKoryk, Andre L Brisson, Carolyn J Sparrey
Manufacturers recommend removing fall protection system components from service for any indication of weld spatter or tool damage; however, little is known about the specific effects of lanyard damage on fall arrest dynamics. Thirty-two energy absorbing lanyards were drop tested after being damaged with weld spatter, plasma torches and cutting tools and compared with new, undamaged lanyards. Two lanyards damaged with a plasma torch failed completely without deploying the energy absorber while weld spatter damage and tool cuts, up to 2/3 through the width of the webbing, had no effect on fall arrest dynamics...
January 26, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28093008/hearing-loss-associated-gene-detection-in-neonatal-intensive-care-unit
#17
S M Yang, Ying Liu, C Liu, A H Yin, Y F Wu, X E Zheng, H M Yang, J Yang
OBJECTIVE: To investigate the frequency and mutation spectrum of hearing loss-associated gene mutation in Neonatal Intensive Care Unit (NICU). METHODS: Neonates (n=2305) admitted to NICU were enrolled in this study. Nine prominent hearing loss-associated genes, GJB2 (35 del G, 176 del 16,235 del C, 299 del AT), GJB3 (538 C > T), SLC26A4 (IVS7-2A > G, 2168 A > G) and mtDNA 12S rRNA(1555 A > G, 1494 C > T), were detected. RESULT: There were 73 cases hearing-loss-associated gene mutation among 2305 cases, the mutation frequency was 3...
March 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28063118/environmental-monitoring-by-surface-sampling-for-cytotoxics-a-review
#18
Petit Marie, Curti Christophe, Roche Manon, Montana Marc, Bornet Charleric, Vanelle Patrice
Environmental monitoring is usually conducted by surface sampling to detect and quantify the presence of cytotoxic drugs after their reconstitution and administration. This technique reveals the origins of residual contamination and is an important component in order to protect healthcare workers from the potential risk of occupational exposure. The aim of this work is to compare various techniques and results of surface sampling for cytotoxics. For each technique, sample processing methods and their analysis were compared from literature data...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28025587/panel-conditioning-in-the-general-social-survey
#19
Andrew Halpern-Manners, John Robert Warren, Florencia Torche
Does participation in one wave of a survey have an effect on respondents' answers to questions in subsequent waves? In this article, we investigate the presence and magnitude of "panel conditioning" effects in one of the most frequently used data sets in the social sciences: the General Social Survey (GSS). Using longitudinal records from the 2006, 2008, and 2010 surveys, we find evidence that at least some GSS items suffer from this form of bias. To rule out the possibility of contamination due to selective attrition and/or unobserved heterogeneity, we strategically exploit a series of between-person comparisons across time-in-survey groups...
January 2017: Sociological Methods & Research
https://www.readbyqxmd.com/read/28002851/prenatal-ultrasonographic-diagnosis-of-cataract-in-utero-manifestations-of-cryptic-disease
#20
Eran Ashwal, Asaf Achiron, Yinon Gilboa, Michal Berkenstadt, Mordecai Rosner, Reuven Achiron
Purpose To report and review our experience with antenatal evaluation for fetuses diagnosed with congenital cataract. Materials and Methods We retrospectively identified pregnancies diagnosed with fetal cataract during antenatal ultrasound. Evaluation of fetal eyes included intraocular anatomy and biometry. Data on fetal malformations, serology and fetal karyotype were collected. Results 8 cases, identified over the course of 10 years, were reviewed. Week 15 was the mean time for diagnosis (range 11 - 34)...
December 21, 2016: Ultraschall in der Medizin
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