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JOURNAL ARTICLE
Hassold Nolan, Dusser Perrine, Laurent Audrey, Lemelle Irene, Pillet Pascal, Comarmond Cloé, Mekinian Arsene, Lambert Marc, Mirault Tristan, Benhamou Ygal, Belot Alexandre, Jeziorski Eric, Reumaux Héloïse, Sibilia Jean, Desdoits Alexandra, Espitia Olivier, Faye Albert, Quartier Pierre, Saadoun David, Koné-Paut Isabelle
OBJECTIVES: We aimed to compare clinical spectrum and outcome between adults and children with Takayasu's arteritis (TAK) in a European population. METHODS: We made a nationwide retrospective observational study between 1988 and 2019. All adult patients met the ACR diagnostic criteria for TAK and all children met the EULAR/PRINTO/PRES criteria for paediatric TAK. RESULTS: We identified 46 children and 389 adults with TAK. The male to female ratio was 34/46 (0...
April 15, 2024: Joint, Bone, Spine: Revue du Rhumatisme
#2
JOURNAL ARTICLE
Nolan Hassold, Hélène Bihan, Yolène Pambo Moumba, Isabelle Poilane, Frédéric Méchaï, Nabil Assad, Véronique Labbe-Gentils, Meriem Sal, Omar Nouhou Koutcha, Antoine Martin, Dana Radu, Emmanuel Martinod, Hugues Cordel, Nicolas Vignier, Sopio Tatulashvili, Narimane Berkane, Etienne Carbonnelle, Olivier Bouchaud, Emmanuel Cosson
OBJECTIVE: We aimed to assess the feasibility and diagnostic performance of ultrasound-guided bone biopsies at the bedside of diabetic patients admitted for suspected foot osteitis not requiring surgery. RESEARCH DESIGN AND METHODS: In this retrospective monocentric study, we compared the performance of ultrasound-guided (n = 29 consecutive patients, Dec.2020-Oct.2022) versus surgical (n = 24 consecutive patients, Jan.2018-Nov.2020) bone biopsies at confirming or ruling out diabetic foot osteitis (primary outcome)...
March 3, 2024: Diabetes & Metabolism
#3
JOURNAL ARTICLE
Liza-Marie Beckers, Rolf Altenburger, Werner Brack, Beate I Escher, Jörg Hackermüller, Enken Hassold, Gianina Illing, Martin Krauss, Janet Krüger, Paul Michaelis, Andreas Schüttler, Sarah Stevens, Wibke Busch
Aquatic environments are polluted with a multitude of organic micropollutants, which challenges risk assessment due the complexity and diversity of pollutant mixtures. The recognition that certain source-specific background pollution occurs ubiquitously in the aquatic environment might be one way forward to approach mixture risk assessment. To investigate this hypothesis, we prepared one typical and representative WWTP effluent mixture of organic micropollutants (EWERBmix) comprised of 81 compounds selected according to their high frequency of occurrence and toxic potential...
August 17, 2023: Environment International
#4
JOURNAL ARTICLE
Arsène Mekinian, Lucie Biard, Dagna Lorenzo, Pavel I Novikov, Carlo Salvarani, Olivier Espitia, Savino Sciascia, Martin Michaud, Marc Lambert, José Hernández-Rodríguez, Nicolas Schleinitz, Abid Awisat, Xavier Puechal, Achille Aouba, Helene Munoz Pons, Ilya Smitienko, Jean Baptiste Gaultier, Le Mouel Edwige, Ygal Benhamou, Antoinette Perlat, Patrick Jego, Tiphaine Goulenok, Karim Sacre, Bertrand Lioger, Nolan Hassold, Jonathan Broner, Virginie Dufrost, Thomas Sené, Julie Seguier, Francois Maurier, Sabine Berthier, Alexandre Belot, Faten Frikha, Guillaume Denis, Alexandra Audemard-Verger, Isabelle Koné-Paut, Sebastien Humbert, Pascal Woaye-Hune, Alessandro Tomelleri, Elena Marina Baldissera, Masataka Kuwana, Alberto Logullo, Vahan Mukuchyan, Azeddine Dellal, Francis Gaches, Pierre Zeminsky, Elena Galli, Moya Alvarado, Luigi Boiardi, Muratore Francesco, Mathieu Vautier, Campochiaro Corrado, Sergey Moiseev, Matheus Vieira, Patrice Cacoub, Olivier Fain, David Saadoun
OBJECTIVES: In this large multicentre study, we compared the effectiveness and safety of tocilizumab intravenous versus subcutaneous (SC) in 109 Takayasu arteritis (TAK) patients. METHODS: We conducted a retrospective multicentre study in referral centres from France, Italy, Spain, Armenia, Israel, Japan, Tunisia and Russia regarding biological-targeted therapies in TAK, since January 2017 to September 2019. RESULTS: A total of 109 TAK patients received at least 3 months tocilizumab therapy and were included in this study...
June 2023: RMD Open
#5
JOURNAL ARTICLE
Nolan Hassold, Ségolène Brichler, Elise Ouedraogo, Delphine Leclerc, Sophie Carroue, Yamina Gater, Chakib Alloui, Etienne Carbonnelle, Olivier Bouchaud, Frederic Mechai, Hugues Cordel, Heloise Delagreverie
OBJECTIVES: COVID-19 vaccination is reportedly efficient in people living with HIV (PLHIV) but vaccine trials included participants with normal CD4+ T-cell counts. We analyzed seroconversion rates and antibody titers following 2-dose vaccination in PLHIV with impaired CD4+ T-cell counts. METHODS: We collected retrospective post-vaccination SARS-COV-2 serology results available in a university hospital for PLHIV vaccinated between March and September, 2021 who were tested for anti-spike antibodies from 8 to 150 days following dose 2...
January 10, 2022: AIDS
#6
JOURNAL ARTICLE
David L Nelson, Janelle Clark, Kathryn Garber, Thomas Glover, Terry Hassold, Peng Jin, Harry T Orr, Stephanie L Sherman, Huda Zoghbi, Karen L Warren
No abstract text is available yet for this article.
January 6, 2022: American Journal of Human Genetics
#7
Stéphane Mitrovic, Nolan Hassold, Aly Kamissoko, Nicolas Rosine, Alexis Mathian, Guillaume Mercy, Edouard Pertuiset, Gaëtane Nocturne, Bruno Fautrel, Isabelle Koné-Paut
No abstract text is available yet for this article.
November 30, 2021: Rheumatology
#8
JOURNAL ARTICLE
Stéphane Mitrovic, Nolan Hassold, Aly Kamissoko, Nicolas Rosine, Alexis Mathian, Guillaume Mercy, Edouard Pertuiset, Gaëtane Nocturne, Bruno Fautrel, Isabelle Koné-Paut
OBJECTIVES: Systemic-onset JIA (SJIA) and adult-onset Still's disease (AOSD) are the same sporadic systemic auto-inflammatory disease. SpA is a group of inflammatory non-autoimmune disorders. We report the observations of eight patients with SJIA/AOSD who also presented features of SpA during their disease evolution and estimate the prevalence of SpA in SJIA/AOSD. METHODS: This was a retrospective national survey of departments of paediatric and adult rheumatology and internal medicine...
May 30, 2022: Rheumatology
#9
MULTICENTER STUDY
Arsène Mekinian, Lucie Biard, Lorenzo Dagna, Pavel Novikov, Carlo Salvarani, Olivier Espitia, Savino Sciascia, Martin Michaud, Marc Lambert, José Hernández-Rodríguez, Nicolas Schleinitz, Abid Awisat, Xavier Puéchal, Achille Aouba, Helene Munoz Pons, Ilya Smitienko, Jean Baptiste Gaultier, Edwige Le Mouel, Ygal Benhamou, Antoinette Perlat, Patrick Jego, Tiphaine Goulenok, Karim Sacre, Bertrand Lioger, Nolan Hassold, Jonathan Broner, Virginie Dufrost, Thomas Sene, Julie Seguier, Francois Maurier, Sabine Berthier, Alexandre Belot, Faten Frikha, Guillaume Denis, Alexandra Audemard-Verger, Isabelle Kone Pault, Sebastien Humbert, Pascal Woaye-Hune, Alessandro Tomelleri, Elena Baldissera, Masataka Kuwana, Alberto Lo Gullo, Francis Gaches, Pierre Zeminsky, Elena Galli, Moya Alvarado, Luigi Boiardi, Francesco Muratore, Mathieu Vautier, Corrado Campochiaro, Sergey Moiseev, Patrice Cacoub, Olivier Fain, David Saadoun
OBJECTIVE: To assess the safety and the efficacy of TNF-α antagonists and tocilizumab in patients with Takayasu arteritis (TAK). METHODS: A total of 209 patients with TAK [median age 29 years (interquartile range 7-62)], 186 (89%) females] were included. They received either TNF-α antagonists [n = 132 (63%) with 172 lines; infliximab (n = 109), adalimumab (n = 45), golimumab (n = 8), certolizumab (n = 6) and etanercept (n = 5)] or tocilizumab [n = 77 (37%) with 121 lines; i...
April 11, 2022: Rheumatology
#10
JOURNAL ARTICLE
Nolan Hassold, Virginie Baltes, Antoine Martin, Frédéric Méchaï, Olivier Bouchaud, Hugues Cordel
No abstract text is available yet for this article.
May 1, 2021: AIDS
#11
JOURNAL ARTICLE
Terry J Hassold, Patricia A Hunt
The physical exchange of DNA between homologs, crossing-over, is essential to orchestrate the unique, reductional first meiotic division (MI). In females, the events of meiotic recombination that serve to tether homologs and facilitate their disjunction at MI occur during fetal development, preceding the MI division by several decades in our species. Data from studies in humans and mice demonstrate that placement of recombination sites during fetal development influences the likelihood of an MI nondisjunction event that results in the production of an aneuploid egg...
January 23, 2021: Prenatal Diagnosis
#12
JOURNAL ARTICLE
Wiebke Galert, Enken Hassold
The REACH regulation (EG) 1907/2006 is the European chemicals regulation for the registration, evaluation, authorization and restriction of chemical substances. REACH has been in force since 2007 and is intended to ensure a high level of protection for human health and the environment. REACH is based on the principle that manufacturers, importers and downstream users take responsibility for their chemicals. Currently about 23,000 single chemicals are registered within the REACH legislation. A large proportion of substances registered under REACH end up in technical mixtures, intentionally manufactured as such, or generated mixtures containing by-products of processes...
January 15, 2021: Integrated Environmental Assessment and Management
#13
JOURNAL ARTICLE
Terry Hassold, Heather Maylor-Hagen, Anna Wood, Jennifer Gruhn, Eva Hoffmann, Karl W Broman, Patricia Hunt
Failure of homologous chromosomes to recombine is arguably the most important cause of human meiotic nondisjunction, having been linked to numerous autosomal and sex chromosome trisomies of maternal origin. However, almost all information on these "exchangeless" homologs has come from genetic mapping studies of trisomic conceptuses, so the incidence of this defect and its impact on gametogenesis are not clear. If oocytes containing exchangeless homologs are selected against during meiosis, the incidence may be much higher in developing germ cells than in zygotes...
January 7, 2021: American Journal of Human Genetics
#14
JOURNAL ARTICLE
Jonathan M Chernus, Emily G Allen, Zhen Zeng, Eva R Hoffman, Terry J Hassold, Eleanor Feingold, Stephanie L Sherman
Human nondisjunction errors in oocytes are the leading cause of pregnancy loss, and for pregnancies that continue to term, the leading cause of intellectual disabilities and birth defects. For the first time, we have conducted a candidate gene and genome-wide association study to identify genes associated with maternal nondisjunction of chromosome 21 as a first step to understand predisposing factors. A total of 2,186 study participants were genotyped on the HumanOmniExpressExome-8v1-2 array. These participants included 749 live birth offspring with standard trisomy 21 and 1,437 parents...
December 12, 2019: PLoS Genetics
#15
JOURNAL ARTICLE
N Hassold, L Hu, U Michon-Pasturel, D Roscoulet, J Damiano
We report the case of a 51-year-old patient who presented necrosis affecting all of the toes in a context of confusion and declining general health. The etiology work-up disclosed a lung mass. Biopsy and search for extension led to the diagnosis of adenocarcinoma with liver metastasis. Unfortunately, symptomatic treatment of the digital necrosis did not lead to improvement and the patient was given palliative care. Digital necrosis generally affects the fingers. Localization on the toes is atypical and few cases have been reported in the literature...
May 2019: Journal de Médecine Vasculaire
#16
Nolan Hassold, Germain Jelin, Elisabeth Palazzo, Lydia Deschamps, Marine Forien, Sèbastien Ottaviani, Vincent Descamp, Philippe Dieudé
No abstract text is available yet for this article.
February 2019: JAAD Case Reports
#17
JOURNAL ARTICLE
Stephan Brendel, Christian Polleichtner, Andreas Behnke, Sönke Jessel, Enken Hassold, Christian Jennemann, Doreen Einhenkel-Arle, Albrecht Seidel
Little is known about the ecotoxicity of heterocyclic aromatic hydrocarbons (NSO-HETs) to aquatic organisms. In the environment, NSO-HETs have been shown to occur in a strong association with their unsubstituted carbocyclic analogues, the polycyclic aromatic hydrocarbons (PAH), for which much more information is available. The present study addressed this issue by investigating the toxicity of four selected NSO-HETs in green algae (Desmodesmus subspicatus), daphnids (Daphnia magna) and fish embryos (Danio rerio)...
November 15, 2018: Ecotoxicology and Environmental Safety
#18
JOURNAL ARTICLE
Anja Coors, Pia Vollmar, Frank Sacher, Christian Polleichtner, Enken Hassold, Daniela Gildemeister, Ute Kühnen
The aquatic environment is continually exposed to a complex mixture of chemicals, whereby effluents of wastewater treatment plants (WWTPs) are one key source. The aim of the present study was to investigate whether environmental risk assessments (ERAs) addressing individual substances are sufficiently protective for such coincidental mixtures. Based on a literature review of chemicals reported to occur in municipal WWTP effluents and mode-of-action considerations, four different types of mixtures were composed containing human pharmaceuticals, pesticides, and chemicals regulated under REACH...
September 1, 2018: Water Research
#19
JOURNAL ARTICLE
Micka C Bertucci, Arunika Das, Harriet C Fitzgerald, Daniel E Goszczynski
No abstract text is available yet for this article.
March 2018: Molecular Reproduction and Development
#20
Tegan S Horan, Alyssa Marre, Terry Hassold, Crystal Lawson, Patricia A Hunt
[This corrects the article DOI: 10.1371/journal.pgen.1006885.].
August 2017: PLoS Genetics
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