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https://www.readbyqxmd.com/read/29656400/pkd-regulates-actin-polymerization-neutrophil-deformability-and-transendothelial-migration-in-response-to-fmlp-and-trauma
#1
Christoph Wille, Tim Eiseler, Sven-Thorben Langenberger, Julia Richter, Kensaku Mizuno, Peter Radermacher, Uwe Knippschild, Markus Huber-Lang, Thomas Seufferlein, Stephan Paschke
Neutrophils are important mediators of the innate immune defense and of the host response to a physical trauma. Because aberrant infiltration of injured sites by neutrophils was shown to cause adverse effects after trauma, we investigated how neutrophil infiltration could be modulated at the cellular level. Our data indicate that protein kinase D (PKD) is a vital regulator of neutrophil transmigration. PKD phosphorylates the Cofilin-phosphatase Slingshot-2L (SSH-2L). SSH-2L in turn dynamically regulates Cofilin activity and actin polymerization in response to a chemotactic stimulus for neutrophils, for example, fMLP...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29579043/experiments-in-interdisciplinarity-responsible-research-and-innovation-and-the-public-good
#2
Ana Delgado, Heidrun Åm
In Europe, responsible research and innovation (RRI) has emerged as a science policy measure that demands the early integration of a broad range of social actors and perspectives into research and development (R&D). More collaboration of the social sciences and humanities (SSH) with science and engineering appears within this policy framework as a crucial element that will enable better technological development. However, RRI is new to both natural scientists and SSH scholars, and interdisciplinary collaborations are challenging for many reasons...
March 26, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29551678/hemocyanin-of-litopenaeus-vannamei-agglutinates-vibrio-parahaemolyticus-ahpnd-vp-ahpnd-and-neutralizes-its-toxin
#3
Pakpoom Boonchuen, Phattarunda Jaree, Anchalee Tassanakajon, Kunlaya Somboonwiwat
Acute hepatopancreatic necrosis disease, AHPND, caused by a specific strain of Vibrio parahaemolyticus (VPAHPND ), results in great loss of global shrimp production. Despite this, studies on shrimp defense mechanisms protecting against AHPND are few. In this study, suppression subtractive hybridization (SSH) was performed to identify differentially expressed genes from white shrimp Litopenaeus vannamei hepatopancreas upon VPAHPND infection at the early stages: 3 and 6 h post challenge and in the late stage at 48 h post challenge...
March 15, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29537884/current-status-of-sperm-functional-genomics-and-its-diagnostic-potential-of-fertility-in-bovine-bos-taurus
#4
Sellappan Selvaraju, Sivashanmugam Parthipan, Lakshminarayana Somashekar, B Krishnan Binsila, Atul P Kolte, Arunachalam Arangasamy, Janivara Parameshwaraiah Ravindra, Stephen A Krawetz
With artificial insemination (AI) and other precision dependent assisted reproductive technologies (ART) being followed in large scale in human and animal reproduction, assessing semen quality and fertilizability is under continuous scrutiny. Various tests have been developed to predict semen quality, but so far no single, highly reliable test is available. In this regard, transcriptomic profiling of spermatozoa assumes significance as it carries the information about spermatogenesis, sperm function, and paternal roles in post-fertilization events...
March 14, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29510742/molecular-and-biochemical-responses-in-the-midgut-of-the-silkworm-bombyx-mori-infected-with-nosema-bombycis
#5
Zhi Li, Yu Wang, Linling Wang, Zeyang Zhou
BACKGROUND: Microsporidia are a group of eukaryotic intracellular parasites that infect almost all vertebrates and invertebrates. However, there is little information available of how microsporidia obtain nutrients and energy from host cells. The purpose of this study was to investigate the energy and material requirements of Nosema bombycis for the invasion procedure through analyzing the global variation of the gene expression, protein abundance, fatty acids level and ATP flux induced by the microsporidia N...
March 6, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29438454/comparative-efficacy-of-antihypertensive-agents-in-salt-sensitive-hypertensive-patients-a-network-meta-analysis
#6
Han Qi, Zheng Liu, Han Cao, Wei-Ping Sun, Wen-Juan Peng, Bin Liu, Sheng-Jie Dong, Yu-Tao Xiang, Ling Zhang
Background: Salt-sensitive hypertension (SSH) is an intermediate inherited phenotype of essential hypertension as well as being an independent risk factor for cardiovascular disease. However, effective medications for the treatment of SSH have not been clarified. This study was to compare the efficacious of different classes of antihypertensive agents combined with salt intake on the reduction of blood pressure in patients with salt-sensitive hypertension (SSH). Methods: We used sources as PubMed, EMBASE, Cochrane Library, CENTRAL, ClinicalTrials...
February 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29431773/a-near-infrared-fluorescent-probe-for-sensitive-detection-and-imaging-of-sulfane-sulfur-in-living-cells-and-in-vivo
#7
Xiaoyue Han, Xinyu Song, Bowei Li, Fabiao Yu, Lingxin Chen
Sulfane sulfur refers to ionized sulfur that is reversibly attached to other sulfur atoms in the form of 6-valence electrons (S0). Sulfane sulfur possesses stronger nucleophilicity and reducibility than hydrogen sulfide in a series of physiological reactions, which probably makes sulfane sulfur the actual signal molecule in cells. Herein, we designed and synthesized a near-infrared (NIR) fluorescent probe BD-diSH for sensitive detection and imaging of sulfane sulfur in living cells and in vivo. The probe BD-diSH is composed of two moieties: the fluorophore azo-BODIPY and the sulfane sulfur recognition unit, viz...
February 12, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29417346/transcript-profiling-and-gene-expression-analysis-under-drought-stress-in-ziziphus-nummularia-burm-f-wright-arn
#8
Radha Yadav, Om Prakash Verma, Jasdeep Chatrath Padaria
Drought is one of the prime abiotic stresses responsible for limiting agricultural productivity. A number of drought responsive genes have been isolated and functionally characterized but these studies have been restricted to a few model plant systems. Very few drought responsive genes have been reported till date from non model drought tolerant plants. The present study aimed at identifying differentially expressed genes from a drought tolerant, non-model plant, Ziziphus nummularia (Burm.f.) Wight & Arn. One month old seedlings of Z...
February 7, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29401820/robust-manipulation-of-light-using-topologically-protected-plasmonic-modes
#9
Chenxu Liu, M V Gurudev Dutt, David Pekker
We propose using a topological plasmonic crystal structure composed of an array of nearly parallel nanowires with unequal spacing for manipulating light. In the paraxial approximation, the Helmholtz equation that describes the propagation of light along the nanowires maps onto the Schrödinger equation of the Su-Schrieffer-Heeger (SSH) model. Using a full three-dimensional finite difference time domain solution of the Maxwell equations, we verify the existence of topological defect modes, with sub-wavelength localization, bound to domain walls of the plasmonic crystal...
February 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29394254/differential-expression-of-genes-identified-by-suppression-subtractive-hybridization-in-liver-and-adipose-tissue-of-gerbils-with-diabetes
#10
Jingjing Gong, Xiaoyan Du, Zhenkun Li, Xiaohong Li, Meng Guo, Jing Lu, Ying Wang, Zhenwen Chen, Changlong Li
OBJECTIVES: We aimed at identifying genes related to hereditary type 2 diabetes expressed in the liver and the adipose tissue of spontaneous diabetic gerbils using suppression subtractive hybridization (SSH) screening. METHODS: Two gerbil littermates, one with high and the other with normal blood glucose level, from our previously bred spontaneous diabetic gerbil strain were used in this study. To identify differentially expressed genes in the liver and the adipose tissue, mRNA from these tissues was extracted and SSH libraries were constructed for screening...
2018: PloS One
https://www.readbyqxmd.com/read/29375807/from-population-connectivity-to-the-art-of-striping-russian-dolls-the-lessons-from-pocillopora-corals
#11
Pauline Gélin, Cécile Fauvelot, Lionel Bigot, Joseph Baly, Hélène Magalon
Here, we examined the genetic variability in the coral genus Pocillopora, in particular within the Primary Species Hypothesis PSH09, identified by Gélin, Postaire, Fauvelot and Magalon (2017) using species delimitation methods [also named Pocillopora eydouxi/meandrina complex sensu, Schmidt-Roach, Miller, Lundgren, & Andreakis (2014)] and which was found to split into three secondary species hypotheses (SSH09a, SSH09b, and SSH09c) according to assignment tests using multi-locus genotypes (13 microsatellites)...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29352327/limk-cofilin-pathway-and-slingshot-are-implicated-in-human-colorectal-cancer-progression-and-chemoresistance
#12
Helen Aggelou, Panagiota Chadla, Sofia Nikou, Sofia Karteri, Ioannis Maroulis, Haralabos P Kalofonos, Helen Papadaki, Vasiliki Bravou
Cofilin phospho-regulation is important for actin filament turnover and is implicated in cancer. Phosphorylation of cofilin is mediated by LIM kinases (LIMKs) and dephosphorylation by Slingshot phosphatases (SSH). LIMKs and SSH promote cancer cell invasion and metastasis and represent novel anti-cancer targets. However, little is known regarding LIMK/cofilin and SSH in human colorectal cancer (CRC). In this study, we aimed to address their expression and significance in human CRC. We evaluated expression of non-phosphorylated (active) and phosphorylated cofilin, LIMK1, LIMK2, and SSH1 by immunohistochemistry in 143 human CRC samples in relation to clinicopathologic parameters, response of metastatic disease to chemotherapy, and epithelial-mesenchymal transition (EMT) markers β-catenin, E-cadherin, and ZEB...
January 19, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29327094/association-between-secondhand-smoke-exposure-and-quality-of-life-in-pregnant-women-and-postpartum-women-and-the-consequences-on-the-newborns
#13
Rasmon Kalayasiri, Waranya Supcharoen, Pichanan Ouiyanukoon
PURPOSE: Secondhand smoke (SHS) exposure is prevalent and could damage the health of non-smokers, especially that of pregnant women (PW) and postpartum women (PPW). Nevertheless, there is no study on the impact of SHS during pregnancy on the quality of life (QOL) of PW and PPW. The study's purpose is to study the effects of exposure to SHS on the QOL of pregnant and postpartum women and health of the newborns. METHODS: Self-reports and urine tests for cotinine were used to obtain data on SSH exposure in 296 women in the second trimester of pregnancy and 106 women in the postpartum period at the Obstetrics & Gynecology Clinic located in a university hospital...
April 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29301177/iatrogenic-spinal-subarachnoid-hematoma-after-diagnostic-lumbar-puncture
#14
Jung Hyun Park, Jong Yeol Kim
Spinal subarachnoid hematoma (SSH) following diagnostic lumbar puncture is very rare. Generally, SSH is more likely to occur when the patient has coagulopathy or is undergoing anticoagulant therapy. Unlike the usual complications, such as headache, dizziness, and back pain at the needle puncture site, SSH may result in permanent neurologic deficits if not properly treated within a short period of time. An otherwise healthy 43-year-old female with no predisposing factors presented with fever and headache. Diagnostic lumbar puncture was performed under suspicion of acute meningitis...
December 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/29275012/progress-in-pharmacological-research-of-chemokine-like-factor-1-cklf1
#15
REVIEW
Dan-Dan Liu, Xiu-Yun Song, Peng-Fei Yang, Qi-Di Ai, Ying-Ying Wang, Xiao-Ye Feng, Xin He, Nai-Hong Chen
Currently, the research of chemokines has penetrated into many fields of life science. A new kind of chemokines, chemokine like factor 1 (CKLF1), which is cloned through suppression subtractive hybridisation (SSH) technology is expressed widely in human body, especially in the lung and peripheral blood leukocytes. CKLF1 has a broad spectrum of chemotaxic activity for many cells, such as lymphocytes, macrophages, bone marrow cells, nerve cells and so on. In addition, CKLF1 also stimulates the regeneration of skeletal muscle cells in vivo...
February 2018: Cytokine
https://www.readbyqxmd.com/read/29251797/an-ecophysiological-perspective-on-likely-giant-panda-habitat-responses-to-climate-change
#16
Yuke Zhang, Paul D Mathewson, Qiongyue Zhang, Warren P Porter, Jianghong Ran
Threatened and endangered species are more vulnerable to climate change due to small population and specific geographical distribution. Therefore, identifying and incorporating the biological processes underlying a species' adaptation to its environment are important for determining whether they can persist in situ. Correlative models are widely used to predict species' distribution changes, but generally fail to capture the buffering capacity of organisms. Giant pandas (Ailuropoda melanoleuca) live in topographically complex mountains and are known to avoid heat stress...
April 2018: Global Change Biology
https://www.readbyqxmd.com/read/29203369/gasotransmitter-hydrogen-sulfide-signaling-in-neuronal-health-and-disease
#17
REVIEW
Bindu D Paul, Solomon H Snyder
Hydrogen sulfide is a gaseous signaling molecule or gasotransmitter which plays important roles in a wide spectrum of physiologic processes in the brain and peripheral tissues. Unlike nitric oxide and carbon monoxide, the other major gasotransmitters, research on hydrogen sulfide is still in its infancy. One of the modes by which hydrogen sulfide signals is via a posttranslational modification termed sulfhydration/persulfidation, which occurs on reactive cysteine residues on target proteins, where the reactive SH group is converted to an SSH group...
December 1, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29201979/quantitative-evaluation-of-pregnant-women-delivery-status-records-in-akure-nigeria
#18
Adebowale O Adejumo, Esivue A Suleiman, Hilary I Okagbue, Pelumi E Oguntunde, Oluwole A Odetunmibi
In this data article, monthly records (datasets) of total delivery, normal delivery, delivery through Caesarean section and number of still births from pregnant women in Akure, the capital city of Ondo state Nigeria, for a period of ten years, between January 2007 and December 2016 were considered. Correlational and time series analyses were conducted on the monthly records of total delivery, normal delivery (delivery through woman virginal), delivery through Caesarean section, and number of still births, in order to observe the patterns each of these indicators follows and to recommend appropriate model for forecasting their future values...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29184730/outcomes-comparison-for-microsurgical-breast-reconstruction-in-specialty-surgery-hospitals-versus-tertiary-care-facilities
#19
Rahul Vemula, Matthew J Bartow, Matt Freeman, Cameron Callaghan, Tim Matatov, David Jansen, Bob Allen, Hugo St Hilaire, Oren Tessler
Background: Postoperative monitoring is crucial in the care of free flap breast reconstruction patients. Tertiary care facilities (TCFs) provide postoperative monitoring in an ICU after surgery. Specialty surgery hospitals (SSHs) do not have ICUs, but these facilities perform free flap breast reconstruction as well. Are outcomes comparable between the 2 facilities in terms of flap reexploration times and overall success? Methods: Retrospective study including 163 SSH and 157 TCF patients...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29141638/diffusion-weighted-imaging-of-the-brains-of-dogs-with-idiopathic-epilepsy
#20
Antje Hartmann, Steffen Sager, Klaus Failing, Marion Sparenberg, Martin J Schmidt
BACKGROUND: Idiopathic epilepsy is one of the most common neurological disorders in dogs. Unfortunately, up to 30% of dogs with idiopathic epilepsy show no improvement under antiepileptic drug treatment. Diffusion-weighted imaging is used in human medicine to identify epileptogenic foci in the brain to allow for more invasive treatments such as deep brain stimulation or surgical removal. The aim of this study was to ass the feasibility of interictal diffusion-weighted MRI in dogs and to evaluate the distribution of diffusion in the brains of dogs with idiopathic epilepsy (IE) and to compare these values to previously published values from healthy beagle dogs...
November 15, 2017: BMC Veterinary Research
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