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https://www.readbyqxmd.com/read/27913853/the-role-of-intestinal-oxalate-transport-in-hyperoxaluria-and-the-formation-of-kidney-stones-in-animals-and-man
#1
REVIEW
Jonathan M Whittamore, Marguerite Hatch
The intestine exerts a considerable influence over urinary oxalate in two ways, through the absorption of dietary oxalate and by serving as an adaptive extra-renal pathway for elimination of this waste metabolite. Knowledge of the mechanisms responsible for oxalate absorption and secretion by the intestine therefore have significant implications for understanding the etiology of hyperoxaluria, as well as offering potential targets for future treatment strategies for calcium oxalate kidney stone disease. In this review, we present the recent developments and advances in this area over the past 10 years, and put to the test some of the new ideas that have emerged during this time, using human and mouse models...
December 2, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27847292/the-role-of-the-microbiome-in-kidney-stone-formation
#2
REVIEW
Mansi Mehta, David S Goldfarb, Lama Nazzal
Nephrolithiasis is a complex disease of worldwide prevalence that is influenced by both genetic and environmental factors. About 75% of kidney stones are predominantly composed of calcium oxalate and urinary oxalate is considered a crucial risk factor. Microorganisms may have a role in the pathogenesis and prevention of kidney stones and the involvement of the intestinal microbiome in this renal disease has been a recent area of interest. Oxalobacter formigenes is a gram negative bacteria that degrades oxalate in the gut decreasing urinary oxalate excretion...
November 12, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27738124/oxalobacter-formigenes-derived-bioactive-factors-stimulate-oxalate-transport-by-intestinal-epithelial-cells
#3
Donna Arvans, Yong-Chul Jung, Dionysios Antonopoulos, Jason Koval, Ignacio Granja, Mohamed Bashir, Eltayeb Karrar, Jayanta Roy-Chowdhury, Mark Musch, John Asplin, Eugene Chang, Hatim Hassan
Hyperoxaluria is a major risk factor for kidney stones and has no specific therapy, although Oxalobacter formigenes colonization is associated with reduced stone risk. O. formigenes interacts with colonic epithelium and induces colonic oxalate secretion, thereby reducing urinary oxalate excretion, via an unknown secretagogue. The difficulties in sustaining O. formigenes colonization underscore the need to identify the derived factors inducing colonic oxalate secretion. We therefore evaluated the effects of O...
October 13, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27708409/hyperoxaluria-leads-to-dysbiosis-and-drives-selective-enrichment-of-oxalate-metabolizing-bacterial-species-in-recurrent-kidney-stone-endures
#4
Mangesh V Suryavanshi, Shrikant S Bhute, Swapnil D Jadhav, Manish S Bhatia, Rahul P Gune, Yogesh S Shouche
Hyperoxaluria due to endogenously synthesized and exogenously ingested oxalates is a leading cause of recurrent oxalate stone formations. Even though, humans largely rely on gut microbiota for oxalate homeostasis, hyperoxaluria associated gut microbiota features remain largely unknown. Based on 16S rRNA gene amplicons, targeted metagenomic sequencing of formyl-CoA transferase (frc) gene and qPCR assay, we demonstrate a selective enrichment of Oxalate Metabolizing Bacterial Species (OMBS) in hyperoxaluria condition...
October 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27663026/response-of-germ-free-mice-to-colonization-with-o-formigenes-and-altered-schaedler-flora
#5
Xingsheng Li, Melissa L Ellis, Alexander E Dowell, Ranjit Kumar, Casey D Morrow, Trenton R Schoeb, John Knight
: Colonization with Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stone disease. To improve our limited understanding of host/O.formigenes and microbe/O.formigenes interactions, germ-free or altered Schaedler flora (ASF) mice were colonized with O.formigenes Germ-free mice were stably colonized with O.formigenes suggesting O.formigenes does not require other organisms to sustain its survival. Examination of intestinal material indicated no viable O.formigenes in the small intestine, ∼4 × 10(6) O...
September 23, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27524723/co2-sequestration-by-ureolytic-microbial-consortia-through-microbially-induced-calcite-precipitation
#6
Tugba O Okyay, Hang N Nguyen, Sarah L Castro, Debora F Rodrigues
Urea is an abundant nitrogen-containing compound found in urine of mammals and widely used in fertilizers. This compound is part of the nitrogen biogeochemical cycle and is easily biodegraded by ureolytic microorganisms that have the urease enzyme. Previous studies, with ureolytic isolates, have shown that some ureolytic microorganisms are able to sequester CO2 through a process called microbially-induced calcium carbonate precipitation. The present study investigates 15 ureolytic consortia obtained from the "Pamukkale travertines" and the "Cave Without A Name" using different growth media to identify the possible bacterial genera responsible for CO2 sequestration through the microbially-induced calcite precipitation (MICP)...
August 11, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27449000/probiotic-properties-of-oxalobacter-formigenes-an-in-vitro-examination
#7
Melissa L Ellis, Alexander E Dowell, Xingsheng Li, John Knight
Oxalobacter formigenes (O. formigenes) is a nonpathogenic, Gram-negative, obligate anaerobic bacterium that commonly inhabits the human gut and degrades oxalate as its major energy and carbon source. Results from a case-controlled study suggested that lack of O. formigenes colonization is a risk factor for recurrent calcium oxalate stone formation. Hence, O. formigenes colonization may prove to be an efficacious method for limiting calcium oxalate stone risk. However, challenges exist in the preparation of O...
December 2016: Archives of Microbiology
https://www.readbyqxmd.com/read/27312892/microbial-community-transplant-results-in-increased-and-long-term-oxalate-degradation
#8
Aaron W Miller, Kelly F Oakeson, Colin Dale, M Denise Dearing
Gut microbes are essential for the degradation of dietary oxalate, and this function may play a role in decreasing the incidence of kidney stones. However, many oxalate-degrading bacteria are susceptible to antibiotics and the use of oxalate-degrading probiotics has only led to an ephemeral reduction in urinary oxalate. The objective of the current study was to determine the efficacy of using whole-community microbial transplants from a wild mammalian herbivore, Neotoma albigula, to increase oxalate degradation over the long term in the laboratory rat, Rattus norvegicus...
August 2016: Microbial Ecology
https://www.readbyqxmd.com/read/26924912/proteome-dynamics-of-the-specialist-oxalate-degrader-oxalobacter-formigenes
#9
Melissa E Ellis, James A Mobley, Ross P Holmes, John Knight
Oxalobacter formigenes is a unique intestinal organism that relies on oxalate degradation to meet most of its energy and carbon needs. A lack of colonization is a risk factor for calcium oxalate kidney stone disease. The release of the genome sequence of O. formigenes has provided an opportunity to increase our understanding of the biology of O. formigenes. This study used mass spectrometry based shotgun proteomics to examine changes in protein levels associated with the transition of growth from log to stationary phase...
2016: Journal of Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/26292041/the-presence-of-oxalobacter-formigenes-in-the-microbiome-of-healthy-young-adults
#10
Clea Barnett, Lama Nazzal, David S Goldfarb, Martin J Blaser
PURPOSE: Oxalobacter formigenes, a member of the human colonic microbiota with a major role in net colonic oxalate transport and secretion, is protective against the formation of calcium oxalate kidney stones. We describe the prevalence, relative abundance and stability of O. formigenes in healthy young adults in the United States. MATERIALS AND METHODS: We used HMP (Human Microbiome Project) data on fecal samples from 242 healthy young adults who had 1 to 3 study visits...
February 2016: Journal of Urology
https://www.readbyqxmd.com/read/26235248/renal-failure-due-to-excessive-intake-of-almonds-in-the-absence-of-oxalobacter-formigenes
#11
LETTER
Yngvar Lunde Haaskjold, Aslaug Drotningsvik, Sabine Leh, Hans-Peter Marti, Einar Svarstad
No abstract text is available yet for this article.
December 2015: American Journal of Medicine
https://www.readbyqxmd.com/read/26195968/the-relationship-between-serum-oxalic-acid-central-hemodynamic-parameters-and-colonization-by-oxalobacter-formigenes-in-hemodialysis-patients
#12
Baris Gulhan, Kultigin Turkmen, Merve Aydin, Murat Gunay, Aytekin Cıkman, Murat Kara
BACKGROUND/OBJECTIVE: Elevated pulse wave velocity (PWV) and central aortic blood pressures are independent predictors of increased cardiovascular morbidity and mortality in hemodialysis (HD) patients. Oxalic acid is a uremic retention molecule that is extensively studied in the pathogenesis of calcium oxalate stones. Oxalobacter formigenes, a member of the colon microbiota, has important roles in oxalate homeostasis. Data regarding the colonization by and the exact role of O. formigenes in the pathogenesis of oxalic acid metabolism in HD patients are scant...
June 2015: Cardiorenal Medicine
https://www.readbyqxmd.com/read/26195376/re-analysis-of-commercial-kidney-stone-probiotic-supplements
#13
COMMENT
Dean G Assimos
No abstract text is available yet for this article.
August 2015: Journal of Urology
https://www.readbyqxmd.com/read/26195373/re-oxalobacter-formigenes-opening-the-door-to-probiotic-therapy-for-the-treatment-of-hyperoxaluria
#14
COMMENT
Dean G Assimos
No abstract text is available yet for this article.
August 2015: Journal of Urology
https://www.readbyqxmd.com/read/26088584/-urinary-stones-and-bowel-diseases-systematic-review
#15
REVIEW
B Pradere, B Peyronnet, C Brochard, É Le Balc'h, C Vigneau, L Siproudhis, O Traxer, K Bensalah
PURPOSE: The aim of the study was to explain the relationship between urinary stones and bowel disease. METHODS: A systematic review was performed on Medline, Embase and Cochrane using following keywords: urinary stones; urolithiasis; bowel; enteric and digestive. The literature selection was based on evidence and practical considerations. RESULTS: Fifty-three articles were selected. Three types of urolthiasis are mainly involved in digestive pathologies: calcium oxalate stones, uric acid and ammonium acid urate stones...
September 2015: Progrès en Urologie
https://www.readbyqxmd.com/read/25979889/oxalobacter-formigenes-colonization-and-oxalate-dynamics-in-a-mouse-model
#16
Xingsheng Li, Melissa L Ellis, John Knight
Animal and human studies have provided compelling evidence that colonization of the intestine with Oxalobacter formigenes reduces urinary oxalate excretion and lowers the risk of forming calcium oxalate kidney stones. The mechanism providing protection appears to be related to the unique ability of O. formigenes to rely on oxalate as a major source of carbon and energy for growth. However, much is not known about the factors that influence colonization and host-bacterium interactions. We have colonized mice with O...
August 2015: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/25804778/-oxalate-a-poorly-soluble-organic-waste-with-consequences
#17
REVIEW
Yimin Lu, Olivier Bonny
Oxalate is a highly insoluble metabolic waste excreted by the kidneys. Disturbances of oxalate metabolism are encountered in enteric hyperoxaluria (secondary to malabsorption, gastric bypass or in case of insufficient Oxalobacter colonization), in hereditary hyperoxaluria and in intoxication (ethylene glycol, vitamin C). Hyperoxaluria causes a large spectrum of diseases, from isolated hyperoxaluria to kidney stones and nephrocalcinosis formation, eventually leading to kidney failure and systemic oxalosis with life-threatening deposits in vital organs...
March 25, 2015: Praxis
https://www.readbyqxmd.com/read/25733259/analysis-of-commercial-kidney-stone-probiotic-supplements
#18
Melissa L Ellis, Karen J Shaw, Shelby B Jackson, Steven L Daniel, John Knight
OBJECTIVE: To examine the levels of Oxalobacter formigenes in probiotic supplements marketed by PRO-LAB, Ltd, Toronto, Canada, and capsules of Oxalo purchased from Sanzyme Ltd, Hyderabad, India, and to measure the ability of these preparations to degrade oxalate in vitro. METHODS: Probiotic supplements and pure cultures of O. formigenes were cultured in a number of media containing oxalate. Optical density at 595 nm (OD595) was used to measure bacterial growth, and ion chromatography was used to measure loss of oxalate in culture media...
March 2015: Urology
https://www.readbyqxmd.com/read/25645091/oxalobacter-formigenes-opening-the-door-to-probiotic-therapy-for-the-treatment-of-hyperoxaluria
#19
RANDOMIZED CONTROLLED TRIAL
Ankush Jairath, Narendra Parekh, Natalia Otano, Shashikant Mishra, Arvind Ganpule, Ravindra Sabnis, Mahesh Desai
OBJECTIVE: The aim of this study was to determine the early effect of the administration of Oxalobacter formigenes on the metabolic pattern of patients with calcium oxalate stones, comparing it with potassium magnesium citrate (KMgCit). MATERIALS AND METHODS: Eighty patients were randomized to receive either 30 mEq of KMgCit or 700 million O. formigenes, both twice a day. Serum creatinine, serum urate, serum calcium and phosphorus, serum intact parathyroid hormone (if serum calcium >10...
2015: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/25630805/the-relationship-between-colonization-of-oxalobacter-formigenes-serum-oxalic-acid-and-endothelial-dysfunction-in-hemodialysis-patients-from-impaired-colon-to-impaired-endothelium
#20
K Turkmen, F M Erdur
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients receiving hemodialysis (HD). Oxalic acid is a uremic retention molecule that has been extensively studied in the pathogenesis of calcium-oxalate stones. Oxalobacter formigenes (O. formigenes), a component of the colonic microbiota, plays an important role in oxalate homeostasis. Little is known regarding the colonization of HD patients by O. formigenes and the exact role of this bacterial species in oxalic acid metabolism in these patients...
March 2015: Medical Hypotheses
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