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https://www.readbyqxmd.com/read/27762349/hypericum-perforatum-as-a-cognitive-enhancer-in-rodents-a-meta-analysis
#1
Daniel Ben-Eliezer, Eldad Yechiam
Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competitive synergistic manner, and may have nootropic potential. We quantitatively reviewed the pre-clinical literature to examine if there is a cognitive-enhancing effect of H. perforatum in healthy rodents. Additionally, within these studies, we compared the effects observed in intact rodents versus those whose performance has been impaired, mostly through stress manipulations. The meta-analysis incorporated studies that examined the effect of H...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27589952/a-systematic-review-of-st-john-s-wort-for-major-depressive-disorder
#2
Eric A Apaydin, Alicia R Maher, Roberta Shanman, Marika S Booth, Jeremy N V Miles, Melony E Sorbero, Susanne Hempel
BACKGROUND: This systematic review evaluated St. John's wort (SJW) for the treatment of Major Depressive Disorder (MDD). The objectives of this review are to (1) evaluate the efficacy and safety of SJW in adults with MDD compared to placebo and active comparator and (2) evaluate whether the effects vary by severity of MDD. METHODS: We searched PubMed, CINAHL, PsycINFO, CENTRAL, Embase, AMED, MANTIS, Web of Science, and ICTRP and existing reviews to November 2014...
September 2, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27462333/neuroprotective-activity-of-hypericum-perforatum-and-its-major-components
#3
REVIEW
Ana I Oliveira, Cláudia Pinho, Bruno Sarmento, Alberto C P Dias
Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as St. John's wort. It has been used for centuries in traditional medicine for the treatment of several disorders, such as minor burns, anxiety, and mild to moderate depression. In the past years, its antidepressant properties have been extensively studied. Despite that, other H. perforatum biological activities, as its neuroprotective properties have also been evaluated. The present review aims to provide a comprehensive summary of the main biologically active compounds of H...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27446151/benzophenone-synthase-and-chalcone-synthase-accumulate-in-the-mesophyll-of-hypericum-perforatum-leaves-at-different-developmental-stages
#4
Asma K Belkheir, Mariam Gaid, Benye Liu, Robert Hänsch, Ludger Beerhues
The active medicinal constituents in Hypericum perforatum, used to treat depression and skin irritation, include flavonoids and xanthones. The carbon skeletons of these compounds are formed by chalcone synthase (CHS) and benzophenone synthase (BPS), respectively. Polyclonal antisera were raised against the polyketide synthases from Hypericum androsaemum and their IgG fractions were isolated. Immunoblotting and immunotitration were used to test the IgGs for crossreactivity and monospecificity in H. perforatum leaf protein extract...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27343017/st-john-s-wort-versus-counterfeit-st-john-s-wort-an-hptlc-study
#5
Débora A Frommenwiler, Eike Reich, Sidney Sudberg, Maged H M Sharaf, Anton Bzhelyansky, Ben Lucas
Hypericum perforatum L. is the most commonly used herb for treating depression. Due to the popularity of this botanical, there is a potential for economically driven adulteration of St. John's wort (SJW) products. The goal of this study was to investigate SJW ingredients suspected to be adulterated based on simple preliminary HPTLC tests. Commercial samples were analyzed by HPTLC following the United States Pharmacopeia (USP) monograph methodology, with additional visualization under white light. A number of these samples presented odd methanolic solution colors and unconventional HPTLC fingerprints, suggesting the presence of other species and/or extraneous polar additives...
September 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27161105/efficacy-of-hypericum-extract-ws-%C3%A2-5570-compared-with-paroxetine-in-patients-with-a-moderate-major-depressive-episode-a-subgroup-analysis
#6
Erich Seifritz, Martin Hatzinger, Edith Holsboer-Trachsler
OBJECTIVES: efficacy and tolerability of WS(®) 5570 for the treatment of acute mild-to-moderate depression, has been demonstrated in various studies. Here, we present a subgroup analysis of a double blind, randomised trial to compare the therapeutic efficacy of WS(®) 5570 with paroxetine in patients suffering from a major depressive episode with moderate symptom intensity. METHODS: moderate depression was defined by a baseline Hamilton Depression Rating Scale (HAM-D) total score between 22 and 25...
September 2016: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/27148343/molecular-cloning-and-expression-analysis-of-hyp-1-type-pr-10-family-genes-in-hypericum-perforatum
#7
Katja Karppinen, Emese Derzsó, Laura Jaakola, Anja Hohtola
Hypericum perforatum L. is an important medicinal plant for the treatment of depression. The plant contains bioactive hypericins that accumulate in dark glands present especially in reproductive parts of the plant. In this study, pathogenesis-related class 10 (PR-10) family genes were identified in H. perforatum, including three previously unidentified members with sequence homology to hyp-1, a phenolic coupling protein that has earlier been suggested to participate in biosynthesis and binding/transportation of hypericin...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/26994552/elemental-fingerprinting-of-hypericum-perforatum-st-john-s-wort-herb-and-preparations-using-icp-oes-and-chemometrics
#8
Jade D Owen, Stewart B Kirton, Sara J Evans, Jacqueline L Stair
St. John's wort (SJW) (Hypericum perforatum) is a herbal remedy commonly used to treat mild depression. The elemental profiles of 54 samples (i.e., dry herbs, tablets and capsules) were evaluated by monitoring 25 elements using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The major elemental constituents in the SJW samples were Ca (300-199,000μg/g), Mg (410-3,530μg/g), Al (4.4-900μg/g), Fe (1.154-760μg/g), Mn (2.4-261μg/g), Sr (0.88-83.6μg/g), and Zn (7-64μg/g). For the sixteen elements that could be reliably quantified, principal component analysis (PCA) was used to investigate underlying patterns in the data...
June 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26938817/state-of-the-art-psychopharmacological-treatment-options-in-seasonal-affective-disorder
#9
REVIEW
Mesut Yildiz, Sedat Batmaz, Emrah Songur, Esat Timuçin Oral
Seasonal affective disorder (SAD) is defined as a subtype of mood disorders in DSM 5, and it is characterized by a seasonal onset. SAD is proposed to be related to the seasonal changes in naturally occurring light, and the use of bright light therapy for depressive symptoms has been shown to reduce them in placebo controlled trials. Cognitive behavioral therapy has also been demonstrated to be effective in SAD. This review article aims to focus on the psychopharmacological treatment options for SAD. According to clinical trial results, first line treatment options seem to be sertraline and fluoxetine, and are well tolerated by the patients...
March 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/26876610/hyperforin-production-in-hypericum-perforatum-root-cultures
#10
Mariam Gaid, Paul Haas, Till Beuerle, Stephan Scholl, Ludger Beerhues
Extracts of the medicinal plant Hypericum perforatum are used to treat depression and skin irritation. A major API is hyperforin, characterized by sensitivity to light, oxygen and temperature. Total synthesis of hyperforin is challenging and its content in field-grown plants is variable. We have established in vitro cultures of auxin-induced roots, which are capable of producing hyperforin, as indicated by HPLC-DAD and ESI-MS analyses. The extraction yield and the productivity upon use of petroleum ether after solvent screening were ∼5 mg/g DW and ∼50 mg/L culture after six weeks of cultivation...
March 20, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/26857948/nonpharmacologic-versus-pharmacologic-treatment-of-adult-patients-with-major-depressive-disorder-a-clinical-practice-guideline-from-the-american-college-of-physicians
#11
Amir Qaseem, Michael J Barry, Devan Kansagara
DESCRIPTION: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the comparative effectiveness of treatment with second-generation antidepressants versus nonpharmacologic treatments for major depressive disorder in adults. METHODS: This guideline is based on a systematic review of published, English-language, randomized, controlled trials from 1990 through September 2015 identified using several databases and through hand searches of references of relevant studies...
March 1, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26649557/depression-in-children-and-adolescents-complementary-therapies
#12
Philip Hazell
INTRODUCTION: Depression is the world's leading cause of disability-adjusted life years lost among adolescents. Depression may affect 2% to 8% of children and adolescents, with a peak incidence around puberty. It may be self-limiting, but about 40% of affected children experience a recurrent attack, one third of affected children will make a suicide attempt, and 3% to 4% will die from suicide. METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of complementary treatments for depression in children and adolescents? We searched: Medline, Embase, The Cochrane Library, and other important databases up to August 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview)...
2015: Clinical Evidence
https://www.readbyqxmd.com/read/26634391/st-john-s-wort-and-its-component%C3%A2-hyperforin-alleviate-experimental-autoimmune-encephalomyelitis-through-expansion-of-regulatory-t-cells
#13
Reza Nosratabadi, Maryam Rastin, Mojtaba Sankian, Dariush Haghmorad, Nafiseh Tabasi, Shahrzad Zamani, Azita Aghaee, Zohre Salehipour, Mahmoud Mahmoudi
Multiple sclerosis (MS) is a central nervous system disorder mainly characterized by inflammation, demyelination and axonal injury. Anti-inflammatory agents can be used to ameliorate the disease process. Hypericum perforatum L or St. John's wort is widely used as an anti-depressant and anti-inflammatory remedy in traditional and herbal medicine. Based on St. John's wort properties, the therapeutic potentials of an H. perforatum extract (HPE) and a single component, hyperforin were evaluated for effectiveness against MOG35-55-induced experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis...
May 2016: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/26536653/hypericum-perforatum-use-during-pregnancy-and-pregnancy-outcome
#14
Line Kolding, Lars Henning Pedersen, Tine Brink Henriksen, Jørn Olsen, Luke E Grzeskowiak
Hypericum perforatum (HP; also known as St. John's Wort) is one of the most commonly used herbal therapies in the management of depressive illness. The aim of this study was to evaluate the potential side effects of HP during pregnancy on pregnancy outcome. Using data from the Danish National Birth Cohort (DNBC), we investigated outcomes among 38 HP exposed pregnancies compared to a group of 90,128 women. Associations between HP use and gestational age, preterm birth, birth weight, malformations and Apgar scores were investigated...
December 2015: Reproductive Toxicology
https://www.readbyqxmd.com/read/26510970/antimicrobial-effect-of-the-extracts-from-hypericum-perforatum-against-oral-bacteria-and-biofilm-formation
#15
Ipek Süntar, Ozlem Oyardı, Esra Küpeli Akkol, Berrin Ozçelik
CONTEXT: One traditional medicines, Hypericum perforatum L. (Hypericaceae), possesses several beneficial effects against depression, ulcers, dyspepsia, abdominal pains, burns, bacterial infections, migraine headaches, and sciatica. OBJECTIVE: The present study investigates the antimicrobial activity of the ethanol extract (HP-EtOH) of H. perforatum and its sub-extracts, namely n-hexane (HP-hexane), chloroform (HP-CHCl3), ethyl acetate (HP-EtOAc), n-butanol (HP-n-BuOH), and water (HP-H2O) extracts, against Streptococcus mutans, S...
2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/26384487/hyperforin-to-be-or-not-to-be-an-activator-of-trpc-6
#16
REVIEW
Kristina Friedland, Christian Harteneck
Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the question regarding the underlying mechanism leading to the pharmacological profile of the plant extract used in therapy of depression. We will summarize the different concepts described for hyperforin's antidepressive activity...
2015: Reviews of Physiology, Biochemistry and Pharmacology
https://www.readbyqxmd.com/read/26276913/natural-products-of-relevance-in-the-prevention-and-supportive-treatment-of-depression
#17
Bożena Muszyńska, Maciej Łojewski, Jacek Rojowski, Włodzimierz Opoka, Katarzyna Sułkowska-Ziaja
The use of herbs or their parts: leaves, roots, rhizomes, flowers, seeds, natural strains, as well as extracts or isolated metabolites is becoming more and more popular. Natural remedies not only act prophylactically, but also help to alleviate symptoms of many diseases and enhance the overall functioning of the internal organs. Many raw materials of natural origin plays a role in treatment of health problems, and also in case of serious diseases such as depression. Depression (affective disorder) now affects about 10% of the population, but in next few years due to the development of civilization and increasing pace of life, the probable number of people suffering from this disease can grow rapidly...
May 2015: Psychiatria Polska
https://www.readbyqxmd.com/read/26156546/new-potential-pharmaceutical-applications-of-hypericum-species
#18
Mariangela Marrelli, Giancarlo Statti, Filomena Conforti, Francesco Menichini
The genus Hypericum includes more than 450 species distributed in Europe, North America, North Africa and West Asia. These plants are widely used in folk medicine for the treatment of inflammation, bacterial and viral infections, burns and gastric disorders. The use for alleviating inflammation and promoting wound healing is well known for H. Perforatum L. (St. John's wort) and other species. Because of its pharmacological activity, H. perforatum L. is one of the most important species of this genus. This plant has been largely utilized for its efficacy in the treatment of mild to moderate depression...
2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/26119304/hypericum-perforatum-hydroalcoholic-extract-mitigates-motor-dysfunction-and-is-neuroprotective-in-intrastriatal-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#19
Zahra Kiasalari, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Parkinson's disease is the second most common neurodegenerative disorder with selective and progressive decline of nigral dopaminergic neurons. Hypericum perforatum L. (H. perforatum, St. John's wort) has been traditionally used for management of different disorders, especially mild-to-moderate depression. This study was conducted to evaluate the effect of H. perforatum extract against unilateral striatal 6-hydroxydopamine (6-OHDA) toxicity and to unmask some involved mechanisms. Intrastriatal 6-OHDA-lesioned rats were treated with H...
May 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/26092515/phytopharmaceutical-treatment-of-anxiety-depression-and-dementia-in-the-elderly-evidence-from-randomized-controlled-clinical-trials
#20
Siegfried Kasper
Based on subgroup analyses of randomized, controlled clinical trials, we review the efficacy of three phytopharmaceutical drugs, respectively of the corresponding active substances silexan® (WS® 1265, lavender oil) in anxiety disorders, WS® 5570 (Hypericum extract) in major depression, and EGb 761® (Ginkgo biloba extract) in Alzheimer, vascular, or mixed type dementia, in elderly patients aged ≥ 60 years. Four trials were eligible in each indication. Meta-analyses and analyses based on pooled raw data showed that the three drugs were significantly superior to placebo in the elderly subset, and that their treatment effects reflected in the main outcome measures (Hamilton Anxiety scale, Hamilton Depression scale, Neuropsychiatric Inventory) were comparable with those observed in the original trials without age restrictions...
June 2015: Wiener Medizinische Wochenschrift
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