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Dopamine tonic phasic

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https://www.readbyqxmd.com/read/28739583/tonic-or-phasic-stimulation-of-dopaminergic-projections-to-prefrontal-cortex-causes-mice-to-maintain-or-deviate-from-previously-learned-behavioral-strategies
#1
Ian T Ellwood, Tosha Patel, Varun Wadia, Anthony T Lee, Alayna T Liptak, Kevin J Bender, Vikaas S Sohal
Dopamine neurons in the ventral tegmental area (VTA) encode reward prediction errors and can drive reinforcement learning through their projections to striatum, but much less is known about their projections to prefrontal cortex (PFC). Here we studied these projections, and observed phasic VTA-PFC fiber photometry signals following the delivery of rewards. Next, we studied how optogenetic stimulation of these projections affects behavior, using conditioned place preference (CPP), and a task in which mice learn associations between cues and food rewards, then use those associations to make choices...
July 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28734459/the-roles-of-phasic-and-tonic-dopamine-in-tic%C3%A2-learning-and-expression
#2
REVIEW
Tiago V Maia, Vasco A Conceição
Tourette syndrome (TS) prominently involves dopaminergic disturbances, but the precise nature of those disturbances has remained elusive. A substantial body of empirical work and recent computational models have characterized the specific roles of phasic and tonic dopamine (DA) in action learning and selection, respectively. Using insights from this work and models, we suggest that TS involves increases in both phasic and tonic DA, which produce increased propensities for tic learning and expression, respectively...
June 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28666811/%C3%AE-6%C3%AE-2-subunit-containing-nicotinic-acetylcholine-receptors-exert-opposing-actions-on-rapid-dopamine-signaling-in-the-nucleus-accumbens-of-rats-with-high-versus-low-response-to-novelty
#3
Cody A Siciliano, J Michael McIntosh, Sara R Jones, Mark J Ferris
Determining neurobiological factors that contribute to individual variance in drug addiction vulnerability allows for identification of at-risk populations, use of preventative measures and personalized medicine in the treatment of substance use disorders. Rodents that exhibit high locomotor activity when exploring an inescapable novel environment (high-responder; HR) are more susceptible to the reinforcing effects of many abused compounds, including nicotine, as compared to animals that exhibit low locomotor activity (low-responder; LR)...
June 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28543679/the-missing-the-short-and-the-long-levodopa-responses-and-dopamine-actions
#4
Roger L Albin, Daniel K Leventhal
No abstract text is available yet for this article.
July 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28531297/mechanisms-of-kappa-opioid-receptor-potentiation-of-dopamine-d2-receptor-function-in-quinpirole-induced-locomotor-sensitization-in-rats
#5
Angélica P Escobar, Marcela P González, Rodrigo C Meza, Verónica Noches, Pablo Henny, Katia Gysling, Rodrigo A España, José A Fuentealba, María E Andrés
Background: Increased locomotor activity in response to the same stimulus is an index of behavioral sensitization observed in preclinical models of drug addiction and compulsive behaviors. Repeated administration of Quinpirole (QNP), a D2/D3 dopamine agonist, induces locomotor sensitization. This effect is potentiated and accelerated by co-administration of U69593, a kappa opioid receptor agonist (KOR). The mechanism underlying KOR potentiation of QNP-induced locomotor sensitization remains to be elucidated...
May 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28371807/nicotine-withdrawal-induces-neural-deficits-in-reward-processing
#6
Jason A Oliver, David E Evans, Merideth A Addicott, Geoffrey F Potts, Thomas H Brandon, David J Drobes
Introduction: Nicotine withdrawal reduces neurobiological responses to nonsmoking rewards. Insight into these reward deficits could inform the development of targeted interventions. This study examined the effect of withdrawal on neural and behavioral responses during a reward prediction task. Methods: Smokers (N = 48) attended two laboratory sessions following overnight abstinence. Withdrawal was manipulated by having participants smoke three regular nicotine (0...
June 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28286427/intraindividual-and-interindividual-di%C3%AF-erences-in-spontaneous-eye-blinking-relationships-to-working-memory-performance-and-frontal-eeg-asymmetry
#7
Leigh F Bacher, Shirley Retz, Courtney Lindon, Martha Ann Bell
The rate and timing of spontaneous eye blinking (SB) may be used to explore mechanisms of cognitive activity in infancy. In particular, SB rate is believed to reflect some dimensions of dopamine function; therefore, we hypothesized that SB rate would relate to working memory performance and to frontal electroencephalogram (EEG) asymmetry. Forty, 10-mo-old infants completed an A-not-B task while SB and EEG were measured throughout. We found that SB rate varied across phases of the task, variability in SB rate was positively related to working memory performance, and frontal EEG asymmetry was related to individual differences in the rate of SB...
March 2017: Infancy: the Official Journal of the International Society on Infant Studies
https://www.readbyqxmd.com/read/28196657/dopamine-release-in-the-nucleus-accumbens-is-altered-following-traumatic-brain-injury
#8
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J Hoffer, Jonathan Miller, Yu-Ching Chou, Yung-Hsiao Chiang
Mild-to-severe traumatic brain injury (TBI) is frequently associated with prolonged dysfunction of reward circuitry, including motivation and salience, which suggests alterations of dopamine (DA) processing within the core and shell of the nucleus accumbens (NAC). Using fast-scan cyclic voltammetry in a rodent model of traumatic brain injury, we found that stimulus-evoked DA release is distinct in the core and shell of the NAC, with the shell being less responsive to tonic stimulation and more sensitive to the number of pulses when phasic stimulation is applied...
April 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28145492/hypocretin-orexin-peptides-excite-rat-neuroendocrine-dopamine-neurons-through-orexin-2-receptor-mediated-activation-of-a-mixed-cation-current
#9
David J Lyons, Arash Hellysaz, Rachida Ammari, Christian Broberger
Hypocretin/Orexin (H/O) neurons of the lateral hypothalamus are compelling modulator candidates for the chronobiology of neuroendocrine output and, as a consequence, hormone release from the anterior pituitary. Here we investigate the effects of H/O peptides upon tuberoinfundibular dopamine (TIDA) neurons - cells which control, via inhibition, the pituitary secretion of prolactin. In whole cell recordings performed in male rat hypothalamic slices, application of H/O-A, as well as H/O-B, excited oscillating TIDA neurons, inducing a reversible depolarising switch from phasic to tonic discharge...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28053043/habenula-induced-inhibition-of-midbrain-dopamine-neurons-is-diminished-by-lesions-of-the-rostromedial-tegmental-nucleus
#10
P Leon Brown, Heather Palacorolla, Dana Brady, Katelyn Riegger, Greg I Elmer, Paul D Shepard
Neurons in the lateral habenula (LHb) are transiently activated by aversive events and have been implicated in associative learning. Functional changes associated with tonic and phasic activation of the LHb are often attributed to a corresponding inhibition of midbrain dopamine (DA) neurons. Activation of GABAergic neurons in the rostromedial tegmental nucleus (RMTg), a region that receives dense projections from the LHb and projects strongly to midbrain monoaminergic nuclei, is believed to underlie the transient inhibition of DA neurons attributed to activation of the LHb...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28007998/pathological-glutamatergic-neurotransmission-in-gilles-de-la-tourette-syndrome
#11
Ahmad Seif Kanaan, Sarah Gerasch, Isabel García-García, Leonie Lampe, André Pampel, Alfred Anwander, Jamie Near, Harald E Möller, Kirsten Müller-Vahl
Gilles de la Tourette syndrome is a hereditary, neuropsychiatric movement disorder with reported abnormalities in the neurotransmission of dopamine and γ-aminobutyric acid (GABA). Spatially focalized alterations in excitatory, inhibitory and modulatory neurochemical ratios within specific functional subdivisions of the basal ganglia, may lead to the expression of diverse motor and non-motor features as manifested in Gilles de la Tourette syndrome. Current treatment strategies are often unsatisfactory thus provoking the need for further elucidation of the underlying pathophysiology...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27909103/habenula-induced-inhibition-of-midbrain-dopamine-neurons-is-diminished-by-lesions-of-the-rostromedial-tegmental-nucleus
#12
P Leon Brown, Heather Palacorolla, Dana Brady, Katelyn Riegger, Greg I Elmer, Paul D Shepard
Neurons in the lateral habenula (LHb) are transiently activated by aversive events and have been implicated in associative learning. Functional changes associated with tonic and phasic activation of the LHb are often attributed to a corresponding inhibition of midbrain dopamine (DA) neurons. Activation of GABAergic neurons in the rostromedial tegmental nucleus (RMTg), a region that receives dense projections from the LHb and projects strongly to midbrain monoaminergic nuclei, is believed to underlie the transient inhibition of DA neurons attributed to activation of the LHb...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27883923/gilles-de-la-tourette-syndrome-is-associated-with-hypermethylation-of-the-dopamine-d2-receptor-gene
#13
Kirsten R Müller-Vahl, Gesa Loeber, Alexandra Kotsiari, Linda Müller-Engling, Helge Frieling
Several lines of evidence support a "dopaminergic hypothesis" in the pathophysiology of Gilles de la Tourette syndrome (TS). The aim of this study was to investigate for the first time epigenetic changes in DNA methylation in different dopamine genes in adult patients with TS. We included 51 well characterized adult patients with TS (41 males, 10 females, mean age = 35 ± 12.6 years, range, 18-71 years) and compared results with data from a group of 51 sex- and age-matched healthy controls. Bisulfite sequencing was used to measure peripheral DNA methylation of the dopamine transporter (DAT), the dopamine D2 receptor (DRD2), and the catechol-O-methyltransferase (COMT) genes...
March 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27822182/dopaminergic-medication-modulates-learning-from-feedback-and-error-related-negativity-in-parkinson-s-disease-a-pilot-study
#14
Chiara Volpato, Sami Schiff, Silvia Facchini, Stefano Silvoni, Marianna Cavinato, Francesco Piccione, Angelo Antonini, Niels Birbaumer
Dopamine systems mediate key aspects of reward learning. Parkinson's disease (PD) represents a valuable model to study reward mechanisms because both the disease process and the anti-Parkinson medications influence dopamine neurotransmission. The aim of this pilot study was to investigate whether the level of levodopa differently modulates learning from positive and negative feedback and its electrophysiological correlate, the error related negativity (ERN), in PD. Ten PD patients and ten healthy participants performed a two-stage reinforcement learning task...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27780050/the-basal-ganglia-over-500-million-years
#15
REVIEW
Sten Grillner, Brita Robertson
The lamprey belongs to the phylogenetically oldest group of vertebrates that diverged from the mammalian evolutionary line 560 million years ago. A comparison between the lamprey and mammalian basal ganglia establishes a detailed similarity regarding its input from cortex/pallium and thalamus, as well as its intrinsic organisation and projections of the output nuclei. This means that the basal ganglia circuits now present in rodents and primates most likely had evolved already at the dawn of vertebrate evolution...
October 24, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27774784/monitoring-in-vivo-changes-in-tonic-extracellular-dopamine-level-by-charge-balancing-multiple-waveform-fast-scan-cyclic-voltammetry
#16
Yoonbae Oh, Cheonho Park, Do Hyoung Kim, Hojin Shin, Yu Min Kang, Mark DeWaele, Jeyeon Lee, Hoon-Ki Min, Charles D Blaha, Kevin E Bennet, In Young Kim, Kendall H Lee, Dong Pyo Jang
Dopamine (DA) modulates central neuronal activity through both phasic (second to second) and tonic (minutes to hours) terminal release. Conventional fast-scan cyclic voltammetry (FSCV), in combination with carbon fiber microelectrodes, has been used to measure phasic DA release in vivo by adopting a background subtraction procedure to remove background capacitive currents. However, measuring tonic changes in DA concentrations using conventional FSCV has been difficult because background capacitive currents are inherently unstable over long recording periods...
November 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27739396/neural-substrates-of-trait-impulsivity-anhedonia-and-irritability-mechanisms-of-heterotypic-comorbidity-between-externalizing-disorders-and-unipolar-depression
#17
REVIEW
Aimee Zisner, Theodore P Beauchaine
Trait impulsivity, which is often defined as a strong preference for immediate over delayed rewards and results in behaviors that are socially inappropriate, maladaptive, and short-sighted, is a predisposing vulnerability to all externalizing spectrum disorders. In contrast, anhedonia is characterized by chronically low motivation and reduced capacity to experience pleasure, and is common to depressive disorders. Although externalizing and depressive disorders have virtually nonoverlapping diagnostic criteria in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, heterotypic comorbidity between them is common...
November 2016: Development and Psychopathology
https://www.readbyqxmd.com/read/27677943/high-reward-expectancy-during-methylphenidate-depresses-the-dopaminergic-response-to-gain-and-loss
#18
E A Evers, P Stiers, J G Ramaekers
Dopamine plays an important role in goal-directed behavior, through its modulatory influence on striatal neurons. It is unclear whether tonic dopamine levels, which regulate the vigor of acting, interact with the phasic dopamine response to reward that drives instrumental behavior. In a randomized placebo-controlled study in healthy volunteers, we show that methylphenidate, a drug that increases tonic dopamine levels, systematically reduced striatal phasic BOLD responses to gain and loss in a gambling task as measured with fMRI...
February 1, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/27457507/ppar%C3%AE-modulation-of-mesolimbic-dopamine-transmission-rescues-depression-related-behaviors
#19
Simona Scheggi, Miriam Melis, Marta De Felice, Sonia Aroni, Anna Lisa Muntoni, Teresa Pelliccia, Carla Gambarana, Maria Graziella De Montis, Marco Pistis
Depressive disorders cause a substantial burden for the individual and the society. Key depressive symptoms can be modeled in animals and enable the development of novel therapeutic interventions. Chronic unavoidable stress disrupts rats' competence to escape noxious stimuli and self-administer sucrose, configuring a depression model characterized by escape deficit and motivational anhedonia associated to impaired dopaminergic responses to sucrose in the nucleus accumbens shell (NAcS). Repeated treatments that restore these responses also relieve behavioral symptoms...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27426276/a-randomised-open-label-crossover-study-of-the-dopamine-agonist-pramipexole-in-patients-with-sleep-bruxism
#20
Birgitta Johansson Cahlin, Jan Hedner, Lars Dahlström
Sleep bruxism bears several similarities to restless legs syndrome, and a link to changes in central dopamine activity has been considered in both conditions. The dopamine agonist pramipexole is currently indicated for the symptomatic treatment of restless legs. The effect of pramipexole on sleep bruxism was investigated in subjects with 'probable bruxism' recruited at the Orofacial Pain Clinic. Thirteen patients underwent polysomnographic recordings, including bilateral masseter electromyographic activity...
February 2017: Journal of Sleep Research
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