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Dopamine tonic phasic

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https://www.readbyqxmd.com/read/29773910/the-l-type-calcium-channel-blocker-isradipine-attenuates-cue-induced-cocaine-seeking-by-enhancing-dopaminergic-activity-in-the-ventral-tegmental-area-to-nucleus-accumbens-pathway
#1
Nii A Addy, Eric J Nunes, Shannon M Hughley, Keri M Small, Sarah J Baracz, Joshua L Haight, Anjali M Rajadhyaksha
Previous preclinical and clinical investigations have focused on the L-type calcium channel (LTCC) as a potential therapeutic target for substance abuse. While some clinical studies have examined the ability of LTCC blockers to alter cocaine's subjective effects, very few LTCC studies have examined cocaine relapse. Here, we examined whether ventral tegmental area (VTA)-specific or systemic administration of the LTCC inhibitor, isradipine, altered cocaine-seeking behavior in a rat model. Male Sprague-Dawley rats first received 10 days of cocaine self-administration training (2 h sessions), where active lever depression resulted in delivery of a ∼0...
May 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29760524/what-does-dopamine-mean
#2
REVIEW
Joshua D Berke
Dopamine is a critical modulator of both learning and motivation. This presents a problem: how can target cells know whether increased dopamine is a signal to learn or to move? It is often presumed that motivation involves slow ('tonic') dopamine changes, while fast ('phasic') dopamine fluctuations convey reward prediction errors for learning. Yet recent studies have shown that dopamine conveys motivational value and promotes movement even on subsecond timescales. Here I describe an alternative account of how dopamine regulates ongoing behavior...
May 14, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29746399/tourette-syndrome-clinical-spectrum-mechanisms-and-personalized-treatments
#3
Andreas Hartmann, Yulia Worbe
PURPOSE OF REVIEW: To describe recent advances regarding the disease spectrum in Tourette syndrome, offer new mechanistic insights into tic generation and provide clues for personalized treatments in this disorder. RECENT FINDINGS: Apart from tics, which define Tourette syndrome, comorbidities are the rule and not the exception. They significantly define clinical presentation, disease severity and quality of life. Recent studies have highlighted the importance of screening for depression, anxiety and autism spectrum disorders in Tourette syndrome...
May 8, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29678723/modulatory-effect-of-dopamine-receptor-5-on-the-neurosecretory-dahlgren-cells-of-the-olive-flounder-paralichthys-olivaceus
#4
Zhaohui Lan, Wei Zhang, Jinling Xu, Mo Zhou, Yingxin Chen, Huafeng Zou, Weiqun Lu
A neuromodulatory role for dopamine has been reported for magnocellular neuroendocrine cells in the mammalian hypothalamus. We examined its potential role as a local intercellular messenger in the neuroendocrine Dahlgren cell population of the caudal neurosecretory system (CNSS) of the euryhaline flounder Paralichthys olivaceus. In vitro application of dopamine (DA) caused an increase in electrical activity (firing frequency, recorded extracellularly) of Dahlgren cells, recruitment of previously silent cells, together with a greater proportion of cells showing phasic (irregular) activity...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29656800/dopaminergic-disturbances-in-tourette-syndrome-an-integrative-account
#5
REVIEW
Tiago V Maia, Vasco A Conceição
Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters that cause low tonic but high phasic dopamine, 3) presynaptic dysfunction in dopamine neurons, or 4) dopaminergic hyperinnervation. We review evidence that contradicts the first two hypotheses; we also note that the last two hypotheses have traditionally been considered too narrowly, explaining only small subsets of findings...
March 9, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29608992/central-fatigue-theory-and-endurance-exercise-toward-an-interoceptive-model
#6
REVIEW
Terry McMorris, Martin Barwood, Jo Corbett
We propose a model of exercise-induced central fatigue based on interoception and motivation. Predictions of the expected sensory feedback are fed forward by the dorsolateral (DL) prefrontal cortex (PFC) to the anterior insula cortex (AIC). During exercise, the AIC receives feedback from lamina Ⅰ lateral spinothalamic and nucleus tractus solitarii medullothalamic pathways. The feedback is compared to the predictions in order to generate a current awareness state, which is forwarded to the anterior cingulate cortex (ACC), ventromedial (VM)PFC and lateral (L)PFC...
March 30, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29515787/effect-of-traumatic-brain-injury-on-nicotine-induced-modulation-of-dopamine-release-in-the-striatum-and-nucleus-accumbens-shell
#7
Yuan-Hao Chen, Tung-Tai Kuo, Eagle Yi-Kung Huang, Yu-Ching Chou, Yung-Hsiao Chiang, Barry J Hoffer, Jonathon Miller
Background: Traumatic brain injury is associated with substantial alterations in reward processing, but underlying mechanisms are controversial. Objective: A better understanding of alterations in dopamine (DA) release patterns from the dorsal striatum and nucleus accumbens shell (NAc) may provide insights into posttraumatic reward pathology. Materials and Methods: The patterns of DA release with or without exposure to nicotine in brain slices with striatum and NAc, isolated from Sprague-Dawley rats with 6 psi fluid percussion (FPI) or sham injury were analysis by using fast-scan cyclic voltammetry...
February 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29420469/dopamine-neuron-activity-before-action-initiation-gates-and-invigorates-future-movements
#8
Joaquim Alves da Silva, Fatuel Tecuapetla, Vitor Paixão, Rui M Costa
Deciding when and whether to move is critical for survival. Loss of dopamine neurons (DANs) of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease causes deficits in movement initiation and slowness of movement. The role of DANs in self-paced movement has mostly been attributed to their tonic activity, whereas phasic changes in DAN activity have been linked to reward prediction. This model has recently been challenged by studies showing transient changes in DAN activity before or during self-paced movement initiation...
February 8, 2018: Nature
https://www.readbyqxmd.com/read/29367407/an-interaction-between-serotonin-receptor-signaling-and-dopamine-enhances-goal-directed-vigor-and-persistence-in-mice
#9
Matthew R Bailey, Olivia Goldman, Estefanía P Bello, Muhammad O Chohan, Nuri Jeong, Vanessa Winiger, Eileen Chun, Elke Schipani, Abigail Kalmbach, Joseph F Cheer, Peter D Balsam, Eleanor H Simpson
The functionally selective 5-HT2C receptor ligand SB242084 can increase motivation and have rapid onset anti-depressant-like effects. We sought to identify the specific behavioral effects of SB242084 treatment and elucidate the mechanism in female and male mice. Using a quantitative behavioral approach, we determined that SB242084 increases the vigor and persistence of goal-directed activity across different types of physical work, particularly when work requirements are demanding. We found this influence of SB242084 on effort, rather than reward to be reflected in striatal DA measured during behavior...
February 28, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29175028/17%C3%AE-estradiol-locally-increases-phasic-dopamine-release-in-the-dorsal-striatum
#10
Waqqas M Shams, Marie-Pierre Cossette, Peter Shizgal, Wayne G Brake
Studies using in vivo microdialysis have shown that 17β-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anesthetized (1.5mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29163075/pauses-in-striatal-cholinergic-interneurons-what-is-revealed-by-their-common-themes-and-variations
#11
REVIEW
Yan-Feng Zhang, Stephanie J Cragg
Striatal cholinergic interneurons, the so-called tonically active neurons (TANs), pause their firing in response to sensory cues and rewards during classical conditioning and instrumental tasks. The respective pause responses observed can demonstrate many commonalities, such as constant latency and duration, synchronous occurrence in a population of cells, and coincidence with phasic activities of midbrain dopamine neurons (DANs) that signal reward predictions and errors. Pauses can however also show divergent properties...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29090830/a-novel-biosensor-with-high-signal-to-noise-ratio-for-real-time-measurement-of-dopamine-levels-in-vivo
#12
Akimasa Ishida, Atsushi Imamura, Yoshitomo Ueda, Takeshi Shimizu, Ryosuke Marumoto, Cha-Gyun Jung, Hideki Hida
Fast-scan cyclic voltammetry (FSCV) is an established method for measuring dopamine (DA) levels in the brain in real time. However, it is difficult to discriminate DA from other monoamines such as serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). We report a novel DA-specific biosensor consisting of a carbon-fiber electrode coated with an ion-exchange membrane, a layer containing monoamine oxidase B, and a cellulose membrane. We performed FSCV using the probe to monitor the amount of DA in vitro and in vivo...
November 1, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29056964/hyperbolic-modeling-of-subthalamic-nucleus-cells-to-investigate-the-effect-of-dopamine-depletion
#13
Mohammad Daneshzand, Miad Faezipour, Buket D Barkana
To investigate how different types of neurons can produce well-known spiking patterns, a new computationally efficient model is proposed in this paper. This model can help realize the neuronal interconnection issues. The model can demonstrate various neuronal behaviors observed in vivo through simple parameter modification. The behaviors include tonic and phasic spiking, tonic and phasic bursting, class 1 and class 2 excitability, rebound spike, rebound burst, subthreshold oscillation, and accommodated spiking along with inhibition neuron responses...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28949036/subthalamic-nucleus-and-globus-pallidus-interna-influence-firing-of-tonically-active-neurons-in-the-primate-striatum-through-different-mechanisms
#14
Asuka Nakajima, Yasushi Shimo, Takanori Uka, Nobutaka Hattori
Both the subthalamic nucleus (STN) and the globus pallidus pars interna (GPi) are major targets for neuromodulation therapy for movement disorders. An example of such a therapy is deep brain stimulation (DBS). The striatum is the primary target for pharmacological treatment of these disorders. To further our understanding of both the functional relationships among motor nuclei and the mechanisms of therapies for movement disorders, it is important to clarify how changing the neuronal activity of one target, either by medication or by artificial electrical stimulation, affects the other connected nuclei...
December 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28930994/measuring-in-vivo-changes-in-extracellular-neurotransmitters-during-naturally-rewarding-behaviors-in-female-syrian-hamsters
#15
Kelsey M Moore, Brett T Himmler, Benjamin A Teplitzky, Matthew D Johnson, Robert L Meisel
The ability to measure neurotransmitter release on a rapid time scale allows patterns of neurotransmission to be linked to specific behaviors or manipulations; a powerful tool in elucidating underlying mechanisms and circuitry. While the technique of microdialysis has been used for decades to measure nearly any analyte of interest in the brain, this technique is limited in temporal resolution. Alternatively, fast scan cyclic voltammetry is both temporally precise and extremely sensitive; however, because this technically difficult method relies on the electroactivity of the analyte of interest, the possibility to detect nonelectroactive substances (e...
September 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28739583/tonic-or-phasic-stimulation-of-dopaminergic-projections-to-prefrontal-cortex-causes-mice-to-maintain-or-deviate-from-previously-learned-behavioral-strategies
#16
Ian T Ellwood, Tosha Patel, Varun Wadia, Anthony T Lee, Alayna T Liptak, Kevin J Bender, Vikaas S Sohal
Dopamine neurons in the ventral tegmental area (VTA) encode reward prediction errors and can drive reinforcement learning through their projections to striatum, but much less is known about their projections to prefrontal cortex (PFC). Here, we studied these projections and observed phasic VTA-PFC fiber photometry signals after the delivery of rewards. Next, we studied how optogenetic stimulation of these projections affects behavior using conditioned place preference and a task in which mice learn associations between cues and food rewards and then use those associations to make choices...
August 30, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28734459/the-roles-of-phasic-and-tonic-dopamine-in-tic%C3%A2-learning-and-expression
#17
REVIEW
Tiago V Maia, Vasco A Conceição
Tourette syndrome (TS) prominently involves dopaminergic disturbances, but the precise nature of those disturbances has remained elusive. A substantial body of empirical work and recent computational models have characterized the specific roles of phasic and tonic dopamine (DA) in action learning and selection, respectively. Using insights from this work and models, we suggest that TS involves increases in both phasic and tonic DA, which produce increased propensities for tic learning and expression, respectively...
June 8, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28666811/%C3%AE-6%C3%AE-2-subunit-containing-nicotinic-acetylcholine-receptors-exert-opposing-actions-on-rapid-dopamine-signaling-in-the-nucleus-accumbens-of-rats-with-high-versus-low-response-to-novelty
#18
Cody A Siciliano, J Michael McIntosh, Sara R Jones, Mark J Ferris
Determining neurobiological factors that contribute to individual variance in drug addiction vulnerability allows for identification of at-risk populations, use of preventative measures and personalized medicine in the treatment of substance use disorders. Rodents that exhibit high locomotor activity when exploring an inescapable novel environment (high-responder; HR) are more susceptible to the reinforcing effects of many abused compounds, including nicotine, as compared to animals that exhibit low locomotor activity (low-responder; LR)...
November 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28543679/the-missing-the-short-and-the-long-levodopa-responses-and-dopamine-actions
#19
Roger L Albin, Daniel K Leventhal
No abstract text is available yet for this article.
July 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28531297/mechanisms-of-kappa-opioid-receptor-potentiation-of-dopamine-d2-receptor-function-in-quinpirole-induced-locomotor-sensitization-in-rats
#20
Angélica P Escobar, Marcela P González, Rodrigo C Meza, Verónica Noches, Pablo Henny, Katia Gysling, Rodrigo A España, José A Fuentealba, María E Andrés
Background: Increased locomotor activity in response to the same stimulus is an index of behavioral sensitization observed in preclinical models of drug addiction and compulsive behaviors. Repeated administration of quinpirole, a D2/D3 dopamine agonist, induces locomotor sensitization. This effect is potentiated and accelerated by co-administration of U69593, a kappa opioid receptor agonist. The mechanism underlying kappa opioid receptor potentiation of quinpirole-induced locomotor sensitization remains to be elucidated...
August 1, 2017: International Journal of Neuropsychopharmacology
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