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https://www.readbyqxmd.com/read/27599805/impaired-insulin-sensitivity-and-secretion-in-patients-with-alzheimer-s-disease-the-relationship-with-other-atherosclerosis-risk-factors
#1
Marija Macesic, Nebojsa M Lalic, Vladimir S Kostic, Aleksandra Jotic, Katarina Lalic, Elka Stefanova, Tanja Milicic, Ljiljana Lukic, Jelena Stanarcic Gajovic, Nina Krako
OBJECTIVE: We analysed: (a) insulin sensitivity, (b) insulin secretion capacity, (c) plasma insulin, (d) adiponectin levels, and, (e) lipid parameters in normoglycaemic, nonobese patients with Alzheimer's disease (AD) (group A, n=62), mild cognitive impairment (MCI) (group B, n=41), and healthy controls (group C, n=25). METHOD: Insulin sensitivity was determined both by euglycemic hyperinsulinaemic clamp (M value) and homeostasis model assessment (HOMA-IR), insulin secretion capacity by acute insulin response and first-phase insulin response (FPIR), plasma insulin by RIA and adiponectin by ELISA methods, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides by enzymatic method...
September 5, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27428377/a-novel-microbicide-contraceptive-intravaginal-ring-protects-macaque-genital-mucosa-against-shiv-rt-infection-ex-vivo
#2
Guillermo Villegas, Giulia Calenda, Shweta Ugaonkar, Shimin Zhang, Larisa Kizima, Olga Mizenina, Agegnehu Gettie, James Blanchard, Michael L Cooney, Melissa Robbiani, José A Fernández-Romero, Thomas M Zydowsky, Natalia Teleshova
Women need multipurpose prevention products (MPTs) that protect against sexually transmitted infections (STIs) and provide contraception. The Population Council has developed a prototype intravaginal ring (IVR) releasing the non-nucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 (M), zinc acetate (ZA), carrageenan (CG) and levonorgestrel (LNG) (MZCL IVR) to protect against HIV, HSV-2, HPV and unintended pregnancy. Our objective was to evaluate the anti-SHIV-RT activity of MZCL IVR in genital mucosa...
2016: PloS One
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