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JOURNAL ARTICLE
Song Han Lee, Hyun Gyung Lee, Eun Mi Yang, Chan Jong Kim
PURPOSE: Congenital hypothyroidism (CH) is diagnosed with neonatal screening and is treated early in the neonatal period. Among these patients, transient CH (TCH) is included and requires re-evaluation. The purpose of this study was to find the best way to discontinue levothyroxine and to find trends in thyroid function tests (TFTs) after re-evaluation. METHODS: We retrospectively reviewed 388 patients diagnosed with CH. They were classified as permanent CH (PCH) and TCH...
December 2023: Annals of Pediatric Endocrinology & Metabolism
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JOURNAL ARTICLE
Fabiana Santamaria, Cristiano Scandurra, Selene Mezzalira, Vincenzo Bochicchio, Mariacarolina Salerno, Raffaella Di Mase, Donatella Capalbo
INTRODUCTION: The aim of this study was to evaluate (i) the knowledge about different dimensions of sexual identity in a group of family pediatricians and (ii) the efficacy of a training program to improve knowledge and reduce genderism and heteronormativity. METHODS: A pre-post-follow-up study was conducted with 96 Italian pediatricians (48 men and 48 women) who participated in a 6-h training program and divided into 2 sections. The first section was theoretical and focused on the conceptual foundations of sexual identity, the depathologizing approach to gender diversity, and the role of pediatricians as the first contacts of children's or adolescents' family...
September 25, 2023: Hormone Research in Pædiatrics
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JOURNAL ARTICLE
Shi-En Fu, Rou-Mei Wang, Xing-Huan Liang, Jing Xian, Jie Pan, Xue-Lan Chen, Cheng-Cheng Qiu, Zhi-Ping Tang, Ying-Fen Qin, Hai-Yan Yang, Li-Li Huang, Ya-Qi Kuang, Yan Ma, Zuo-Jie Luo
INTRODUCTION: Chronic thyrotoxic myopathy (CTM) is a common, easily neglected complication of hyperthyroidism. There are currently no standard diagnostic criteria for CTM, and the ultrasonic characteristics of CTM-affected skeletal muscle remain unclear. Herein, we aimed to evaluate hyperthyroid patients for CTM by ultrasound and identify ultrasonic muscle parameter cut-offs for CTM diagnosis. MATERIALS AND METHODS: Each participant underwent ultrasonography. The original (muscle thickness (MT), pennation angle (PA), and cross-sectional area (CSA)) and corrected (MT/height (HT), MT/body mass index (BMI), CSA/HT, and CSA/BMI) parameters of the vastus lateralis (VL) and vastus medialis (VM) were evaluated...
September 1, 2023: Endocrine Connections
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JOURNAL ARTICLE
Timothy Ferrand, Justine Boulant, Chloe He, Jérôme Chambost, Céline Jacques, Chris-Alexandre Pena, Cristina Hickman, Arnaud Reignier, Thomas Fréour
STUDY QUESTION: Can machine learning predict the number of oocytes retrieved from controlled ovarian hyperstimulation (COH)? SUMMARY ANSWER: Three machine-learning models were successfully trained to predict the number of oocytes retrieved from COH. WHAT IS KNOWN ALREADY: A number of previous studies have identified and built predictive models on factors that influence the number of oocytes retrieved during COH. Many of these studies are, however, limited in the fact that they only consider a small number of variables in isolation...
August 15, 2023: Human Reproduction
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JOURNAL ARTICLE
Jeffrey Carbillet, Rupert Palme, Marie-Line Maublanc, Nicolas Cebe, Emmanuelle Gilot-Fromont, Hélène Verheyden, Benjamin Rey
The use of fecal corticosteroid metabolites (FCMs) has proven to be well suited to evaluate adrenocortical activity, a major component of the stress response, particularly in wildlife. As with any tools, confounding factors and drawbacks must be carefully considered. Among them, sample preservation and storage are of particular importance, as they can affect stability of FCMs and lead to biased results and interpretations. Arguably, immediate freezing of fecal samples upon collection is the best practice to preserve FCM integrity, however, for logistical reasons, this condition is rarely feasible in the field...
April 14, 2023: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
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REVIEW
Josephina P M Vrouwe, Pauline M L Hennus, Neveen A T Hamdy, Susanne Osanto, Peter-Paul M Willemse
CONTEXT: Testicular germ cell tumour (TGCT) survivors are potentially at risk of developing osteoporosis, because of increased risk for disturbed bone remodelling associated with hypogonadism and anti-cancer treatment. A number of studies show bone loss and increased fracture risk in TGCT survivors, but data are scarce. There are no clinical guidelines or recommendations issued to address skeletal health in this group of patients potentially at high risk for osteoporosis. OBJECTIVE: To conduct a systematic review of available literature addressing bone health in TGCT patients...
January 2023: BJUI compass
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JOURNAL ARTICLE
Franklin N Tessler, Johnson Thomas
BACKGROUND: Artificial intelligence (AI) is broadly defined as the ability of machines to apply human-like reasoning to problem-solving. Recent years have seen a rapid growth of AI in many disciplines. This review will focus on AI applications in the assessment of thyroid nodules. SUMMARY: AI encompasses two related computational techniques: machine learning, in which computers learn by observing data provided by humans, and deep learning, which employ neural networks that mimic brain structure and function to analyze data...
November 24, 2022: Thyroid: Official Journal of the American Thyroid Association
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REVIEW
Marie-Madeleine Dolmans, Jacques Donnez
Endometriosis is a chronic inflammatory disease causing distressing symptoms and requiring a life-long management strategy. The objective of this review is to evaluate endometriosis-related pathways and identify novel therapies to treat it. We focused on the crucial role of inflammation and inflammatory molecules in order to define new perspectives for non-hormonal treatment of the disease by targeting inflammation, nuclear factor kappa B and cytokines, or reactive oxygen species, apoptotic and autophagic pathways, regulators of epithelial-mesenchymal transition, and angiogenesis and neuroangiogenesis...
November 8, 2022: Biomolecules
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REVIEW
Maria Balomenaki, Dimitra A Vassiliadi, Stylianos Tsagarakis
The treatment of choice for Cushing's disease (CD) is trans-sphenoidal surgery (TSS). However, TSS is not always curative and, even when curative it is associated with a substantial rate of recurrence. Published recurrence rates vary between 5 and 20%; half of these recurrences appear within 5-years and the remaining half within or even after 10 years post-surgery. A low or undetectable cortisol in the immediate post-op period is regarded as the best criterion of remission. However, low post-op cortisol levels do not accurately predict long-term remission...
October 2022: Pituitary
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JOURNAL ARTICLE
Andrea Sabina Llera, Eliana Saul Furquim Werneck Abdelhay, Nora Artagaveytia, Adrián Daneri-Navarro, Bettina Müller, Carlos Velazquez, Elsa B Alcoba, Isabel Alonso, Daniela B Alves da Quinta, Renata Binato, Alicia Inés Bravo, Natalia Camejo, Dirce Maria Carraro, Mónica Castro, Juan M Castro-Cervantes, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raúl Delgadillo-Cisterna, Lucía Delgado, Marisa Dreyer-Breitenbach, Laura Fejerman, Elmer A Fernández, Jorge Fernández, Wanda Fernández, Ramón A Franco-Topete, Carolina Gabay, Fancy Gaete, Adriana Garibay-Escobar, Jorge Gómez, Gonzalo Greif, Thomas G Gross, Marisol Guerrero, Marianne K Henderson, Miguel E Lopez-Muñoz, Alejandra Lopez-Vazquez, Silvina Maldonado, Andrés J Morán-Mendoza, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Miguel A Ortiz-Martínez, Jael Quintero, Antonio Quintero-Ramos, Rui M Reis, Javier Retamales, Ernesto Rivera-Claisse, Darío Rocha, Robinson Rodríguez, Cristina Rosales, Efrain Salas-González, Verónica Sanchotena, Laura Segovia, Juan Martín Sendoya, Aida A Silva-García, Alejandra Trinchero, Olivia Valenzuela, Vidya Vedham, Livia Zagame, Osvaldo L Podhajcer
Purposes: Most molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches. Patients and Methods: We collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort...
2022: Frontiers in Oncology
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REVIEW
Kavita Arora, Sangeeta Sen
In order to meet the global challenges of food security, one of the foremost solutions lies in enhancing the crop productivity. This can be attained by considering key plant hormones such as cytokinins as agrochemicals as cytokinins in particular are known to control the essential processes of the plants. Even though, it has already been established since 1980s that the enzyme, cytokinin oxidase/dehydrogenase (CKO/CKX) deactivates cytokinins; the potential applications of manipulating these enzymes have mostly been speculated to have a high potential in the biotechnology industry and spreads to agriculture, horticulture and agroforestry...
2022: Frontiers in Genetics
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JOURNAL ARTICLE
Sophie Moog, Betty Salgues, Yasmine Braik-Djellas, Thomas Viel, Daniel Balvay, Gwennhael Autret, Estelle Robidel, Anne-Paule Gimenez-Roqueplo, Bertrand Tavitian, Charlotte Lussey-Lepoutre, Judith Favier
Therapies for metastatic SDHB-dependent pheochromocytoma and paraganglioma (PPGL) are limited and poorly efficient. New targeted therapies and identification of early non-invasive biomarkers of response are thus urgently needed for these patients. We characterized an in vivo allograft model of spontaneously immortalized murine chromaffin cells (imCC) with inactivation of the Sdhb gene by dynamic contrast-enhanced MRI (DCE-MRI) and 18FDG-PET. We evaluated the response to several therapies: IACS-010759 (mitochondrial respiratory chain complex I inhibitor), sunitinib (tyrosine kinase inhibitor with anti-angiogenic activity), talazoparib (poly ADP ribose polymerase (PARP) inhibitor) combined or not to temozolomide (alkylating agent), pharmacological inhibitors of HIF2a (PT2385 and PT2977 (belzutifan)) and molecular inactivation of HIF2a (imCC Sdhb-/- shHIF2a)...
May 11, 2022: Endocrine-related Cancer
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JOURNAL ARTICLE
Julia Ramalho Amalio da Silva Breder, Paulo Alonso Garcia Alves, Mario Lucio Araújo, Barbara Pires, Priscila Valverde, Daniel Alves Bulzico, Fernanda Andrade Accioly, Rossana Corbo, Mario Vaisman, Fernanda Vaisman
OBJECTIVE: A sharp increase in pediatric thyroid cancer incidence is observed during adolescence, driven mainly by girls. Differences in disease presentation across sexual maturity stages raise the question of whether sex steroids have a role in the heterogeneity. The aims of this study were to analyze the influence of puberty and sex on clinical presentation and prognosis and to evaluate the correlation between the expression of sex hormone receptors. DESIGN AND METHODS: Clinical records and immunohistochemical of specimens from 79 patients was analyzed...
February 1, 2022: European Thyroid Journal
#14
REVIEW
Shoba Dawson, Lorna Duncan, Ahmed Ahmed, Amy Gimson, Emily J Henderson, Jonathan Rees, Ed Strong, Marcus J Drake, Nikki Cotterill, Alyson L Huntley, Robert C Andrews
CONTEXT: Salt and water homeostasis is regulated hormonally, so polyuria can result from endocrine disease directly or via secondary effects. These mechanisms are not consistently considered in primary care management of nocturia. OBJECTIVE: To conduct a systematic review (SR) of nocturia in endocrine disease and reach expert consensus for primary care management. EVIDENCE ACQUISITION: Four databases were searched from January 2000 to April 2020...
January 2022: European Urology Focus
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JOURNAL ARTICLE
Priscila C Palhares, Isadora de L Assis, Gilmara J Machado, Renata M P de Freitas, Mariella B D de Freitas, Daniella A J Paula, William F Carneiro, Naiara C Motta, Luis D S Murgas
The objective of this study was to evaluate extender supplemented with melatonin and freezing curves on the antioxidant enzyme activity, peroxidation lipid and sperm characteristics of cryopreserved Brycon orbignyanus milt. Males (n = 16) and females (n = 5) were hormonally induced with two doses (0.5 mg and 5.0 mg kg-1 ) of carp pituitary extract, and their gametes were collected by light abdominal massage. The fresh milt was diluted at a ratio of 1:4 (milt:extender) in the following solutions: (Control) 10% methyl glycol (MG) + 5% Beltsville thawing solution; (M1) Control + 1 mM melatonin; and (M2) Control + 2 mM melatonin...
September 20, 2021: Theriogenology
#16
REVIEW
Peter Scalia, Katherine M Tighe, Glyn Elwyn, Pamela J Bagley, Heather B Blunt, Benjamin Boh, Oakland C Walters, Rachel A Moses
BACKGROUND: Transgender and gender diverse (TGD) persons considering gender affirming therapy have to make many complex medical decisions, potentially without understanding the associated harms or benefits of hormonal and surgical interventions. Further, clinicians are often unaware of how best to communicate information to persons seeking gender affirming therapy. Patient decision aids have been developed to provide evidence-based information as a way to help people make decisions in collaboration with their clinicians...
June 2021: Translational Andrology and Urology
#17
JOURNAL ARTICLE
Peng-Fei Zhang, Dan Xie, Qiu Li
Background: The aim of this study is to evaluate the pharmacoeconomic profile of adding enzalutamide to first-line treatment for metastatic, hormone-sensitive prostate cancer (mHSPC) from the US and Chinese payers' perspectives. Materials and Methods: A Markov model with three health states: progression-free survival (PFS), progressive disease (PD), and death, was constructed. All patients were assumed to enter the model in the PFS state and transit according to the transition structure. Efficacy data were derived from the ENZAMET trial and Weibull distribution curves were modeled to fit the survival curves...
2021: Frontiers in Public Health
#18
JOURNAL ARTICLE
J C Trussell, Ava Delu, Robert J Kiltz, Vladimir A Kuznetsov
INTRODUCTION: Men with unexplained infertility (UI) should undergo an initial hormonal evaluation including serum FSH and total testosterone (TT). Unfortunately, there is no consensus regarding which TT cut point should be used to define hypogonadism in such men. To determine the best definition for hypogonadism, three different, literature-based TT cut points were used to assess associations between TT and semen parameters. The hypothesis was that the lowest TT cut point would associate with poorest sperm parameters...
August 2020: Canadian Journal of Urology
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JOURNAL ARTICLE
Thiago Gonçalves de Souza, Rafael Yutaka Kuradomi, Suely Marlene Rodrigues, Sergio Ricardo Batlouni
Breeding technology is of utmost importance for reproduction of wild fish in captivity for the reintroduction and selective breeding programs purposes. The main challenge is that when applied to wild undomesticated specimens, conventional protocols often cause breeders and/or embryo mortality and spawning failure. In this study, we evaluated the reproductive performance of wild Leporinus friderici , a great importance fish for subsistence fishing in South American rivers, applying conventional and lower-dose hormonal therapies by means of two consecutive experiments...
February 20, 2020: Animal Reproduction
#20
REVIEW
An Update on Clinical and Surgical Interventions to Reduce Sperm DNA Fragmentation in Infertile Men.
Sandro C Esteves, Daniele Santi, Manuela Simoni
BACKGROUND: Sperm chromatin integrity is essential for normal embryo development and pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to measure the proportion of sperm with damaged chromatin in the ejaculate. SDF is associated with potentially treatable conditions, including varicocele, male accessory gland infections, inadequate lifestyle, and gonadotoxin exposure, thus prompting their treatment as a means of improving sperm DNA quality and the reproductive outcomes...
November 6, 2019: Andrology
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