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Best way to evaluate hormones

Panpan Zhang, Lin Shen
Multidisciplinary team(MDT) has been considered as the best practice in the treatment planning and care for patients with cancer around the world. With the increased range and number of specialists involved, multidisciplinary coordination and communication have been enhanced, and the efficiency and quality of diagnosis and treatment of cancer have been improved. Neuroendocrine neoplasm (NEN) is a heterogeneous group of tumors originating from neuroendocrine cells located throughout the body, most of which is gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN)...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Silky Jain, Sandeep Jain, Gauri Kapoor, Anju Virmani, Ram Bajpai
BACKGROUND: Acute lymphoblastic leukemia (ALL) and its treatment are often implicated in adversely affecting bone health. Conflicting reports in the literature and a paucity of studies from the developing world prompted us to study bone mineral density (BMD) in childhood ALL survivors. METHODS: BMD lumbar spine (LS) and whole body (WB) were evaluated, using dual energy x-ray absorptiometry in 65 pediatric ALL survivors who had been off-therapy for at least 2 years...
September 26, 2016: Pediatric Blood & Cancer
Bahram Mofid, Hossein Rezaeizadeh, Abdulkarim Termos, Afshin Rakhsha, Ahmad Rezazadeh Mafi, Taiebeh Taheripanah, Mehran Mirabzadeh Ardakani, Seyed Mohammad Esmaeil Taghavi, Seyyed Alireza Moravveji, Amir Shahram Yousefi Kashi
BACKGROUND: Cancer-related fatigue (CRF) is experienced by 50% to 90% of cancer patients and can severely affect their quality of life and functional capacity. Several randomized trials have recommended various ways to alleviate the symptoms of CRF with or without recourse to medications. OBJECTIVE: The aim of this study is to evaluate the effectiveness of processed honey and royal jelly on the symptoms of CRF in cancer patients who are undergoing hormone therapy, chemotherapy, chemo-radiation, or radiotherapy...
June 2016: Electronic Physician
E Griffo, M Cotugno, G Nosso, G Saldalamacchia, A Mangione, L Angrisani, A A Rivellese, B Capaldo
BACKGROUND: Bariatric surgery (BS) is known to favorably impact fasting lipid profile. Fasting and postprandial lipids were evaluated before and 2 years after BS in obese type 2 diabetic (T2DM) patients. METHODS: A prospective study was conducted in 19 obese T2DM patients: ten undergoing sleeve gastrectomy (SG) and nine undergoing Roux-en-Y gastric bypass (RYGB). Before and 2 years after BS, clinical parameters and the response of lipid and incretin hormones to a mixed meal (MM) were assessed...
June 2016: Obesity Surgery
William Mm Levack, Betty Poot, Mark Weatherall, Justin Travers
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) are believed be at higher risk of problems with sexual function than age-matched peers. Problems with sexuality or sexual function associated with COPD may arise as a results of hormonal, physiological, or psychological problems, or as a result of changes in intimate relationships arising from the chronic nature of the condition. OBJECTIVES: To evaluate the effectiveness of interventions for sexual dysfunction in people with COPD...
2015: Cochrane Database of Systematic Reviews
Jessica Pepe, Ivano Mezzaroma, Alessandra Fantauzzi, Mario Falciano, Alessandra Salotti, Mario Di Traglia, Daniele Diacinti, Piergianni Biondi, Cristiana Cipriani, Mirella Cilli, Salvatore Minisola
The best repletion and maintenance dosing regimens with cholecalciferol in vitamin D-deficient HIV-1 patients remain unknown. Protease inhibitors (PIs) have been shown to inhibit vitamin D 1α- and 25α-hydroxylation in hepatocyte and monocyte cultures. We therefore evaluated the effect of a single high dose of cholecalciferol in vitamin D-deficient HIV-1 postmenopausal women undergoing treatment with highly active anti-retroviral therapy (cART), with and without PIs. Forty HIV-1 postmenopausal women treated with cART, with hypovitaminosis D (<20 ng/ml), were enrolled...
July 2016: Endocrine
Thomas P Thomopoulos, Alkistis Skalkidou, Nick Dessypris, George Chrousos, Maria A Karalexi, Theodoros G Karavasilis, Margarita Baka, Emmanuel Hatzipantelis, Maria Kourti, Sophia Polychronopoulou, Vasiliki Sidi, Eftichia Stiakaki, Maria Moschovi, Dimitrios Loutradis, Eleni Th Petridou
The long-term impact of cesarean delivery (CD) on the health of the offspring is being explored methodically. We sought to investigate the effect of birth by (a) prelabor and (b) during-labor CD on the risk of early-onset (≤3 years) acute lymphoblastic leukemia (ALL), specifically of its prevailing precursor B (B-ALL) subtype. A total of 1099 incident cases of ALL (957 B-ALL), 131 of acute myeloid leukemia (AML), and their 1 : 1 age-matched and sex-matched controls, derived from the Nationwide Registry for Childhood Hematological Malignancies (1996-2013), were analyzed using multivariate regression models...
March 2016: European Journal of Cancer Prevention
Brian M Slomovitz, Yunyun Jiang, Melinda S Yates, Pamela T Soliman, Taren Johnston, Maureen Nowakowski, Charles Levenback, Qian Zhang, Kari Ring, Mark F Munsell, David M Gershenson, Karen H Lu, Robert L Coleman
PURPOSE: The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). Hormonal manipulation leads to response in some patients with EC, but resistance derived from PI3K pathway activation has been documented. Targeting mammalian target of rapamycin (mTOR) may overcome endocrine resistance. We conducted a two-institution phase II trial of everolimus and letrozole in women with recurrent EC. PATIENTS AND METHODS: Patients were considered incurable, had measurable disease, and were treated with up to two prior cytotoxic regimens...
March 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Baoxin Zhang, Chunpo Ge, Juan Yao, Yaping Liu, Huichen Xie, Jianguo Fang
Selenium (Se) is an essential micronutrient element, and the biological significance of Se is predominantly dependent on its incorporation as selenocysteine (Sec), the genetically encoded 21st amino acid in protein synthesis, into the active site of selenoproteins, which have broad functions, ranging from redox regulation and anti-inflammation to the production of active thyroid hormones. Compared to its counterpart Cys, there are only limited probes for selective recognition of Sec, and such selectivity is strictly restricted at low pH conditions...
January 21, 2015: Journal of the American Chemical Society
Yuanyuan Cui, Brendan Murphy, Anastasia Gentilcore, Yugal Sharma, Lori M Minasian, Barnett S Kramer, Paul M Coates, John K Gohagan, Juergen Klenk, Bruce Tidor
BACKGROUND: Clinical trials are the main method for evaluating safety and efficacy of medical interventions and have produced many advances in improving human health. The Women's Health Initiative overturned a half-century of harmful practice in hormone therapy, the National Lung Screening Trial identified the first successful lung cancer screening tool and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial overturned decades-long assumptions. While some trials identify unforeseen safety issues or harms, many fail to demonstrate efficacy...
2014: BMC Systems Biology
A Graziottin
UNLABELLED: The contraceptive pill containing estradiol valerate and dienogest meets women's requests for: a more natural contraceptive, that is reliable and easy to use, with positive cosmetic effects; less intense and shorter bleeding, reduced anaemia and increased vital energy; reduced dysmenorrhoea and all the specific cycle-related symptoms linked to a drop in oestrogen and the related systemic inflammation, the result of a hormone free interval (HFI) of just two days; with a good impact on sexuality and overall well-being, all associated with a high level of efficacy: (uncorrected Pearl Index: 0...
October 2014: Minerva Ginecologica
Poupak Fallahi, Silvia Martina Ferrari, Valeria Mazzi, Roberto Vita, Salvatore Benvenga, Alessandro Antonelli
Although generally the prognosis of differentiated thyroid carcinoma (DTC) is good, approximately 5% of people are likely to develop metastases which fail to respond to radioactive iodine, and other traditional therapies, exhibiting a more aggressive behavior. Nowadays, therapy is chosen and implemented on a watch-and-wait basis for most DTC patients. Which regimen is likely to work best is decided on the basis of an individual's clinical information, but only data referring to outcomes of groups of patients are employed...
June 2014: Current Genomics
Edith A Perez, Hope S Rugo, Linda T Vahdat
The treatment of metastatic breast cancer continues to be a challenging area for medical oncologists. Breast tumors are classified into several groups based on immunohistochemistry: those that are estrogen-receptor–positive and human epidermal growth factor receptor 2 (HER2)-negative; those that are HER2-positive and either estrogen-receptor–positive or estrogen-receptor–negative; and those that are negative for the estrogen receptor, progesterone receptor, and HER2 (known as triple-negative). These biologic factors are an important component of the risk assessment and treatment strategy...
2013: Clinical Advances in Hematology & Oncology: H&O
Matthias D'Hondt, Maria Fedorova, Chien-Yu Peng, Bert Gevaert, Lien Taevernier, Ralf Hoffmann, Bart De Spiegeleer
Buserelin is a GnRH agonist peptide drug, comprising a nine amino acid sequence (pGlu-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NH-Et) and most commonly known for its application in hormone dependent cancer therapy, e.g. prostate cancer. In order to evaluate its hot-melt extrusion (HME) capabilities, buserelin powder in its solid state was exposed to elevated temperatures for prolonged time periods. A stability indicating UPLC-PDA method was used for quantification of buserelin and the formed degradants. Different solid state kinetic models were statistically evaluated of which the Ginstling-Brounshtein model fitted the data best...
June 5, 2014: International Journal of Pharmaceutics
S T Chahvar, T Al-Shawaf, A L Tranquilli
The prognosis of malignancies in young women undergoing chemotherapy has dramatically improved recently, and more attention is given to the long term quality of life, including fertility and reproductive function preservation. Some chemotherapeutic drugs are known to be associated with gonadal toxicity (cyclophosphamide, L-phenylanine mustard, busulfan and nitrogen mustard) and others have less or un-quantified effects (doxorubicin, bleomycin, vinca alkaloids, as vincristine and vinblastin, cisplatin, nitrosoureas, cytosine arabinoside)...
2014: Current Medicinal Chemistry
Soodabeh Saeidnia, Mohammad Abdollahi
Phthalic acid esters (PAEs) have been employed in polymer materials as a plasticizer to form them more flexible, adhesive, and soluble. These compounds are mainly used in paints, varnishes, personal cares, cosmetics, paper coatings, and adhesives even in bottled waters, shampoo, body deodorant, hairspray, and gels. Phthalates are able to possess remarkable toxic variations depending on their structures. So far, Di-(2-EthylHexyl) Phthalate DEHP and Di-n- Butyl Phthalate DBP have been found to cause reproductive and developmental toxicities...
2013: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Yanping Gong, Haiying Xiao, Chunlin Li, Jie Bai, Xiaoling Cheng, Mengmeng Jin, Boruo Sun, Yanhui Lu, Yinghong Shao, Hui Tian
OBJECTIVE: To investigate the relationship between sex hormones and the risk of vascular disease in elderly men and to evaluate the advantages and disadvantages of testosterone replacement. METHODS: A total of 337 men, aged 60 to 91 years, were enrolled in this single-center, cross-sectional study, and their sex hormone levels were assessed. Linear and logistic regression analyses were utilized to compare the sex hormone levels between patients with and without vascular disease...
2013: PloS One
Marta Hidalgo-Rodríguez, Sara Soriano-Meseguer, Elisabet Fuguet, Clara Ràfols, Martí Rosés
Several chromatographic systems (three systems of high-performance liquid chromatography and two micellar electrokinetic chromatography systems) besides the reference octanol-water partition system are evaluated by a systematic procedure previously proposed in order to know their ability to model human skin permeation. The precision achieved when skin-water permeability coefficients are correlated against chromatographic retention factors is predicted within the framework of the solvation parameter model. It consists in estimating the contribution of error due to the biological and chromatographic data, as well as the error coming from the dissimilarity between the human skin permeation and the chromatographic systems...
December 18, 2013: European Journal of Pharmaceutical Sciences
N Rives, J P Milazzo, A Perdrix, M Castanet, G Joly-Hélas, L Sibert, A Bironneau, A Way, B Macé
STUDY QUESTION: Is fertility preservation feasible after the onset of puberty in adolescents with Klinefelter syndrome (KS)? SUMMARY ANSWER: Fertility preservation counseling should be an integral part of the care of XXY adolescents. Frozen ejaculated or testicular spermatozoa and even frozen immature germ cells can give them the potential to conceive their genetic progeny. However, no biological or clinical parameters were predictive of mature or immature germ cell retrieval...
June 2013: Human Reproduction
Judy Jin, Matthew T Allemang, Christopher R McHenry
BACKGROUND: The goal of this study was to identify a simple and effective way of calculating levothyroxine doses for postsurgical hypothyroidism. METHODS: Levothyroxine dosage was calculated using a weight (μg/kg)-based formula for patients who underwent thyroidectomy for benign disease from 2001 to 2011. Other formulas using age, sex, ideal body weight, body mass index, and body surface area were also evaluated. RESULTS: Four hundred four patients were included; 85% were women...
March 2013: American Journal of Surgery
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