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salivary hormonal analysis

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https://www.readbyqxmd.com/read/28420859/ultrastructural-and-physico-chemical-characterization-of-saliva-during-menstrual-cycle-in-perspective-of-ovulation-in-human
#1
Ganesan Saibaba, Mahalingam Srinivasan, Archunan Priya Aarthy, Velliyangiri Silambarasan, Govindaraju Archunan
Human saliva is a potential diagnostic fluid and any alteration in body might be reflected in saliva so that saliva is considered as "mirror of the body". Variations in salivary hormone level, ultra structure, pH, flow rate, buffering capacity and electrolytes level are found during menstrual cycle in regard to ovulation. Thirty healthy volunteers were used for the assessment of physico-chemical changes in saliva. Reproductive cycle was categorized as pre-ovulation phase (5 to 12 days), ovulation phase (13 or 14 days) and post-ovulation phase (15 to 25 days) according to salivary arborization test and hormonal analysis...
April 14, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28319688/attenuated-dhea-and-dhea-s-response-to-acute-psychosocial-stress-in-individuals-with-depressive-disorders
#2
Xiaoling Jiang, Wen Zhong, Haiyan An, Mingyu Fu, Yuanyuan Chen, Zhenggang Zhang, Zhongju Xiao
BACKGROUND: In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders. In this study, we examined salivary DHEA, DHEA-S, and cortisol/DHEA response to the Trier Social Stress Test (TSST) in individuals with depressive disorders and in healthy controls to discover whether the responses of DHEA and DHEA-S to acute psychosocial stress could be a more sensitive marker of HPA dysfunction in depressive disorders...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28249655/salivary-gland-pleomorphic-adenoma-in-the-netherlands-a-nationwide-observational-study-of-primary-tumor-incidence-malignant-transformation-recurrence-and-risk-factors-for-recurrence
#3
M H Valstar, M de Ridder, E C van den Broek, M M Stuiver, B A C van Dijk, M L F van Velthuysen, A J M Balm, L E Smeele
INTRODUCTION: Whereas salivary gland pleomorphic adenoma (SGPA) is the most common type of salivary gland tumor, little is known about its epidemiology because national cancer registries do not register this disease. OBJECTIVES: To establish SGPA incidence trends, rates of secondary malignant transformation and recurrence and associated factors in the Netherlands. MATERIALS AND METHODS: Data on incidence, epidemiology, secondary malignant transformation and recurrence were retrieved from the Dutch pathology registry (PALGA) for the years 1992, 1997, 2002, 2007, and 2012...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28139061/immunohistochemical-and-molecular-profile-of-salivary-gland-cancer-in-children
#4
Laura D Locati, Paola Collini, Martina Imbimbo, Marta Barisella, Adele Testi, Lisa F Licitra, Thomas Löning, Katharina Tiemann, Pasquale Quattrone, Emanuela Bimbatti, Stefano Chiaravalli, Michela Casanova, Elena Tamborini, Roberto Carta, Patrizia Gasparini, Marco Guzzo, Maura Massimino, Andrea Ferrari
BACKGROUND: Pediatric salivary gland carcinomas (SGCs) are very rare. They differ from the adult SGCs in terms of epidemiologic and clinical behavior, being generally limited only to selected histotypes (e.g. low-grade mucoepidermoid [LG-MEC] and acinic cell cancer [AcCC]) and characterized by very good outcome. Our aim was to investigate therapeutic targets on a series of pediatric SGCs by immunohistochemical and molecular analysis. METHODS: A retrospective analysis was performed to search for cases of pediatric SGCs in the database of the Pediatric Oncology Unit at the Istituto Nazionale Tumori and in the Pathology database at the Gerhard-Seifert-Reference-Centre...
January 31, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28039871/high-salivary-testosterone-to-androstenedione-ratio-and-adverse-metabolic-phenotypes-in-women-with-polycystic-ovary-syndrome
#5
J Münzker, L Lindheim, J Adaway, C Trummer, E Lerchbaum, T R Pieber, B Keevil, B Obermayer-Pietsch
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by a combination of hormonal and metabolic disturbances, such as insulin resistance, glucose intolerance, anovulation and hyperandrogenism. Clinical phenotypes of PCOS show different patterns of steroid hormones that have been investigated to some extent. This study aimed to establish a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of salivary testosterone and androstenedione and to describe the salivary testosterone-to-androstenedione (T/A4) ratio as a new tool for the assessment of hyperandrogenism and metabolic health...
April 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28006716/biomolecular-aspects-of-depression-a-retrospective-analysis
#6
Brandon N Peacock, David J Scheiderer, Gottfried H Kellermann
OBJECTIVE: The effects of psychological stress, oxidative stress, and chronic low grade inflammation on the neuro-immune connection have been implicated in the pathogenesis of depression. Thus, in the recent past, there has been a growing effort in determining the mechanism of this pathogenesis. While attempting to map out, this mechanism researchers and clinicians have searched for clinically relevant biomarkers for use in the diagnosis and for the assessment of those suffering from depression...
February 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27891109/pulling-rank-military-rank-affects-hormone-levels-and-fairness-in-an-allocation-experiment
#7
Benjamin Siart, Lena S Pflüger, Bernard Wallner
Status within social hierarchies has great effects on the lives of socially organized mammals. Its effects on human behavior and related physiology, however, is relatively little studied. The present study investigated the impact of military rank on fairness and behavior in relation to salivary cortisol (C) and testosterone (T) levels in male soldiers. For this purpose 180 members of the Austrian Armed Forces belonging to two distinct rank groups participated in two variations of a computer-based guard duty allocation experiment...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27777045/playful-activity-post-learning-improves-training-performance-in-labrador-retriever-dogs-canis-lupus-familiaris
#8
Nadja Affenzeller, Rupert Palme, Helen Zulch
Situations that are emotional and arousing have an effect on cognitive performance. It is thought that beta adrenergic activation and the release of stress hormones enhance memory consolidation and lead to an increase in memorability of emotional events. This beneficial effect has been shown in humans, non-human primates and rodents. Techniques which could enhance memory for learning specific tasks would be highly valuable, especially in dogs, which are extensively trained to aid humans. A pseudo-randomized, counterbalanced, between subject study designs was utilised and 16 Labrador Retrievers ranging from 1 to 9years of age were trained in a 2-choice discrimination paradigm...
January 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27723957/potential-detection-of-low-dose-transdermal-testosterone-administration-in-blood-urine-and-saliva
#9
M Schönfelder, H Hofmann, T Schulz, T Engl, D Kemper, B Mayr, C Rautenberg, R Oberhoffer, D Thieme
Administration of low amounts of endogenous hormones - so-called micro-dosages - are supposed to represent a major challenge in doping analysis. To model such a situation, we have studied transdermal administrations of 2.4 mg/24 h testosterone patches and examined various steroid concentrations in blood, urine, and saliva of 11 volunteers. Multiple samples were collected at t = 0, 3, 6, 9, 24, 48, and 72 h in four different phases, i.e., all combinations with/without physical exercise and with/without testosterone...
November 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27589836/the-rate-of-change-in-declining-steroid-hormones-a-new-parameter-of-healthy-aging-in-men
#10
Andreas Walther, Michel Philipp, Niclà Lozza, Ulrike Ehlert
Research on healthy aging in men has increasingly focused on age-related hormonal changes. Testosterone (T) decline is primarily investigated, while age-related changes in other sex steroids (dehydroepiandrosterone [DHEA], estradiol [E2], progesterone [P]) are mostly neglected. An integrated hormone parameter reflecting aging processes in men has yet to be identified. 271 self-reporting healthy men between 40 and 75 provided both psychometric data and saliva samples for hormone analysis. Correlation analysis between age and sex steroids revealed negative associations for the four sex steroids (T, DHEA, E2, and P)...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27536322/evaluation-of-salivary-leptin-levels-in-healthy-subjects-and-patients-with-advanced-periodontitis
#11
Afshin Khorsand, Mojtaba Bayani, Siamak Yaghobee, Sepehr Torabi, Mohammad Javad Kharrazifard, Fatemeh Mohammadnejhad
OBJECTIVES: Leptin is a hormone-like protein produced by the adipose tissue. It plays an important role in protection of host against inflammation and infection. Some studies have reported changes in leptin levels in the gingival crevicular fluid (GCF), saliva and blood serum of patients with periodontal disease compared to healthy individuals. The aim of the present study was to compare the salivary leptin levels in patients with advanced periodontitis and healthy individuals. MATERIALS AND METHODS: In this case-control study, the salivary samples of healthy individuals and patients with advanced periodontitis with clinical attachment loss >5mm were obtained using a standardized method and the leptin levels were measured in the salivary samples by means of ELISA...
January 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27512490/adrenal-cushing-s-syndrome-in-pregnancy-clinical-and-molecular-characterisation-of-a-case
#12
Anne Trinh, Irene Chan, Maria Alexiadis, Medina Pell, Beena Kumar, Peter J Fuller
BACKGROUND: Cushing's syndrome is rare during pregnancy and more commonly due to adrenal pathology, in contrast to the non-pregnant population. Increased levels of cortisol-binding globulin and placental production of corticotropin-releasing hormone and adrenocorticotropic hormone complicate the diagnostic strategies usually employed. CASE: A 32-year-old G1P0 at 15/40 gestation presented with severe peripheral oedema and excessive weight gain. Examination revealed pitting oedema to the abdominal wall, wide violaceous striae, moon facies and acne...
March 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27474909/diurnal-coupling-between-testosterone-and-cortisol-from-adolescence-to-older-adulthood
#13
K Paige Harden, Cornelia Wrzus, Gloria Luong, Andrew Grotzinger, Malek Bajbouj, Antje Rauers, Gert G Wagner, Michaela Riediger
The hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes are typically conceptualized as mutually inhibitory systems; however, previous studies have found evidence for positive within-person associations (i.e., coupling) between cortisol and testosterone. One developmental hypothesis is that positive testosterone-cortisol coupling is unique to the adolescent period and that coupling becomes attenuated, or even switches direction, in adulthood. This study used a lifespan sample (N=292, ages 11-88) to test for age-related differences in coupling between cortisol and testosterone in daily life...
November 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27335194/-sj%C3%A3-gren-s-syndrome-ss-a-review-of-the-subject-and-saliva-as-a-diagnostic-method
#14
REVIEW
Janett Carmen Luzmila Riega-Torres, Antonio Jaime Villarreal-Gonzalez, Luis Ángel Ceceñas-Falcon, Julio Cesar Salas-Alanis
Sjögren's syndrome is a chronic autoimmune disease whose main clinical manifestation is oral dryness (xerostomia) and ocular dryness (xerophthalmia). It is characterized by progressive mononuclear infiltration of the exocrine glands and can affect a variety of organ systems. The prevalence of primary Sjögren's syndrome varies from 0.01 up to 4.8%; this variability reflects differences in definition, application of diagnostic criteria, and geographic differences in age groups. The etiology of primary Sjögren's syndrome is unknown, but the interaction between genetic and environmental factors (viruses, hormones, vitamins, stress) is important...
May 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27315597/a-systematic-review-and-meta-analysis-of-salivary-cortisol-measurement-in-domestic-canines
#15
M L Cobb, K Iskandarani, V M Chinchilli, N A Dreschel
Salivary cortisol is widely used as an indicator of stress and welfare in canine research. However, much remains unclear about the basic features of this hormone marker in domestic dogs. This systematic review and meta-analysis aimed to determine a reference range for cortisol concentration in the saliva of dogs and examine how canine characteristics, environmental effects and experimental considerations relate to salivary cortisol concentrations. A systematic review of literature databases and conference proceedings from 1992 to 2012 identified 61 peer-reviewed studies using domestic dog salivary cortisol...
October 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27235638/stressing-over-anxiety-a-novel-interaction-of-5-httplr-genotype-and-anxiety-related-phenotypes-in-older-adults
#16
Nia Fogelman, Anatoly Mikhailik, Anett Mueller-Alcazar, Kristin Bernard, Turhan Canli
Variation within the serotonin transporter gene-linked polymorphic region (5-HTTPLR) contributes to individual differences in trait neuroticism and increases risk for the development of psychopathology in the context of stressful life events. The underlying mechanisms may involve dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the release of stress-related hormones. Yet, observed effects are small, possibly because they occur against the background of many other, mostly unknown, genetic and environmental variables...
September 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27226164/a-genetic-mosaic-screen-reveals-ecdysone-responsive-genes-regulating-drosophila-oogenesis
#17
Elizabeth T Ables, Grace H Hwang, Danielle S Finger, Taylor D Hinnant, Daniela Drummond-Barbosa
Multiple aspects of Drosophila oogenesis, including germline stem cell activity, germ cell differentiation, and follicle survival, are regulated by the steroid hormone ecdysone. While the transcriptional targets of ecdysone signaling during development have been studied extensively, targets in the ovary remain largely unknown. Early studies of salivary gland polytene chromosomes led to a model in which ecdysone stimulates a hierarchical transcriptional cascade, wherein a core group of ecdysone-sensitive transcription factors induce tissue-specific responses by activating secondary branches of transcriptional targets...
2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/26998108/novel-possibilities-in-the-study-of-the-salivary-proteomic-profile-using-seldi-tof-ms-technology
#18
Fatima Ardito, Donatella Perrone, Roberto Cocchi, Lucio Lo Russo, Alfredo DE Lillo, Giovanni Giannatempo, Lorenzo Lo Muzio
There is currently an increasing interest in exploring human saliva to identify salivary diagnostic and prognostic biomarkers, since the collection of saliva is rapid, non-invasive and stress-free. Diagnostic tests on saliva are common and cost-effective, particularly for patients who need to monitor their hormone levels or the effectiveness of undergoing therapies. Furthermore, salivary diagnostics is ideal for surveillance studies and in situations where fast results and inexpensive technologies are required...
March 2016: Oncology Letters
https://www.readbyqxmd.com/read/26766119/acute-stress-alters-autonomic-modulation-during-sleep-in-women-approaching-menopause
#19
RANDOMIZED CONTROLLED TRIAL
Massimiliano de Zambotti, David Sugarbaker, John Trinder, Ian M Colrain, Fiona C Baker
Hot flashes, hormones, and psychosocial factors contribute to insomnia risk in the context of the menopausal transition. Stress is a well-recognized factor implicated in the pathophysiology of insomnia; however the impact of stress on sleep and sleep-related processes in perimenopausal women remains largely unknown. We investigated the effect of an acute experimental stress (impending Trier Social Stress Task in the morning) on pre-sleep measures of cortisol and autonomic arousal in perimenopausal women with and without insomnia that developed in the context of the menopausal transition...
April 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/26655829/a-longitudinal-analysis-of-women-s-salivary-testosterone-and-intrasexual-competitiveness
#20
Amanda C Hahn, Claire I Fisher, Kelly D Cobey, Lisa M DeBruine, Benedict C Jones
Research on within-subject changes in women's intrasexual competitiveness has generally focused on possible relationships between women's intrasexual competitiveness and estimates of their fertility. While this approach is useful for testing hypotheses about the adaptive function of changes in women's intrasexual competitiveness, it offers little insight into the proximate mechanisms through which such changes might occur. To investigate this issue, we carried out a longitudinal study of the hormonal correlates of changes in intrasexual competitiveness in a large sample of heterosexual women (N=136)...
February 2016: Psychoneuroendocrinology
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