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Autism and diet

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https://www.readbyqxmd.com/read/30005820/dietary-intake-nutrient-status-and-growth-parameters-in-children-with-autism-spectrum-disorder-and-severe-food-selectivity-an-electronic-medical-record-review
#1
William G Sharp, Valentina Postorino, Courtney E McCracken, Rashelle C Berry, Kristen K Criado, T Lindsey Burrell, Lawrence Scahill
BACKGROUND: Food selectivity is common in children with autism spectrum disorder (ASD). The clinical characteristics, however, of severe food selectivity in children with ASD is not well documented. OBJECTIVE: This study examined the demographic characteristics, anthropometric parameters, risk of nutritional inadequacy, dietary variety, and problematic mealtime behaviors in a sample of children with ASD with severe food selectivity. DESIGN: The study involved a cross-sectional electronic medical record review...
July 10, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29983812/associations-between-diet-dietary-and-oral-hygiene-habits-with-caries-occurrence-and-severity-in-children-with-autism-at-dammam-city-saudi-arabia
#2
Sunil Babu Kotha, Norah Saud Mohammed AlFaraj, Tasneem Hassan Ramdan, Maymoonah Abdullah Alsalam, Maryam Jawad Al Ameer, Zainab Mohammed Almuzin
AIM: The purpose of the study is to achieve the baseline information of the autistic child's oral health status about the diet, dietary and hygiene habits. The association of these factors with dental caries were assessed. MATERIAL AND METHODS: The survey was composed of self-administered questionnaires to parents about their children's' demographic data followed by questions related to diet, dietary and hygiene habits. This is later followed by oral examination for estimating the decayed, missing and filled [dmft] scores as per WHO norms...
June 20, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29967385/prenatal-immune-activation-alters-the-adult-neural-epigenome-but-can-be-partly-stabilised-by-a-n-3-polyunsaturated-fatty-acid-diet
#3
Paul Basil, Qi Li, Hongsheng Gui, Tomy C K Hui, Vicki H M Ling, Chloe C Y Wong, Jonathan Mill, Grainne M McAlonan, Pak-Chung Sham
An unstable epigenome is implicated in the pathophysiology of neurodevelopmental disorders such as schizophrenia and autism. This is important because the epigenome is potentially modifiable. We have previously reported that adult offspring exposed to maternal immune activation (MIA) prenatally have significant global DNA hypomethylation in the hypothalamus. However, what genes had altered methylation state, their functional effects on gene expression and whether these changes can be moderated, have not been addressed...
July 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29870270/impact-of-gut-microbiota-on-neurological-diseases-diet-composition-and-novel-treatments
#4
Ana Larroya-García, Diana Navas-Carrillo, Esteban Orenes-Piñero
Gut microbiota has significant effects on the structure and function of the enteric and central nervous system including human behaviour and brain regulation. Herein, we analyze the role of this intestinal ecosystem, the effects of dietary changes and the administration of nutritional supplements, such as probiotics, prebiotics, or fecal transplantation in neuropsychiatric disorders. Numerous factors have been highlighted to influence gut microbiota composition, including genetics, health status, mode of birth delivery and environment...
June 5, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29868601/dietary-considerations-in-autism-spectrum-disorders-the-potential-role-of-protein-digestion-and-microbial-putrefaction-in-the-gut-brain-axis
#5
REVIEW
Megan R Sanctuary, Jennifer N Kain, Kathleen Angkustsiri, J Bruce German
Children with autism spectrum disorders (ASD), characterized by a range of behavioral abnormalities and social deficits, display high incidence of gastrointestinal (GI) co-morbidities including chronic constipation and diarrhea. Research is now increasingly able to characterize the "fragile gut" in these children and understand the role that impairment of specific GI functions plays in the GI symptoms associated with ASD. This mechanistic understanding is extending to the interactions between diet and ASD, including food structure and protein digestive capacity in exacerbating autistic symptoms...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29868333/the-effects-of-a-video-enhanced-schedule-on-exercise-behavior
#6
Raquel Torres, Ruth M DeBar, Sharon A Reeve, Linda S Meyer, Tina M Covington
Research focusing on physical exercise and individuals with autism spectrum disorder (ASD) is limited. Activity- and video-enhanced schedules have successfully increased leisure, academic, social, and daily living skills for individuals with ASD and may be effective in increasing exercise. We evaluated the effects of a video-enhanced schedule presented on an iPad® on exercise behavior with adolescents with ASD using a multiple probe across participants design. Specifically, the effects of a video-enhanced exercise schedule with graduated guidance on independent schedule-following behavior and on-task behavior was evaluated...
June 2018: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29846886/are-therapeutic-diets-an-emerging-additional-choice-in-autism-spectrum-disorder-management
#7
REVIEW
M Gogou, G Kolios
BACKGROUND: A nutritional background has been recognized in the pathophysiology of autism and a series of nutritional interventions have been considered as complementary therapeutic options. As available treatments and interventions are not effective in all individuals, new therapies could broaden management options for these patients. Our aim is to provide current literature data about the effect of therapeutic diets on autism spectrum disorder. DATA SOURCE: A systematic review was conducted by two reviewers independently...
June 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29780794/pediatric-scurvy-when-contemporary-eating-habits-bring-back-the-past
#8
Alice Brambilla, Cristina Pizza, Donatella Lasagni, Lucia Lachina, Massimo Resti, Sandra Trapani
Vitamin C deficiency is anecdotal in developed countries, mainly associated with underling clinical morbidities as autism or neurological impairment. Chronic insufficient dietary supply is responsible for vascular fragility and impaired bone formation, resulting in gingival bleeding, petechial lesions, articular and bone pain or limb swelling. Children may present anorexia, irritability, failure to thrive, limping or refusal to walk. Accordingly, pediatric scurvy is frequently misdiagnosed with osteomyelitis, septic arthritis, bone and soft tissue tumor, leukemia, bleeding disorders, and rheumatologic conditions...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29669486/diet-the-keystone-of-autism-spectrum-disorder
#9
S Peretti, M Mariano, C Mazzocchetti, M Mazza, M C Pino, A Verrotti Di Pianella, M Valenti
Children with autism are characterized by an impairment of social interaction and repetitive patterns of behaviour. Autism is a heterogeneous span of disorders with unknown aetiology. Research has grown significantly and has suggested that environmental risk factors acting during the prenatal period could influence the neurodevelopment of offspring. The literature suggests that the maternal diet during pregnancy has a fundamental role in the etiopathogenesis of autism. Indeed, a maternal diet that is high in some nutrients has been associated with an increase or reduction in the risk of develop Autism Spectrum Disorders (ASD)...
April 19, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29655594/no-effect-of-prenatal-vitamin-d-deficiency-on-autism-relevant-behaviours-in-multiple-inbred-strains-of-mice
#10
M Langguth, M Fassin, S Alexander, K M Turner, T H J Burne
Autism Spectrum Disorders (ASD) is a group of neurodevelopmental disorders commonly characterised by verbal and non-verbal communication deficits, impaired social interaction and repetitive, stereotypic behaviours. The aetiology of ASD is most likely a combination of genetic and environmental factors. Epidemiological evidence suggests that prenatal vitamin D deficiency is associated with an increased incidence of ASD. The overall aim of this study was to investigate prenatal vitamin D deficiency on ASD-related behavioural phenotypes in multiple inbred strains of mice...
August 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29644487/therapeutic-use-of-carbohydrate-restricted-diets-in-an-autistic-child-a-case-report-of-clinical-and-18fdg-pet-findings
#11
Iwona Żarnowska, Beata Chrapko, Grażyna Gwizda, Anna Nocuń, Krystyna Mitosek-Szewczyk, Maciej Gasior
The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that has been used successfully in the treatment of refractory epilepsies for almost 100 years. There has been accumulating evidence to show that the KD may provide a therapeutic benefit in autism spectrum disorders, albeit by a yet-unknown mechanism. We report a case of a 6-year-old patient with high-functioning autism and subclinical epileptic discharges who responded poorly to several behavioural and psychopharmacological treatments...
April 11, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29600698/role-of-microbiota-in-the-autism-spectrum-disorders
#12
Daniela Campion, Paola Ponzo, Carlo Alessandria, Giorgio M Saracco, Federico Balzola
Autism Spectrum Disorder (ASD) defines a set of neurodevelopmental disorders characterized by persistent deficits in social communication and interaction, along with repetitive patterns of behavior. Symptoms generally appear in the early developmental period and cause significant impairment in individual and social functioning. In recent years the increased prevalence of ASD, along with the evidence of a significant link between autism and gastrointestinal (GI) disturbances, raised a special interest in exploringì the reciprocal influences between gut and brain...
March 30, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29563885/interplay-between-peripheral-and-central-inflammation-in-autism-spectrum-disorders-possible-nutritional-and-therapeutic-strategies
#13
REVIEW
Claudia Cristiano, Adriano Lama, Francesca Lembo, Maria P Mollica, Antonio Calignano, Giuseppina Mattace Raso
Pre- and post-natal factors can affect brain development and function, impacting health outcomes with particular relevance to neurodevelopmental diseases, such as autism spectrum disorders (ASDs). Maternal obesity and its associated complications have been related to the increased risk of ASDs in offspring. Indeed, animals exposed to maternal obesity or high fat diets are prone to social communication impairment and repetitive behavior, the hallmarks of autism. During development, fatty acids and sugars, as well as satiety hormones, like insulin and leptin, and inflammatory factors related to obesity-induced low grade inflammation, could play a role in the impairment of neuroendocrine system and brain neuronal circuits regulating behavior in offspring...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29562612/comprehensive-nutritional-and-dietary-intervention-for-autism-spectrum-disorder-a-randomized-controlled-12-month-trial
#14
James B Adams, Tapan Audhya, Elizabeth Geis, Eva Gehn, Valeria Fimbres, Elena L Pollard, Jessica Mitchell, Julie Ingram, Robert Hellmers, Dana Laake, Julie S Matthews, Kefeng Li, Jane C Naviaux, Robert K Naviaux, Rebecca L Adams, Devon M Coleman, David W Quig
This study involved a randomized, controlled, single-blind 12-month treatment study of a comprehensive nutritional and dietary intervention. Participants were 67 children and adults with autism spectrum disorder (ASD) ages 3-58 years from Arizona and 50 non-sibling neurotypical controls of similar age and gender. Treatment began with a special vitamin/mineral supplement, and additional treatments were added sequentially, including essential fatty acids, Epsom salt baths, carnitine, digestive enzymes, and a healthy gluten-free, casein-free, soy-free (HGCSF) diet...
March 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29559544/vitamin-d-is-crucial-for-maternal-care-and-offspring-social-behaviour-in-rats
#15
Nathanael J Yates, Dijana Tesic, Kirk W Feindel, Jeremy T Smith, Michael W Clarke, Celeste Wale, Rachael C Crew, Michaela D Wharfe, Andrew J O Whitehouse, Caitlin S Wyrwoll
Early life vitamin D plays a prominent role in neurodevelopment and subsequent brain function, including schizophrenic-like outcomes and increasing evidence for an association with autism spectrum disorder (ASD). Here, we investigate how early life vitamin D deficiency during rat pregnancy and lactation alters maternal care and influences neurodevelopment and affective, cognitive and social behaviours in male adult offspring. Sprague-Dawley rats were placed on either a vitamin D control (2195 IU/kg) or deficient diet (0 IU/kg) for five weeks before timed mating, and diet exposure was maintained until weaning of offspring on postnatal day (PND) 23...
May 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29526827/toxin-profile-of-fecal-clostridium-perfringens-strains-isolated-from-children-with-autism-spectrum-disorders
#16
Bartłomiej Góra, Zygmunt Gofron, Magdalena Grosiak, Małgorzata Aptekorz, Beata Kazek, Piotr Kocelak, Halina Radosz-Komoniewska, Jerzy Chudek, Gayane Martirosian
Infectious factors are taken into consideration in pathophysiology of autism spectrum disorders (ASD). ASD patients often suffer from gastrointestinal disorders. The intestinal microbiota of autistic patients significantly differs from that in healthy individuals. The aim of the study was to compare the profile of toxins produced by C. perfringens strains isolated from feces of children with ASD, with healthy individuals and obese subjects. This study included 111 strains of C. perfringens: 49 isolates from 29 children with ASD, 30 - from 17 healthy individuals and 32 - from 24 young obese subjects...
June 2018: Anaerobe
https://www.readbyqxmd.com/read/29425711/scurvy-as-a-mimicker-of-osteomyelitis-in-a-child-with-autism-spectrum-disorder
#17
Laura M Kinlin, Ana C Blanchard, Shawna Silver, Shaun K Morris
A case of scurvy in a 10-year-old boy with autism spectrum disorder is described. His clinical presentation was initially thought to be due to osteomyelitis, for which empirical antimicrobial therapy was initiated. Further invasive and ultimately unnecessary investigations were avoided when scurvy was considered in the context of a restricted diet and classic signs of vitamin C deficiency. Infectious diseases specialists should be aware of scurvy as an important mimicker of osteoarticular infections when involved in the care of patients at risk of nutritional deficiencies...
April 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29421589/a-modified-ketogenic-gluten-free-diet-with-mct-improves-behavior-in-children-with-autism-spectrum-disorder
#18
Ryan W Y Lee, Michael J Corley, Alina Pang, Gaye Arakaki, Lisa Abbott, Michael Nishimoto, Rob Miyamoto, Erica Lee, Susan Yamamoto, Alika K Maunakea, Annette Lum-Jones, Miki Wong
No abstract text is available yet for this article.
May 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29411548/searching-for-the-gut-microbial-contributing-factors-to-social-behavior-in-rodent-models-of-autism-spectrum-disorder
#19
REVIEW
Brittany D Needham, Weiyi Tang, Wei-Li Wu
Social impairment is one of the major symptoms in multiple psychiatric disorders, including autism spectrum disorder (ASD). Accumulated studies indicate a crucial role for the gut microbiota in social development, but these mechanisms remain unclear. This review focuses on two strategies adopted to elucidate the complicated relationship between gut bacteria and host social behavior. In a top-down approach, researchers have attempted to correlate behavioral abnormalities with altered gut microbial profiles in rodent models of ASD, including BTBR mice, maternal immune activation (MIA), maternal valproic acid (VPA) and maternal high-fat diet (MHFD) offspring...
May 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29409733/nutrition-and-bone-density-in-boys-with-autism-spectrum-disorder
#20
Ann M Neumeyer, Natalia Cano Sokoloff, Erin I McDonnell, Eric A Macklin, Christopher J McDougle, Tara M Holmes, Jane L Hubbard, Madhusmita Misra
BACKGROUND: Boys with autism spectrum disorder (ASD) have lower bone mineral density (BMD) than typically developing controls. Differences in diet and exercise may contribute to low BMD. OBJECTIVE: Our aim was to examine macro- and micronutrient intakes and self-reported physical activity in boys with ASD compared to TDC and the relationship of these variables with BMD. DESIGN/METHODS: We conducted a cross-sectional study of 49 boys (25 ASD, 24 typically developing controls) assessed for 3-day food records and physical activity records, and BMD of the whole body less head, hip, and spine using dual-energy x-ray absorptiometry...
May 2018: Journal of the Academy of Nutrition and Dietetics
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