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Brain perfusion imaging

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https://www.readbyqxmd.com/read/29441225/assessment-of-the-agreement-between-cerebral-hemodynamic-indices-quantified-using-dynamic-susceptibility-contrast-and-dynamic-contrast-enhanced-perfusion-magnetic-resonance-imagings
#1
Seyed Salman Zakariaee, Mohammad Ali Oghabian, Kavous Firouznia, Guive Sharifi, Farshid Arbabi, Farhad Samiei
Background: Brain tumor is one of the most common tumors. A successful treatment might be achieved with an early identification. Pathological investigation as the gold standard method for tumor identification has some limitations. Noninvasive assessment of tumor specifications may be possible using perfusion-weighted magnetic resonance imaging (MRI). Cerebral blood volume (CBV) and cerebral blood flow (CBF) could be calculated based on dynamic contrast-enhanced MRI (DCE-MRI) in addition to dynamic susceptibility contrast MRI (DSC-MRI) modality...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29439196/reduced-intravoxel-incoherent-motion-microvascular-perfusion-predicts-delayed-cerebral-ischemia-and-vasospasm-after-aneurysm-rupture
#2
Jeremy J Heit, Max Wintermark, Blake W Martin, Guangming Zhu, Michael P Marks, Greg Zaharchuk, Robert L Dodd, Huy M Do, Gary K Steinberg, Maarten G Lansberg, Gregory W Albers, Christian Federau
BACKGROUND AND PURPOSE: Proximal artery vasospasm and delayed cerebral ischemia (DCI) after cerebral aneurysm rupture result in reduced cerebral perfusion and microperfusion and significant morbidity and mortality. Intravoxel incoherent motion (IVIM) magnetic resonance imaging extracts microvascular perfusion information from a multi-b value diffusion-weighted sequence. We determined whether decreased IVIM perfusion may identify patients with proximal artery vasospasm and DCI. METHODS: We performed a pilot retrospective cohort study of patients with ruptured cerebral aneurysms...
February 9, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29436885/cerebral-perfusion-and-compensatory-blood-supply-in-patients-with-recent-small-subcortical-infarcts
#3
Salvatore Rudilosso, Carlos Laredo, Marco Mancosu, Nuria Moya-Planas, Yashu Zhao, Oscar Chirife, Ángel Chamorro, Xabier Urra
Hypoperfusion is the typical perfusion pattern associated with recent small subcortical infarcts of the brain, but other perfusion patterns may be present in patients with these infarcts. Using CT perfusion, we studied 67 consecutive patients who had a small subcortical infarct at a follow-up MRI study to investigate the correlation between the perfusion pattern and the clinical and radiological course. On CT perfusion map analysis, 51 patients (76%) had focal hypoperfusion, 4 patients (6%) had hyperperfusion and the remaining 12 patients (18%) showed no abnormalities...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29436733/placental-perfusion-imaging-using-velocity-selective-arterial-spin-labeling
#4
Zungho Zun, Catherine Limperopoulos
PURPOSE: The placenta remains the least understood human organ, in large part because of the lack of noninvasive tools currently available to examine placental function in vivo. This study investigates the feasibility of using velocity-selective arterial spin labeling (VSASL) to assess placental perfusion. METHODS: In placental perfusion imaging, VSASL was compared with pseudocontinuous ASL (PCASL), which is currently the standard technique in brain arterial spin labeling (ASL)...
February 13, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29429985/posterior-associative-and-cingulate-cortex-involvement-of-brain-single-photon-emission-computed-tomography-spect-imaging-in-semantic-dementia-with-probable-alzheimer-disease-pathology-a-case-report
#5
Yumi Takano, Keiko Kunitoki, Yasuko Tatewaki, Tatsushi Mutoh, Tomoko Totsune, Hideo Shimomura, Manabu Nakagawa, Hiroyuki Arai, Yasuyuki Taki
BACKGROUND Semantic dementia (SD) is a type of primary progressive aphasia with prominent language dysfunction, mostly within the spectrum of frontotemporal lobar degeneration (FTLD). Although there is an overlap in clinical manifestations of SD attributable to FTLD and neuropathologically proven Alzheimer disease (AD), clinical diagnostic clues are not readily available. We present a characteristic finding based on a single-photon emission computed tomography (SPECT)-based regional cerebral blood flow study and its statistical imaging analysis for a rare case of SD with AD-like pathology...
February 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29428249/computed-tomography-perfusion-aids-in-the-prognostication-of-comatose-postcardiac-arrest-patients
#6
Jai Jai Shiva Shankar, Brandie Stewart-Perrin, Ata-Ur-Rehman Quraishi, Iqbal Bata, Robert Vandorpe
Early assessment of the potential for neurologic recovery in comatose cardiac arrest patients (CCAP) has been a challenge despite significant evolution in management and imaging techniques. The purpose of study was to determine if the use of computed tomography perfusion (CTP) in CCAPs is feasible and if this technique can predict the likelihood that CCAPs will have a devastating outcome at hospital discharge. We prospectively enrolled 10 newly admitted comatose adults who had an out-of-hospital cardiac arrest and were treated with standard therapeutic hypothermia protocols...
January 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29417380/assessing-long-term-neuroinflammatory-responses-to-encephalopathy-using-mri-approaches-in-a-rat-endotoxemia-model
#7
Rheal A Towner, D Saunders, N Smith, W Towler, M Cruz, S Do, J E Maher, K Whitaker, M Lerner, K A Morton
Sepsis-associated encephalopathy (SAE) induces neuroinflammation, which is associated with cognitive impairment (CI). CI is also correlated with aging. We used contrast-enhanced magnetic resonance imaging (MRI), perfusion MRI, and MR spectroscopy to assess long-term alterations in BBB permeability, microvascularity, and metabolism, respectively, in a rat lipopolysaccharide-induced SAE model. Free radical-targeted molecular MRI was used to detect brain radical levels at 24 h and 1 week post-LPS injection. CE-MRI showed increased Gd-DTPA uptake in LPS rat brains at 24 h in cerebral cortex, hippocampus, thalamus, and perirhinal cortex regions...
February 7, 2018: GeroScience
https://www.readbyqxmd.com/read/29412496/characterization-of-active-and-infiltrative-tumorous-subregions-from-normal-tissue-in-brain-gliomas-using-multiparametric-mri
#8
Anahita Fathi Kazerooni, Mahnaz Nabil, Mehdi Zeinali Zadeh, Kavous Firouznia, Farid Azmoudeh-Ardalan, Alejandro F Frangi, Christos Davatzikos, Hamidreza Saligheh Rad
BACKGROUND: Targeted localized biopsies and treatments for diffuse gliomas rely on accurate identification of tissue subregions, for which current MRI techniques lack specificity. PURPOSE: To explore the complementary and competitive roles of a variety of conventional and quantitative MRI methods for distinguishing subregions of brain gliomas. STUDY TYPE: Prospective. POPULATION: Fifty-one tissue specimens were collected using image-guided localized biopsy surgery from 10 patients with newly diagnosed gliomas...
February 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29412000/measurement-of-the-perfusion-fraction-in-brain-tumors-with-intravoxel-incoherent-motion-mr-imaging-validation-with-histopathologic-vascular-density-in-meningiomas
#9
Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Koji Yoshimoto, Daisuke Kuga, Masahiro Mizoguchi, Satoshi O Suzuki, Toru Iwaki, Marc Van Cauteren, Koji Iihara, Hiroshi Honda
OBJECTIVE: To evaluate the quantification performance of the perfusion fraction (f) measured with intravoxel incoherent motion (IVIM) MR imaging in a comparison with the histologic vascular density in meningiomas. METHODS: Twenty-nine consecutive patients with meningioma (59.0 ± 16.8 years old, 8 males and 21 females) who underwent a subsequent surgical resection were examined with both IVIM imaging and a histopathologic analysis. IVIM imaging was conducted using a single-shot SE-EPI sequence with 13 b-factors (0, 10, 20, 30, 50, 80, 100, 200, 300, 400, 600, 800, 1000 s mm-2) at 3T...
February 7, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29409311/effect-of-multiple-intraperitoneal-injections-of-human-bone-marrow-mesenchymal-stem-cells-on-cuprizone-model-of-multiple-sclerosis
#10
Mohsen Marzban, Kazem Mousavizadeh, Masoomeh Bakhshayesh, Nasim Vousooghi, Gelareh Vakilzadeh, Anahita Torkaman-Boutorabi
Background: Bone marrow mesenchymal stem cells (BM-MSCs) elicit neuroprotective effects, and their repair ability has been investigated in different experimental models. We aimed to investigate the effect of multiple i.p. BM-MSCs injections in the cuprizone model of multiple sclerosis in mice. Methods: Adult male C57BL/6 mice (n = 40) were fed a regular diet or a diet containing cuprizone (0.2% w/w) for 6 six weeks. Bone marrow samples were taken from patients with spinal cord injury...
February 7, 2018: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29405229/effects-of-omega-3-fatty-acids-on-resting-cerebral-perfusion-in-patients-with-mild-cognitive-impairment-a-randomized-controlled-trial
#11
C Schwarz, M Wirth, L Gerischer, U Grittner, A V Witte, T Köbe, A Flöel
Alteration of cerebral perfusion can be considered as a possible therapeutic target in mild cognitive impairment. This randomized, placebo-controlled, double-blind proof-of-concept study assessed effects of omega-3 fatty acids on cerebral perfusion in patients with mild cognitive impairment. In thirteen patients (omega:n=5; placebo:n=8) cerebral perfusion was measured before and after 26-weeks intervention within posterior cortical regions using magnetic resonance imaging. There was a medium effect of intervention on cerebral blood flow (η2=0...
2018: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29402765/computed-tomography-perfusion-derived-blood-brain-barrier-permeability-does-not-yet-improve-prediction-of-hemorrhagic-transformation
#12
Alexander D Horsch, Edwin Bennink, Tom van Seeters, L Jaap Kappelle, Yolanda van der Graaf, Willem P T M Mali, Hugo W A M de Jong, Birgitta K Velthuis, Jan Willem Dankbaar
INTRODUCTION: Hemorrhagic transformation (HT) in acute ischemic stroke can occur as a result of reperfusion treatment. While withholding treatment may be warranted in patients with increased risk of HT, prediction of HT remains difficult. Nonlinear regression analysis can be used to estimate blood-brain barrier permeability (BBBP). The aim of this study was to identify a combination of clinical and imaging variables, including BBBP estimations, that can predict HT. MATERIALS AND METHODS: From the Dutch acute stroke study, 545 patients treated with intravenous recombinant tissue plasminogen activator and/or intra-arterial treatment were selected, with available admission extended computed tomography (CT) perfusion and follow-up imaging...
January 8, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29398151/differentiation-between-radiation-induced-brain-injury-and-glioma-recurrence-using-3d-pcasl-and-dynamic-susceptibility-contrast-enhanced-perfusion-weighted-imaging
#13
Yu-Lin Wang, Si Chen, Hua-Feng Xiao, Ying Li, Yan Wang, Gang Liu, Xin Lou, Lin Ma
PURPOSE: This study was performed to validate the efficacy of three-dimensional pseudocontinuous arterial spin labeling (pCASL) compared with dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI) in distinguishing radiation-induced brain injury from glioma recurrence in patients with glioma. METHODS: Both 3D pCASL and DSC-PWI were performed using a 3.0 Tesla scanner in 69 patients with previously resected and irradiated glioma who displayed newly developed abnormal contrast-enhanced lesions...
February 1, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29392588/clinical-applicability-of-and-changes-in-perfusion-mr-imaging-in-brain-metastases-after-stereotactic-radiotherapy
#14
M Kerkhof, I Ganeff, R G J Wiggenraad, G J Lycklama À Nijeholt, S Hammer, M J B Taphoorn, L Dirven, M J Vos
To assess the applicability of perfusion-weighted (PWI) magnetic resonance (MR) imaging in clinical practice, as well as to evaluate the changes in PWI in brain metastases before and after stereotactic radiotherapy (SRT), and to correlate these changes to tumor status on conventional MR imaging. Serial MR images at baseline and at least 3 and 6 months after SRT were retrospectively evaluated. Size of metastases and the relative cerebral blood volume (rCBV), assessed with subjective visual inspection in the contrast enhanced area, were evaluated at each time point...
February 1, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29391824/altered-perfusion-of-the-sensorimotor-cortex-in-patients-with-cervical-spondylotic-myelopathy-an-arterial-spin-labeling-study
#15
Fuqing Zhou, Muhua Huang, Lin Wu, Yongming Tan, Jianqiang Guo, Yong Zhang, Laichang He, Honghan Gong
Objective: Advanced magnetic resonance imaging studies have shown functional plasticity or reorganization and metabolite alterations of N-acetyl aspartate in the sensorimotor cortex (SMC), a hallmark region and key brain network, in patients with cervical spondylotic myelopathy (CSM). However, the nature of perfusion in the SMC and the relationship between regional cerebral blood flow (CBF), motor function scores, and structural damage of the cervical cord in patients with CSM are not fully understood...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29390403/tumor-recurrence-versus-treatment-effects-in-glioma-a-comparative-study-of-three-dimensional-pseudo-continuous-arterial-spin-labeling-and-dynamic-susceptibility-contrast-imaging
#16
Qian Xu, Qi Liu, Haitao Ge, Xinting Ge, Jiangfen Wu, Jianxun Qu, Kai Xu
BACKGROUND: Gliomas constitute over 90% of primary brain tumors. Accurate identification of glioma recurrence and treatment effects is important, as it can help determine whether to continue with standard adjuvant chemotherapy or to switch to a second-line therapy for recurrence. Our purpose is to compare three dimensional pseudo-continuous arterial spin labeling (3D-pcASL) technique and dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for differentiation tumor recurrence from treatment-related effects in gliomas...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29389985/multiband-multi-echo-simultaneous-asl-bold-for-task-induced-functional-mri
#17
Alexander D Cohen, Andrew S Nencka, Yang Wang
Typical simultaneous blood oxygenation-level dependent (BOLD) and arterial spin labeling (ASL) sequences acquire two echoes, one perfusion-sensitive and one BOLD-sensitive. However, for ASL, spatial resolution and brain coverage are limited due to the T1 decay of the labeled blood. This study applies a sequence combining a multiband acquisition with four echoes for simultaneous BOLD and pseudo-continuous ASL (pCASL) echo planar imaging (MBME ASL/BOLD) for block-design task-fMRI. A multiband acceleration of four was employed to increase brain coverage and reduce slice-timing effects on the ASL signal...
2018: PloS One
https://www.readbyqxmd.com/read/29371433/staging-hemodynamic-failure-with-blood-oxygen-level-dependent-functional-magnetic-resonance-imaging-cerebrovascular-reactivity-a-comparison-versus-gold-standard-15o-h2o-positron-emission-tomography
#18
Jorn Fierstra, Christiaan van Niftrik, Geoffrey Warnock, Susanne Wegener, Marco Piccirelli, Athina Pangalu, Giuseppe Esposito, Antonios Valavanis, Alfred Buck, Andreas Luft, Oliver Bozinov, Luca Regli
BACKGROUND AND PURPOSE: Increased stroke risk correlates with hemodynamic failure, which can be assessed with (15O-)H2O positron emission tomography (PET) cerebral blood flow (CBF) measurements. This gold standard technique, however, is not established for routine clinical imaging. Standardized blood oxygen-level-dependent (BOLD) functional magnetic resonance imaging+CO2 is a noninvasive and potentially widely applicable tool to assess whole-brain quantitative cerebrovascular reactivity (CVR)...
January 25, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29364767/thrombectomy-for-stroke-at-6-to-16-hours-with-selection-by-perfusion-imaging
#19
Gregory W Albers, Michael P Marks, Stephanie Kemp, Soren Christensen, Jenny P Tsai, Santiago Ortega-Gutierrez, Ryan A McTaggart, Michel T Torbey, May Kim-Tenser, Thabele Leslie-Mazwi, Amrou Sarraj, Scott E Kasner, Sameer A Ansari, Sharon D Yeatts, Scott Hamilton, Michael Mlynash, Jeremy J Heit, Greg Zaharchuk, Sun Kim, Janice Carrozzella, Yuko Y Palesch, Andrew M Demchuk, Roland Bammer, Philip W Lavori, Joseph P Broderick, Maarten G Lansberg
Background Thrombectomy is currently recommended for eligible patients with stroke who are treated within 6 hours after the onset of symptoms. Methods We conducted a multicenter, randomized, open-label trial, with blinded outcome assessment, of thrombectomy in patients 6 to 16 hours after they were last known to be well and who had remaining ischemic brain tissue that was not yet infarcted. Patients with proximal middle-cerebral-artery or internal-carotid-artery occlusion, an initial infarct size of less than 70 ml, and a ratio of the volume of ischemic tissue on perfusion imaging to infarct volume of 1...
January 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29361626/-secondary-dementia-due-to-leptomeningeal-metastasis-of-breast-cancer-improved-by-whole-brain-radiation
#20
Mariko Asai, Hiroshi Tanaka, Yasutomo Goto, Tetsuya Yamada, Norihiro Yuasa, Eiji Takeuchi, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Masataka Okuno, Natsuko Kawai, Takayuki Minami, Takuya Nagao, Shingo Maeda, Koichi Mouri, Kouji Fukata, Hironori Mizuno, Takuji Iwase, Kanji Miyata
A 62-year-old woman received chemotherapy for breast cancer with bone metastasis and malignant pleural and pericardial effusion. She was examined by imaging for progressive cognitive impairment and headache. Enhanced MRI findings showed multiple solid tumors on brain surface, and brain perfusion scintigraphy showed blood flow decrease in both parietal lobes. She was diagnosed with secondary dementia due to leptomeningeal metastases of breast cancer, and whole brain external irradiation was performed(30 Gy/15 Fr)...
December 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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