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Brain perfusion imaging

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https://www.readbyqxmd.com/read/29682448/cortical-hypoperfusion-and-reduced-cerebral-metabolic-rate-of-oxygen-in-the-arca%C3%AE-mouse-model-of-alzheimer-s-disease
#1
Ruiqing Ni, Markus Rudin, Jan Klohs
The effect of cerebral amyloidosis on cerebral hemodynamics was investigated with photoacoustic tomography (PAT) and magnetic resonance imaging (MRI). First, the sensitivity and robustness of PAT for deriving metrics of vascular and tissue oxygenation in the murine brain was assessed in wild-type mice with a hyperoxia-normoxia challenge. Secondly, cerebral oxygenation was assessed in young and aged arcAβ mice and wild-type controls with PAT, while cerebral blood flow (CBF) was determined by perfusion MRI. The investigations revealed that PAT can sensitively and robustly detect physiological changes in vascular and tissue oxygenation...
June 2018: Photoacoustics
https://www.readbyqxmd.com/read/29676844/differentiation-of-brain-infection-from-necrotic-glioblastoma-using-combined-analysis-of-diffusion-and-perfusion-mri
#2
Sanjeev Chawla, Sumei Wang, Suyash Mohan, MacLean Nasrallah, Gaurav Verma, Steven Brem, Donald M O'Rourke, Ronald L Wolf, Harish Poptani, S Ali Nabavizadeh
BACKGROUND: Accurate differentiation of brain infections from necrotic glioblastomas (GBMs) may not always be possible on morphologic MRI or on diffusion tensor imaging (DTI) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) if these techniques are used independently. PURPOSE: To investigate the combined analysis of DTI and DSC-PWI in distinguishing brain injections from necrotic GBMs. STUDY TYPE: Retrospective. POPULATION: Fourteen patients with brain infections and 21 patients with necrotic GBMs...
April 20, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29672930/clinical-and-imaging-correlates-of-amyloid-deposition-in-dementia-with-lewy-bodies
#3
Paul C Donaghy, Michael J Firbank, Alan J Thomas, Jim Lloyd, George Petrides, Nicola Barnett, Kirsty Olsen, John T O'Brien
BACKGROUND: Amyloid deposition is common in dementia with Lewy bodies, but its pathophysiological significance is unclear. OBJECTIVE: The objective of this study was to investigate the relationship between amyloid deposition and clinical profile, gray matter volume, and brain perfusion in dementia with Lewy bodies. METHODS: Dementia with Lewy bodies (n = 37), Alzheimer's disease (n = 20), and controls (n = 20) underwent a thorough clinical assessment, 3T MRI, and early- and late-phase 18 F-Florbetapir PET-CT to assess cortical perfusion and amyloid deposition, respectively...
April 19, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29656881/fundamentals-of-functional-imaging-i-current-clinical-techniques
#4
A Luna, T Martín Noguerol, L Alcalá Mata
Imaging techniques can establish a structural, physiological, and molecular phenotype for cancer, which helps enable accurate diagnosis and personalized treatment. In recent years, various imaging techniques that make it possible to study the functional characteristics of tumors quantitatively and reproducibly have been introduced and have become established in routine clinical practice. Perfusion studies enable us to estimate the microcirculation as well as tumor angiogenesis and permeability using ultrafast dynamic acquisitions with ultrasound, computed tomography, or magnetic resonance (MR) imaging...
April 12, 2018: Radiología
https://www.readbyqxmd.com/read/29652661/combined-brain-and-heart-magnetic-resonance-imaging-in-systemic-vasculitides-fiction-or-real-need
#5
REVIEW
Sophie I Mavrogeni, George Kitas, Hildo J Lamb, Klearchos Psychoyios, Theodoros Dimitroulas, Loukia Koutsogeorgopoulou, Kyriaki Boki, Vasiliki Vartela, Genovefa Kolovou, George Markousis-Mavrogenis, Cees G Kallenberg, Loic Guillevin, Dimitrios Vassilopoulos
Systemic vasculitides (SVs) is a group of diseases characterised by inflammation/necrosis of the blood vessel wall in various organs. Simultaneous brain and heart involvement is a cause of increased morbidity/mortality in SV. We aimed to present evidence of concurrent brain/heart involvement in SV and the role of a combined brain/heart magnetic resonance imaging (MRI) in their risk stratification. Cerebral vasculitis (CV) can be presented as focal deficits, seizures, headache, neuropsychiatric manifestations or cognitive dysfunction and cardiovascular disease (CVD) as myocardial/vascular inflammation, perfusion/function defects and fibrosis...
April 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29649783/radiation-dose-reduction-in-perfusion-ct-imaging-of-the-brain-using-a-256-slice-ct-80-mas-versus-160-mas
#6
Isabelle Riederer, Claus Zimmer, Daniela Pfeiffer, Silke Wunderlich, Holger Poppert, Ernst J Rummeny, Armin Huber
PURPOSE: To examine CTP of the brain in real patient data after reducing tube current down to 80 mAs to decrease radiation dose. METHODS: CTP was acquired in 60 suspected stroke patients with 80 (n: 30) or 160 (n: 30) mAs. Data were analyzed retrospectively by two independent readers. SNR, perfusion maps and image quality were compared in hypoperfused and non-affected areas. RESULTS: SNR was significantly higher in CTP with 160 mAs compared to 80 mAs (p < 0...
April 5, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29625153/brain-ct-perfusion-improves-intracranial-vessel-occlusion-detection-on-ct-angiography
#7
Marinus J Becks, Rashindra Manniesing, Jeroen Vister, Sjoert A H Pegge, Stefan C A Steens, Ewoud J van Dijk, Mathias Prokop, Frederick J A Meijer
BACKGROUND AND PURPOSE: To evaluate whether brain CT perfusion (CTP) aids in the detection of intracranial vessel occlusion on CT angiography (CTA) in acute ischemic stroke. MATERIALS AND METHODS: Medical-ethical committee of our hospital was obtained and informed consent was waived. Patients suspected of acute ischemic stroke who underwent non-contrast CT(NCCT), CTA and whole-brain CTP in our center in the year 2015 were included. Three observers with different levels of experience evaluated the imaging data of 110 patients for the presence or absence of intracranial arterial vessel occlusion with two strategies...
April 3, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29620513/reliability-of-three-dimentional-pseudo-continuous-arterial-spin-labeling-a-volumetric-cerebral-perfusion-imaging-with-different-post-labeling-time-and-functional-state-in-health-adults
#8
Meng-Qi Liu, Zhi-Ye Chen, Lin Ma
Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling (3D pc-ASL) in measuring cerebral blood flow (CBF) with different post-labeling delay time (PLD) in the resting state and the right finger taping state. Methods 3D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequence were applied to eight healthy subjects twice at the same time each day for one week interval. ASL data acquisition was performed with post-labeling delay time (PLD) 1...
March 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29619517/perfusion-mri-as-a-diagnostic-biomarker-for-differentiating-glioma-from-brain-metastasis-a-systematic-review-and-meta-analysis
#9
Chong Hyun Suh, Ho Sung Kim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim
OBJECTIVES: Differentiation of glioma from brain metastasis is clinically crucial because it affects the clinical outcome of patients and alters patient management. Here, we present a systematic review and meta-analysis of the currently available data on perfusion magnetic resonance imaging (MRI) for differentiating glioma from brain metastasis, assessing MRI protocols and parameters. METHODS: A computerised search of Ovid-MEDLINE and EMBASE databases was performed up to 3 October 2017, to find studies on the diagnostic performance of perfusion MRI for differentiating glioma from brain metastasis...
April 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29605982/regional-brain-activity-during-rest-and-gastric-water-load-in-subtypes-of-functional-dyspepsia-a-preliminary-brain-functional-magnetic-resonance-imaging-study
#10
Yanwen Chen, Ruifeng Wang, Bo Hou, Feng Feng, Xiucai Fang, Liming Zhu, Xiaohong Sun, Zhifeng Wang, Meiyun Ke
Background/Aims: Functional dyspepsia (FD) remains a great clinical challenge since the FD subtypes, defined by Rome III classification, still have heterogeneous pathogenesis. Previous studies have shown notable differences in visceral sensation processing in the CNS in FD compared to healthy subjects (HS). However, the role of CNS in the pathogenesis of each FD subtype has not been recognized. Methods: Twenty-eight FD patients, including 10 epigastric pain syndrome (EPS), 9 postprandial distress syndrome (PDS), and 9 mixed-type, and 10 HS, were enrolled...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29605630/-99m-tc-hmpao-brain-spect-in-the-monitoring-of-cerebral-vasculitis-therapy
#11
V Frantellizzi, M Morreale, M Pontico, A Francia, F M Drudi, A Farcomeni, M Liberatore
OBJECTIVE: The central nervous system (CNS) may be involved in a variety of inflammatory diseases of the blood vessels, generally known as vasculitis. The clinical diagnosis of such involvement in early stages is difficult, since a mild cognitive impairment can be the only symptom. It was hypothesized that brain-perfusion SPECT would be able to reveal CNS involvement and to monitor the course of the disease. The purpose of this study was assess if and when an improvement of cerebral perfusion can be registered by SPECT during the follow-up of these diseases...
March 28, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29604980/imaging-studies-of-the-hiv-infected-brain
#12
Linda Chang, Dinesh K Shukla
Human immunodeficiency virus (HIV) enters the brain early after infecting humans and may remain in the central nervous system despite successful antiretroviral treatment. Many neuroimaging techniques were used to study HIV+ patients with or without opportunistic infections. These techniques assessed abnormalities in brain structures (using computed tomography, structural magnetic resonance imaging (MRI), diffusion MRI) and function (using functional MRI at rest or during a task, and perfusion MRI with or without a contrast agent)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29595192/blockade-of-the-swelling-induced-chloride-current-attenuates-the-mouse-neonatal-hypoxic-ischemic-brain-injury-in-vivo
#13
Raymond Wong, Ahmed Abussaud, Joseph Wh Leung, Bao-Feng Xu, Fei-Ya Li, Sammen Huang, Nai-Hong Chen, Guan-Lei Wang, Zhong-Ping Feng, Hong-Shuo Sun
Activation of swelling-induced Cl- current (ICl,swell ) during neonatal hypoxia-ischemia (HI) may induce brain damage. Hypoxic-ischemic brain injury causes chronic neurological morbidity in neonates as well as acute mortality. In this study, we investigated the role of ICl,swell in hypoxic-ischemic brain injury using a selective blocker, 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl) oxybutyric acid (DCPIB). In primary cultured cortical neurons perfusion of a 30% hypotonic solution activated ICl,swell , which was completely blocked by the application of DCPIB (10 μmol/L)...
March 29, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29583046/quantitative-analysis-of-brain-perfusion-parameters-in-dogs-with-idiopathic-epilepsy-by-use-of-magnetic-resonance-imaging
#14
Antje Hartmann, Clea von Klopmann, Ines E Lautenschläger, Volkher B Scholz, Martin J Schmidt
OBJECTIVE To quantitatively analyze brain perfusion parameters in dogs with idiopathic epilepsy (IE) by use of MRI and to compare those findings with brain perfusion parameters for healthy dogs. ANIMALS 12 client-owned dogs with IE. PROCEDURES For each dog, standard MRI and perfusion-weighted imaging (before and after injection of gadoteric acid contrast medium) sequences of the brain were obtained during the interictal period by means of the same protocol used in a comparable study of healthy dogs. Time of contrast medium arrival, time to peak contrast enhancement, mean contrast transit time, and cerebral blood flow were calculated for the caudate nucleus, thalamus, piriform lobe, hippocampus, semioval center, and temporal cerebral cortex...
April 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29578481/deficits-in-regional-cerebral-blood-flow-on-brain-spect-predict-treatment-resistant-depression
#15
Daniel G Amen, Derek V Taylor, Somayeh Meysami, Cyrus A Raji
BACKGROUND: Depression remains an important risk factor for Alzheimer's disease, yet few neuroimaging biomarkers are available to identify treatment response in depression. OBJECTIVE: To analyze and compare functional perfusion neuroimaging in persons with treatment resistant depression (TRD) compared to those experiencing full remission. METHODS: A total of 951 subjects from a community psychiatry cohort were scanned with perfusion single photon emission computed tomography (SPECT) of the brain in both resting and task related settings...
March 22, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29578039/in-vivo-assessment-of-the-human-cerebral-microcirculation-and-its-glycocalyx-a-technical-report
#16
R H L Haeren, K Rijkers, O E M G Schijns, J Dings, G Hoogland, M A M J van Zandvoort, H Vink, J J van Overbeeke
INTRODUCTION: The cerebral microcirculation and its glycocalyx, a matrix coating the luminal endothelium, are key regulators of capillary permeability and cerebral blood flow. Microvascular abnormalities are described in several neurological disorders. However, assessment of the cerebral microcirculation and glycocalyx has mainly been performed ex vivo. NEW METHOD: Here, the technical feasibility of in vivo assessment of the human cerebral microcirculation and its glycocalyx using sidestream dark field (SDF) imaging is discussed...
March 22, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29577377/improved-calculation-of-the-equilibrium-magnetization-of-arterial-blood-in-arterial-spin-labeling
#17
André Ahlgren, Ronnie Wirestam, Linda Knutsson, Esben Thade Petersen
PURPOSE: To propose and assess an improved method for calculating the equilibrium magnetization of arterial blood ( M0a), used for calibration of perfusion estimates in arterial spin labeling. METHODS: Whereas standard M0a calculation is based on dividing a proton density-weighted image by an average brain-blood partition coefficient, the proposed method exploits partial-volume data to adjust this ratio. The nominator is redefined as the magnetization of perfused tissue, and the denominator is redefined as a weighted sum of tissue-specific partition coefficients...
March 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29561214/glucose-transporter-2-mediates-the-hypoglycemia-induced-increase-in-cerebral-blood-flow
#18
Hongxia Lei, Frédéric Preitner, Gwenaël Labouèbe, Rolf Gruetter, Bernard Thorens
Glucose transporter 2 ( Glut2)-positive cells are sparsely distributed in brain and play an important role in the stimulation of glucagon secretion in response to hypoglycemia. We aimed to determine if Glut2-positive cells can influence another response to hypoglycemia, i.e. increased cerebral blood flow (CBF). CBF of adult male mice devoid of Glut2, either globally ( ripglut1:glut2- / - ) or in the nervous system only (NG2KO), and their respective controls were studied under basal glycemia and insulin-induced hypoglycemia using quantitative perfusion magnetic resonance imaging at 9...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29557515/susceptibility-weighted-imaging-predicts-infarct-size-and-early-stage-clinical-prognosis-in-acute-ischemic-stroke
#19
Song Luo, Lijuan Yang, Yanfei Luo
Susceptibility-weighted imaging (SWI) is a non-invasive technique that can reveal venous structures and iron in the brain. This retrospective study evaluated SWI, relative to other imaging techniques, for determining cerebral infarct size and early-stage clinical prognosis in patients with acute ischemic stroke. Within 3 days after onset, 22 patients with acute ischemic stroke underwent SWI, diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), fluid-attenuated inversion recovery (FLAIR), and magnetic resonance angiography (MRA)...
March 20, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29555872/can-diffusion-and-perfusion-weighted-imaging-alone-accurately-triage-anterior-circulation-acute-ischemic-stroke-patients-to-endovascular-therapy
#20
Dylan N Wolman, Michael Iv, Max Wintermark, Gregory Zaharchuk, Michael P Marks, Huy M Do, Robert L Dodd, Gregory W Albers, Maarten G Lansberg, Jeremy J Heit
BACKGROUND AND PURPOSE: Acute ischemic stroke (AIS) patients who benefit from endovascular treatment have a large vessel occlusion (LVO), small core infarction, and salvageable brain. We determined if diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) alone can correctly identify and localize anterior circulation LVO and accurately triage patients to endovascular thrombectomy (ET). MATERIALS AND METHODS: This retrospective cohort study included patients undergoing MRI for the evaluation of AIS symptoms...
March 19, 2018: Journal of Neurointerventional Surgery
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