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https://www.readbyqxmd.com/read/28213711/implantable-cardioverter-defibrillators-for-primary-prevention-in-dilated-cardiomyopathy-post-danish-an-updated-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#1
Georg Wolff, Yingfeng Lin, Athanasios Karathanos, Maximilian Brockmeyer, Susanne Wolters, Bernd Nowak, Alexander Fürnkranz, Hisaki Makimoto, Malte Kelm, Volker Schulze
BACKGROUND: Sudden cardiac death (SCD) is frequent in patients with heart failure due to dilated cardiomyopathy (DCM). Implantable cardioverter/defibrillator (ICD) device therapy is currently used for primary prevention. However, publication of the DANISH trial has recently given reason for doubt, showing no significant improvement in all-cause mortality in comparison to contemporary medical therapy. METHODS: We performed a meta-analysis of all randomized controlled trials comparing ICD therapy to medical therapy (MT) for primary prevention in DCM...
February 17, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28204917/-ecg-score-to-predict-icd-therapies-in-patients-with-nonischemic-cardiomyopathy-and-primary-prophylactic-crt-d
#2
Martin Grett, Martin Christ, Jan-Peter Röing Gen Nölke, Hans-Joachim Trappe
BACKGROUND AND PROBLEM: Recently published results of the DANISH study raise concerns, if primary prophylactic ICD implantations in patients with nonischemic cardiomyopathy (NICM) and severe reduced left ventricular ejection fraction (LVEF) should be performed without further risk stratification. There was no significant difference in the overall mortality of patients with or without ICD and CRT defibrillator (CRT-D) or CRT pacemaker (CRT-P), respectively. Clinical risk scores to identify patients with ischemic cardiomyopathy (ICM) who benefit most from an ICD have been recommended...
February 15, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28181727/significant-discrepancy-between-estimated-and-actual-longevity-in-st-jude-medical-sjm-implantable-cardioverter-defibrillators
#3
Harish Doppalapudi, James Barrios, Jose Cuellar, Melanie Gannon, Takumi Yamada, Vineet Kumar, William R Maddox, Vance J Plumb, Todd M Brown, H Tom McElderry
BACKGROUND: Real-time estimated longevity has been reported in pacemakers for several years, and was recently introduced in ICDs. OBJECTIVE: We sought to evaluate the accuracy of this longevity estimate in St. Jude Medical (SJM) ICDs, especially as the device battery approaches depletion. METHODS: Among patients with SJM ICDs who underwent generator replacements due to reaching elective replacement indicator (ERI) at our institution, we identified those with devices that provided longevity estimates and reviewed their device interrogations in the 18 months prior to ERI...
February 9, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28176981/reuse-of-pacemakers-defibrillators-and-cardiac-resynchronisation-devices
#4
Raja J Selvaraj, R Sakthivel, Santhosh Satheesh, Ajith Ananthakrishna Pillai, Pascal Sagnol, Xavier Jouven, Bernard Dodinot, Jayaraman Balachander
OBJECTIVE: Access to pacemakers remains poor among many patients in low/middle-income countries. Reuse of explanted pacemakers is a possible solution, but is still not widespread because of concerns regarding outcomes, especially infection. Our objective was to study early outcomes with implants using reused devices and compare them with those with implants using new devices. METHODS: We studied all patients who underwent implantation of a new or reused pacemaker, cardiac resynchronisation therapy (CRT) device or implantable cardioverter defibrillator (ICD) in the last 5 years at a single institution...
2017: Heart Asia
https://www.readbyqxmd.com/read/28176442/impact-of-remote-monitoring-on-long-term-prognosis-in-heart-failure-patients-in-a-real-world-cohort-results-from-all-comers-commit-hf-trial
#5
Anna Kurek, Mateusz Tajstra, Elzbieta Gadula-Gacek, Piotr Buchta, Michal Skrzypek, Lukasz Pyka, Michal Wasiak, Malgorzata Swietlinska, Michal Hawranek, Lech Polonski, Mariusz Gasior, Jedrzej Kosiuk
BACKGROUND: Randomized controlled trials demonstrate that remote monitoring (RM) of implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy devices (CRT-D) may improve quality of care and prognosis in heart failure (HF) patients. However, the impact of RM on long-term mortality in a real-world cohort is still not well examined. METHODS AND RESULTS: This study was designed as a matched cohort study based on the COMMIT-HF trial - a single-center, ongoing prospective observational registry (NCT02536443)...
February 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28176416/association-between-demographic-organizational-clinical-and-socio-economic-characteristics-and-underutilization-of-cardiac-resynchronization-therapy-results-from-the-swedish-heart-failure-registry
#6
Lars H Lund, Frieder Braunschweig, Lina Benson, Marcus Ståhlberg, Ulf Dahlström, Cecilia Linde
AIMS: Cardiac resynchronization therapy (CRT) improves outcomes in heart failure (HF) but may be underutilized. The reasons are unknown. METHODS AND RESULTS: We linked the Swedish Heart Failure Registry to national registries with ICD-10 (International Classification of Diseases-10th Revision) co-morbidity diagnoses and demographic and socio-economic data. In patients with EF ≤39% and NYHA II-IV, we assessed prevalence of CRT indication and CRT use. In those with CRT indication, we assessed the association between 37 potential baseline covariates and CRT non-use using multivariable generalized estimating equation (GEE) models...
February 7, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28173045/increasing-age-does-not-affect-time-to-appropriate-therapy-in-primary-prevention-icd-crt-d-a-competing-risks-analysis
#7
David G Wilson, Hrvojka Marija Zeljko, Georgios Leventopoulos, Ahmed Nauman, George E H Sylvester, Arthur Yue, Paul R Roberts, Glyn Thomas, Edward R Duncan, Paul J Roderick, John M Morgan
No abstract text is available yet for this article.
February 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28160975/prescription-of-guideline-recommended-implantable-cardioverter-defibrillator-and-cardiac-resynchronization-therapy-among-patients-hospitalized-with-heart-failure-and-varying-degrees-of-renal-function
#8
Patrick H Pun, Shubin Sheng, Gillian Sanders, Adam D DeVore, Daniel Friedman, Gregg C Fonarow, Paul A Heidenreich, Clyde W Yancy, Adrian F Hernandez, Sana M Al-Khatib
Implantable cardioverter defibrillators (ICD) and cardiac resynchronization therapy (CRT) reduce mortality in many patients with heart failure (HF), but the current use and effectiveness of ICD/CRT in patients with chronic kidney disease (CKD) are uncertain. We examined associations between kidney function and guideline-recommended prescription of ICD/CRT in the Get With The Guidelines-Heart Failure registry, a performance improvement program for hospitalized patients with HF. We compared differences in ICD and CRT prescription between the following categories of estimated glomerular filtration rate (eGFR; mL/min/1...
December 18, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28156008/a-device-histogram-based-simple-predictor-of-mortality-risk-in-icd-and-crt-d-patients-the-heart-rate-score
#9
Bruce L Wilkoff, Mark Richards, Arjun Sharma, Nicholas Wold, Paul Jones, David Perschbacher, Brian Olshansky
BACKGROUND: We hypothesized survival in cardioverter defibrillator (ICD) and cardiac resynchronization defibrillator (CRT-D) patients is predicted by baseline Heart rate Score. METHODS: Heart rate Score is determined from the atrial paced and sensed histogram of a DDD ICD or CRT-D, and defined as percent of beats in the histogram in the tallest 10 beat/minute range bin. It was calculated at initial remote monitoring for patients enrolled in LATITUDE® without persistent atrial fibrillation (AF), and with pulse generators implanted 2006-2011...
February 3, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28154584/temporal-trends-of-hospitalized-patients-with-heart-failure-in-korea
#10
REVIEW
Jong-Chan Youn, Seongwoo Han, Kyu-Hyung Ryu
Heart failure (HF) is an important cardiovascular disease because of its increasing prevalence, significant morbidity, high mortality and rapidly expanding health care costs. The number of HF patients is increasing worldwide and Korea is no exception. Temporal trends of four representative Korean hospitalized HF registries-the Hallym HF study, the Korean Multicenter HF study, the Korean Heart Failure (KorHF) registry and the Korean Acute Heart Failure (KorAHF) registry showed mild survival improvement reflecting overall HF patient care development in Korea despite the increased severity of enrolled patients with higher incidence of multiple comorbidities...
January 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28153995/atrial-fibrillation-and-ventricular-arrhythmias-sex-differences-in-electrophysiology-epidemiology-clinical-presentation-and-clinical-outcomes
#11
Anne M Gillis
Sex-specific differences in the epidemiology, pathophysiology, clinical presentation, clinical treatment, and clinical outcomes of atrial fibrillation (AF), sustained ventricular arrhythmias, and sudden cardiac death are recognized. Sex hormones cause differences in cardiac electrophysiological parameters between men and women that may affect the risk for arrhythmias. The incidence and prevalence of AF is lower in women than in men. However, because women live longer and AF prevalence increases with age, the absolute number of women with AF exceeds that of men...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28150288/the-impact-of-remote-monitoring-of-implanted-cardioverter-defibrillator-icd-and-cardiac-resynchronization-therapy-device-crt-d-patients-on-healthcare-costs-in-the-silesian-population-3-year-follow-up
#12
Piotr Buchta, Mateusz Tajstra, Anna Kurek, Michał Skrzypek, Małgorzata Świetlińska, Elżbieta Gadula-Gacek, Michał Wasiak, Łukasz Pyka, Mariusz Gąsior
BACKGROUND: The population of patients with implanted cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy devices (CRT-Ds) is constantly growing. The use of remote-monitoring (RM) techniques in this group can significantly improve clinical outcomes, but there are limited data about the impact of RM on healthcare costs from a payer's perspective. AIM: The aim of the study was to assess the impact on costs for the healthcare system of RM in patients with ICDs or CRT-Ds...
February 2, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28134226/-the-evaluation-of-the-ventricular-arrhythmias-and-interventions-of-cardiac-implantable-electronic-devices-in-patients-with-dilated-cardiomyopathy-for-primary-prevention-of-sudden-cardiac-death-in-ambulatory-and-telemetric-follow-up
#13
Jacek Lelakowski, Anna Rydlewska, Maria Lelakowska, Joanna Pudło, Justyna Piekarz
: Telemetric follow-up (RM) after cardiac devices implantation is not inferior to classic follow-up and enables earlier clinical complications detection. AIM: The aim of the study was to evaluation of the ventricular arrhythmias and interventions of ICD/CRTD in ambulatory and telemetric follow-up in patients with dilated cardiomyopathy. MATERIALS AND METHODS: Group A (CRT-D+ICD) - retrospective, patients followed-up in outpatient clinic - was consisted with 273 patients (mean age 65±11 years, 230M)...
January 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28122073/use-of-cardiac-resynchronization-therapy-among-eligible-patients-receiving-an-implantable-cardioverter-defibrillator-insights-from-the-national-cardiovascular-data-registry-implantable-cardioverter-defibrillator-registry
#14
Lucas N Marzec, Pamela N Peterson, Haikun Bao, Jeptha P Curtis, Frederick A Masoudi, Paul D Varosy, Steven M Bradley
Importance: Cardiac resynchronization therapy (CRT) reduces the risk for mortality and heart failure-related events in select patients. Little is known about the use of CRT in combination with an implantable cardioverter defibrillator (ICD) in patients who are eligible for this therapy in clinical practice. Objective: To (1) identify patient, clinician, and hospital characteristics associated with CRT defibrillator (CRT-D) use and (2) determine the extent of hospital-level variation in the use of CRT-D among guideline-eligible patients undergoing ICD placement...
January 25, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28117620/association-between-patient-activity-and-long-term-cardiac-death-in-patients-with-implantable-cardioverter-defibrillators-and-cardiac-resynchronization-therapy-defibrillators
#15
Shuang Zhao, Keping Chen, Yangang Su, Wei Hua, Silin Chen, Zhaoguang Liang, Wei Xu, Yan Dai, Zhimin Liu, Xiaohan Fan, Cuihong Hou, Shu Zhang
Background Patient activity (PA) has been demonstrated to predict all-cause mortality. However, the association between PA and cardiac death is unclear. Aims The aims of this study were to determine whether PA can predict cardiac death and what is the cut-off of PA to discriminate cardiac death, as well as the mechanism underlying the relationship between PA and survival in patients with home monitoring. Methods This study retrospectively analysed clinical and implantable cardioverter-defibrillator/cardiac resynchronization therapy defibrillator device data in 845 patients...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28104669/sex-specific-outcomes-with-addition-of-defibrillation-to-resynchronisation-therapy-in-patients-with-heart-failure
#16
Sérgio Barra, Rui Providência, Rudolf Duehmke, Serge Boveda, Eloi Marijon, Christian Reitan, Rasmus Borgquist, Didier Klug, Pascal Defaye, Nicolas Sadoul, Jean-Claude Deharo, Iannish Sadien, Kiran Patel, Khang-Li Looi, David Begley, Anthony W Chow, Jean-Yves Le Heuzey, Sharad Agarwal
OBJECTIVE: Among primary prevention patients with heart failure receiving cardiac resynchronisation therapy (CRT), the impact of additional implantable cardioverter defibrillator (ICD) treatment on outcomes and its interaction with sex remains uncertain. We aim to assess whether the addition of the ICD functionality to CRT devices offers a more pronounced survival benefit in men compared with women, as previous research has suggested. METHODS: Observational multicentre cohort study of 5307 consecutive patients with ischaemic or non-ischaemic dilated cardiomyopathy and no history of sustained ventricular arrhythmias having CRT implantation with (cardiac resynchronisation therapy defibrillator (CRT-D), n=4037) or without (cardiac resynchronisation therapy pacemaker (CRT-P), n=1270) defibrillator functionality...
January 19, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28079553/end-of-life-decisions-in-heart-failure-to-turn-off-the-intracardiac-device-or-not
#17
Bilal Ayach, Amrit Malik, Colette Seifer, Shelley Zieroth
PURPOSE OF REVIEW: Heart failure is a significant public health concern around the world. Implantable cardioverter defibrillators with or without cardiac resynchronization therapy (CRT-D) have proven survival benefit. As patients progress to end-stage disease, management shifts to palliative care, and cardiologists are often confronted with how to best manage these devices. RECENT FINDINGS: Studies suggest that up to one-third of patients with an implantable cardioverter defibrillator receive painful shocks in the last 24 h of life...
March 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28079009/emerging-roles-of-calreticulin-in-cancer-implications-for-therapy
#18
Kavya Venkateswaran, Amit Verma, Anant Narayan Bhatt, Anju Shrivastava, Kailash Manda, Hanumantharao G Raj, Ashok Prasad, Christophe Len, Virinder S Parmar, Bilikere Dwarakanath
Calreticulin (CRT), initially identified as a ubiquitous calcium-binding protein in the endoplasmic reticulum, has emerged as a multifunctional protein with roles in calcium homeostasis, molecular chaperoning and cell adhesion. Emerging evidence suggests its involvement in tumorigenesis facilitating proliferation, migration, and adhesion. CRT translocated to the cell surface (ecto-CRT) serves as a phagocytic signal for immunogenic cell death (ICD) mediated through dendritic cells (DCs) and cytotoxic T-cell activation thereby making tumors susceptible to immunotherapy-based anti-cancer strategies...
11, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28073883/infective-endocarditis-and-risk-of-death-after-cardiac-implantable-electronic-device-implantation-a-nationwide-cohort-study
#19
Cengiz Özcan, Jakob Raunsø, Morten Lamberts, Lars Køber, Tommi Bo Lindhardt, Niels Eske Bruun, Marie Louise Laursen, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Morten Lock Hansen
AIMS: To determine the incidence, risk factors, and mortality of infective endocarditis (IE) following implantation of a first-time, permanent, cardiac implantable electronic device (CIED). METHODS AND RESULTS: From Danish nationwide administrative registers (beginning in 1996), we identified all de-novo permanent pacemakers (PMs) and implantable cardioverter defibrillators (ICDs) together with the occurrence of post-implantation IE-events in the period from 2000-2012...
January 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28065904/increasing-sex-differences-in-the-use-of-cardiac-resynchronization-therapy-with-or-without-implantable-cardioverter-defibrillator
#20
Neal A Chatterjee, Rasmus Borgquist, Yuchiao Chang, Jennifer Lewey, Vicki A Jackson, Jagmeet P Singh, Joshua P Metlay, Charlotta Lindvall
AIMS: Previous studies have identified sex disparities in the use of cardiac resynchronization therapy (CRT) and implantable cardioverter defibrillators (ICD), although the basis of underutilization in women remains poorly understood. The aim of this study was to assess sex differences in patterns of CRT use with our without ICD. METHODS AND RESULTS: In this cross-sectional study using the National Inpatient Sample database we identified 311 009 patients undergoing CRT implantation in the United States between 2006 and 2012...
January 8, 2017: European Heart Journal
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