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https://www.readbyqxmd.com/read/28922648/a-theoretical-and-empirical-modeling-of-anxiety-integrated-with-rdoc-and-temporal-dynamics
#1
Brandon Frank, Nicholas C Jacobson, Landon Hurley, Dean McKay
The newly launched Research Domain Criteria (RDoC) emphasize specific mechanisms over diagnostic categories of psychopathology. In our view, RDoC provides a useful heuristic for mental health disorders, but does not capture the complexity of psychological data when proposed mechanisms are viewed as static entities. However, temporal and complex system dynamics may advance RDoC's utility. By investigating temporal patterns within trajectories and the interaction of complex networks, we propose that dynamic modeling provides comprehensive methods with which to investigate the etiopathology and maintenance of mental health disorders...
September 8, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28922619/identification-of-angiogenesis-inhibitors-using-a-co-culture-cell-model-in-a-high-content-and-high-throughput-screening-platform
#2
Shuaizhang Li, Chia-Wen Hsu, Srilatha Sakamuru, Chaozhong Zou, Ruili Huang, Menghang Xia
Angiogenesis is an important hallmark of cancer, contributing to tumor formation and metastasis. In vitro angiogenesis models for analyzing tube formation serve as useful tools to study these processes. However, current in vitro co-culture models using primary cells have limitations in usefulness and consistency. Therefore, in the present study, an in vitro co-culture assay system was optimized in a 1536-well format for high-throughput screening using human telomerase reverse transcriptase (hTERT)-immortalized mesenchymal stem cells and aortic endothelial cells...
September 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28922416/multi-level-computational-methods-for-interdisciplinary-research-in-the-hathitrust-digital-library
#3
Jaimie Murdock, Colin Allen, Katy Börner, Robert Light, Simon McAlister, Andrew Ravenscroft, Robert Rose, Doori Rose, Jun Otsuka, David Bourget, John Lawrence, Chris Reed
We show how faceted search using a combination of traditional classification systems and mixed-membership topic models can go beyond keyword search to inform resource discovery, hypothesis formulation, and argument extraction for interdisciplinary research. Our test domain is the history and philosophy of scientific work on animal mind and cognition. The methods can be generalized to other research areas and ultimately support a system for semi-automatic identification of argument structures. We provide a case study for the application of the methods to the problem of identifying and extracting arguments about anthropomorphism during a critical period in the development of comparative psychology...
2017: PloS One
https://www.readbyqxmd.com/read/28919862/changes-in-dimensionality-and-fractal-scaling-suggest-soft-assembled-dynamics-in-human-eeg
#4
Travis J Wiltshire, Matthew J Euler, Ty L McKinney, Jonathan E Butner
Humans are high-dimensional, complex systems consisting of many components that must coordinate in order to perform even the simplest of activities. Many behavioral studies, especially in the movement sciences, have advanced the notion of soft-assembly to describe how systems with many components coordinate to perform specific functions while also exhibiting the potential to re-structure and then perform other functions as task demands change. Consistent with this notion, within cognitive neuroscience it is increasingly accepted that the brain flexibly coordinates the networks needed to cope with changing task demands...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28919781/clinicopathological-and-prognostic-significance-of-ki-67-immunohistochemical-expression-in-gastric-cancer-a-systematic-review-and-meta-analysis
#5
Gang Liu, Disheng Xiong, Junjie Zeng, Borong Chen, Zhengjie Huang
The prognostic significance of Ki-67 in patients with gastric cancer (GC) remains controversial. The aim of our meta-analysis is to evaluate its association with clinicopathological characteristics and prognostic value in patients with GC. PubMed, EMBASE, and Web of Science were systematically searched up to May 2017. Twenty-two studies including 3,825 patients with GC were analyzed. The meta-analysis indicated that the incidence difference of Ki-67 expression in GC patients was significant when comparing the older group to younger group (odds ratio [OR] =1...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28919651/land-use-change-impacts-on-floods-at-the-catchment-scale-challenges-and-opportunities-for-future-research
#6
M Rogger, M Agnoletti, A Alaoui, J C Bathurst, G Bodner, M Borga, V Chaplot, F Gallart, G Glatzel, J Hall, J Holden, L Holko, R Horn, A Kiss, S Kohnová, G Leitinger, B Lennartz, J Parajka, R Perdigão, S Peth, L Plavcová, J N Quinton, M Robinson, J L Salinas, A Santoro, J Szolgay, S Tron, J J H van den Akker, A Viglione, G Blöschl
Research gaps in understanding flood changes at the catchment scale caused by changes in forest management, agricultural practices, artificial drainage, and terracing are identified. Potential strategies in addressing these gaps are proposed, such as complex systems approaches to link processes across time scales, long-term experiments on physical-chemical-biological process interactions, and a focus on connectivity and patterns across spatial scales. It is suggested that these strategies will stimulate new research that coherently addresses the issues across hydrology, soil and agricultural sciences, forest engineering, forest ecology, and geomorphology...
July 2017: Water Resources Research
https://www.readbyqxmd.com/read/28919614/use-of-acute-physiology-and-chronic-health-evaluation-apache-ii-and-red-cell-distribution-width-rdw-for-assessment-of-mortality-of-patients-with-sepsis-in-icu
#7
A Q Huda, M R Karim, M A Mahmud, M S Islam, M F Haque, M R Islam, M A Hossain
Critically ill patients of Intensive Care Unit (ICU) need highest level of monitoring, intense nursing care and integrated management which are very expensive and consume significant part of hospital resources. Prediction of outcome from disease has become an essential component of health science. So, various scoring systems have been developed to predict outcome of critically ill patients in ICU. There is no perfect model of severity score to predict ICU mortality. Search for new system is still remaining as continuous efforts to find the best model to get accurate information about the prognosis and outcome of critically ill patients...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28918567/expansion-of-parents-undetermined-experience-in-socioeducational-programs-extending-the-dialogical-self-theory
#8
Dany Boulanger
The Dialogic Self Theory (DST-Hermans et al. Integrative Psychology and Behavioral Sciences, 51(4), 1-31, 2017) is extended here in its dynamic aspects through focusing on the notions of indeterminacy, emptiness and movement. Linking with Husserl, I propose moving the dialogical self (DS) from a clear position in the "repertory of the Self" to an undetermined horizon. This makes it possible to introduce "holes" (emptiness) into the schematic representation of the "repertory of the Self". Yet Husserl's concept of horizon seems to focus too much on making the indeterminable determinate...
September 16, 2017: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/28918566/understanding-the-science-of-resistance-training-an-evolutionary-perspective
#9
William J Kraemer, Nicholas A Ratamess, Shawn D Flanagan, Jason P Shurley, Janice S Todd, Terry C Todd
The history of resistance training research began with anecdotal ideas and a slow growth of research from the late 1890s through the 1970s. The mid-1970s were a nexus point when resistance training studies evolved from just strength assessments to importance in physiological systems, physical health, and physical performance capabilities for individuals interested in physical fitness through to those seeking elite athletic performances. The pursuit of understanding program design and what mediated successful programs continues today as new findings, replication of old concepts, and new visions with the latest technologies fuel both our understanding and interest in this modality...
September 16, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28918526/coupling-population-dynamics-with-earth-system-models-the-popem-model
#10
Andrés Navarro, Raúl Moreno, Alfonso Jiménez-Alcázar, Francisco J Tapiador
Precise modeling of CO2 emissions is important for environmental research. This paper presents a new model of human population dynamics that can be embedded into ESMs (Earth System Models) to improve climate modeling. Through a system dynamics approach, we develop a cohort-component model that successfully simulates historical population dynamics with fine spatial resolution (about 1°×1°). The population projections are used to improve the estimates of CO2 emissions, thus transcending the bulk approach of existing models and allowing more realistic non-linear effects to feature in the simulations...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28917704/accuracy-of-pedicle-screw-insertion-among-three-image-guided-navigation-systems-a-systematic-review-and-meta-analysis
#11
REVIEW
Jin Peng Du, Yong Fan, Qi Ning Wu, Dai Hua Wang, Jing Zhang, Ding Jun Hao
BACKGROUND: Many retrospective studies of pedicle screw placement have revealed that intraoperative navigation systems provide higher accuracy rates and safety than do free-hand techniques. The accuracy of various image-guided navigation systems has been studied; however, differences have not been well defined due to the lack of adequate evidence-based comparative studies. OBJECTIVE: A meta-analysis was conducted to focus on the variation in pedicle screw insertion among three navigation systems: a three-dimensional fluoroscopy-based navigation system (3D FluoroNav), a two-dimensional fluoroscopy-based navigation system (2D FluoroNav) and a conventional computed tomography navigation system (CT Nav)...
September 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28916578/nutritional-sustainability-aligning-priorities-in-nutrition-and-public-health-with-agricultural-production
#12
REVIEW
John W Finley, Dennis Dimick, Elizabeth Marshall, Gerald Charles Nelson, Jonathan R Mein, David I Gustafson
Nutrition science-based dietary advice urges changes that may have a great impact on agricultural systems. For example, the 2016 Dietary Guidelines for Americans (DGA) recommends greatly increased fruit and vegetable consumption, but the present domestic production is insufficient to accommodate large-scale adoption of these guidelines. Increasing production to the extent needed to meet the DGA will necessitate changes in an already stressed agriculture and food system and will require nutrition and agriculture professionals to come together in open and collegial discourse...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28915973/compassionomics-hypothesis-and-experimental-approach
#13
Stephen Trzeciak, Brian W Roberts, Anthony J Mazzarelli
Recent reports indicate that healthcare is experiencing a compassion crisis - an absence of (or inconsistency in) compassionate patient care. It is currently unclear if, or to what extent, this exerts significant effects on health and healthcare. Experimental data are few, and this represents a critical knowledge gap for all health sciences. We hypothesize that compassionate care is beneficial for patients (better outcomes), healthcare systems and payers (lower costs), and healthcare providers (lower burnout)...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915462/abundance-of-large-old-trees-in-wood-pastures-of-transylvania-romania
#14
Tibor Hartel, Jan Hanspach, Cosmin I Moga, Lucian Holban, Árpád Szapanyos, Réka Tamás, Csaba Hováth, Kinga-Olga Réti
Wood-pastures are special types of agroforestry systems that integrate trees with livestock grazing. Wood pastures can be hotspots for large old tree abundance and have exceptional natural values; but they are declining all over Europe. While presence of large old trees in wood-pastures can provide arguments for their maintenance, actual data on their distribution and abundance are sparse. Our study is the first to survey large old trees in Eastern Europe over such a large area. We surveyed 97 wood-pastures in Transylvania (Romania) in order to (i) provide a descriptive overview of the large old tree abundance; and (ii) to explore the environmental determinants of the abundance and persistence of large old trees in wood-pastures...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28915215/mechanisms-involved-in-secondary-cardiac-dysfunction-in-animal-models-of-trauma-and-hemorrhagic-shock
#15
Nick M Wilson, Johanna Wall, Veena Naganathar, Karim Brohi, Henry D De'Ath
Clinical evidence reveals the existence of a trauma-induced secondary cardiac injury (TISCI) that is associated with poor patient outcomes. The mechanisms leading to TISCI in injured patients are uncertain. Conversely, animal models of trauma hemorrhage have repeatedly demonstrated significant cardiac dysfunction following injury, and highlighted mechanisms through which this might occur. The aim of this review was to provide an overview of the animal studies describing TISCI and its pathophysiology.Basic science models of trauma show evidence of innate immune system activation via Toll-like receptors, the exact protagonists of which remain unclear...
October 2017: Shock
https://www.readbyqxmd.com/read/28915003/the-evolution-of-dna-templated-synthesis-as-a-tool-for-materials-discovery
#16
Rachel K O'Reilly, Andrew J Turberfield, Thomas R Wilks
Precise control over reactivity and molecular structure is a fundamental goal of the chemical sciences. Billions of years of evolution by natural selection have resulted in chemical systems capable of information storage, self-replication, catalysis, capture and production of light, and even cognition. In all these cases, control over molecular structure is required to achieve a particular function: without structural control, function may be impaired, unpredictable, or impossible. The search for molecules with a desired function is often achieved by synthesizing a combinatorial library, which contains many or all possible combinations of a set of chemical building blocks (BBs), and then screening this library to identify "successful" structures...
September 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28914775/new-methods-to-address-old-challenges-the-use-of-administrative-data-for-longitudinal-replication-studies-of-child-maltreatment
#17
Emily Hurren, Anna Stewart, Susan Dennison
Administrative data are crucial to the "big data" revolution of social science and have played an important role in the development of child maltreatment research. These data are also of value to administrators, policy makers, and clinicians. The focus of this paper is the use of administrative data to produce and replicate longitudinal studies of child maltreatment. Child protection administrative data have several advantages. They are often population-based, and allow longitudinal examination of child maltreatment and complex multi-level analyses...
September 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28912890/glioma-dual-targeting-nanohybrid-protein-toxin-constructed-by-intein-mediated-site-specific-ligation-for-multistage-booster-delivery
#18
Yingzhi Chen, Meng Zhang, Hongyue Jin, Dongdong Li, Fan Xu, Aihua Wu, Jinyu Wang, Yongzhuo Huang
Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the impermeable nature of BBB against effective delivery of biologics. Indeed, it is a long unsolved problem for brain delivery of macromolecular drugs, which becomes the Holy Grail in medical and pharmaceutical sciences...
2017: Theranostics
https://www.readbyqxmd.com/read/28912424/electric-field-and-aging-effects-of-uniaxial-ferroelectrics-sr-x-ba1-x-nb2o6-probed-by-brillouin-scattering
#19
M Aftabuzzaman, M A Helal, R Paszkowski, J Dec, W Kleemann, S Kojima
Static and dynamic heterogeneity of disordered system is one of the current topics in materials science. In disordered ferroelectric materials with random fields, dynamic polar nanoregions (PNRs) appear at Burns temperature and freeze into nanodomain state below Curie temperature (T C). This state is very sensitive to external electric field and aging by which it gradually switches into macrodomain state. However, the role of PNRs in such states below T C is still a puzzling issue of materials science. Electric field and aging effects of uniaxial ferroelectric Sr x Ba1-x Nb2O6 (x = 0...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911665/nanostructures-current-uses-and-future-applications-in-food-science
#20
REVIEW
Kavitha Pathakoti, Manjunath Manubolu, Huey-Min Hwang
Recent developments in nanoscience and nanotechnology intend novel and innovative applications in the food sector, which is rather recent compared with their use in biomedical and pharmaceutical applications. Nanostructured materials are having applications in various sectors of the food science comprising nanosensors, new packaging materials, and encapsulated food components. Nanostructured systems in food include polymeric nanoparticles, liposomes, nanoemulsions, and microemulsions. These materials enhance solubility, improve bioavailability, facilitate controlled release, and protect bioactive components during manufacture and storage...
April 2017: Journal of Food and Drug Analysis
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