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https://www.readbyqxmd.com/read/28813636/using-systems-science-to-inform-population-health-strategies-in-local-health-departments-a-case-study-in-san-antonio-texas
#1
Yan Li, Norma A Padrón, Anil T Mangla, Pamela G Russo, Thomas Schlenker, José A Pagán
OBJECTIVES: Because of state and federal health care reform, local health departments play an increasingly prominent role leading and coordinating disease prevention programs in the United States. This case study shows how a local health department working in chronic disease prevention and management can use systems science and evidence-based decision making to inform program selection, implementation, and assessment; enhance engagement with local health systems and organizations; and possibly optimize health care delivery and population health...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28813442/a-parallel-metaheuristic-for-large-mixed-integer-dynamic-optimization-problems-with-applications-in-computational-biology
#2
David R Penas, David Henriques, Patricia González, Ramón Doallo, Julio Saez-Rodriguez, Julio R Banga
BACKGROUND: We consider a general class of global optimization problems dealing with nonlinear dynamic models. Although this class is relevant to many areas of science and engineering, here we are interested in applying this framework to the reverse engineering problem in computational systems biology, which yields very large mixed-integer dynamic optimization (MIDO) problems. In particular, we consider the framework of logic-based ordinary differential equations (ODEs). METHODS: We present saCeSS2, a parallel method for the solution of this class of problems...
2017: PloS One
https://www.readbyqxmd.com/read/28813426/sexual-reproduction-in-plagiogrammacean-diatoms-first-insights-into-the-early-pennates
#3
Irena Kaczmarska, Benjamin S Gray, James M Ehrman, Mary Thaler
The genera Plagiogramma and Dimeregramma are members of a small, but evolutionarily important group of diatoms, the "basal" araphids. They are sister to all other pennates, both araphid and raphid taxa. Thus, their phylogenetic position carries the potential for providing insights into the earliest pennates. We documented sexual reproduction, mating system and sex cell development in the first members of the "basal" araphid clade ever investigated. The mating system in all these species involved heterothally...
2017: PloS One
https://www.readbyqxmd.com/read/28812832/exploring-the-functioning-of-decision-space-a-review-of-the-available-health-systems-literature
#4
REVIEW
Tamlyn Eslie Roman, Susan Cleary, Diane McIntyre
BACKGROUND: The concept of decision space holds appeal as an approach to disaggregating the elements that may influence decision-making in decentralized systems. This narrative review aims to explore the functioning of decision space and the factors that influence decision space. METHODS: A narrative review of the literature was conducted with searches of online databases and academic journals including PubMed Central, Emerald, Wiley, Science Direct, JSTOR, and Sage...
February 27, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812617/improved-tree-ring-archives-will-support-earth-system-science
#5
Flurin Babst, Benjamin Poulter, Paul Bodesheim, Miguel D Mahecha, David C Frank
No abstract text is available yet for this article.
January 24, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811950/autoscopic-hallucination-in-alcohol-dependence-syndrome-a-rare-or-missed-phenomenon
#6
Sulochana Joshi, Binita Thapa, Rabi Shakya
Autoscopic phenomenon, a psychic illusionary duplication of one's own self, has been the subject of interest in the literature and science for years. It has been reported in various diseases of the central nervous system but with an unknown mechanism. Hallucinations are a common presentation in alcohol dependence syndrome during delirium tremens and as induced disorder. However, autoscopic hallucination has been rarely reported in the cases of alcohol dependence. We present a case of a 40-year-old man who experienced autoscopic hallucination during the withdrawal state of alcohol...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28811337/first-person-dougall-norris
#7
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Dougall Norris is co-first author on 'An improved Akt reporter reveals intra- and intercellular heterogeneity and oscillations in signal transduction', published in Journal of Cell Science. Dougall is a PhD student in the Metabolic Systems Biology Group at The University of Sydney Charles Perkins Centre in Australia, where his project focuses on live-cell imaging, multiplexing fluorescent constructs and imaging modalities, coupled with powerful computational analysis...
August 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28811201/the-unmet-need-in-rheumatology-reports-from-the-targeted-therapies-meeting-2017
#8
Kevin L Winthrop, Vibeke Strand, Désirée van der Heijde, Philip Mease, Mary Crow, Michael Weinblatt, Joan Bathon, Gerd R Burmester, Maxime Dougados, Johnathan Kay, Xavier Mariette, Ronald Van Vollenhoven, Joachim Sieper, Fritz Melchers, Ferdinand C Breedfeld, Joachim Kalden, Josef S Smolen, Daniel E Furst
The 19th annual international Targeted Therapies meeting brought together over 100 leading basic scientists and clinical researchers from around the world in the field of immunology, molecular biology and rheumatology and other specialties. During the meeting, breakout sessions were held consisting of 5 disease-specific groups with 20-40 experts assigned to each group based on clinical or scientific expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematous, connective tissue diseases (e...
August 12, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28810201/the-association-between-non-hodgkin-lymphoma-and-organophosphate-pesticides-exposure-a-meta-analysis
#9
REVIEW
Liqin Hu, Dan Luo, Tingting Zhou, Yun Tao, Jingwen Feng, Surong Mei
Several epidemiological studies show the association between organophosphate pesticides (OPs) and the risk of non-Hodgkin lymphoma (NHL), yet various research results remain controversial. To explore the hazard of OPs exposure to human health, three kinds of OPs (Terbufos, Malathion, and Diazinon) that are non-halogenated aliphatic compounds were included in the meta-analysis. We searched PubMed and Web of Science Databases for articles published from 1985 to February 2017. The databases were also searched for eligible studies through a manual references search...
August 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28809588/applying-adult-development-theories-to-improvement-science
#10
Sofia Kjellström, Ann-Christine Andersson
Purpose The purpose of this paper is to address how adult development (AD) theories can contribute to quality improvement (QI). Design/methodology/approach A theoretical analysis and discussion on how personal development empirical findings can relate to QI and Deming's four improvement knowledge domains. Findings AD research shows that professionals have qualitatively diverse ways of meaning-making and ways to approach possibilities in improvement efforts. Therefore, professionals with more complex meaning-making capacities are needed to create successful transformational changes and learning, with the recognition that system knowledge is a developmental capacity...
August 14, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28809372/coffee-is-protective-against-oral-and-pharyngeal-cancer-a-systematic-review-and-meta-analysis
#11
J Miranda, L Monteiro, R Albuquerque, J-J Pacheco, Z Khan, J Lopez-Lopez, S Warnakulasuryia
OBJECTIVES: Coffee is one of the most popular and consumable drinks worldwide. However, there are conflicting results on the influence of this drink in oral and pharyngeal cancer risk. To clarify this, we aimed to systemically review and carry out a meta-analysis of the relevant literature on the association between coffee and oral and pharyngeal cancer. STUDY DESIGN: We carried out an electronic search of publications up to August 2016 from PubMed, National Library of Medicines Medline, Embase, Science Direct and the Cochrane Central Register...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28809179/qualitative-research-for-patient-safety-using-icts-methodological-considerations-in-the-technological-age
#12
Kwang Chien Yee, Ming Chao Wong, Paul Turner
Considerable effort and resources have been dedicated to improving the quality and safety of patient care through health information systems, but there is still significant scope for improvement. One contributing factor to the lack of progress in patient safety improvement especially where technology has been deployed relates to an over-reliance on purely objective, quantitative, positivist research paradigms as the basis for generating and validating evidence of improvement. This paper argues the need for greater recognition and accommodation of evidence of improvement generated through more subjective, qualitative and pragmatic research paradigms to aid patient safety especially where technology is deployed...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28809060/the-phytochemistry-and-pharmacology-of-butia-sp-a-systematic-review-and-an-overview-of-the-technological-monitoring-process
#13
REVIEW
Lara Rodrigues Schneider, Daniela Coelho Dos Santos, Angela Diniz Campos, Rafael Guerra Lund
The Butia sp. are native South America trees, whose fruits are consumed in natura and have significant biological properties; however, trees of this genus plant are in danger of extinction. A systematic review of the literature and a technological overview were carried out to summarize the available evidence on the therapeutic uses and the phytochemical compounds of Butia sp. The following electronic databases were researched: MedLine (PubMed), Web of Science, Scopus, Scielo, and the gray literature. Furthermore, the online system such as the US Patent and Trademark Office, Espacenet, National Institute of Industrial Property, and Google Patents were accessed to obtain patent data...
August 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28809017/crispr-cas9-in-the-chicken-embryo
#14
Valérie Morin, Nadège Véron, Christophe Marcelle
Genome editing is driving a revolution in the biomedical sciences that carries the promise for future treatments of genetic diseases. The CRISPR/Cas9 system of RNA-guided genome editing has been successfully applied to modify the genome of a wide spectrum of organisms. We recently showed that this technique can be combined with in vivo electroporation to inhibit the function of genes of interest in somatic cells of the developing chicken embryo. We present here a simplified version of the previously described technique that leads to effective gene loss-of-function...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28808629/return-to-sport-following-tibial-plateau-fractures-a-systematic-review
#15
Greg A J Robertson, Seng J Wong, Alexander M Wood
AIM: To systemically review all studies reporting return to sport following tibial plateau fracture, in order to provide information on return rates and times to sport, and to assess variations in sporting outcome for different treatment methods. METHODS: A systematic search of CINAHAL, Cochrane, EMBASE, Google Scholar, MEDLINE, PEDro, Scopus, SPORTDiscus and Web of Science was performed in January 2017 using the keywords "tibial", "plateau", "fractures", "knee", "athletes", "sports", "non-operative", "conservative", "operative", "return to sport"...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28808452/root-morphology-and-canal-configuration-of-first-and-second-maxillary-molars-in-a-selected-iranian-population-a-cone-beam-computed-tomography-evaluation
#16
Abbasali Khademi, Asieh Zamani Naser, Zahra Bahreinian, Mojdeh Mehdizadeh, Mojtaba Najarian, Saber Khazaei
INTRODUCTION: The aim of this investigation was to evaluate root canal morphology of maxillary first and second molars and also to assess the prevalence and morphology of the second mesiobuccal canal (MB2) in these teeth, using cone-beam computed tomography (CBCT). METHODS AND MATERIALS: In this cross-sectional study, the total of 470 CBCT images from the archive of Radiology Department of Isfahan University of Medical Sciences (IUMS), Iran, was evaluated and 295 images were selected...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28808262/generation-of-broadband-ultraviolet-frequency-entangled-photons-using-cavity-quantum-plasmonics
#17
Hisaki Oka
Application of quantum entangled photons is now extending to various fields in physics, chemistry and biology. In particular, in terms of application to molecular science, broadband ultraviolet frequency-entangled photons are desired because molecules inducing photochemical reactions of interest often have electronic transition energies in the ultraviolet region. Recent standard method for generating such entangled photons is a chirped quasi-phase-matching method, however this method is not suitable for the generation of ultraviolet frequency-entangled photons because it requires down-conversion of a photon with a wavelength shorter than ultraviolet into an entangled photon pair...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806989/maximising-value-from-a-united-kingdom-biomedical-research-centre-study-protocol
#18
Trisha Greenhalgh, Pavel V Ovseiko, Nick Fahy, Sara Shaw, Polly Kerr, Alexander D Rushforth, Keith M Channon, Vasiliki Kiparoglou
BACKGROUND: Biomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country's international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) apply the evidence base on how best to support the various partnerships in this large, multi-stakeholder research system and (2) research how these partnerships play out in a new, ambitious programme of translational research...
August 14, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28806612/pilots-using-selective-serotonin-reuptake-inhibitors-compared-to-other-fatally-injured-pilots
#19
Paul Rogers, Christy Hileman, Guillermo Salazar, Kacey Cliburn, Lawrence Paskoff, William Hathaway, Kevin Gildea, Victor Hugo Tejera Villalaz
Selective Serotonin Reuptake Inhibitors (SSRI) were a disqualifying medication for U.S. civil pilots before April 5, 2010. After this date, a Federal Aviation Administration policy was created that allowed airmen, on select SSRIs, a pathway to hold a valid medical certificate. The purpose of this study was to provide a detailed look at SSRIs in the U.S. pilot population since the inception of this new policy. We examined the toxicology results from fatally injured airmen in addition to outcomes concerning pilots who are participating in the program...
August 11, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28805695/infants-investigated-by-the-child-welfare-system-exploring-a-distinct-profile-of-risks-service-needs-and-referrals-for-support-in-ontario
#20
Joanne Filippelli, Barbara Fallon, Esme Fuller-Thomson, Nico Trocmé
The science of early childhood development underscores that maltreatment and other adversities experienced during infancy heightens the risk for poor developmental and socio-emotional outcomes. Referrals to supportive services by the child welfare system are particularly critical during infancy given the rapidity of brain development and infants' sensitivity to their environment. The main objectives of the current study are to: (1) examine age-specific differences in clinical and case characteristics; (2) determine the factors associated with the service referral decision involving infants; and (3) explore the types of services families have been referred to at the conclusion of a maltreatment-related investigation...
August 12, 2017: Brain Sciences
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