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PAWP in PAH

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https://www.readbyqxmd.com/read/27687597/-pulmonary-hypertension-definition-classification-and-treatments
#1
Etienne-Marie Jutant, Marc Humbert
Pulmonary hypertension (PH) is a cardio-pulmonary disorder that may involve multiple clinical conditions and can complicate the majority of cardiovascular and respiratory diseases. Its definition is an increase in mean pulmonary artery pressure (mPAP) \hbox{$\geqslant $} ⩾ 25 mmHg at rest, leading to right heart failure and ultimately death. The clinical classification of pulmonary hypertension (PH) categorizes PH into groups which share similar pathophysiological and hemodynamic characteristics and treatments...
2016: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/27677579/risk-factors-for-development-of-pulmonary-arterial-hypertension-in-australian-systemic-sclerosis-patients-results-from-a-large-multicenter-cohort-study
#2
Kathleen Morrisroe, Molla Huq, Wendy Stevens, Candice Rabusa, Susanna M Proudman, Mandana Nikpour
BACKGROUND: Pulmonary arterial hypertension (PAH) is the leading cause of mortality in patients with systemic sclerosis (SSc). We sought to determine the incidence, prevalence and risk factors for PAH development in a large Australian SSc cohort. METHODS: PAH was diagnosed on right heart catheterisation (mPAP >25 and PAWP <15 mmHg at rest). Patients with PH secondary to interstitial lung disease (ILD; defined as abnormal HRCT scan and FVC < 60 %) were excluded...
September 27, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27575357/clinical-relevance-of-fluid-challenge-in-patients-evaluated-for-pulmonary-hypertension
#3
Michele D'Alto, Emanuele Romeo, Paola Argiento, Yoshiki Motoji, Anna Correra, Giovanni Maria Di Marco, Agostino Mattera Iacono, Rosaria Barracano, Antonello D'Andrea, Gaetano Rea, Berardo Sarubbi, Maria Giovanna Russo, Robert Naeije
BACKGROUND: A fluid challenge may help to the differential diagnosis between pre- and post-capillary pulmonary hypertension (PH). However the test is still in need of standardization and better defined clinical relevance. METHODS AND RESULTS: Two-hundred-twelve patients referred for PH underwent a right heart catheterization with measurements before and after rapid infusion of 7 ml/kg of saline. PH was defined by a mean pulmonary artery pressure (mPAP) ≥ 25 mmHg and post-capillary PH by a wedged PAP (PAWP) > 15 mmHg...
August 26, 2016: Chest
https://www.readbyqxmd.com/read/27232660/update-on-pulmonary-arterial-hypertension-pharmacotherapy
#4
Arash Velayati, Marcos G Valerio, Michael Shen, Sohaib Tariq, Gregg M Lanier, Wilbert S Aronow
Pulmonary artery hypertension (PAH) refers to several subgroups of disease in which the mean pulmonary artery pressure (mPAP) is elevated to more than 25 mm Hg, pulmonary artery wedge pressure (PAWP) ≤ 15 mmHg, and an elevated pulmonary vascular resistance (PVR) > 3 Wood units as confirmed by right heart catheterization. The prevalence and geographic distribution of PAH vary depending on the type and etiology of the disease. Despite enormous efforts in the research and development of therapeutic agents in the last twenty years, the disease remains relatively incurable and the overall prognosis remains guarded...
June 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/26856665/right-atrial-pressure-pulmonary-artery-wedge-pressure-ratio-a-more-specific-predictor-of-survival-in-pulmonary-arterial-hypertension
#5
Wassim H Fares, Lavanya Bellumkonda, Adriano R Tonelli, Shannon S Carson, Paul M Hassoun, Terence K Trow, Erica L Herzog, Naftali Kaminski, Cyrus A Kholdani, Lixia Zhang, Yi Zhou, Jeffrey P Hammel, Raed A Dweik
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive, fatal disease. Current prognostic models are not ideal, and identifying more accurate prognostic variables is needed. The objective of this study was to evaluate the relative prognostic value of the right atrial pressure/pulmonary artery wedge pressure (RAP/PAWP) ratio in PAH patients. We hypothesized that the RAP/PAWP ratio is more predictive of survival than any of the other measured or calculated hemodynamic variables...
June 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26557477/why-there-is-a-need-to-discuss-pulmonary-hypertension-other-than-pulmonary-arterial-hypertension
#6
Athanasios Papathanasiou, George Nakos
Pulmonary hypertension (PH) is a condition characterized by the elevation of the mean pulmonary artery pressure above 25 mmHg and the pulmonary vascular resistance above 3 wood units. Pulmonary arterial hypertension (PAH) is an uncommon condition with severe morbidity and mortality, needing early recognition and appropriate and specific treatment. PH is frequently associated with hypoxemia, mainly chronic obstructive pulmonary disease and DPLD and/or left heart diseases (LHD), mainly heart failure with reduced or preserved ejection fraction...
November 4, 2015: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/26501213/a-simple-derived-prediction-score-for-the%C3%A2-identification-of-an-elevated-pulmonary%C3%A2-artery-wedge-pressure-using-precatheterization-clinical-data-in-patients-referred-to-a-pulmonary-hypertension-center
#7
Stefan E Richter, Kari E Roberts, Ioana R Preston, Nicholas S Hill
BACKGROUND: One of the foremost diagnostic challenges in clinical pulmonary hypertension is discriminating between pulmonary arterial hypertension (group 1) and heart failure with preserved ejection fraction (group 2.2). Group 2.2 is defined as a normal left ventricular ejection fraction (> 50%) and a pulmonary arterial wedge pressure (PAWP) > 15 mm Hg. We aimed to determine whether patient history, demographics, and noninvasive measures could predict PAWP before to right heart catheterization...
May 2016: Chest
https://www.readbyqxmd.com/read/25823269/-impact-of-bosentan-therapy-on-stress-induced-pulmonary-hypertension-in-patients-with-systemic-sclerosis
#8
A V Volkov, I A Kurmukov, N N Iudkina, S I Glukhova, E V Nikolaeva
AIM: To describe hemodynamic and clinical changes in patients with elevated mean pulmonary artery pressure (MPAP) > 30 mm Hg during exercise and the impact of bosentan therapy on stress-induced pulmonary hypertension (SIPH). SUBJECTS AND METHODS: The study included 19 patients with systemic sclerosis (SDS) in whom possible causes of pulmonary hypertension (PH) (lung and left heart injuries and thromboembolism) were excluded. All the patients underwent pulmonary artery catheterization at rest and during exercise...
2015: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/25697034/-definitions-and-diagnosis-of-pulmonary-hypertension
#9
Marius M Hoeper, Harm Jan Bogaard, Robin Condliffe, Robert Frantz, Dinesh Khanna, Marcin Kurzyna, David Langleben, Alessandra Manes, Toru Satoh, Fernando Torres, Martin R Wilkins, David B Badesch
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure 25 mm Hg at rest, measured during right heart catheterization. There is still insufficient .evidence to add an exercise criterion to this definition. The term pulmonary arterial hypertension (PAH) describes a subpopulation of patients with PH characterized hemodynamically by the presence of pre-capillary PH including an end-expiratory pulmonary artery wedge pressure (PAWP) 15 mm Hg and a pulmonary vascular resistance >3 Wood units...
October 2014: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/24355641/definitions-and-diagnosis-of-pulmonary-hypertension
#10
REVIEW
Marius M Hoeper, Harm Jan Bogaard, Robin Condliffe, Robert Frantz, Dinesh Khanna, Marcin Kurzyna, David Langleben, Alessandra Manes, Toru Satoh, Fernando Torres, Martin R Wilkins, David B Badesch
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure ≥ 25 mm Hg at rest, measured during right heart catheterization. There is still insufficient evidence to add an exercise criterion to this definition. The term pulmonary arterial hypertension (PAH) describes a subpopulation of patients with PH characterized hemodynamically by the presence of pre-capillary PH including an end-expiratory pulmonary artery wedge pressure (PAWP) ≤ 15 mm Hg and a pulmonary vascular resistance >3 Wood units...
December 24, 2013: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/23662176/comparison-of-acute-hemodynamic-effects-of-inhaled-nitric-oxide-and-inhaled-epoprostenol-in-patients-with-pulmonary-hypertension
#11
Ioana R Preston, Kristen D Sagliani, Kari E Roberts, Archan M Shah, Shilpa A Desouza, William Howard, John Brennan, Nicholas S Hill
Inhaled nitric oxide (iNO) is used for acute vasoreactivity testing in pulmonary arterial hypertension (PAH) patients. Inhaled epoprostenol (iPGI2) has pulmonary selectivity and is less costly. We sought to compare acute hemodynamic effects of iNO (20 ppm) and iPGI2 (50 ng/kg/min) and determine whether their combination has additive effects. We conducted a prospective, single center, randomized, cross-over study in 12 patients with PAH and seven with heart failure with preserved ejection fraction (HFpEF). In PAH patients, iNO lowered mean pulmonary artery pressure (mPAP) by 9 ± 12% and pulmonary vascular resistance (PVR) by 14 ± 32% (mean ± SD)...
January 2013: Pulmonary Circulation
https://www.readbyqxmd.com/read/23258775/high-prevalence-of-occult-left-heart-disease-in-scleroderma-pulmonary-hypertension
#12
Benjamin D Fox, Avi Shimony, David Langleben, Andrew Hirsch, Lawrence Rudski, Robert Schlesinger, Mark J Eisenberg, Dominique Joyal, Marie Hudson, Kim Boutet, Alexandrina Serban, Ariel Masetto, Murray Baron
Our study aimed to determine the prevalence of occult left-heart disease in patients with scleroderma and pulmonary hypertension. In patients with pulmonary hypertension (mean pulmonary artery pressure (mean PAP)≥25 mmHg), differentiation between pre- and post-capillary pulmonary hypertension has been made according to pulmonary artery wedge pressure (PAWP) less than or more than 15 mmHg, respectively. We performed a retrospective chart review of 107 scleroderma patients. All patients with suspected pulmonary hypertension had routine right or left heart catheterisation with left ventricular end-diastolic pressure (LVEDP) measurement pre-/post-fluid challenge...
October 2013: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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