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https://www.readbyqxmd.com/read/28202041/the-microtubule-plus-end-tracking-protein-tacc3-promotes-persistent-axon-outgrowth-and-mediates-responses-to-axon-guidance-signals-during-development
#1
Burcu Erdogan, Garrett M Cammarata, Eric J Lee, Benjamin C Pratt, Andrew F Francl, Erin L Rutherford, Laura Anne Lowery
BACKGROUND: Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and their plus-end tracking proteins (+TIPs) are thought to play integrative roles during this navigation. TACC3 is a + TIP that we have previously implicated in regulating MT dynamics within axons. However, the role of TACC3 in axon guidance has not been previously explored...
February 15, 2017: Neural Development
https://www.readbyqxmd.com/read/28186473/minimally-invasive-scoliosis-surgery-assisted-by-o-arm-navigation-for-lenke-type-5c-adolescent-idiopathic-scoliosis-a-comparison-with-standard-open-approach-spinal-instrumentation
#2
Weiguo Zhu, Weixiang Sun, Leilei Xu, Xu Sun, Zhen Liu, Yong Qiu, Zezhang Zhu
OBJECTIVE Recently, minimally invasive scoliosis surgery (MISS) was introduced for the correction of adult scoliosis. Multiple benefits including a good deformity correction rate and fewer complications have been demonstrated. However, few studies have reported on the use of MISS for the management of adolescent idiopathic scoliosis (AIS). The purpose of this study was to investigate the outcome of posterior MISS assisted by O-arm navigation for the correction of Lenke Type 5C AIS. METHODS The authors searched a database for all patients with AIS who had been treated with either MISS or PSF between November 2012 and January 2014...
February 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28186470/image-guidance-based-on-mri-for-spinal-interstitial-laser-thermotherapy-technical-aspects-and-accuracy
#3
Claudio E Tatsui, Clarissa N G Nascimento, Dima Suki, Behrang Amini, Jing Li, Amol J Ghia, Jonathan G Thomas, R Jason Stafford, Laurence D Rhines, Juan P Cata, Ashok J Kumar, Ganesh Rao
OBJECTIVE Image guidance for spinal procedures is based on 3D-fluoroscopy or CT, which provide poor visualization of soft tissues, including the spinal cord. To overcome this limitation, the authors developed a method to register intraoperative MRI (iMRI) of the spine into a neuronavigation system, allowing excellent visualization of the spinal cord. This novel technique improved the accuracy in the deployment of laser interstitial thermal therapy probes for the treatment of metastatic spinal cord compression...
February 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28184002/renal-cell-carcinoma-metastasis-involving-vertebral-hemangioma-dual-percutaneous-treatment-by-navigational-bipolar-radiofrequency-ablation-and-high-viscosity-cement-vertebroplasty
#4
Jean-Baptiste Zerlauth, Reto Meuli, Vincent Dunet
The case of a 70-year-old woman with progressive renal cell carcinoma (RCC) metastatic invasion of a L3 vertebral hemangioma treated by dual percutaneous radiofrequency ablation (RFA) and vertebroplasty is reported. The patient was surgically treated for RCC in 2001. Chemotherapy and immunotherapy were introduced in 2013 for ovarian, bladder and cerebral metastatic disease. An asymptomatic L3 benign hemangioma was noticed at this time. One-year CT and MRI follow-up studies demonstrated a nodular isolated soft tissue lesion involving the anterior edge of the hemangioma...
February 9, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28177300/spinal-pedicle-screw-planning-using-deformable-atlas-registration
#5
Joseph Goerres, Ali Uneri, Tharindu De Silva, Michael Ketcha, Sureerat Reaungamornrat, Matthew Jacobson, Sebastian Vogt, Gerhard Kleinszig, Greg Osgood, Jean-Paul Wolinsky, Jeffrey Siewerdsen
Spinal screw placement is a challenging task due to small bone corridors and high risk of neurological or vascular complications, benefiting from precision guidance / navigation and quality assurance (QA). Implicit to both guidance and QA is the definition of a surgical plan - i.e., the desired trajectories and device selection for target vertebrae - conventionally requiring time-consuming manual annotations by a skilled surgeon. We propose automation of such planning by deriving the pedicle trajectory and device selection from a patient's preoperative CT or MR...
February 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28168338/radiation-exposure-to-the-patients-in-thoracic-and-lumbar-spine-fusion-using-a-new-intraoperative-cone-beam-computed-tomography-imaging-technique-a-preliminary-study
#6
Ludovic Kaminski, V Cordemans, O Cartiaux, M Van Cauter
PURPOSE: The goals of this paper are to assess the ionizing radiation exposure to the patients during thoracic and lumbar spinal fusion using a new intraoperative 3D imaging system and to evaluate the factors that could explain the variability in the observed doses. METHOD: We retrospectively reviewed 97 patients who underwent posterior instrumented thoracic and/or lumbar spinal fusion from December 2013 to November 2014. Primary data were the total dose area product (total DAP, Gy cm(2)) and total skin dose (total SD, mGy)...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28163511/use-of-frameless-stereotactic-neuronavigation-and-o-arm-for-transoral-transpalatal-odontoidectomy-to-treat-a-very-high-basilar-invagination
#7
Skanda Moorthy, Amol Raheja, Deepak Agrawal
Frameless stereotactic neuronavigation system has been in wide use since many years for precise localization of cranial tumors and navigation for spinal instrumentation. We present its usage in the localization of odontoid process in a very high basilar invagination for a transoral transpalatal resection of the same. We discuss the technical aspects of assembly of neuronavigation system, O-arm and Mayfield head frame on Allen spine system to achieve precise and accurate localization of high riding odontoid process through an extremely narrow operative corridor...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28156208/image-guided-intrathecal-baclofen-pump-catheter-implantation-a-technical-note-and-case-series
#8
Shenandoah Robinson, Faith C Robertson, Hormuzdiyar H Dasenbrock, Cormac P O'Brien, Charles Berde, Horacio Padua
OBJECTIVE Medically refractory spasticity and dystonia are often alleviated with intrathecal baclofen (ITB) administration through an indwelling catheter inserted in the lumbar spine. In patients with cerebral palsy, however, there is a high incidence of concomitant neuromuscular scoliosis. ITB placement may be technically challenging in those who have severe spinal deformity or who have undergone prior instrumented thoracolumbar fusion. Although prior reports have described drilling through the lumbar fusion mass with a high-speed bur, as well as IT catheter implantation at the foramen magnum or cervical spine, these approaches have notable limitations...
February 3, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28154154/renal-cell-carcinoma-metastasis-involving-vertebral-hemangioma-dual-percutaneous-treatment-by-navigational-bipolar-radiofrequency-ablation-and-high-viscosity-cement-vertebroplasty
#9
Jean-Baptiste Zerlauth, Reto Meuli, Vincent Dunet
The case of a 70-year-old woman with progressive renal cell carcinoma (RCC) metastatic invasion of a L3 vertebral hemangioma treated by dual percutaneous radiofrequency ablation (RFA) and vertebroplasty is reported. The patient was surgically treated for RCC in 2001. Chemotherapy and immunotherapy were introduced in 2013 for ovarian, bladder and cerebral metastatic disease. An asymptomatic L3 benign hemangioma was noticed at this time. One-year CT and MRI follow-up studies demonstrated a nodular isolated soft tissue lesion involving the anterior edge of the hemangioma...
February 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28152039/individualized-3d-printing-navigation-template-for-pedicle-screw-fixation-in-upper-cervical-spine
#10
Fei Guo, Jianhao Dai, Junxiang Zhang, Yichuan Ma, Guanghui Zhu, Junjie Shen, Guoqi Niu
PURPOSE: Pedicle screw fixation in the upper cervical spine is a difficult and high-risk procedure. The screw is difficult to place rapidly and accurately, and can lead to serious injury of spinal cord or vertebral artery. The aim of this study was to design an individualized 3D printing navigation template for pedicle screw fixation in the upper cervical spine. METHODS: Using CT thin slices data, we employed computer software to design the navigation template for pedicle screw fixation in the upper cervical spine (atlas and axis)...
2017: PloS One
https://www.readbyqxmd.com/read/28120092/transpedicular-approach-to-thoracic-disc-herniaton-guided-by-3d-navigation-system
#11
Gualtiero Innocenzi, Manuela D'Ercole, Giovanni Cardarelli, Simona Bistazzoni, Francesco Ricciardi, Francesco Marzetti, Francesco Sasso
BACKGROUND: The choice of surgical approach for thoracic disc herniation should consider the location on the axial plane and the consistency of the herniated disc. Calcified midline disc herniations are difficult to remove with a transpedicular approach because of limitations due to blind spots; so they are usually treated via a transthoracic approach, although this entails a high risk of thoracopulmonary injuries. METHODS: In this work we present two cases of calcified midline thoracic disc herniations treated with a transpedicular approach, improved by using a three-dimensional (3D) neuronavigation system to verify the extent of removal on the blind side...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28104526/total-navigation-in-spine-surgery-a-concise-guide-to-eliminate-fluoroscopy-using-a-portable-intraoperative-ct-3d-navigation-system
#12
Rodrigo Navarro-Ramirez, Gernot Lang, Xiaofeng Lian, Connor Berlin, Insa Janssen, Ajit Jada, Marjan Alimi, Roger Härtl
BACKGROUND: Portable intraoperative computed tomography (iCT) with integrated 3D navigation offers new opportunities for more precise navigation in spinal surgery, eliminates radiation exposure for the surgical team and accelerates surgical workflows. We present the concept of "total navigation" using iCT NAV in spinal surgery. Therefore, we propose a step-by-step guideline demonstrating how total navigation can eliminate fluoroscopy with time efficient workflows integrating iCT NAV into daily practice...
January 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28068277/initial-experience-with-o-arm-navigated-spinal-surgery-report-on-two-cases
#13
Ivo I Kehayov, Christo B Zhelyazkov, Borislav M Kalnev, Atanas N Davarski, Borislav D Kitov, Stefan D Raykov
Image-guided spinal surgery is becoming increasingly popular because it allows surgeons to achieve minimal invasiveness and maximum precision in the performed procedures. We present our initial experience with two cases operated on using O-arm-based spinal navigation at the Clinic of Neurosurgery in St George University Hospital, Plovdiv, Bulgaria. In the first case, we performed removal of extradural spinal tumor of the sixth thoracic vertebra and O-arm-navigated pedicle screw fixation. In the second case, we performed O-arm-navigated corpectomy of the fifth cervical vertebra and anterior spinal reconstruction and fusion with titanium expandable mesh and cervical plate in connection with degenerative narrowing of the cervical spinal canal that lead to clinically manifested myelopathy...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28047736/su-f-p-42-to-navigate-or-not-to-navigate-hdr-bt-in-recurrent-spine-lesions
#14
L Voros, G Cohen, M Zaider, Y Yamada
PURPOSE: We compare the accuracy of HDR catheter placement for paraspinal lesions using O-arm CBCT imaging combined with StealthStation navigation and traditional fluoroscopically guided catheter placement. METHODS: CT and MRI scans were acquired pre-treatment to outline the lesions and design treatment plans (pre-plans) to meet dosimetric constrains. The pre-planned catheter trajectories were transferred into the StealthStation Navigation system prior to the surgery...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27965053/the-spinal-cord-shows-the-way-how-axons-navigate-intermediate-targets
#15
REVIEW
Gemma de Ramon Francàs, Nikole R Zuñiga, Esther T Stoeckli
Functional neural circuits depend on the establishment of specific connections between neurons and their target cells. To this end, many axons have to travel long distances to reach their target cells during development. Studies addressing the molecular mechanisms of axon guidance have to overcome the complexity of subpopulation-specific requirements with respect to pathways, guidance cues, and target recognition. Compared to the brain, the relatively simple structure of the spinal cord provides an advantage for experimental studies of axon guidance mechanisms...
December 10, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27955617/planar-cell-polarity-genes-frizzled3a-vangl2-and-scribble-are-required-for-spinal-commissural-axon-guidance
#16
Simon D Sun, Ashley M Purdy, Gregory S Walsh
BACKGROUND: A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. Spinal commissural neurons are an attractive model to investigate the multiple guidance cues that control growth cone navigation both pre- and post-midline crossing, as well as along both the dorsal-ventral (D-V) and anterior-posterior (A-P) axes. Accumulating evidence suggests that guidance of spinal commissural axons along the A-P axis is dependent on components of the planar cell polarity (PCP) signaling pathway...
December 12, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27847133/c1-lateral-mass-screw-insertion-caudally-from-c2-nerve-root-an-alternate-method-for-insertion-of-c1-screws-a-technical-note-and-preliminary-clinical-results
#17
Keiji Wada, Ryo Tamaki, Mitsuru Yui, Daisuke Numaguchi, Yasuaki Murata
BACKGROUND: C1 lateral mass screw was widely used for fixation of the upper cervical spine. However, massive bleeding from the C1-2 venous plexus is sometimes encountered. In this study, we proposed an alternate method for C1 lateral mass screw insertion, which involves insertion of the screws caudally from the C2 nerve root to reduce bleeding from C1-2 venous plexus. METHODS: Seven patients with atlantoaxial lesions were included in this study. The mean age at surgery was 65...
November 12, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27846359/-o-arm-navigation-in-spinal-surgery-for-complex-cases
#18
D Pescador, D Rendón, J Blanco, R González, J M Martín, C Cano-Gala, D Pescador
The intraoperative computer-assisted navigation technique has evolved and changed the way we approach certain complex cases in the vertebral pathologies. The main advantages of this technique are that it increases the accuracy of the procedure, reduces its morbidity and invasiveness, diminishes the radiation dose and improves surgical protocols. In addition to the transpedicular fixation, the navigation system is useful in a high variety of pathologies such as spinal decompression or tumor resection. In the present study, we show several cases where navigation is used intraoperatively in different pathologies and their clinical outcomes...
March 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27832013/surgical-resection-of-osteoid-osteoma-and-osteoblastoma-of-the-spine
#19
Muayad Kadhim, Odion Binitie, Patrick O'Toole, Emmanouil Grigoriou, Camila B De Mattos, John P Dormans
: Intraoperative radiographic guidance has traditionally been utilized in orthopedic surgery through 2-D navigation with the C-arm and recently with 3-D navigation with the O-arm. The aim of this study was to describe the outcome of surgical treatment of spinal osteoblastoma and osteoid osteoma with the utilization of the O-arm and conventional C-arm guidance. This is a retrospective cohort study of patients with spinal osteoid osteoma and or osteoblastoma who were treated at our institution between 2002 and 2011...
November 9, 2016: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/27779161/three-dimensional-fluoroscopy-based-navigation-for-the-pedicle-screw-placement-in-patients-with-primary-invasive-spinal-tumors
#20
Bo Jin, Yi-Bing Su, Ji-Zong Zhao
BACKGROUND: Although pedicle screw placement (PSP) is a well-established technique for spine surgery, the treatment of patients with primary invasive spinal tumor (PIST) has high surgical risks secondary to destroyed pedicles. Intraoperative three-dimensional fluoroscopy-based navigation (ITFN) system permits safe and accurate instrumentation of the spine with the advantage of obtaining intraoperative real-time three-dimensional images and automatic registration. The aim of this study is to evaluate the feasibility and accuracy of PSP using ITFN system for patients afflicted with PIST in the thoracic spine...
2016: Chinese Medical Journal
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