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https://www.readbyqxmd.com/read/29155340/ambulatory-anterior-cervical-discectomy-and-fusion-is-associated-with-a-higher-risk-of-revision-surgery-and-perioperative-complications-an-analysis-of-a-large-nationwide-database
#1
Armin Arshi, Christopher Wang, Howard Y Park, Gideon W Blumstein, Zorica Buser, Jeffrey C Wang, Arya N Shamie, Don Y Park
BACKGROUND CONTEXT: With the changing landscape of healthcare, outpatient spine surgery is being more commonly performed to reduce cost and improve efficiency. Anterior cervical discectomy and fusion (ACDF) is one of the most common spine surgeries performed and demand is expected to increase with an aging population. PURPOSE: To determine the nationwide trends and relative complication rates associated with outpatient ACDF. STUDY DESIGN/SETTING: Large-scale retrospective case control study PATIENT SAMPLE: Humana-insured patients who underwent 1-2 level ACDF as either outpatients or inpatients from 2011-2016 OUTCOME MEASURES: Incidence and adjusted odds ratio (OR) of postoperative medical and surgical complications within one year of the index surgery METHODS: A retrospective review was performed of the PearlDiver® Humana insurance records database to identify patients undergoing 1-2 level ACDF (CPT-22551 AND ICD-9-816...
November 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29152647/cryptotanshinone-exhibits-therapeutical-effects-on-cerebral-stroke-through-the-pi3k-akt%C3%A2-enos-signaling-pathway
#2
Weixin Zhu, Weihong Qiu, Ailan Lu
Cerebral stroke is a kind of acute cerebrovascular disease with high incidence, morbidity and disability. Treatments against various types of cerebral stroke are limited at preventive measurements due to the lack of effective therapeutic method. The present study aimed to investigate the protective effect of cryptotanshinone (CPT) on cerebral stroke, and investigate the possible mechanism involved in order to develop a novel therapy against stoke. The phosphoinositide 3‑kinase membrane translocation of cerebral stroke rats pretreated with CPT at various concentrations were measured, as well as the phosphorylation of protein kinase B (AKT) and endothelial nitric oxide synthase (eNOS)...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29150857/a-randomized-double-blind-placebo-controlled-dose-finding-trial-with-lolium-perenne-peptide-immunotherapy
#3
Ralph Mösges, Elena M Kasche, Esther Raskopf, Jaswinder Singh, Lea Sohlich, Anatoli Astvatsatourov, Kija Shah-Hosseini, Sabine Pirotton, Ludo Haazen, Stephen R Durham, Thierry Legon, Gregor Zadoyan, Mohamed H Shamji
BACKGROUND: A novel subcutaneous allergen immunotherapy formulation (gpASIT+(™) ) containing Lolium perenne peptides (LPP) and having a short up-dosing phase has been developed to treat grass pollen-induced seasonal allergic rhinoconjunctivitis. We investigated peptide immunotherapy containing the hydrolysate from perennial ryegrass allergens for the optimum dose in terms of clinical efficacy, immunogenicity, and safety. METHODS: This prospective, double-blind, placebo-controlled, phase IIb, parallel, four-arm, dose-finding study randomized 198 grass pollen-allergic adults to receive placebo or cumulative doses of 70, 170, or 370 μg LPP...
November 18, 2017: Allergy
https://www.readbyqxmd.com/read/29147969/effect-of-dietary-phospholipid-levels-on-growth-lipid-metabolism-and-antioxidative-status-of-juvenile-hybrid-snakehead-channa-argus%C3%A3-channa-maculata
#4
Shi-Mei Lin, Fa-Jian Li, Bundit Yuangsoi, Sompong Doolgindachbaporn
The study was conducted to evaluate the effect of dietary phospholipids (PLs) on growth, lipid metabolism, and antioxidative status of hybrid snakehead (Channa argus × Channa maculata). Five isonitrogenous and isolipidic diets with graded levels of PLs (8.5, 19.3, 30.7, 41.5, and 50.8 g kg(-1)) were fed to triplicate groups of juveniles (initial body weight 12.6 ± 0.23 g) for 8 weeks. Results showed that dietary PL supplementation significantly improved growth of juveniles. The final body weight (FBW) and specific growth rate (SGR) significantly increased with dietary PLs increasing from 8...
November 16, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29146242/acid-activatable-oxidative-stress-inducing-polysaccharide-nanoparticles-for-anticancer-therapy
#5
Wooyoung Yoo, Donghyuck Yoo, Eunmi Hong, Eunkyeong Jung, Yebin Go, Berwin Singh, Gilson Khang, Dongwon Lee
Drug delivery systems have been extensively developed to enhance the therapeutic efficacy of drugs by altering their pharmacokinetics and biodistribution. However, the use of high quantities of drug delivery systems can cause toxicity due to their poor metabolism and elimination. In this study, we developed polysaccharide-based drug delivery systems which exert potent therapeutic effects and could display synergistic therapeutic effects with drug payloads, leading to dose reduction. Cinnamaldehyde, a major component of cinnamon is known to induce anticancer activity by generating ROS (reactive oxygen species)...
November 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29145788/quality-of-life-following-treatment-for-ptsd-comparison-of-videoconferencing-and-in-person-modalities
#6
Lisa H Glassman, Margaret-Anne Mackintosh, Alexander Talkovsky, Stephanie Y Wells, Kristen H Walter, Induni Wickramasinghe, Leslie A Morland
Introduction Quality of life (QOL) is significantly impaired among individuals with post-traumatic stress disorder (PTSD); however, few treatment outcome studies examine QOL following treatment. Furthermore, the use of videoconferencing to deliver evidence-based treatments for PTSD is increasing dramatically. Although videoconferencing has demonstrated non-inferiority to in-person treatment modalities for improving PTSD symptom severity, no studies to date have directly compared QOL outcomes of an evidence-based intervention delivered via videoconferencing to one delivered in-person...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29145770/camptothecin-prodrug-nanomicelle-based-on-a-boronate-ester-linked-diblock-copolymer-as-the-carrier-of-doxorubicin-with-enhanced-cellular-uptake
#7
Ya Gao, Yi Xiao, Shiyuan Liu, Jiahui Yu
A novel pH-sensitive polymeric prodrug of camptothecin (CPT) by polymerizing γ-camptothecin-glutamate N-carboxyanhydride (Glu (CPT)-NCA) on boronate ester-linked poly (ethyleneglycol) (PEG) directly via the amine-initiated ring open polymerization (ROP) has been developed. The resulting amphiphilic prodrug (mPEG-BC-PGluCPT) could self-assemble into nanoparticles and encapsulate doxorubicin (Dox) simultaneously in aqueous solution for dual-drug delivery. The formation of polymeric prodrug micelles (mPEG-BC@PGluCPT) was confirmed by the measurements of critical aggregation concentration (CAC), particle size, and morphology observations...
November 17, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29143193/cigarette-demand-among-smokers-with-elevated-depressive-symptoms-an-experimental-comparison-with-low-depressive-symptoms
#8
Roberto Secades-Villa, Sara Weidberg, Alba González-Roz, Derek D Reed, José R Fernández-Hermida
RATIONALE: Individuals with depression smoke more than smokers without depression. Research has shown that cigarette demand is a useful tool for quantifying tobacco reinforcement and supposes a clinical predictor of treatment outcomes. Despite previous studies examining the relative reinforcing efficacy of nicotine among different populations of smokers, to date, no study has assessed cigarette demand among individuals with elevated depressive symptoms. OBJECTIVE: The aim of this study was to compare cigarette demand among samples of smokers with low and elevated depressive symptoms...
November 15, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29139118/di-2-ethylhexyl-phthalate-dehp-exposure-disturbs-lipid-metabolism-in-juvenile-yellow-catfish-tachysurus-fulvidraco
#9
F X Meng, M Li, M Z Song, L X Yuan, Y F Gong, Y X Qian, G Shi, R X Wang
This study was conducted to determine the mechanism by which di-2-ethylhexyl phthalate (DEHP) exposure influences lipid metabolism of juvenile yellow catfish Tachysurus fulvidraco. Fish were exposed to three DEHP concentrations (0, 0·1 and 0·5 mg l(-1) DEHP) for 8 weeks. Fatty acid synthase (FAS) activity significantly decreased with increasing DEHP concentrations, the highest value was in the Tween control group, whereas the lowest activities of carnitine palmitoyltransferase (CPT) and lipoprotein lipase (LPL) were in this group...
November 15, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29137181/structure-and-functional-analysis-of-promoters-from-two-liver-isoforms-of-cpt-i-in-grass-carp-ctenopharyngodon-idella
#10
Yi-Huan Xu, Zhi Luo, Kun Wu, Yao-Fang Fan, Wen-Jing You, Li-Han Zhang
Carnitine palmitoyltransferase I (CPT I) is a key enzyme involved in the regulation of lipid metabolism and fatty acid β-oxidation. To understand the transcriptional mechanism of CPT Iα1b and CPT Iα2a genes, we cloned the 2695-bp and 2631-bp regions of CPT Iα1b and CPT Iα2a promoters of grass carp (Ctenopharyngodon idella), respectively, and explored the structure and functional characteristics of these promoters. CPT Iα1b had two transcription start sites (TSSs), while CPT Iα2a had only one TSS. DNase I foot printing showed that the CPT Iα1b promoter was AT-rich and TATA-less, and mediated basal transcription through an initiator (INR)-independent mechanism...
November 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29133057/development-of-11-c-labeled-%C3%AF-sulfhydryl-fatty-acid-tracer-for-myocardial-imaging-with-pet
#11
Xiangxiang Wu, Peizhi Wang, Ruixin Liu, Huahui Zeng, Fangfang Chao, Hao Liu, Caiyun Xu, Haifeng Hou, Qiong Yao
[(11)C]-S-methyl-16-thiopalmitic acid (a) was developed with excellent heart-to-background uptake ratios and higher retention in heart. Myocardial uptake and metabolism of the tracer is markedly higher CPT I dependent. When compared to [(11)C]-S-methyl-14-thiomyristic acid (b), [(11)C]-S-methyl-12-thiododecanoic acid (c) and [(11)C]-palmitate, a showed an early high uptake and a significantly slower late clearance in heart and a prolonged myocardial elimination half-life (30 min). Analysis of heart tissue and urine samples showed that a was metabolized via beta-oxidation in myocardium...
October 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29131708/processes-in-increasing-participation-of-african-american-women-in-cancer-prevention-trials-development-and-pretesting-of-an-audio-card
#12
Donna Kenerson, Saudat Fadeyi, Jianguo Liu, Mirabel Kleriwoh, Katina Beard, Margaret K Hargreaves
The enrollment of African American women into cancer prevention trials (CPTs) continues to be low despite their higher cancer mortality rates. Clinical trials are vital to the discovery of new prevention, diagnostic, and treatment methods that improve cancer outcomes. This study addressed attitudes and beliefs associated with the sub optimal participation of African American women in CPTs through the development and pretesting of an educational tool. The use of community-engaged research (CER) in the formative phase of this study was the basis for developing an audio-card...
November 13, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/29131398/response-to-cognitive-processing-therapy-in-veterans-with-and-without-obstructive-sleep-apnea
#13
Franklin Mesa, Benjamin D Dickstein, Virgil D Wooten, Kathleen M Chard
Recent studies have called attention to the need for enhancing treatment outcome in trauma-focused psychotherapies, such as cognitive processing therapy (CPT), with veterans. Given the prevalence of posttraumatic-related sleep disturbances, and the role of sleep in emotional learning and processing, sleep quality may be a target for improving CPT outcome. Elevated rates of obstructive sleep apnea (OSA) have been reported in samples of veterans with posttraumatic stress disorder (PTSD); however, the impact of OSA on response to CPT is unclear...
November 13, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29127776/working-memory-capacity-and-intra-individual-variability-of-proactive-control
#14
Elizabeth A Wiemers, Thomas S Redick
Two datasets of 110 young adults were examined to investigate the relationship between individual differences in working memory capacity (WMC) and dynamic cognitive control. The results delve into the specific differences between high- and low-WMC individuals' ability to enact and maintain cognitive control using the AX version of the continuous performance test (AX-CPT). Compared to high-WMC individuals, low-WMC individuals: (a) made more errors, specifically to AX targets; (b) exhibited a partial shift to proactive control with more time-on-task; (c) had more exaggerated slower AX target responses in the tail of the response time distribution; and (d) were equally likely to adjust control after conflict...
November 8, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/29127035/the-high-production-volume-fungicide-pyraclostrobin-induces-triglyceride-accumulation-associated-with-mitochondrial-dysfunction-and-promotes-adipocyte-differentiation-independent-of-ppar%C3%AE-activation-in-3t3-l1-cells
#15
Anthony L Luz, Christopher D Kassotis, Heather M Stapleton, Joel N Meyer
Pyraclostrobin is one of the most heavily used fungicides, and has been detected on a variety of produce, suggesting human exposure occurs regularly. Recently, pyraclostrobin exposure has been linked to a variety of toxic effects, including neurodegeneration and triglyceride (TG) accumulation. As pyraclostrobin inhibits electron transport chain complex III, and as mitochondrial dysfunction is associated with metabolic syndrome (cardiovascular disease, type II diabetes, obesity), we designed experiments to test the hypothesis that mitochondrial dysfunction underlies its adipogenic activity...
November 7, 2017: Toxicology
https://www.readbyqxmd.com/read/29125991/effects-of-quercetin-combined-with-anticancer-drugs-on-metastasis-associated-factors-of-gastric-cancer-cells-in-vitro-and-in-vivo-studies
#16
Cing-Syuan Lei, Yu-Chen Hou, Man-Hui Pai, Ming-Tsan Lin, Sung-Ling Yeh
Chemotherapy is essential to most patients with gastric cancer and the anticancer drug, irinotecan (CPT-11), and its metabolite, SN-38, an inhibitor of DNA topoisomerase I, are first-line chemotherapies for gastric cancer. Quercetin, a flavonoid that is widely found in various vegetables and fruits, has the ability to potentiate the efficacy of anticancer drugs. The purpose of this study was to investigate the therapeutic effect of quercetin combined with irinotecan/SN-38 in the AGS human gastric cancer cell line in vitro and in vivo...
September 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29124529/eeg-indices-correlate-with-sustained-attention-performance-in-patients-affected-by-diffuse-axonal-injury
#17
Stefania Coelli, Riccardo Barbieri, Gianluigi Reni, Claudio Zucca, Anna Maria Bianchi
The aim of this study is to assess the ability of EEG-based indices in providing relevant information about cognitive engagement level during the execution of a clinical sustained attention (SA) test in healthy volunteers and DAI (diffused axonal injury)-affected patients. We computed three continuous power-based engagement indices (P β /P α , 1/P α , and P β / (P α + P θ )) from EEG recordings in a control group (n = 7) and seven DAI-affected patients executing a 10-min Conners' "not-X" continuous performance test (CPT)...
November 9, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29124328/efficacy-of-combination-chemotherapy-using-irinotecan-and-nedaplatin-for-patients-with-recurrent-and-refractory-endometrial-carcinomas-preliminary-analysis-and-literature-review
#18
Morikazu Miyamoto, Masashi Takano, Mika Kuwahara, Hiroaki Soyama, Kento Kato, Hiroko Matuura, Takahiro Sakamoto, Kazuki Takasaki, Tadashi Aoyama, Tomoyuki Yoshikawa, Kenichi Furuya
PURPOSE: We aimed to retrospectively evaluate the efficacy and toxicity of an irinotecan hydrochloride (CPT) and nedaplatin (N) combination therapy for recurrent and refractory endometrial carcinoma, administered based on UGT1A1 genotype. METHODS: Between 2009 and 2017, 21 patients who received CPT-N therapy for recurrent endometrial carcinoma as second- or third-line chemotherapy at our hospital were identified. The CPT-N regimen included 40-70 mg/m(2) of CPT-11 on days 1, 8, and 15, and 50 mg/m(2) of nedaplatin on day 1, q4 weeks...
November 9, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29122653/validation-of-an-automated-bilateral-feet-cold-pressor-test
#19
Petra Bachmann, Xinwei Zhang, Mauro F Larra, Dagmar Rebeck, Karsten Schönbein, Klaus P Koch, Hartmut Schächinger
The Cold Pressor Test (CPT) is often used in psychobiological research. However, the classical CPT version (unilateral hand immersion into ice-water) involves some disadvantages: hands may be needed for further applications, attentional drift towards the affected sensory hemi-field and/or physiological activation of the contralateral hemisphere may produce a laterality bias. Furthermore, instruction-induced motor activity may bias physiologic reactivity. To avoid these problems, a fully automated bilateral feet CPT was developed and tested for validity and feasibility...
November 6, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29121130/optical-coherence-tomography-in-dermatology
#20
Michelle Schwartz, Amanda Levine, Orit Markowitz
Optical coherence tomography (OCT), an emerging noninvasive imaging modality, recently received category III Current Procedural Terminology (CPT) codes from the American Medical Association, enabling tracking of its use in the medical community. In this article, we review OCT imaging and its variant systems, discussing its applications and limitations for clinical use. Future directions of OCT technology and goals for obtaining category I CPT codes and reimbursement also are discussed.
September 2017: Cutis; Cutaneous Medicine for the Practitioner
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