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beta lactamase inhibitors esbl

Young Lee, Dong Gi Lee, Sang Hyub Lee, Koo Han Yoo
The objectives of this study were to investigate risk factors and the incidence of ciprofloxacin resistance and extended-spectrum beta-lactamases (ESBL) in patients with acute bacterial prostatitis (ABP). We reviewed the medical records of 307 patients who were diagnosed with ABP between January 2006 and December 2015. The etiologic pathogens and risk factors for ciprofloxacin-resistant E. coli and ESBL-producing microbes, susceptibility to ciprofloxacin, and the incidence of ESBL in patients with ABP were described...
November 2016: Journal of Korean Medical Science
Bamidele Tolulope Odumosu, Olabayo Ajetunmobi, Hannah Dada-Adegbola, Idowu Odutayo
Multidrug resistant organisms (MDROs) constitute a major public health threat globally. Clinical isolates of Pseudomonas aeruginosa remains one of the most studied MDROs however there is paucity of information regarding the susceptibility of its animal and plants isolates to antipseudomonas drug in Nigeria. From a total of 252 samples consisting of plants, animals and clinical samples, 54, 24 and 22 P. aeruginosa were isolated from vegetables, animals and clinical sources respectively. All the isolates were identified by standard biochemical methods...
2016: SpringerPlus
Jose A Hidalgo, Celeste M Vinluan, Nishaal Antony
There has been greater interest in developing additional antimicrobial agents due to the increasing health care costs and resistance resulting from bacterial pathogens to currently available treatment options. Gram-negative organisms including Enterobacteriaceae and Pseudomonas aeruginosa are some of the most concerning threats due to their resistance mechanisms: extended-spectrum beta-lactamase production and Klebsiella pneumoniae carbapenemase enzymes. Ceftazidime is a third-generation broad-spectrum cephalosporin with activity against P...
2016: Drug Design, Development and Therapy
I Tuerena, N J Williams, T Nuttall, G Pinchbeck
INTRODUCTION: Antimicrobial resistance is a growing concern with implications for animal health. This study investigated the prevalence of antimicrobial resistance among commensal and environmental Escherichia coli isolated from animals sampled in referral hospitals in the UK. MATERIALS AND METHODS: Resistant Escherichia coli isolated from animal faeces and practice environments were tested for susceptibility to antimicrobial agents. PCR and sequencing techniques were used to identify extended spectrum beta-lactamase and AmpC-producer genotypes...
July 2016: Journal of Small Animal Practice
M Zhang, J A Huang, Y B Chen
OBJECTIVE: To explore the clinical features of Escherichia coli bloodstream infection. METHODS: The clinical data of underlying diseases, antimicrobial susceptibility, temperature at blood sampling, results of routine blood tests, venous catheterization, therapy and prognosis of Escherichia coli bloodstream infection in the First Affiliated Hospital of Soochow University from January 2007 to December 2014 were analyzed retrospectively. The pathogens were routinely isolated and identified...
May 17, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Faruk Pehlivanoglu, Hulya Turutoglu, Dilek Ozturk
In the present study, 3 quarter milk samples from 3 cows showing clinical signs of mastitis were investigated. Three Escherichia coli were isolated and were found resistant to ceftiofur and cefquinome. The isolates were detected as extended-spectrum beta-lactamase (ESBL) producers by the Clinical and Laboratory Standards Institute (CLSI) ESBL screening test and combined disc method. CTX-M- and TEM-type beta-lactamase genes (blaCTX-M blaTEM) were detected by polymerase chain reaction in the isolates. Sequencing of blaCTX-M and blaTEM genes showed that the isolates were both TEM-1- and CTX-M-15-type beta-lactamase producers...
September 2016: Foodborne Pathogens and Disease
Yumei Guo, Haijian Zhou, Liyun Qin, Zhizhao Pang, Tian Qin, Hongyu Ren, Zhuo Pan, Jikun Zhou
This study aimed to assess the frequency of Klebsiella pneumoniae in food samples and to detect antibiotic resistance phenotypes, antimicrobial resistance genes and the molecular subtypes of the recovered isolates. A total of 998 food samples were collected, and 99 (9.9%) K. pneumoniae strains were isolated; the frequencies were 8.2% (4/49) in fresh raw seafood, 13.8% (26/188) in fresh raw chicken, 11.4% (34/297) in frozen raw food and 7.5% (35/464) in cooked food samples. Antimicrobial resistance was observed against 16 antimicrobials...
2016: PloS One
Ali M Somily, Ghada A Garaween, Norah Abukhalid, Muhammad M Absar, Abiola C Senok
In recent years, there has been a rapid dissemination of carbapenem resistant Enterobacteriaceae (CRE). This study aimed to compare phenotypic and molecular methods for detection and characterization of CRE isolates at a large tertiary care hospital in Saudi Arabia. This study was carried out between January 2011 and November 2013 at the King Khalid University Hospital (KKUH) in Saudi Arabia. Determination of presence of extended-spectrum beta-lactamases (ESBL) and carbapenem resistance was in accordance with Clinical and Laboratory Standards Institute (CLSI) guidelines...
March 2016: Acta Microbiologica et Immunologica Hungarica
Iman Dandachi, Elie Salem Sokhn, Elie Najem, Eid Azar, Ziad Daoud
BACKGROUND: Multidrug-resistant (MDR) Enterobacteriaceae can cause severe infections with high morbidity, mortality, and health care costs. Individuals can be fecal carriers of these resistant organisms. Data on the extent of MDR Enterobacteriaceae fecal carriage in the community setting in Lebanon are very scarce. The aim of this study was to investigate the fecal carriage of MDR Enterobacteriaceae among the elderly residents of two nursing homes located in north Lebanon. METHODS: Over a period of 4 months, five fecal swab samples were collected from each of 68 elderly persons at regular intervals of 3-4 weeks...
April 2016: International Journal of Infectious Diseases: IJID
Jaspal Kaur, Gomty Mahajan, Kailash Chand, Sheevani, Shashi Chopra
INTRODUCTION: Routine phenotypic methods employing clavulanate and third generation cephalosporins to detect ESBL are not promising for isolates that co-produce an inhibitor-resistant beta lactamase like AmpC. AIM: Enhancing phenotypic detection of ESBL in AmpC co-producers by using cefepime and tazobactam. MATERIALS AND METHODS: A total of 245 isolates of Escherichia coli (123), Klebsiella spp. (87), Proteus spp.(20), Enterobacter spp. (9) and Citrobacter spp...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Ryan G D'Angelo, Jennifer K Johnson, Jacqueline T Bork, Emily L Heil
INTRODUCTION: Extended spectrum β-lactamases (ESBL) and AmpC β-lactamases are increasing causes of resistance in many Gram-negative pathogens of common infections. This has led to a growing utilization of broad spectrum antibiotics, most predominately the carbapenem agents. As the prevalence of ESBL and AmpC-producing isolates and carbapenem resistance has increased, interest in effective alternatives for the management of these infections has also developed. AREAS COVERED: This article summarizes clinical literature evaluating the utility of carbapenem-sparing regimens for the treatment of ESBL and AmpC-producing Enterobacteriaceae, mainly β-lactam-β-lactamase inhibitor combinations and cefepime (FEP)...
2016: Expert Opinion on Pharmacotherapy
Pisake Boontham, Rattaphon Soontomrak
BACKGROUND: Extended-Spectrum Beta-Lactamases (ESBLs)-producing bacteria are increasing challenge in the treatment of both community acquired and nosocomial intra-abdominal infections (IAIs). Investigating the characteristics ofpatients with the IAIs caused by ESBL-producing bacteria and assessing the risk factors of ESBLs infection will lead to appropriate therapeutic management. OBJECTIVE: To determine prevalence of ESBL-producing bacteria in IAIs in Phramongkutklao Hospital and identify risk factor of the ESBL-infections...
November 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Cheryl R Durand, Mohammad Alsharhan, Kristine C Willett
The purpose of this review is to evaluate the efficacy and safety of ceftazidime/avibactam and ceftolozane/tazobactam in patients with complicated intra-abdominal infections (cIAI), and review eravacycline and other agents in the pipeline for management of cIAI. The increasing incidence of multidrug resistant strains of bacteria has led to the need for additional antibiotics with activity against these organisms. There are 2 newly approved antibiotics, ceftazidime/avibactam and ceftolazane/tazobactam for treatment of cIAI...
January 19, 2016: American Journal of Therapeutics
O O Oduyebo, O M Falayi, P Oshun, A O Ettu
AIMS AND OBJECTIVES: Carbapenemase production among clinical isolates of Enterobacteriaceae has been widely reported with prevalence rates ranging from between 2.8% and 53.6%. The aim of this study was to assess the prevalence of carbapenemase production among clinical isolates of Enterobacteriaceae from a Tertiary Hospital in Lagos, Nigeria, and to characterize the type of carbapenemase produced. MATERIALS AND METHODS: Carbapenemase production was detected phenotypically using a commercially available combination disc test (Rosco Diagnostica carbapenemase detection Neo-Sensitab) containing inhibitors to the various carbapenemase classes...
October 2015: Nigerian Postgraduate Medical Journal
Murali Alagesan, Ram Gopalakrishnan, Senthur Nambi Panchatcharam, Sureshkumar Dorairajan, Thirunarayan Mandayam Ananth, Ramasubramanian Venkatasubramanian
BACKGROUND: Gram-negative bacteremia is one of the leading causes of mortality and morbidity in Indian hospitals. We hereby describe changing trends in Gram-negative isolates from blood cultures from a single center over a ten-year period. METHODS: Antibiotic susceptibility patterns were collected for a total of 4128 non-repetitive blood culture isolates from 2003 to 2013. We analyzed clinically important Gram-negative isolates (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii) and their susceptibility pattern...
September 2015: Germs
Amit Kumar Singh, Sonali Jain, Dinesh Kumar, Ravinder Pal Singh, Hitesh Bhatt
OBJECTIVE: There is an increased prevalence of extended-spectrum beta-lactamase producing Klebsiella pneumoniae (ESBL-KP) worldwide including India, which is a major concern for the clinicians, especially in intensive care units and pediatric patients. This study aims to determine the prevalence of ESBL-KP and antimicrobial sensitivity profile to plan a proper hospital infection control program to prevent the spread of resistant strains. METHODS: KP isolates obtained from various clinical samples were evaluated to detect the production of ESBL by phenotypic methods...
July 2015: Journal of Research in Pharmacy Practice
Étienne Ruppé, Paul-Louis Woerther, François Barbier
The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In Enterobacteriaceae, the dramatic increase in the rates of resistance to third-generation cephalosporins mainly results from the spread of plasmid-borne extended-spectrum beta-lactamase (ESBL), especially those belonging to the CTX-M family. The efficacy of beta-lactam/beta-lactamase inhibitor associations for severe infections due to ESBL-producing Enterobacteriaceae has not been adequately evaluated in critically ill patients, and carbapenems still stands as the first-line choice in this situation...
December 2015: Annals of Intensive Care
M-A Vibet, J Roux, E Montassier, S Corvec, M-E Juvin, C Ngohou, D Lepelletier, E Batard
The influence of hospital use of antibiotics other than cephalosporins and fluoroquinolones on extended-spectrum beta-lactamase (ESBL) resistance among Enterobacteriaceae is poorly known. Our objective was to explore the association between ESBL and hospital use of various classes of antibacterial agents. The relationship between monthly use of 19 classes of antibacterial agents and incidence of nosocomial ESBL-producing Enterobacteriaceae in a French hospital was studied between 2007 and 2013. Five antibiotic classes were significantly and independently associated with ESBL resistance...
October 2015: European Journal of Clinical Microbiology & Infectious Diseases
Anand Prakash Maurya, Debarati Choudhury, Anupam Das Talukdar, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee
BACKGROUND & OBJECTIVES: Pseudomonas extended resistant (PER) enzymes are rare type of extended-spectrum beta lactamases (ESBLs) that confer third generation cephalosporin resistance. These are often integron borne and laterally transmitted. The aim of the present study was to investigate the emergence of integron borne cephalosporin resistant PER-1 gene in diverse incompatibility (Inc) group plasmids among Gram-negative bacteria. METHODS: A total of 613 consecutive, non-duplicate, Gram-negative bacteria of Enterobacteriaceae family and non-fermenting Gram-negative bacteria were isolated from different clinical specimens during a period of 18 months...
June 2015: Indian Journal of Medical Research
Nevreste Çelikbilek, Ayşegül Gözalan, Birsen Özdem, Fisun Kırca, Ziya Cibali Açıkgöz
The aim of the study was to evaluate the change of the frequency of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae isolates from urine samples of outpatients in years and to analyse the antibiotic resistance profiles for a rational drug use. The urine samples cultured in our laboratory from the patients who were admitted to outpatient clinics of our hospital between years 2007-2013 were included in this study. Enterobacteriaceae strains were isolated and identified by conventional methods and API 20E system (BioMérieux, France)...
April 2015: Mikrobiyoloji Bülteni
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