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https://www.readbyqxmd.com/read/27718101/erratum-to-mitochondrial-chchd-containing-proteins-physiologic-functions-and-link-with-neurodegenerative-diseases
#1
Zhi-Dong Zhou, Wuan-Ting Saw, Eng-King Tan
No abstract text is available yet for this article.
October 7, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27631878/mitochondrial-chchd-containing-proteins-physiologic-functions-and-link-with-neurodegenerative-diseases
#2
Zhi-Dong Zhou, Wuan-Ting Saw, Eng-King Tan
The coiled-coil-helix-coiled-coil-helix domain (CHCHD)-containing proteins are evolutionarily conserved nucleus-encoded small mitochondrial proteins with important functions. So far, nine members have been identified in this protein family. All CHCHD proteins have at least one functional coiled-coil-helix-coiled-coil-helix (CHCH) domain, which is stabilized by two pairs of disulfide bonds between two helices. CHCHD proteins have various important pathophysiological roles in mitochondria and other key cellular processes...
September 8, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26530328/mitofilin-and-chchd6-physically-interact-with-sam50-to-sustain-cristae-structure
#3
Chengli Ding, Zhifei Wu, Lei Huang, Yajie Wang, Jie Xue, Si Chen, Zixin Deng, Lianrong Wang, Zhiyin Song, Shi Chen
The inner mitochondrial membrane (IMM) invaginates to form cristae and the maintenance of cristae depends on the mitochondrial contact site (MICOS) complex. Mitofilin and CHCHD6, which physically interact, are two components of the MICOS. In this study, we performed immunoprecipitation experiments with Mitofilin and CHCHD6 antibodies and identified a complex containing Mitofilin, Sam50, and CHCHD 3 and 6. Using transcription activator-like effector nucleases (TALENs), we generated knockdown/knockout clones of Mitofilin and CHCHD6...
November 4, 2015: Scientific Reports
https://www.readbyqxmd.com/read/17242405/identification-of-chchd3-as-a-novel-substrate-of-the-camp-dependent-protein-kinase-pka-using-an-analog-sensitive-catalytic-subunit
#4
Sharmin Schauble, Charles C King, Manjula Darshi, Antonius Koller, Kavita Shah, Susan S Taylor
Due to the numerous kinases in the cell, many with overlapping substrates, it is difficult to find novel substrates for a specific kinase. To identify novel substrates of cAMP-dependent protein kinase (PKA), the PKA catalytic subunit was engineered to accept bulky N(6)-substituted ATP analogs, using a chemical genetics approach initially pioneered with v-Src (1). Methionine 120 was mutated to glycine in the ATP-binding pocket of the catalytic subunit. To express the stable mutant C-subunit in Escherichia coli required co-expression with PDK1...
May 18, 2007: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/15056759/mechanistic-studies-of-the-molybdenum-catalyzed-asymmetric-alkylation-reaction
#5
David L Hughes, Guy C Lloyd-Jones, Shane W Krska, Laure Gouriou, Veronique D Bonnet, Kevin Jack, Yongkui Sun, David J Mathre, Robert A Reamer
Enantiomerically enriched, deuterated branched carbonates (Z)-(S)-PhCH(OCO(2)Me)-CH = CHD (1-D), (Z)-(R)-PhCH(OCO(2)Me)CH = CHD (2-D), and linear carbonate (E)-(S)-PhCH = CHCHD(OCO(2)Me) (3-D) were used as probes in the Mo-catalyzed asymmetric allylic alkylation with sodium dimethyl malonate, catalyzed by ligand-complex 11 derived from the mixed benzamide/picolinamide of (S,S)-transdiaminocyclohexane and (norbornadiene)Mo(CO)(4). The results of these studies, along with x-ray crystallography and solution NMR structural analysis of the pi-allyl intermediate, conclusively established the reaction proceeded by a retention-retention pathway...
April 13, 2004: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/14733529/conclusive-evidence-for-a-retention-retention-pathway-for-the-molybdenum-catalyzed-asymmetric-alkylation
#6
Guy C Lloyd-Jones, Shane W Krska, David L Hughes, Laure Gouriou, Veronique D Bonnet, Kevin Jack, Yongkui Sun, Robert A Reamer
Enantiomerically enriched, deuterated branched carbonates (Z)-(S)-PhCH(O2COMe)-CH=CHD (1a), (Z)-(R)-PhCH(O2COMe)CH=CHD (2a), and linear carbonate (E)-(S)-PhCH=CHCHD(O2COMe) (12) were employed as probes in the Mo-catalyzed asymmetric allylic alkylation with sodium dimethyl malonate, catalyzed by ligand complex 10 derived from the mixed benzamide/picolinamide of (S,S)-trans-diaminocyclohexane and (norbornadiene)Mo(CO)4. X-ray crystallography, along with solution NMR structural analysis of the pi-allyl intermediate and competition experiments, conclusively established the reaction proceeded via a retention-retention pathway...
January 28, 2004: Journal of the American Chemical Society
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