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Hepatitis c in children

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https://www.readbyqxmd.com/read/29453464/dietitian-led-lifestyle-modification-programme-for-obese-chinese-adolescents-with-non-alcoholic-fatty-liver-disease-a-randomized-controlled-study
#1
D F Y Chan, H K So, S C N Hui, R S M Chan, A M Li, M M Sea, W C W Chu, M Chan, J Woo, E A S Nelson
BACKGROUND: The prevalence of non-alcoholic fatty liver disease (NAFLD) in children is increasing. This study evaluated the efficacy of a dietitian-led lifestyle modification programme (D-LMP) to reduce NAFLD in obese adolescents. METHODS: Subjects with intra-hepatic triglyceride content (IHTC) equal to or greater than 5% diagnosed by proton-magnetic resonance spectroscopy ( 1 H-MRS) were enroled and randomly assigned to either the D-LMP intervention or conventional paediatrician-led consultation (P-CON) group...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29427256/laparoscopic-cholangiogram-in-biliary-atresia-a-refinement-in-the-gallbladder-hitch-technique
#2
Ravi Kishore, Sundeep M C Kisku, Reju Joseph Thomas, Srinivasa Kishore Jeenipalli
INTRODUCTION: The study describes a refinement in the gallbladder hitch stitch and assesses the value of the laparoscopic cholangiogram in children with suspected biliary atresia. METHODS: Twenty children with neonatal jaundice and no drainage as shown on the HIDA scan underwent a diagnostic laparoscopy through an umbilical 5 mm port. A 3 mm laparoscopic needle holder inserted through a 3.5 mm port to the left of the umbilicus was used to hitch the gallbladder to the abdominal wall...
February 9, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29404447/hepatitis-c-virus-infection-in-children-and-adolescents
#3
REVIEW
James E Squires, William F Balistreri
No abstract text is available yet for this article.
April 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29396792/role-of-interventional-radiology-in-managing-pediatric-liver-tumors-part-2-percutaneous-interventions
#4
REVIEW
C Matthew Hawkins, Alexander J Towbin, Derek J Roebuck, Eric J Monroe, Anne E Gill, Avnesh S Thakor, Richard B Towbin, Anne Marie Cahill, Matthew P Lungren
Hepatoblastoma and hepatocellular carcinoma (HCC) are the most common pediatric liver malignancies, with hepatoblastoma occurring more commonly in younger children and HCC occurring more commonly in older children and adolescents. Although surgical resection (including transplant when necessary) and systemic chemotherapy have improved overall survival rate for hepatoblastoma to approximately 80% from 30%, a number of children with this tumor type are not eligible for operative treatment. In contradistinction, pediatric HCC continues to carry a dismal prognosis with an overall 5-year survival rate of 30%...
February 2, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29396050/association-of-interleukin-il-4-variable-number-of-tandem-repeats-vntrs-and-il-4-590-promoter-polymorphisms-with-susceptibility-to-pediatric-autoimmune-hepatitis-type-1
#5
Amira Ibrahim Mansour, Ola Galal Behairy, Eman Rateb Abd Almonaem, Rasha Mahmoud Abd-Rabuh, Inas Abd Elmonem Ahmed
OBJECTIVE: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to autoimmune hepatitis type 1 in children. SUBJECTS AND METHODS: The study was performed on 101 children diagnosed with AIH and 104 apparently healthy, age and sex-matched control children, diagnosis of AIH was based on the simplified score for the diagnosis of AIH...
January 26, 2018: Cytokine
https://www.readbyqxmd.com/read/29362840/role-of-interventional-radiology-in-managing-pediatric-liver-tumors-part-1-endovascular-interventions
#6
REVIEW
Matthew P Lungren, Alexander J Towbin, Derek J Roebuck, Eric J Monroe, Anne E Gill, Avnesh Thakor, Richard B Towbin, Anne Marie Cahill, C Matthew Hawkins
Primary liver malignancies are rare in children. Hepatoblastoma and hepatocellular carcinoma (HCC) together represent the overwhelming majority of cases. Overall survival of hepatoblastoma approaches 80% with multimodal treatment approaches that include chemotherapy, surgery and transplantation. However, there remains a subset of children with hepatoblastoma in whom resection or transplantation is not possible. The 5-year survival for children diagnosed with HCC is less than 30% and remains a significant therapeutic challenge...
January 23, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29352387/current-perspectives-on-erythema-multiforme
#7
REVIEW
Marianne Lerch, Carlo Mainetti, Benedetta Terziroli Beretta-Piccoli, Thomas Harr
Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions with predominant acral localization as well as histological findings...
January 19, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29342498/patient-reminder-and-recall-interventions-to-improve-immunization-rates
#8
REVIEW
Julie C Jacobson Vann, Robert M Jacobson, Tamera Coyne-Beasley, Josephine K Asafu-Adjei, Peter G Szilagyi
BACKGROUND: Immunization rates for children and adults are rising, but coverage levels have not reached optimal goals. As a result, vaccine-preventable diseases still occur. In an era of increasing complexity of immunization schedules, rising expectations about the performance of primary care, and large demands on primary care providers, it is important to understand and promote interventions that work in primary care settings to increase immunization coverage. One common theme across immunization programs in many nations involves the challenge of implementing a population-based approach and identifying all eligible recipients, for example the children who should receive the measles vaccine...
January 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29341395/health-of-southern-tasmanian-4-to-6-year-old-children-in-out-of-home-care-compared-to-peers
#9
Marie Rauter, Anagha Jayakar, Tom Clemens, Zaharenia Galanos, Louise Newbery, Andrew Whelan
AIM: To compare the health of 4- to 6-year-old children in out-of-home care (OOHC) in Southern Tasmania with their peers. METHODS: Demographic and health data collection and prospective health assessment of all 4- to 6-year olds in OOHC in Southern Tasmania on 30 August 2011 was undertaken. Data were compared to Tasmanian and/or Australian peers. RESULTS: A total of 109 of 129 children aged 4 to 6 years were included in the study. Time in OOHC was on average 38 (range 0-76) months...
January 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29337457/-pharmacovigilance-update
#10
Françoise Livio
The main pharmacovigilance updates in 2017 are reviewed. Denosumab : rebound-associated multiple vertebral fractures after discontinuation. Canagliflozine: increased risk of foot/leg amputations. Biologic and targeted cancer therapies, direct-acting antivirals for chronic hepatitis C: risk of hepatitis B reactivation. Checkpoint inhibitors : immune-related adverse events and graft rejection. Fingolimod : rebound-associated reactivation of MS following withdrawal. Daclizumab: risk of severe liver injury leading to restricted use in MS patients...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29334960/arsenic-exposure-and-risk-of-nonalcoholic-fatty-liver-disease-nafld-among-u-s-adolescents-and-adults-an-association-modified-by-race-ethnicity-nhanes-2005-2014
#11
Jennifer K Frediani, Eric A Naioti, Miriam B Vos, Janet Figueroa, Carmen J Marsit, Jean A Welsh
BACKGROUND: While associated with obesity, the cause of the rapid rise in prevalence of nonalcoholic fatty liver disease (NAFLD) in children, which is highest among Hispanics, is not well understood. Animal experiments have demonstrated that arsenic exposure contributes to liver injury. Our objective was to examine the association between arsenic exposure and NAFLD in humans and to determine if race/ethnicity modifies the association. METHODS: Urinary inorganic arsenic concentrations among those ≥12 years in the National Health and Nutrition Examination Survey, 2005-2014 were used to assess the cross-sectional association with serum alanine aminotransferase (ALT) levels, a marker of liver dysfunction...
January 15, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29328393/paediatric-virology-and-its-interaction-between-basic-science-and-clinical-practice-review
#12
Ioannis N Mammas, Anne Greenough, Maria Theodoridou, Anna Kramvis, Maria Rusan, Angeliki Melidou, Paraskevi Korovessi, Georgia Papaioannou, Alexia Papatheodoropoulou, Chryssie Koutsaftiki, Maria Liston, George Sourvinos, Demetrios A Spandidos
The 3rd Workshop on Paediatric Virology, which took place on October 7th, 2017 in Athens, Greece, highlighted the role of breast feeding in the prevention of viral infections during the first years of life. Moreover, it focused on the long-term outcomes of respiratory syncytial virus and rhinovirus infections in prematurely born infants and emphasised the necessity for the development of relevant preventative strategies. Other topics that were covered included the vaccination policy in relation to the migration crisis, mother‑to‑child transmission of hepatitis B and C viruses, vaccination against human papilloma viruses in boys and advances on intranasal live‑attenuated vaccination against influenza...
January 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29325483/characterization-of-vaccination-policies-for-attendance-and-employment-at-day-summer-camps-in-new-york-state
#13
William A Prescott, Kelsey C Violanti, Nicholas M Fusco
INTRODUCTION: New York state requires day/summer camps to keep immunization records for all enrolled campers and strongly recommends requiring vaccination for all campers and staff. The objective of this study was to characterize immunization requirements/recommendations for children/adolescents enrolled in and staff employed at day/summer camps in New York state. METHODS: An electronic hyperlink to a 9-question survey instrument was distributed via e-mail to 178 day/summer camps located in New York state cities with a population size greater than 100 000 people...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29314568/genetic-determinants-of-hepatic-steatosis-and-serum-cytokeratin-18-fragment-levels-in-taiwanese-children
#14
Yu-Cheng Lin, Pi-Feng Chang, Mei-Hwei Chang, Yen-Hsuan Ni
BACKGROUND/AIMS: There are substantial genetic components contributing to the susceptibility of nonalcoholic NAFLD disease (NAFLD). It has recently been reported that the rs641738 C>T variant in the membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) gene increased severity of NAFLD in adults of European descent. We aimed to test the hypothesis that MBOAT7 rs641738 variant would increase hepatic steatosis and hepatocellular injury in obese children. METHODS: A total of 831 obese children aged 7-15 years were recruited...
January 4, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29298340/the-association-between-a-body-shape-index-and-cardiovascular-risk-in-overweight-and-obese-children-and-adolescents
#15
Chiara Mameli, Nir Y Krakauer, Jesse C Krakauer, Alessandra Bosetti, Chiara Matilde Ferrari, Norma Moiana, Laura Schneider, Barbara Borsani, Teresa Genoni, Gianvincenzo Zuccotti
A Body Shape Index (ABSI) and normalized hip circumference (Hip Index, HI) have been recently shown to be strong risk factors for mortality and for cardiovascular disease in adults. We conducted an observational cross-sectional study to evaluate the relationship between ABSI, HI and cardiometabolic risk factors and obesity-related comorbidities in overweight and obese children and adolescents aged 2-18 years. We performed multivariate linear and logistic regression analyses with BMI, ABSI, and HI age and sex normalized z scores as predictors to examine the association with cardiometabolic risk markers (systolic and diastolic blood pressure, fasting glucose and insulin, total cholesterol and its components, transaminases, fat mass % detected by bioelectrical impedance analysis) and obesity-related conditions (including hepatic steatosis and metabolic syndrome)...
2018: PloS One
https://www.readbyqxmd.com/read/29287014/treatment-of-chronic-hepatitis-c-virus-infection-in-children-a-position-paper-by-the-hepatology-committee-of-european-society-of-paediatric-gastroenterology-hepatology-and-nutrition
#16
Giuseppe Indolfi, Loreto Hierro, Antal Dezsofi, Jörg Jahnel, Dominique Debray, Nedim Hadzic, Piotr Czubowski, Girish Gupte, Yael Mozer-Glassberg, Wendy van der Woerd, Françoise Smets, Henkjan J Verkade, Björn Fischler
OBJECTIVES: In 2017, the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) approved the use of the fixed-dose combination of ledipasvir/sofosbuvir and of the combination of sofosbuvir and ribavirin for treatment of adolescents (12-17 years, weighing more than 35 kg) with chronic hepatitis C virus (HCV) genotype 1, 4, 5 and 6 and genotype 2 and 3 infections, respectively. Although trials with direct acting antivirals (DAAs) are ongoing for younger children, the only available treatment in US and Europe for those < 12 years is still the dual therapy of pegylated interferon (PEG IFN) and ribavirin...
December 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29286012/hepatitis-a-b-c-and-hiv-seroprevalence-among-syrian-refugee-children-admitted-to-outpatient-clinics
#17
Şükran Köse, Ilker Ödemiş, Didem Çelik, Bengü Gireniz Tatar, Ilkay Akbulut, Dilek Yilmaz Çiftdoğan
Viral hepatitis is the most common cause of serious health problems such as liver cirrhosis and hepatocellular carcinoma (HCC). Leading to immunodeficiency disorders through different mechanisms, Human Immunodeficiency Virus (HIV) causes the development of severe secondary infections. Hepatitis A (HAV) is thought to spread by the faecal-oral route, while Hepatitis B (HBV), Hepatitis C (HCV) and HIV are mostly transmitted vertically during childhood. In our study, we aimed to determine the seroprevalence of HAV, HBV, HCV and HIV among Syrian refugee children who were admitted to outpatient clinics...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29278611/utility-of-point-of-care-ultrasound-in-children-with-pulmonary-tuberculosis
#18
Sabine Bélard, Charlotte C Heuvelings, Ebrahim Banderker, Lindy Bateman, Tom Heller, Savvas Andronikou, Lesley Workman, Martin P Grobusch, Heather J Zar
BACKGROUND: Point-of-care ultrasound (POCUS) detects extra-pulmonary tuberculosis (EPTB) in HIV-infected adults but has not been evaluated in children despite their higher risk of EPTB. This study's aims were to investigate feasibility of POCUS for EPTB in children, frequency of POCUS findings suggestive of EPTB, and time to sonographic resolution of findings with treatment. METHODS: This prospective South African cohort study enrolled children with suspected PTB...
December 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29276157/vaccination-coverage-among-school-children-aged-14-15%C3%A2-years-in-the-french-department-of-sarthe
#19
D Huart, S Blanchi
OBJECTIVES: Vaccinations are the main pillar of primary prevention for infectious diseases. To guide and prioritize public health interventions, the Regional Health Agency has asked the Prevention, Vaccination, and Screening Center of the Sarthe department to assess vaccination coverage (VC) at the sub-departmental level. The main objective was to measure the VC among school children aged 14-15 years in Sarthe at the sub-departmental level. PATIENTS AND METHODS: We conducted a VC evaluation survey at the administrative district level among school children aged 14-15 years in the Sarthe department during the first quarter of the 2015-2016 school year...
December 21, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29274889/new-onset-autoimmune-hepatitis-during-anti-tumor-necrosis-factor-alpha-treatment-in-children
#20
Amanda Ricciuto, Binita M Kamath, Thomas D Walters, Karen Frost, Nicholas Carman, Peter C Church, Simon C Ling, Anne M Griffiths
OBJECTIVES: To evaluate a large anti-tumor necrosis factor (TNF)-treated pediatric inflammatory bowel disease cohort for drug-induced liver injury (DILI) following presentation of an index case with suspected DILI with autoimmune features after infliximab exposure. To characterize the incidence, natural history, and risk factors for liver enzyme elevation with anti-TNF use. STUDY DESIGN: We reviewed the index case and performed a retrospective cohort study of 659 children receiving anti-TNF therapy between 2000 and 2015 at a tertiary pediatric inflammatory bowel disease center...
December 21, 2017: Journal of Pediatrics
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