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IBD AND risk factors

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https://www.readbyqxmd.com/read/28333328/the-time-course-of-diagnostic-delay-in-inflammatory-bowel-disease-over-the-last-sixty-years-an-italian-multicentre-study
#1
Laura Cantoro, Antonio Di Sabatino, Claudio Papi, Giovanna Margagnoni, Sandro Ardizzone, Paolo Giuffrida, Diana Giannarelli, Alessandro Massari, Rita Monterubbianesi, Marco Vincenzo Lenti, Gino Roberto Corazza, Anna Kohn
Background and Aims: Inflammatory bowel disease (IBD) patients are still under-diagnosed or diagnosed with serious delay. We examined whether diagnostic delay (DD) in IBD has changed over the last 60 years, and explored the risk factors of longer DD. Methods: 3392 IBD patients recorded in the registry of four IBD Italian centres were divided according to the year of diagnosis into a historical cohort (HC: 1955-1984) and modern cohort (MC: 1985-2014). DD, i.e. time lapse between onset of symptoms indicative of IBD and definitive diagnosis, was divided into four sub-periods (0-6, 7-12, 13-24, >24 months) which were correlated with age and disease location/behaviour at diagnosis...
March 17, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333202/risk-of-rectal-neoplasia-after-colectomy-and-ileorectal-anastomosis-for-ulcerative-colitis
#2
Mathieu Uzzan, Julien Kirchgesner, Nadia Oubaya, Aurélien Amiot, Jean-Marc Gornet, Philippe Seksik, Stéphane Nancey, Eddy Cotte, Matthieu Allez, Gilles Boschetti, David Laharie, Nicola de Angelis, Maria Nachury, Anne-Laure Pelletier, Vered Abitbol, Mathurin Fumery, Antoine Brouquet, Anthony Buisson, Romain Altwegg, Jacques Cosnes, Yves Panis, Xavier Treton
Introduction-: Colectomy can be required in the management of ulcerative colitis (UC). While ileal pouch anal-anastomosis (IPAA) is the recommended reconstruction technique, ileorectal anastomosis (IRA) is still performed and might present some advantages. However, the risk of rectal neoplasia might limit its indication. The aims of our study were to determine the incidence of rectal neoplasias following IRA for UC and to identify risk factors associated with rectal carcinomas. Methods-: We performed a multicenter retrospective study including patients who underwent IRA for UC from 1960 to 2014 in 13 centers...
February 21, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28320072/constitutive-androstane-receptor-regulates-the-intestinal-mucosal-response-to-injury
#3
Grace M Hudson, Kyle L Flannigan, Sarah L Erickson, Fernando A Vicentini, Alexandra Zamponi, Christina L Hirota, Laurie Alston, Christophe Altier, Subrata Ghosh, Kevin P Rioux, Sridhar Mani, Thomas K Chang, Simon A Hirota
BACKGROUND AND PURPOSE: The pathogenesis of the inflammatory bowel diseases(IBD), composed of Crohn's disease(CD) and ulcerative colitis(UC), involves aberrant interactions between a genetically susceptible individual, their microbiota and environmental factors. Alterations in xenobiotic receptor expression and function are associated with increased risk for IBD. In the current study, we assessed the role of the constitutive androstane receptor(CAR), a xenobiotic receptor closely related to the pregnane X receptor, in the regulation of intestinal mucosal homeostasis...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28316376/the-role-of-intestinal-alkaline-phosphatase-in-inflammatory-disorders-of-gastrointestinal-tract
#4
REVIEW
Jan Bilski, Agnieszka Mazur-Bialy, Dagmara Wojcik, Janina Zahradnik-Bilska, Bartosz Brzozowski, Marcin Magierowski, Tomasz Mach, Katarzyna Magierowska, Tomasz Brzozowski
Over the past few years, the role of intestinal alkaline phosphatase (IAP) as a crucial mucosal defence factor essential for maintaining gut homeostasis has been established. IAP is an important apical brush border enzyme expressed throughout the gastrointestinal tract and secreted both into the intestinal lumen and into the bloodstream. IAP exerts its effects through dephosphorylation of proinflammatory molecules including lipopolysaccharide (LPS), flagellin, and adenosine triphosphate (ATP) released from cells during stressful events...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28296825/frequency-and-risk-factors-of-clostridium-difficile-infection-in-hospitalized-patients-with-pouchitis-a-population-based-study
#5
Gaurav Kistangari, Rocio Lopez, Bo Shen
BACKGROUND: Clostridium difficile infection (CDI) in patients with the ileal pouch after proctocolectomy has been increasingly recognized. We sought to evaluate the frequency and risk factors of CDI in patients with the primary or secondary discharge diagnosis of pouchitis in the United States. METHODS: We reviewed the National Inpatient Sample of the Healthcare Cost and Utilization Project and identified patients admitted for pouchitis with underlying inflammatory bowel disease (IBD) or familial adenomatous polyposis (FAP), between 2010 and 2012...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28293027/genetics-of-primary-sclerosing-cholangitis-and-pathophysiological-implications
#6
REVIEW
Xiaojun Jiang, Tom H Karlsen
Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via the development of cholestatic liver cirrhosis, concurrent IBD and a high risk of bile duct cancer. Expectations have been high that genetic studies would determine key factors in PSC pathogenesis to support the development of effective medical therapies. Through the application of genome-wide association studies, a large number of disease susceptibility genes have been identified...
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28281904/genetic-risk-variants-as-therapeutic-targets-for-crohn-s-disease
#7
Tommaso Gabbani, Simona Deiana, Margherita Marocchi, Vito Annese
The pathogenesis of Inflammatory bowel diseases (IBD) is multifactorial, with interactions between genetic and environmental factors. Despite the existence of genetic factors being largely demonstrated by epidemiological data and several genetic studies, only a few findings have been useful in term of disease prediction, disease progression and targeting therapy. Areas covered: This review summarizes the results of genome-wide association studies in Crohn's disease, the role of epigenetics and the recent discovery by genetic studies of new pathogenetic pathways...
April 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28281510/-the-prevalence-of-bacterial-overgrowth-syndrome-and-its-associated-factors-in-patients-with-inflammatory-bowel-diseases-according-to-the-data-of-the-novosibirsk-registry
#8
Yu A Kulygina, M F Osipenko, M I Skalinskaya, K D Pal'chunova
AIM: To assess the prevalence of bacterial overgrowth syndrome (BOS) and its risk factors in patients with inflammatory bowel diseases (IBD). SUBJECTS AND METHODS: The patients from the Novosibirsk IBD registry, who had undergone a hydrogen breath test (HBT) using a Gastro+ device, were examined. RESULTS: In 93 IBD patients who had undergone a HBD, the prevalence of BOS was 48% (46.2% for ulcerative colitis and 51.2% for Crohn's disease). There was a strong correlation between abdominal bloating, abdominal rumbling, and positive HBT results in both patient groups...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28279838/modulation-of-sphingosine-1-phosphate-in-inflammatory-bowel-disease
#9
REVIEW
Laurent Peyrin-Biroulet, Ronald Christopher, Dominic Behan, Cheryl Lassen
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, involve an inappropriate immune reaction in the digestive tract, causing a variety of disabling symptoms. The advent of monoclonal antibodies (anti-tumor necrosis factor, anti-integrin, anti-interleukin -23) has revolutionized IBD management. Nevertheless, these agents, with potential for immunogenicity, are associated with high rates of response loss and disease relapse over time. They are also associated with high production costs...
March 6, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28270247/gut-brain-actions-underlying-comorbid-anxiety-and-depression-associated-with-inflammatory-bowel-disease
#10
Áine Abautret-Daly, Elaine Dempsey, Adolfo Parra-Blanco, Carlos Medina, Andrew Harkin
Introduction Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD...
March 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28267075/surgical-management-of-crohn-disease-in-children-guidelines-from-the-paediatric-ibd-porto-group-of-espghan
#11
Jorge Amil-Dias, Sanja Kolacek, Dan Turner, Anders Pærregaard, Risto Rintala, Nadeem Ahmad Afzal, Katarzyna Karolewska-Bochenek, Jiri Bronsky, Sonny Chong, John Fell, Iva Hojsak, Jean-Pierre Hugot, Sibylle Koletzko, Devinder Kumar, Izabella Lazowska-Przeorek, Craig Lillehei, Paolo Lionetti, Javier Martin-de-Carpi, Mikko Pakarinen, Frank M Ruemmele, Ron Shaoul, Christine Spray, Annamaria Staiano, Ian Sugarman, David C Wilson, Harland Winter, Kaija-Leena Kolho
The incidence of Crohn's disease (CD) has been increasing and surgery needs to be contemplated in a substantial number of cases. The relevant advent of biological treatment has changed but not eliminated the need for surgery in many patients. Despite previous publications on the indications for surgery in CD there was a need for a comprehensive review of existing evidence on the role of elective surgery and options in pediatric patients affected with CD. We present an expert opinion and critical review of the literature to provide evidence-based guidance to manage these patients...
March 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28263759/diagnostic-and-vaccine-strategies-to-prevent-infections-in-patients-with-inflammatory-bowel-disease
#12
REVIEW
Giovanni Mazzola, Fabio Salvatore Macaluso, Lucia Adamoli, Sara Renna, Antonio Cascio, Ambrogio Orlando
OBJECTIVES: The treatment of inflammatory bowel disease (IBD) has been revolutionized by the use of immunomodulatory agents. Although these potent drugs are effective in controlling disease activity, they also cause an increased risk of new infections or reactivation of latent infections. On these premises, we aimed to provide guidance on the definitions of immunocompromised patients, opportunistic infections and the risk factors associated with their occurrence in an IBD context, and to suggest the proper screening tests for infectious diseases and the vaccination schedules to perform before and/or during therapy with immunomodulators...
March 2, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28258930/the-impact-of-hospitalization-on-the-performance-of-capsule-endoscopy-ce
#13
Heinz Albrecht, Marcel Vetter, Wolfgang Dauth, Flavius Zoicas, Markus Friedrich Neurath, Alexander Fritzkarl Hagel
BACKGROUND: For proper evaluation of capsule endoscopy (CE), a complete examination is necessary. AIM: We evaluated risk factors of an incomplete CE with focus on patient hospitalization. METHODS: We retrospectively evaluated 161 consecutive patients who underwent CE between 01.07.2013 and 13.03.2016. Main indications were active bleeding, iron deficiency anemia (IDA), inflammatory bowel disease (IBD), abdominal pain, and familial adenomatous polyposis (FAP)...
February 20, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28251812/risk-factors-and-clinical-outcome-of-clostridium-difficile-infection-in-patients-with-ibd-a-chinese-single-center-retrospective-study-of-260-cases
#14
YuBei Gu, Mao Chen Zhang, Jing Sun, KeZhi Lv, Jie Zhong
AIM: Clostridium difficile infection(CDI) may lead to poor outcome in inflammatory bowel disease(IBD) patients. This study was designed to investigate the cumulative incidence, risk factors, and outcome of CDI in patients with IBD in one Chinese single center. METHODS: Clinical features and endoscopic profiles of consecutive IBD patients from RuiJin Hospital between January 2013 and December 2015 were analyzed retrospectively. CDI was diagnosed based on the positive polymerase chain reaction (PCR)-based stool test...
March 2, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28239320/status-of-serum-vitamin-b12-and-folate-in-patients-with-inflammatory-bowel-disease-in-china
#15
Shaozhong Huang, Jiayi Ma, Mingming Zhu, Zhihua Ran
BACKGROUND/AIMS: Inflammatory bowel disease (IBD) primarily involves the intestinal tract and can affect vitamin absorption. This study was designed to assess the prevalence of vitamin B12 and folate deficiencies in patients with IBD, and to identify the risk factors associated with abnormal serum vitamin B12 and folate levels. METHODS: We evaluated the medical records of 195 patients with Crohn's disease (CD) and 62 patients with ulcerative colitis (UC), and selected 118 healthy subjects for the control group...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28230558/risk-for-overall-infection-with-anti-tnf-and-anti-integrin-agents-used-in-ibd-a-systematic-review-and-meta-analysis
#16
Eric D Shah, Jeremy P Farida, Corey A Siegel, Kelly Chong, Gil Y Melmed
BACKGROUND: The overall risk for infection with contemporary biological agents in treating Crohn's disease (CD) and ulcerative colitis (UC) has not been systematically assessed. METHODS: We performed a PubMed and Cochrane database literature search to evaluate randomized, placebo-controlled trials of biologics in treating UC and CD. Meta-analysis was performed using a DerSimonian and Laird random effects model. We determined relative risk (RR) of harm against placebo; number needed to harm (NNH) was reported when appropriate...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28230274/epidemiology-of-inflammatory-bowel-disease-among-participants-of-the-millennium-cohort-incidence-deployment-related-risk-factors-and-antecedent-episodes-of-infectious-gastroenteritis
#17
C K Porter, M Welsh, M S Riddle, C Nieh, E J Boyko, G Gackstetter, T I Hooper
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are two pathotypes of inflammatory bowel disease (IBD) with unique pathology, risk factors and significant morbidity. AIM: To estimate incidence and identify IBD risk factors in a US military population, a healthy subset of the US population, using information from the Millennium Cohort Study. METHODS: Incident IBD was identified from medical encounters from 2001 to 2009 or by self-report...
February 23, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28225051/low-muscle-mass-at-initiation-of-anti-tnf-therapy-for-inflammatory-bowel-disease-is-associated-with-early-treatment-failure-a-retrospective-analysis
#18
D Q Holt, P Varma, B J G Strauss, A S Rajadurai, G T Moore
BACKGROUND/OBJECTIVES: Delayed treatment failure occurs in a significant proportion of inflammatory bowel disease (IBD) patients treated with tumor necrosis factor-alpha (TNF) antagonists. Identification of predictors of loss of response (LOR) may help to optimize therapy. We sought to determine whether body composition parameters at the commencement of anti-TNF therapy were associated with earlier treatment failure. SUBJECTS/METHODS: A retrospective cohort study was performed on 68 patients who had undergone cross-sectional abdominal imaging coincident with the commencement of anti-TNF drugs...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28222097/a-genome-wide-association-study-identifies-a-lncrna-as-risk-factor-for-pathological-inflammatory-responses-in-leprosy
#19
Vinicius M Fava, Jeremy Manry, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Milton O Moraes, Carolinne Sales-Marques, Mariane M A Stefani, Ana Carla P Latini, Andrea F Belone, Vu Hong Thai, Laurent Abel, Alexandre Alcaïs, Erwin Schurr
Leprosy Type-1 Reactions (T1Rs) are pathological inflammatory responses that afflict a sub-group of leprosy patients and result in peripheral nerve damage. Here, we employed a family-based GWAS in 221 families with 229 T1R-affect offspring with stepwise replication to identify risk factors for T1R. We discovered, replicated and validated T1R-specific associations with SNPs located in chromosome region 10p21.2. Combined analysis across the three independent samples resulted in strong evidence of association of rs1875147 with T1R (p = 4...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28221250/factors-associated-with-discontinuation-of-anti-tnf-inhibitors-among-persons-with-ibd-a-population-based-analysis
#20
Laura E Targownik, Aruni Tennakoon, Stella Leung, Lisa M Lix, Zoann Nugent, Harminder Singh, Charles N Bernstein
INTRODUCTION: Antitumor necrosis factor (anti-TNF) medications are known to be highly efficacious in persons with moderate-to-severe inflammatory bowel disease (IBD). There is a paucity of data from population-based sources to elucidate persistence with these medications in the general population of IBD. Discontinuation of anti-TNF therapy is a marker of lack of effectiveness, intolerance, and patient/physician practice preferences. METHODS: We identified all persons with IBD in Manitoba who were dispensed infliximab (IFX) and adalimumab (ADA) between 2001 and 2014...
March 2017: Inflammatory Bowel Diseases
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