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IBD AND risk factors

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https://www.readbyqxmd.com/read/29789682/the-role-of-diet-in-the-aetiopathogenesis-of-inflammatory-bowel-disease
#1
REVIEW
Hamed Khalili, Simon S M Chan, Paul Lochhead, Ashwin N Ananthakrishnan, Andrew R Hart, Andrew T Chan
Crohn's disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely unknown, it is widely thought that diet has a crucial role in the development and progression of IBD. Indeed, epidemiological and genetic association studies have identified a number of promising dietary and genetic risk factors for IBD. These preliminary studies have led to major interest in investigating the complex interaction between diet, host genetics, the gut microbiota and immune function in the pathogenesis of IBD...
May 22, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29788469/influences-and-impact-of-anxiety-and-depression-in-the-setting-of-inflammatory-bowel-disease
#2
Seyedehsan Navabi, Venkata Subhash Gorrepati, Sanjay Yadav, Jaykrishna Chintanaboina, Sarah Maher, Peter Demuth, Benjamin Stern, August Stuart, Andrew Tinsley, Kofi Clarke, Emmanuelle D Williams, Matthew D Coates
Background: Individuals with inflammatory bowel disease (IBD) are at increased risk of developing anxiety or depression (A&D). Crohn's disease (CD) and ulcerative colitis (UC) with comorbid A&D are both more challenging to manage. IBD providers need to better understand the causes and impact of A&D in order to improve care for IBD patients. We sought to identify clinical factors that influence development of A&D and healthcare utilization in IBD. Methods: This is a retrospective analysis using an IBD natural history registry from a single tertiary care referral center...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788391/distinct-histopathologic-and-molecular-alterations-in-inflammatory-bowel-disease-associated-intestinal-adenocarcinoma-c-myc-amplification-is-common-and-associated-with-mucinous-signet-ring-cell-differentiation
#3
Douglas J Hartman, David G Binion, Miguel D Regueiro, Caitlyn Miller, Cameron Herbst, Reetesh K Pai
Background: Chronic idiopathic inflammatory bowel disease (IBD) is a significant risk factor for the development of intestinal adenocarcinoma. The underlying molecular alterations in IBD-associated intestinal adenocarcinoma remain largely unknown. Methods: We compared the clinicopathologic and molecular features of 35 patients with 47 IBD-associated intestinal adenocarcinomas with a consecutive series of 451 patients with sporadic colorectal carcinoma identified at our institution and published data on sporadic colorectal carcinoma...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788385/systematic-review-and-meta-analysis-vedolizumab-and-postoperative-complications-in-inflammatory-bowel-disease
#4
Diana E Yung, Nir Horesh, Amy L Lightner, Shomron Ben-Horin, Rami Eliakim, Anastasios Koulaouzidis, Uri Kopylov
Background: Several studies have reported the surgical outcomes of inflammatory bowel disease (IBD) patients exposed to vedolizumab (VDZ) preoperatively, with conflicting results. This meta-analysis aims to evaluate the risk of postoperative complications in IBD patients preoperatively exposed to VDZ in comparison with patients exposed to anti-tumor necrosis factor (anti-TNF) treatment or no biologic therapy. Methods: A systematic review with a meta-analysis of the existing literature was conducted...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788383/assessment-of-quality-of-life-in-chinese-patients-with-inflammatory-bowel-disease-and-their-caregivers
#5
Rui Liu, Anliu Tang, Xiaoyan Wang, Shourong Shen
Background: Chronic diseases such as inflammatory bowel disease (IBD) usually affect the psychological status and health-related quality of life (HRQOL) of patients and their caregivers. The aim of this study was to evaluate the level of anxiety, depression, and HRQOL and find the risk factors predictive of HRQOL in IBD patients and their caregivers in a Chinese population. Methods: One hundred four adult patients with IBD, 102 family caregivers, and 99 healthy controls were enrolled...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788338/clinical-pharmacology-in-adult-and-pediatric-inflammatory-bowel-disease
#6
Amy Hemperly, William J Sandborn, Niels Vande Casteele
This review describes the clinical pharmacology of the major drugs used for the treatment of patients with inflammatory bowel disease (IBD). Pharmacokinetics, drug metabolism, mechanism of action, efficacy, and safety profile are discussed. Some small molecules were developed to act systemically (eg, ozanimod) or locally (eg, aminosalicylates) and thus have disparate pharmacokinetic properties. In addition, locally acting compounds have been optimized to mitigate systemic exposure-eg, budesonide, which undergoes extensive first-pass metabolism-thereby reducing systemic bioavailability and side effects...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788269/smoking-and-the-risk-of-pouchitis-in-ulcerative-colitis-patients-with-ileal-pouch-anal-anastomosis
#7
Venkata Subhash Gorrepati, August Stuart, Susan Deiling, Walter Koltun, Andrew Tinsley, Emmanuelle D Williams, Matthew D Coates
Background: Ulcerative colitis (UC) patients who undergo proctocolectomy with ileal pouch-anal anastomosis (IPAA) may develop pouchitis, a poorly understood inflammatory condition. There is controversy over whether tobacco use can protect against pouchitis. We undertook this investigation to further evaluate whether smoking reduces the risk of developing pouchitis and to determine whether other previously associated clinical factors change the risk for pouchitis. Methods: We performed a retrospective analysis using a consented inflammatory bowel disease (IBD) natural history registry between the years 1995-2015 from a single tertiary care referral center...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788244/nonsynonymous-polymorphism-in-guanine-monophosphate-synthetase-is-a-risk-factor-for-unfavorable-thiopurine-metabolite-ratios-in-patients-with-inflammatory-bowel-disease
#8
Rebecca L Roberts, Mary C Wallace, Margien L Seinen, Adriaan A van Bodegraven, Krupa Krishnaprasad, Gregory T Jones, Andre M van Rij, Angela Baird, Ian C Lawrance, Ruth Prosser, Peter Bampton, Rachel Grafton, Lisa A Simms, Corrie Studd, Sally J Bell, Martin A Kennedy, Jacob Halliwell, Richard B Gearry, Graham Radford-Smith, Jane M Andrews, Patrick C McHugh, Murray L Barclay
Background : Up to 20% of patients with inflammatory bowel disease (IBD) who are refractory to thiopurine therapy preferentially produce 6-methylmercaptopurine (6-MMP) at the expense of 6-thioguanine nucleotides (6-TGN), resulting in a high 6-MMP:6-TGN ratio (>20). The objective of this study was to evaluate whether genetic variability in guanine monophosphate synthetase (GMPS) contributes to preferential 6-MMP metabolizer phenotype. Methods: Exome sequencing was performed in a cohort of IBD patients with 6-MMP:6-TGN ratios of >100 to identify nonsynonymous single nucleotide polymorphisms (nsSNPs)...
May 16, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788240/predictors-and-management-of-loss-of-response-to-vedolizumab-in-inflammatory-bowel-disease
#9
Eugenia Shmidt, Gursimran Kochhar, Justin Hartke, Prianka Chilukuri, Joseph Meserve, Khadija Chaudrey, Jenna L Koliani-Pace, Robert Hirten, David Faleck, Morris Barocas, Michelle Luo, Karen Lasch, Brigid S Boland, Siddharth Singh, Niels Vande Casteele, Sashidhar Varma Sagi, Monika Fischer, Shannon Chang, Matthew Bohm, Dana Lukin, Keith Sultan, Arun Swaminath, David Hudesman, Nitin Gupta, Sunanda Kane, Edward V Loftus, William J Sandborn, Corey A Siegel, Bruce E Sands, Jean-Frederic Colombel, Bo Shen, Parambir S Dulai
Background: We quantified loss of response (LOR) to vedolizumab (VDZ) in clinical practice and assessed the effectiveness of VDZ dose intensification for managing LOR. Methods: Retrospective review (May 2014-December 2016) of a prospectively maintained inflammatory bowel disease (IBD) registry. Kaplan-Meier estimates were used to determine rates of LOR to VDZ . Independent predictors of LOR were identified using univariate and multivariable Cox proportional hazard regression...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29766444/toward-a-more-sensitive-endpoint-for-assessing-postoperative-complications-in-patients-with-inflammatory-bowel-disease-a-comparison-between-comprehensive-complication-index-cci-and-clavien-dindo-classification-cdc
#10
Feng Zhu, Dengyu Feng, Tenghui Zhang, Lili Gu, Weiming Zhu, Zhen Guo, Yi Li, Jianfeng Gong, Ning Li, Jieshou Li
BACKGROUND: The comprehensive complication index (CCI) is a novel approach to evaluate complications. However, application of the CCI in inflammatory bowel disease (IBD) population is scarce and the difference between the CCI and the Clavien-Dindo classification (CDC) remains unknown. The aim of this study was to compare the CCI to the conventional CDC by applying the CCI among the IBD patients. METHODS: The data of 426 IBD patients who underwent surgery between September 1, 2015 and August 31, 2017 were collected...
May 15, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29762265/link-between-celiac-disease-and-inflammatory-bowel-disease
#11
Ayesha Shah, Marjorie Walker, Daniel Burger, Neal Martin, Moritz von Wulffen, Natasha Koloski, Mike Jones, Nicholas J Talley, Gerald J Holtmann
GOAL: The aim of this analysis was to assess in patients with inflammatory bowel disease (IBD) the risk of celiac disease and in celiac disease patients the risk of IBD. BACKGROUND: Previous studies report a possible association between IBD and celiac disease; however, this link is controversial. STUDY: Using the search terms "inflammatory bowel disease" and "celiac disease," we identified initially 1525 publications. In total 27 studies met inclusion criteria...
May 14, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29757355/a-prospective-study-to-monitor-for-tuberculosis-during-anti-tumour-necrosis-factor-therapy-in-patients-with-inflammatory-bowel-disease-and-immune-mediated-inflammatory-diseases
#12
Choon Kin Lee, Sunny H Wong, Grace Lui, Whitney Tang, Lai San Tam, Margaret Ip, Esther Hung, Minhu Chen, Justin C Wu, Siew C Ng
Background: Biologic therapies have revolutionised the treatment of immune- mediated diseases including inflammatory bowel disease (IBD) and rheumatological disorders. However, biologic treatments are associated with an increased risk of reactivation of latent tuberculosis. Data of regular monitoring for latent tuberculosis infection (LTBI) during biologic treatment are lacking. Methods: Consecutive patients eligible for biologic therapies were screened for LTBI and prospectively followed-up for 3 years...
May 11, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29743830/predicting-outcomes-to-optimize-disease-management-in-inflammatory-bowel-disease-in-japan-their-differences-and-similarities-to-western-countries
#13
REVIEW
Taku Kobayashi, Tadakazu Hisamatsu, Yasuo Suzuki, Haruhiko Ogata, Akira Andoh, Toshimitsu Araki, Ryota Hokari, Hideki Iijima, Hiroki Ikeuchi, Yoh Ishiguro, Shingo Kato, Reiko Kunisaki, Takayuki Matsumoto, Satoshi Motoya, Masakazu Nagahori, Shiro Nakamura, Hiroshi Nakase, Tomoyuki Tsujikawa, Makoto Sasaki, Kaoru Yokoyama, Naoki Yoshimura, Kenji Watanabe, Miiko Katafuchi, Mamoru Watanabe, Toshifumi Hibi
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease of the gastrointestinal tract, with increasing prevalence worldwide. IBD Ahead is an international educational program that aims to explore questions commonly raised by clinicians about various areas of IBD care and to consolidate available published evidence and expert opinion into a consensus for the optimization of IBD management. Given differences in the epidemiology, clinical and genetic characteristics, management, and prognosis of IBD between patients in Japan and the rest of the world, this statement was formulated as the result of literature reviews and discussions among Japanese experts as part of the IBD Ahead program to consolidate statements of factors for disease prognosis in IBD...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29740202/anti-integrin-therapy-for-inflammatory-bowel-disease
#14
REVIEW
Sung Chul Park, Yoon Tae Jeen
In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Anti-integrin therapy blocks the action of integrin on the surface of circulating immune cells and endothelial cell adhesion molecules, thereby inhibiting the interactions between leukocytes and intestinal blood vessels...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29726897/incidence-and-risk-factor-analysis-of-thromboembolic-events-in-east-asian-patients-with-inflammatory-bowel-disease-a-multinational-collaborative-study
#15
Meng-Tzu Weng, Sang Hyoung Park, Katsuyoshi Matsuoka, Chien-Chih Tung, Jae Yong Lee, Chin-Hao Chang, Suk-Kyun Yang, Mamoru Watanabe, Jau-Min Wong, Shu-Chen Wei
Background: Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism (VTE) events. However, the incidence and necessity of prophylaxis for VTE in Asian IBD patients is unknown. We examined the incidence of VTE in East Asian IBD patients and analyze the possible risk factors. Methods: We conducted a multinational retrospective study of 2562 hospitalized IBD patients from 2010 to 2015. Moreover, a nationwide cohort study from 2001 to 2013 from the Taiwan National Health Insurance Research Database (NHIRD) was conducted to analyze the incidence rate of VTE in IBD and non-IBD patients...
May 3, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29720903/colorectal-cancer-in-inflammatory-bowel-disease
#16
REVIEW
Ryan W Stidham, Peter D R Higgins
Patients with inflammatory bowel disease (IBD) are at significantly increased risk of colorectal cancer (CRC), principally resulting from the pro-neoplastic effects of chronic intestinal inflammation. Epidemiologic studies continue to highlight the increased risk of CRC in IBD. However, the incidence has declined over the past 30 years, attributed to both successful CRC-surveillance programs and improved control of mucosal inflammation. Risk factors that further increase the risk of IBD-related CRC include disease duration, extent and severity, the presence of inflammatory pseudopolyps, coexistent primary sclerosing cholangitis, and a family history of CRC...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29718343/dermatological-manifestations-in-pediatric-patients-with-inflammatory-bowel-diseases-on-anti-tnf-therapy
#17
Shilpa Sridhar, Ross M Maltz, Brendan Boyle, Sandra C Kim
Background: Anti-tumor necrosis factor (anti-TNF) therapies are effective treatments for inflammatory bowel diseases (IBD). However, infections, psoriasis, and eczema are potential manifestations. Descriptions of these are limited. Our aim was to characterize these skin manifestations in children with IBD on anti-TNF therapy. Methods: Our study is a retrospective review of IBD patients ranging in age from 6 to 18 years who were treated with anti-TNFs from 2010-2015...
April 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29718299/improving-quality-in-the-care-of-patients-with-inflammatory-bowel-diseases
#18
Matthew D Egberg, Ajay S Gulati, Ziad F Gellad, Gil Y Melmed, Michael D Kappelman
Efforts to improve healthcare quality were firmly established before the Institute of Medicine (IOM) historic 2000 and 2001 reports, To Err is Human Building a Safer Health System and Crossing the Quality Chasm: A New Health System for the 21st Century Despite the long-standing healthcare quality improvement (QI) efforts that date back to the turn of the 20th century, the IOM reports significantly advanced the awareness of healthcare quality deficits and the resulting risk to patients from those gaps in care...
April 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29718245/systematic-review-and-meta-analysis-preoperative-vedolizumab-treatment-and-postoperative-complications-in-patients-with-inflammatory-bowel-disease
#19
Cindy C Y Law, Alisha Narula, Amy L Lightner, Nicholas P McKenna, Jean-Frederic Colombel, Neeraj Narula
Background and Aims: The impact of vedolizumab, a gut-selective monoclonal antibody, on postoperative outcomes is unclear. This study aimed to assess the impact of preoperative vedolizumab treatment on the rate of postoperative complications in patients with inflammatory bowel disease [IBD] undergoing abdominal surgery. Methods: A systematic search of multiple electronic databases from inception until May 2017 identified studies reporting rates of postoperative complications in vedolizumab-treated IBD patients compared to no biologic exposure or anti-tumor necrosis factor (anti-TNF) treated IBD patients...
April 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29718228/revealing-the-puzzle-of-nonadherence-in-ibd-assembling-the-pieces
#20
Adi Eindor-Abarbanel, Timna Naftali, Nahum Ruhimovich, Ariella Bar-Gil Shitrit, Fabiana Sklerovsky-Benjaminov, Fred Konikoff, Shai Matalon, Haim Shirin, Yael Milgrom, Efrat Broide
Background: Adherence is generally associated with improved treatment outcomes in inflammatory bowel disease (IBD) patients. Different components of the patient profile have an impact on patient adherence. Capturing nonadherent patients by identifying modifiable risk factors in daily practice still remains a challenge. The objective of this study was to identify modifiable and nonmodifiable risk factors for nonadherence in IBD patients. Methods: Patients filled out questionnaires including demographic, clinical, and socioeconomic information and accessibility to gastrointestinal services...
April 26, 2018: Inflammatory Bowel Diseases
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