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IBD AND risk factors

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https://www.readbyqxmd.com/read/29333063/familial-and-ethnic-risk-in-inflammatory-bowel-disease
#1
REVIEW
Maria Pia Costa Santos, Catarina Gomes, Joana Torres
Familial aggregation in inflammatory bowel disease (IBD) has been established for several decades, reflecting shared genetic and environmental susceptibility. A positive family history remains the strongest recognizable risk factor for the development of IBD and is reported in around 8-12% of IBD patients. Crohn's disease shows a more frequent familial pattern than ulcerative colitis. The risk of developing IBD in first-degree relatives of an affected proband is increased 4- to 8-fold. The risk for twins and children born from couples who both have IBD is also substantially higher; a cumulative effect of the number of family members affected has been described, with the highest incidence being described for families with three or more affected members...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29331497/dietary-antioxidant-micronutrients-alter-mucosal-inflammatory-risk-in-a-murine-model-of-genetic-and-microbial-susceptibility
#2
Joseph F Pierre, Reinhard Hinterleitner, Romain Bouziat, Nathan A Hubert, Vanessa Leone, Jun Miyoshi, Bana Jabri, Eugene B Chang
Inflammatory bowel diseases (IBD) are caused by the convergence of microbial, environmental, and genetic factors. Diet significantly alters these interactions by affecting both the host and microbiome. Using a mucosal inflammatory model that resembles the human condition of ileal pouchitis, we investigated the effects of Control (CONT) or Antioxidant (AOX) diet, containing pharmacologically relevant levels of 4 micronutrients, on disease risk in wild-type and IL-10-/- animals following surgical self-filling (SF) ileal blind loop placement...
December 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29321655/evaluation-of-brain-activity-using-near-infrared-spectroscopy-in-inflammatory-bowel-disease-patients
#3
Tatsuo Fujiwara, Soichi Kono, Kyoko Katakura, Kazumichi Abe, Atsushi Takahashi, Naohiko Gunji, Aki Yokokawa, Kazumasa Kawashima, Rieko Suzuki, Akira Wada, Itaru Miura, Hirooki Yabe, Hiromasa Ohira
Depression is implicated as a risk factor for the recurrence of inflammatory bowel disease (IBD). Near-infrared spectroscopy (NIRS) and brain-derived neurotrophic factor (BDNF) are useful tools for evaluation of brain activity and a depressive state, respectively. The aim of this study was to clarify the association between brain activity or depressive symptoms and IBD using NIRS and BDNF. This study included 36 ulcerative colitis (UC) patients, 32 Crohn's disease (CD) patients, and 17 healthy controls (HC)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321166/fetal-and-early-life-antibiotics-exposure-and-very-early-onset-inflammatory-bowel-disease-a-population-based-study
#4
Anne K Örtqvist, Cecilia Lundholm, Jonas Halfvarson, Jonas F Ludvigsson, Catarina Almqvist
OBJECTIVE: Earlier studies on antibiotics exposure and development of IBD (Crohn's disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD. DESIGN: In this cohort study of 827 239 children born in Sweden between 2006 and 2013, we examined the link between exposure to systemic antibiotics and VEO-IBD (diagnosis <6 years of age), using Cox proportional hazard regression models...
January 10, 2018: Gut
https://www.readbyqxmd.com/read/29301479/risk-factors-and-prognosis-for-recurrent-primary-sclerosing-cholangitis-after-liver-transplantation-a-nordic-multicentre-study
#5
Lina Lindström, Kristin K Jørgensen, Kirsten M Boberg, Maria Castedal, Allan Rasmussen, Andreas Arendtsen Rostved, Helena Isoniemi, Matteo Bottai, Annika Bergquist
OBJECTIVES: The risk for recurrent primary sclerosing cholangitis (rPSC) after liver transplantation is associated with inflammatory bowel disease (IBD). We assessed the frequency of rPSC and studied risk factors for recurrent disease with special focus on IBD. We also evaluated the importance of rPSC for prognosis. MATERIALS AND METHODS: All liver transplanted PSC patients in the Nordic countries between 1984 and 2007 (n = 440), identified by the Nordic Liver Transplant Registry, were studied...
January 4, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29290654/prevalence-of-and-risk-factors-for-work-disability-in-dutch-patients-with-inflammatory-bowel-disease
#6
Lieke M Spekhorst, Bas Oldenburg, Ad A van Bodegraven, Dirk J de Jong, Floris Imhann, Andrea E van der Meulen-de Jong, Marieke J Pierik, Janneke C van der Woude, Gerard Dijkstra, Geert D'Haens, Mark Löwenberg, Rinse K Weersma, Eleonora A M Festen
AIM: To determine the prevalence of work disability in inflammatory bowel disease (IBD), and to assess risk factors associated with work disability. METHODS: For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29276397/is-cytomegalovirus-infection-related-to-inflammatory-bowel-disease-especially-steroid-resistant-inflammatory-bowel-disease-a-meta-analysis
#7
Ya-Li Lv, Fei-Fei Han, Yang-Jie Jia, Zi-Rui Wan, Li-Li Gong, He Liu, Li-Hong Liu
Background: Human cytomegalovirus (HCMV) infection has been associated with inflammatory bowel disease (IBD). Numerous studies have been conducted to analyze the association between HCMV infection and risk of IBD and steroid-resistant IBD, but no clear consensus had been reached. Objectives: The aim of this study was to confirm this relationship precisely by doing a systematic review and meta-analysis. Study design: We identified relevant studies through a search of PubMed and Embase...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29275959/mtorc1-inactivation-promotes-colitis-induced-colorectal-cancer-but-protects-from-apc-loss-dependent-tumorigenesis
#8
Marta Brandt, Tatiana P Grazioso, Mohamad-Ali Fawal, Krishna S Tummala, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Cristian Perna, Nabil Djouder
Dietary habits that can induce inflammatory bowel disease (IBD) are major colorectal cancer (CRC) risk factors, but mechanisms linking nutrients, IBD, and CRC are unknown. Using human data and mouse models, we show that mTORC1 inactivation-induced chromosomal instability impairs intestinal crypt proliferation and regeneration, CDK4/6 dependently. This triggers interleukin (IL)-6-associated reparative inflammation, inducing crypt hyper-proliferation, wound healing, and CRC. Blocking IL-6 signaling or reactivating mTORC1 reduces inflammation-induced CRC, so mTORC1 activation suppresses tumorigenesis in IBD...
December 19, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29251424/inadequate-sunlight-exposure-in-patients-with-inflammatory-bowel-disease
#9
Piero Vernia, Giorgia Burrelli Scotti, Anna Dei Giudici, Ambra Chiappini, Santi Cannizzaro, Maria Teresa Afferri, Aurora de Carolis
AIM: Inadequate sun exposure impairs Vitamin D activity and favors low bone density, more so in patients at increased risk for osteoporosis, as those affected by Inflammatory Bowel Disease. Sun exposure (SE) was investigated in a large series of IBD patients in a Mediterranean Country, Italy, where this risk is considered less likely to occur compared to those from higher latitudes. METHODS: Case-control study in 292 IBD patients (132 Crohn's Disease and 160 Ulcerative Colitis), 80 diseased and 540 healthy controls, administering a validated questionnaire to quantify SE...
December 18, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29248579/genetic-profile-of-patients-with-early-onset-inflammatory-bowel-disease
#10
Martina Girardelli, Federica Basaldella, Sara Della Paolera, Josef Vuch, Alberto Tommasini, Stefano Martelossi, Sergio Crovella, Anna Monica Bianco
Inflammatory Bowel disease (IBD) is a widespread pathological condition with clinical heterogeneity and with different levels of severity. Although IBD usually occurs in young adults, onset in childhood and infancy are described in patients within the 10th and second year of age. By genome-wide association studies and meta-analysis several genetic loci have been identified associated with an increased risk of developing IBD in Western populations with variants that may alter the normal mucosal immunity in the gastrointestinal tract...
December 14, 2017: Gene
https://www.readbyqxmd.com/read/29236523/associations-between-inflammatory-bowel-diseases-and-vitamin-d
#11
Sandra Maria Barbalho, Ricardo de Alvares Goulart, Rodrigo Gallhardi Gasparini
Inflammatory Bowel Diseases (IBD) are increasing sharply, and the common medications are not effective for most patients. Vitamin D (VD) has been considerate to reduce inflammatory processes and may be helpful in IBD. The aim of this review was to perform an update on the potential role of VD in the IBD. We performed a search for articles associating VD and IBD published in MEDLINE-PubMed and EMBASE. The focused question used for the search was "What is the association between Inflammatory Bowel Disease and Vitamin D?" The exclusion criteria for this search were studies not in English, editorials, case reports, or poster presentations...
December 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29232213/postoperative-mortality-after-nonelective-surgery-for-inflammatory-bowel-disease-patients-in-the-era-of-biologics
#12
Carla F Justiniano, Christopher T Aquina, Adan Z Becerra, Zhaomin Xu, Courtney I Boodry, Alex A Swanger, John R T Monson, Fergal J Fleming
OBJECTIVE: The aim of the study was to analyze recent trends in the rate of nonelective surgery and corresponding mortality for inflammatory bowel disease (IBD) patients since the rise of biologic use. BACKGROUND: Modern biologic therapy has improved outcomes for IBD, but little is known about the impact on mortality rates after nonelective surgery. METHODS: New York's Statewide Planning & Research Cooperative System was queried for hospital admissions for ulcerative colitis (UC) with concurrent colectomy and Crohn disease (CD) with concurrent small bowel resection or colectomy from 2000 to 2013...
December 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29223833/valve-sparing-repair-with-intraoperative-balloon-dilation-in-tetralogy-of-fallot-midterm-results-and-therapeutic-implications
#13
Sophie C Hofferberth, Meena Nathan, Gerald R Marx, Minmin Lu, Lynn A Sleeper, Audrey C Marshall, Christopher W Baird, John E Mayer, Pedro J Del Nido, Sitaram M Emani
OBJECTIVES: The significant morbidity of long-term pulmonary regurgitation (PR) has driven the development of pulmonary valve (PV) sparing repair strategies in patients with tetralogy of Fallot (ToF). We assessed mid-term PV function in patients who underwent primary ToF repair with valve-sparing intraoperative balloon dilation (IBD) technique. METHODS: We evaluated 162 consecutive patients with ToF and pulmonary stenosis (ToF-PS) who underwent valve-sparing repair with IBD under 1 year of age...
November 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29220427/steroid-but-not-biological-therapy-elevates-the-risk-of-venous-thromboembolic-events-in-inflammatory-bowel-disease-a-meta-analysis
#14
Patricia Sarlos, Kata Szemes, Peter Hegyi, Andras Garami, Imre Szabo, Anita Illes, Margit Solymar, Erika Petervari, Aron Vincze, Gabriella Par, Judit Bajor, Jozsef Czimmer, Orsolya Huszar, Peter Varju, Nelli Farkas
Background and aim: Inflammatory bowel disease [IBD] is associated with 1.5- to 3-fold increased risk of venous thromboembolic events [VTE]. The aim of this study was to determine the risk of VTE in IBD as a complication of systemic corticosteroids and anti-tumor necrosis factor alpha [TNFα] therapies. Methods: A systematic review and meta-analysis was conducted, which conforms to the Preferred Reporting Items for Systematic Reviews and Meta-analyses [PRISMA] statement...
December 6, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29216349/developing-a-standard-set-of-patient-centred-outcomes-for-inflammatory-bowel-disease-an-international-cross-disciplinary-consensus
#15
Andrew H Kim, Charlotte Roberts, Brian G Feagan, Rupa Banerjee, Willem Bemelman, Keith Bodger, Marc Derieppe, Axel Dignass, Richard Driscoll, Ray Fitzpatrick, Janette Gaarentstroom-Lunt, Peter D Higgins, Paulo Gustavo Kotze, Jillian Meissner, Marian O'Connor, Zhi-Hua Ran, Corey A Siegel, Helen Terry, Welmoed K van Deen, C Janneke van der Woude, Alandra Weaver, Suk-Kyun Yang, Bruce E Sands, Séverine Vermeire, Simon Pl Travis
Background and Aims: Success in delivering value-based healthcare involves measuring outcomes that matter most to patients. Our aim was to develop a minimum Standard Set of patient-centred outcome measures for inflammatory bowel disease (IBD), for use in different healthcare settings. Methods: An international working group (n=25) representing patients, patient associations, gastroenterologists, surgeons, specialist nurses, IBD registries and patient-reported outcome measure (PROM) methodologists participated in a series of teleconferences incorporating a modified Delphi process...
December 5, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29215479/major-abdominal-and-perianal-surgery-in-crohn-s-disease-long-term-follow-up-of-australian-patients-with-crohn-s-disease
#16
MULTICENTER STUDY
James W T Toh, Nelson Wang, Christopher J Young, Matthew J F X Rickard, Anil Keshava, Peter Stewart, Viraj Kariyawasam, Rupert Leong
BACKGROUND: Most patients with Crohn's disease still require surgery despite significant advances in medical therapy, surveillance, and management strategies. OBJECTIVE: The purpose of this study was to assess surgical strategies and outcomes in Crohn's disease, including surgical recurrence and emergency surgery. DESIGN: This was a multicenter, retrospective review of a prospectively collected database. SETTINGS: A specialist-referred cohort of patients with Crohn's disease between 1970 and 2009 was studied...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29215434/family-planning-in-inflammatory-bowel-disease-childlessness-and-disease-related-concerns-among-female-patients
#17
Jens Walldorf, Susanne Brunne, Fleur S Gittinger, Patrick Michl
OBJECTIVE: Inflammatory bowel disease (IBD) frequently affects women when family planning and pregnancy (FPP) are important issues. This survey aimed to identify patients with an increased need for medical counselling. PATIENTS AND METHODS: An internet-based questionnaire was offered to women with IBD. Characteristics in terms of FPP were analysed with respect to sociodemographic and disease-related factors. RESULTS: Childlessness was frequently reported (64...
December 5, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29199142/high-risk-of-anal-and-rectal-cancer-in-patients-with-anal-and-or-perianal-crohn-s-disease
#18
Laurent Beaugerie, Fabrice Carrat, Stéphane Nahon, Jean-David Zeitoun, Jean-Marc Sabate, Laurent Peyrin-Biroulet, Jean-Frédéric Colombel, Matthieu Allez, Jean-François Fléjou, Julien Kirchgesner, Magali Svrcek
BACKGROUND AND AIMS: Little is known about the magnitude of the risk of anal and rectal cancer in patients with anal and/or perineal Crohn's disease. We aimed to assess the risk of anal and rectal cancer in patients with Crohn's perianal disease followed in the Cancers Et Surrisque Associé aux Maladies inflammatoires intestinales En France (CESAME) cohort. METHODS: We collected data from 19,486 patients with Inflammatory Bowel Disease (IBD) enrolled in the observational CESAME study in France, from May 2004 through June 2005; 14...
November 30, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29181373/prevalence-of-anxiety-and-depression-in-patients-with-inflammatory-bowel-disease
#19
Glynis Byrne, Greg Rosenfeld, Yvette Leung, Hong Qian, Julia Raudzus, Carlos Nunez, Brian Bressler
Background: Inflammatory bowel disease (IBD) patients are not routinely screened for depression and anxiety despite knowledge of an increased prevalence in people with chronic disease and negative effects on quality of life. Methods: Prevalence of anxiety and depression was assessed in IBD outpatients through retrospective chart review. The presence of anxiety and/or depression was determined using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 self-report questionnaires or by diagnosis through psychiatric interview...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29180383/comparative-risk-of-incident-venous-thromboembolism-in-patients-with-inflammatory-bowel-disease-initiating-tumour-necrosis-factor-%C3%AE-inhibitors-or-nonbiologic-agents-a-cohort-study
#20
Rishi J Desai, Joshua J Gagne, Joyce Lii, Jun Liu, Sonia Friedman, Seoyoung C Kim
BACKGROUND: Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism (VTE) by 2 to 3 times. We compared the reduction in risk of incident VTE associated with use of tumour necrosis factor-α (TNF-α) inhibitors versus nonbiologic immunomodulatory agents in patients with IBD. METHODS: This observational cohort study used data from public (Medicaid, 2000-2010; Medicare, 2007-2013) and private (Optum Clinformatics, 2004-2013) health insurance programs in the United States...
November 27, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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