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https://www.readbyqxmd.com/read/29162383/inhibition-of-ampar-endocytosis-alleviates-pentobarbital-induced-spatial-memory-deficits-and-synaptic-depression
#1
Wei Wang, Tao Tan, Yanzhi Yu, Zhilin Huang, Yehong Du, Huili Han, Zhifang Dong
Our previous study has shown that pentobarbital causes memory deficits and impairs hippocampal synaptic plasticity. The Tat-GluA23Y peptide (GluA23Y) prevents activity-dependent α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) endocytosis. It enables early-phase long-term potentiation (LTP) to proceed to late-phase LTP allowing short-term memory to convert to long-term memory. The purpose of this study is to explore the potential effects of GluA23Y on pentobarbital-induced memory deficits through behavioral and electrophysiological paradigms...
November 18, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29141213/cpeb2-activates-grasp1-mrna-translation-and-promotes-ampa-receptor-surface-expression-long-term-potentiation-and-memory
#2
Wen-Hsin Lu, Nai-Hsing Yeh, Yi-Shuian Huang
Activity-dependent synthesis of plasticity-related proteins is necessary to sustain long-lasting synaptic modifications and consolidate memory. We investigated the role of the translational regulator cytoplasmic polyadenylation element binding protein 2 (CPEB2) in learning and memory because regulated mRNA translation contributes to synaptic plasticity. Forebrain-restricted CPEB2 conditional knockout (cKO) mice exhibited impaired hippocampus-dependent memory in contextual fear conditioning and Morris water maze tests...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29131863/long-term-retinal-cone-rescue-using-a-capsid-mutant-aav8-vector-in-a-mouse-model-of-cnga3-achromatopsia
#3
Xufeng Dai, Ying He, Hua Zhang, Yangyang Zhang, Yan Liu, Muran Wang, Hao Chen, Ji-Jing Pang
Adeno-associated virus (AAV) vectors are important gene delivery tools for the treatment of many recessively inherited retinal diseases. For example, a wild-type (WT) AAV5 vector can deliver a full-length Cnga3 (cyclic nucleotide-gated channel alpha-3) cDNA to target cells of the cone photoreceptor function loss 5 (cpfl5) mouse, a spontaneous animal model of achromatopsia with a Cnga3 mutation. Gene therapy restores cone-mediated function and blocks cone degeneration in the mice. However, since transgene expression delivered by an AAV vector shows relatively short-term effectiveness, this cannot be regarded as a very successful therapy...
2017: PloS One
https://www.readbyqxmd.com/read/29131026/trpml1-participates-in-the-progression-of-alzheimer-s-disease-by-regulating-the-ppar%C3%AE-ampk-mtor-signalling-pathway
#4
Lu Zhang, Yu Fang, Xuan Cheng, Yajun Lian, Hongliang Xu, Zhaoshu Zeng, Hongcan Zhu
BACKGROUND: TRPML1 is reported to be involved in the pathogenesis of Alzheimer's disease (AD) by regulating autophagy; however, the underlying mechanism is not completely clear. METHODS: We developed an APP/PS1 transgenic animal model that presents with AD. TRPML1 was also overexpressed in these mice. Protein expression levels were determined by Western blot. Morris water maze (MWM) and recognition tasks were performed to characterize cognitive ability. TUNEL assays were analysed for the detection of neuronal apoptosis...
October 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29125546/hereditary-nephrogenic-diabetes-insipidus-pathophysiology-and-possible-treatment-an-update
#5
REVIEW
Serena Milano, Monica Carmosino, Andrea Gerbino, Maria Svelto, Giuseppe Procino
Under physiological conditions, excessive loss of water through the urine is prevented by the release of the antidiuretic hormone arginine-vasopressin (AVP) from the posterior pituitary. In the kidney, AVP elicits a number of cellular responses, which converge on increasing the osmotic reabsorption of water in the collecting duct. One of the key events triggered by the binding of AVP to its type-2 receptor (AVPR2) is the exocytosis of the water channel aquaporin 2 (AQP2) at the apical membrane the principal cells of the collecting duct...
November 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29122100/occupational-carbon-monoxide-poisoning-associated-with-diesel-motor-operation-in-an-air-raid-shelter-in-june-2015-jinan-city-china-an-epidemiological-investigation
#6
Liang Liang Cui, Jing Wen Zhou, Xing Yi Geng, Xin Wei Li, Zhong Liu, George A Conway, Ji Zhang
Occupational carbon monoxide (CO) poisoning related to diesel motor fumes in an air-raid shelter (ARS) was first identified in Jinan City, China, in June 2015. A total of 17 cases were identified, including 14 possible cases of firemen and 3 confirmed cases of water channel clean-up workers. The overall attack rate (AR) of firemen was 42% (14/33). The firemen had a significantly higher AR with a longer exposure and more protracted time of rescue in the ARS (P < 0.05). All the cases stated that they did not realize the potentially high level of exposure to CO in the ARS...
October 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29099790/design-of-uav-embedded-microphone-array-system-for-sound-source-localization-in-outdoor-environments
#7
Kotaro Hoshiba, Kai Washizaki, Mizuho Wakabayashi, Takahiro Ishiki, Makoto Kumon, Yoshiaki Bando, Daniel Gabriel, Kazuhiro Nakadai, Hiroshi G Okuno
In search and rescue activities, unmanned aerial vehicles (UAV) should exploit sound information to compensate for poor visual information. This paper describes the design and implementation of a UAV-embedded microphone array system for sound source localization in outdoor environments. Four critical development problems included water-resistance of the microphone array, efficiency in assembling, reliability of wireless communication, and sufficiency of visualization tools for operators. To solve these problems, we developed a spherical microphone array system (SMAS) consisting of a microphone array, a stable wireless network communication system, and intuitive visualization tools...
November 3, 2017: Sensors
https://www.readbyqxmd.com/read/29090669/mir-132-down-regulates-methyl-cpg-binding-protein-2-mecp2-during-cognitive-dysfunction-following-chronic-cerebral-hypoperfusion
#8
Zhao-Hui Yao, Xiao-Li Yao, Yong Zhang, Shao-Feng Zhang, Jichang Hu
BACKGROUND: Chronic Cerebral Hypoperfusion (CCH) is an important vascular risk factor for vascular-related dementia cognitive impairment and there are no effective measures for the prevention and treatment of cognitive deficit by CCH and the underlying mechanisms are still poorly understood. Methyl cytidine-phosphate-guanosine (CpG) binding protein 2 (MeCP2), regulated by microRNA 132 (miR-132), is as a transcriptional repressor in high concentrations in the brain, regulates the expression of synaptic proteins and neuroplasticity, and may be involved in the cognitive deficit after CCH...
November 1, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/29075341/effect-of-docosahexaenoic-acid-on-traumatic-brain-injury-in-rats
#9
Wei Zhu, Nan Chi, Peng Zou, Hongguang Chen, Guotai Tang, Wei Zhao
The present study aimed to investigate the protective effects of docosahexaenoic acid (DHA) on traumatic brain injury (TBI) in rats. A model of TBI was induced by lateral fluid percussion injury in adult rats and rats were randomly divided into the TBI-model group, TBI-low DHA group and TBI-high DHA group, while other healthy rats were assigned to the sham-operated group. Motor recovery was tested with beam-walking trials at 2, 7 and 15 days post-TBI. Cognitive recovery was tested with Morris water maze trials at 15 days post-TBI...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29073219/environmental-enrichment-accelerates-ocular-dominance-plasticity-in-mouse-visual-cortex-whereas-transfer-to-standard-cages-resulted-in-a-rapid-loss-of-increased-plasticity
#10
Evgenia Kalogeraki, Justyna Pielecka-Fortuna, Siegrid Löwel
In standard cage (SC) raised mice, experience-dependent ocular dominance (OD) plasticity in the primary visual cortex (V1) rapidly declines with age: in postnatal day 25-35 (critical period) mice, 4 days of monocular deprivation (MD) are sufficient to induce OD-shifts towards the open eye; thereafter, 7 days of MD are needed. Beyond postnatal day 110, even 14 days of MD failed to induce OD-plasticity in mouse V1. In contrast, mice raised in a so-called "enriched environment" (EE), exhibit lifelong OD-plasticity...
2017: PloS One
https://www.readbyqxmd.com/read/29066195/supplemental-feeding-and-other-anthropogenic-threats-to-green-turtles-chelonia-mydas-in-the-canary-islands
#11
Catalina Monzón-Argüello, Luis Cardona, Pascual Calabuig, María Camacho, José Luis Crespo-Picazo, Daniel García-Párraga, Santiago Mayans, Octavio P Luzardo, Jorge Orós, Nuria Varo-Cruz
Green turtles are found in the waters of the Canary Islands but little is known about the ecology and anthropogenic pressures that threaten them. Our results have revealed that juvenile green turtles, ranging in curve carapace length from 26.9-81.0cm, are regularly found in the archipelago and originate from rookeries in both the eastern and western Atlantic. Photo-identification and satellite tracking showed high levels of site fidelity to coastal foraging grounds associated with seagrass meadows, but stable isotope analysis indicated animal-based omnivorous diets after settlement on the continental shelf, with no increase in the consumption of macrophytes as the turtles grew...
October 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29053824/chemogenetic-locus-coeruleus-activation-restores-reversal-learning-in-a-rat-model-of-alzheimer-s-disease
#12
Jacki M Rorabaugh, Termpanit Chalermpalanupap, Christian A Botz-Zapp, Vanessa M Fu, Natalie A Lembeck, Robert M Cohen, David Weinshenker
No abstract text is available yet for this article.
November 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29039587/protective-effects-of-rosmarinic-acid-against-hydrogen-peroxide%C3%A2-induced-cellular-senescence-and-the-inflammatory-response-in-normal-human-dermal-fibroblasts
#13
Hyung Jin Hahn, Ki Bbeum Kim, In-Sook An, Kyu Joong Ahn, Hyun Joo Han
Hydrogen peroxide (H2O2) is a reactive oxygen species (ROS) that induces numerous cellular events, including cellular senescence and inflammatory responses. Therefore, the aim of this study was to investigate the protective effect of Rosmarinic acid (RA) in H2O2‑induced oxidative stress in normal human dermal fibroblasts (NHDFs). Cytotoxicity assays were performed using a water‑soluble tetrazolium salt, and senescence‑associated β‑galactosidase activity was determined to investigate the proportion of senescent cells...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28970251/exosomes-derived-from-hypoxia-preconditioned-mesenchymal-stromal-cells-ameliorate-cognitive-decline-by-rescuing-synaptic-dysfunction-and-regulating-inflammatory-responses-in-app-ps1-mice
#14
Guo-Hong Cui, Jing Wu, Fang-Fang Mou, Wei-Hua Xie, Fu-Bo Wang, Qiang-Li Wang, Jie Fang, Yan-Wu Xu, You-Rong Dong, Jian-Ren Liu, Hai-Dong Guo
Administration of exosomes derived from mesenchymal stromal cells (MSCs) could improve some neurologic conditions by transferring functional biomolecules to recipient cells. Furthermore, exosomes from hypoxic progenitor cells exerted better therapeutic effects in organ injury through specific cargoes. However, there are no related reports about whether exosomes derived from MSCs or hypoxia-preconditioned MSCs could prevent memory deficits in Alzheimer disease (AD). In this study, the exosomes derived from MSCs or hypoxia-preconditioned MSCs were systemically administered to transgenic APP/PS1 mice...
September 27, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28969693/effects-of-melatonin-administration-on-embryo-implantation-and-offspring-growth-in-mice-under-different-schedules-of-photoperiodic-exposure
#15
Lu Zhang, Zhenzhen Zhang, Feng Wang, Xiuzhi Tian, Pengyun Ji, Guoshi Liu
BACKGROUND: Embryo implantation is crucial for animal reproduction. Unsuccessful embryo implantation leads to pregnancy failure, especially in human-assisted conception. Environmental factors have a profound impact on embryo implantation. Because people are being exposed to more light at night, the influence of long-term light exposure on embryo implantation should be explored. METHODS: The effects of long photoperiodic exposure and melatonin on embryo implantation and offspring growth were examined...
October 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28969075/bptf-inhibits-nk-cell-activity-and-the-abundance-of-natural-cytotoxicity-receptor-co-ligands
#16
Kimberly Mayes, Zeinab Elsayed, Aiman Alhazmi, Michael Waters, Suehyb G Alkhatib, Mark Roberts, Carolyn Song, Kristen Peterson, Vivian Chan, Nikhil Ailaney, Pumoli Malapati, Tana Blevins, Berislav Lisnić, Catherine I Dumur, Joseph W Landry
Using syngeneic BALB/c mouse breast cancer models, we show that the chromatin remodeling subunit bromodomain PHD finger transcription factor (BPTF) suppresses natural killer (NK) cell antitumor activity in the tumor microenvironment (TME). In culture, BPTF suppresses direct natural cytotoxicity receptor (NCR) mediated NK cell cytolytic activity to mouse and human cancer cell lines, demonstrating conserved functions. Blocking mouse NCR1 in vivo rescues BPTF KD tumor weights, demonstrating its importance for the control of tumor growth...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28953468/enhanced-biomass-production-of-duckweeds-by-inoculating-a-plant-growth-promoting-bacterium-acinetobacter-calcoaceticus-p23-in-sterile-medium-and-non-sterile-environmental-waters
#17
T Toyama, M Kuroda, Y Ogata, Y Hachiya, A Quach, K Tokura, Y Tanaka, K Mori, M Morikawa, M Ike
Duckweed offers the promise of a co-benefit culture combining water purification with biomass production. Acinetobacter calcoaceticus P23 is a plant growth-promoting bacterium isolated from a duckweed, Lemna aequinoctialis. This study quantified its growth-promoting effect on three duckweeds (L. aoukikusa, L. minor, and Spirodela polyrhiza) in sterile Hoagland solution and evaluated its usefulness in duckweed culture under non-sterile conditions. P23 promoted growth of three duckweeds in sterile Hoagland solution at low to high nutrient concentrations (1...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28952662/cholera-the-new-strike-of-an-old-foe
#18
Anna Kuna, Michał Gajewski
Cholera is an acute bacterial gastrointestinal infection caused by ingestion of water or food containing the pathogen Vibrio cholerae. The incubation period can be very short and it takes between several hours and 5 days. During the 19th century, cholera was spreading from India across the world. Its original reservoir was located in the Ganges delta. So far, there have been six epidemics of cholera; the current outbreak is the seventh. It started in Asia, attacked Africa and then the Americas. Cholera causes thousands of illnesses and deaths annually, mostly in South Asia and Sub-Saharan Africa...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28939971/pharmacological-chaperones-as-potential-therapeutic-strategies-for-misfolded-mutant-vasopressin-receptors
#19
Bernard Mouillac, Christiane Mendre
Pharmacological chaperones recently opened new possibilities in G protein-coupled receptor drug discovery. Even more interestingly, some unique ligands combine pharmacological chaperoning and biased agonism properties, boosting their therapeutic interest in many human diseases resulting from G protein-coupled receptor mutation and misfolding. These compounds displaying dual characteristics would constitute a perfect treatment for congenital Nephrogenic Diabetes Insipidus, a typical conformational disease. This X-linked genetic pathology is mostly associated with inactivating mutations of the renal arginine-vasopressin V2 receptor leading to misfolding and intracellular retention of the receptor, causing the inability of patients to concentrate their urine in response to the antidiuretic hormone...
September 23, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28922960/cognitive-performance-in-transient-global-hypoxic-brain-injury-due-to-moderate-drowning
#20
Mariana Penteado Nucci, Katerina Lukasova, Gilson Vieira, João Ricardo Sato, Edson Amaro Júnior
INTRODUCTION: Drowning is a serious and frequently neglected public health threat. Primary respiratory impairment after submersion often leads to brain dysfunction. Depending on the period of global hypoxia (respiratory failure), clinical aspects of neurological dysfunction are evident on the first evaluation after the water rescue. Nowadays, many neuropsychological assessments after drowning are inconclusive, with some studies reporting only minor neurological or cognitive impairments...
September 19, 2017: Journal of Clinical and Experimental Neuropsychology
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