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Hearing loose

Jingjing Sherry Wu, Eric D Young, Elisabeth Glowatzki
: Auditory nerve fibers (ANFs) exhibit a range of spontaneous firing rates (SRs) that are inversely correlated with threshold for sounds. To probe the underlying mechanisms and time course of SR differentiation during cochlear maturation, loose-patch extracellular recordings were made from ANF dendrites using acutely excised rat cochlear preparations of different ages after hearing onset. Diversification of SRs occurred mostly between the second and the third postnatal week. Statistical properties of ANF spike trains showed developmental changes that approach adult-like features in older preparations...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Jared J Tompkins, Dana K Petersen, Daniel D Sharbel, Brian J McKinnon, C Bruce MacDonald
Implantation of auditory osseointegrated implants, also known as bone-anchored hearing systems (BAHS), represents a surgical option for select pediatric patients aged 5 years or older with hearing loss. Functional indications in this patient population include conductive or mixed hearing loss. Common complications of implantation include skin infections, chronic skin irritation, hypertrophic skin overgrowth, and loose abutments. In a case series of 15 pediatric patients, we discovered an unexpectedly high skin-related complication rate requiring surgical revision of 53%...
July 2016: International Journal of Pediatric Otorhinolaryngology
Qi Dai, Zhicun Zhang, Quan Liu, Hongmeng Yu
CONCLUSIONS: Transplantation of OECs into the cochlea may protect and increase the survival of SGCs. OBJECTIVE: To investigate the protective effect of the transplantation of olfactory ensheathing cells (OECs) on injured spiral ganglion cells (SGCs) in rats. METHODS: OECs were transplanted into the cochlea in rats with SGCs that were injured by kanamycin sulfate (KM). An equal volume of D-Hanks was injected into the cochlea of control rats...
May 26, 2016: Acta Oto-laryngologica
Haishi Zhang, Jian Xu, Danqi Chen, Xiang Huang, Ping Zhong
Here we reported the first case of left cerebellopontine angle acoustic neurinoma with calcification in our department. The patient was 65 year-old, suffering from progressive loss of hearing in the left ear for about 30 years and headache with unsteady gait for approximately 6 months. Head CT & MRI scan identified an intracranial lesion located on left cerebellopontine angle. Left suboccipital retrosigmoid approach was applied to perform the operation after patient consent. The tumor was completely resected without complication and the patient recovered well...
2015: International Journal of Clinical and Experimental Medicine
Trevor J Wardill, Katie Knowles, Laura Barlow, Gervasio Tapia, Karin Nordström, Robert M Olberg, Paloma T Gonzalez-Bellido
Predatory animals have evolved to optimally detect their prey using exquisite sensory systems such as vision, olfaction and hearing. It may not be so surprising that vertebrates, with large central nervous systems, excel at predatory behaviors. More striking is the fact that many tiny insects, with their miniscule brains and scaled down nerve cords, are also ferocious, highly successful predators. For predation, it is important to determine whether a prey is suitable before initiating pursuit. This is paramount since pursuing a prey that is too large to capture, subdue or dispatch will generate a substantial metabolic cost (in the form of muscle output) without any chance of metabolic gain (in the form of food)...
September 2015: Brain, Behavior and Evolution
Alicia M Quesnel, Hideko Heidi Nakajima, John J Rosowski, Marlan R Hansen, Bruce J Gantz, Joseph B Nadol
After initially successful preservation of residual hearing with cochlear implantation, some patients experience subsequent delayed hearing loss. The etiology of such delayed hearing loss is unknown. Human temporal bone pathology is critically important in investigating the etiology, and directing future efforts to maximize long term hearing preservation in cochlear implant patients. Here we present the temporal bone pathology from a patient implanted during life with an Iowa/Nucleus Hybrid S8 implant, with initially preserved residual hearing and subsequent hearing loss...
March 2016: Hearing Research
Douglas E Vetter
Hearing loss afflicts approximately 15% of the world's population, and crosses all socioeconomic boundaries. While great strides have been made in understanding the genetic components of syndromic and non-syndromic hearing loss, understanding of the mechanisms underlying noise-induced hearing loss (NIHL) have come much more slowly. NIHL is not simply a mechanism by which older individuals loose their hearing. Significantly, the incidence of NIHL is increasing, and is now involving ever younger populations. This may predict future increased occurrences of hearing loss...
September 1, 2015: Biochemical Pharmacology
H G Mueller
Probe-microphone testing was conducted in the laboratory as early as the 1940s (e.g., the classic work of Wiener and Ross, reported in 1946), however, it was not until the late 1970s that a "dispenser friendly" system was available for testing hearing aids in the real ear. In this case, the term "dispenser friendly," is used somewhat loosely. The 1970s equipment that I'm referring to was first described in a paper that was presented by Earl Harford, Ph.D. in September of 1979 at the International Ear Clinics' Symposium in Minneapolis...
June 2001: Trends in Amplification
Eunkyung Kim, Hyejin Kang, Hyekyoung Lee, Hyo-Jeong Lee, Myung-Whan Suh, Jae-Jin Song, Seung-Ha Oh, Dong Soo Lee
Prolonged deprivation of auditory input can change brain networks in pre- and postlingual deaf adults by brain-wide reorganization. To investigate morphological changes in these brains voxel-based morphometry, voxel-wise correlation with the primary auditory cortex, and whole brain network analyses using morphological covariance were performed in eight prelingual deaf, eleven postlingual deaf, and eleven hearing adults. Network characteristics based on graph theory and network filtration based on persistent homology were examined...
September 2014: Hearing Research
Hirohito M Kondo, Iwaki Toshima, Daniel Pressnitzer, Makio Kashino
The perceptual organization of auditory scenes is a hard but important problem to solve for human listeners. It is thus likely that cues from several modalities are pooled for auditory scene analysis, including sensory-motor cues related to the active exploration of the scene. We previously reported a strong effect of head motion on auditory streaming. Streaming refers to an experimental paradigm where listeners hear sequences of pure tones, and rate their perception of one or more subjective sources called streams...
2014: Frontiers in Neuroscience
Hamidreza Taghavi, Bo Håkansson, Måns Eeg-Olofsson, Carina B Johansson, Anders Tjellström, Sabine Reinfeldt, Tomas Bergqvist, Joakim Olsson
HYPOTHESIS: Bone conduction implant (BCI) attached with a flat surface contact will offer efficient and linear vibration transmission over time. BACKGROUND: Despite that percutaneous bone conduction devices (PBCD) are successful in treating patients with conductive hearing loss, there are some drawbacks related to the need of a permanent skin penetration. The BCI system is designed as an alternative to the PBCD because it leaves the skin intact. METHODS: BCI dummy implants were installed in 3 sheep skulls in vivo to study the vibration transmission characteristics over time...
June 2013: Otology & Neurotology
Holger Mitterer, Jochen Müsseler
We investigated the relation between action and perception in speech processing, using the shadowing task, in which participants repeat words they hear. In support of a tight perception-action link, previous work has shown that phonetic details in the stimulus influence the shadowing response. On the other hand, latencies do not seem to suffer if stimulus and response differ in their articulatory properties. The present investigation tested how perception influences production when participants are confronted with regional variation...
April 2013: Attention, Perception & Psychophysics
Susan A Small, Janet F Werker
OBJECTIVE: The acoustic change complex (ACC), an auditory evoked potential (AEP) comprises overlapping slow cortical responses, which reflects discrimination capacity in the absence of attention, has not yet been recorded in infants. Because the ACC is a large response, it may be useful as an index of discrimination for infants at both the individual and group level. This is an advantage compared with mismatch negativity, another AEP that reflects discrimination of a change in stimulus, because mismatch negativity is based on difference waves and is most sensitive to group effects...
November 2012: Ear and Hearing
Elizabeth I Vink, Mark A Yondola, Kai Wu, Patrick Hearing
The adenovirus E4-ORF3 protein promotes viral replication by relocalizing cellular proteins into nuclear track structures, interfering with potential anti-viral activities. E4-ORF3 targets transcriptional intermediary factor 1 alpha (TIF1α), but not homologous TIF1β. Here, we introduce TIF1γ as a novel E4-ORF3-interacting partner. E4-ORF3 relocalizes endogenous TIF1γ in virus-infected cells in vivo and binds to TIF1γ in vitro. We used the homologous nature, yet differing binding capabilities, of these proteins to study how E4-ORF3 targets proteins for track localization...
January 20, 2012: Virology
Kirsten K Osen, David N Furness, Carole M Hackney
The transition between the central (CNS) and peripheral nervous system (PNS) in cranial and spinal nerve roots, referred to here as the CNS-PNS border, is of relevance to nerve root disorders and factors that affect peripheral-central regeneration. Here, this border is described in the cat cochlear nerve using light microscopical sections, and scanning electron microscopy of the CNS-PNS interfaces exposed by fracture of the nerve either prior to or following critical point drying. The CNS-PNS border represents an abrupt change in type of myelin, supporting elements, and vascularization...
July 2011: Hearing Research
Kathryn Lomas, Fernando Montealegre-Z, Stuart Parsons, Larry H Field, Daniel Robert
This paper constitutes a major attempt to associate tympanic deflections with the mechanoreceptor organ location in an acoustic insect. The New Zealand tree weta (Hemideina thoracica) has tympanal ears located on each of the prothoracic tibiae. The tympana exhibit a sclerotized oval plate, membranous processes bulging out from the tibial cuticle and many loosely suspended ripples. We used microscanning laser Doppler vibrometry to determine how such a tympanal membrane vibrates in response to sound and whether the sclerotized region plays a role in hearing...
March 1, 2011: Journal of Experimental Biology
E M R De Leenheer, S Janssens, E Padalko, D Loose, B P Leroy, I J Dhooge
OBJECTIVE: Most industrialized countries have introduced some form of universal newborn hearing screening program. Both identification and rehabilitation of hearing loss in newborns have evolved to an acceptable standard and the need for a standardized etiological protocol is emerging. METHODS: Extensive literature search to determine which investigations can help identifying the cause of congenital hearing loss and how to limit extensive testing in these children by taking into account the most prevalent causes...
January 2011: International Journal of Pediatric Otorhinolaryngology
Veronique J O Verhaegen, Jef J S Mulder, John F P Noten, Bart M A Luijten, Cor W R J Cremers, Ad F M Snik
OBJECTIVE: To optimize intraoperatively the coupling of the floating mass transducer (FMT) of the Vibrant Soundbridge middle ear implant to the round or oval cochlear window in patients with mixed hearing loss. STUDY DESIGN: Intraoperative measurement of objective hearing thresholds using auditory steady state responses (ASSRs). SETTING: Radboud University Nijmegen Medical Centre, tertiary referral hospital. PATIENTS: Four individuals with mixed hearing loss and, at least no incus, in need for a middle ear implant...
December 2010: Otology & Neurotology
M Tartaglia, G Zampino, B D Gelb
Noonan syndrome (NS) is a relatively common, clinically variable and genetically heterogeneous developmental disorder characterized by postnatally reduced growth, distinctive facial dysmorphism, cardiac defects and variable cognitive deficits. Other associated features include ectodermal and skeletal defects, cryptorchidism, lymphatic dysplasias, bleeding tendency, and, rarely, predisposition to hematologic malignancies during childhood. NS is caused by mutations in the PTPN11, SOS1, KRAS, RAF1, BRAF and MEK1 (MAP2K1) genes, accounting for approximately 70% of affected individuals...
February 2010: Molecular Syndromology
Raquel Guijarro-Martínez, Miguel Puche Torres, Mariano Marqués Mateo, Ignacio Solís García, Luis Miragall Alba, María Eugenia Iglesias Gimilio, Gonzalo Pérez-Herrezuelo Hermosa, José Vicente Pascual Gil
PURPOSE: To report an exceptional case of bilateral synovial chondromatosis (SC) of the temporomandibular joint (TMJ) and discuss diagnostic approaches, treatment options and follow-up data. PATIENTS AND METHODS: A 38-year-old woman presented with left preauricular swelling. Initial imaging studies revealed TMJ effusion only. Six years later, synovial calcifications were detected in the left TMJ; the right TMJ space was widened and presented incipient calcium deposits...
June 2011: Journal of Cranio-maxillo-facial Surgery
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