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https://www.readbyqxmd.com/read/28341136/criteria-for-the-evidence-based-categorisation-of-skin-sensitisers
#1
REVIEW
Wolfgang Uter, Jeanne Duus Johansen, Carola Lidén, Jean-Pierre Lepoittevin, Ian R White
No abstract text is available yet for this article.
March 22, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28338928/reply-to-seasonality-of-birth-for-skin-melanoma-deserves-further-investigation
#2
Olaf Gefeller, Cornelia Fiessler, Martin Radespiel-Tröger, Annette B Pfahlberg, Wolfgang Uter
No abstract text is available yet for this article.
March 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28317190/positive-reactions-to-pairs-of-allergens-associated-with-polysensitization-analysis-of-ivdk-data-with-machine-learning-techniques
#3
Werner Adler, Olaf Gefeller, Wolfgang Uter
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28252308/-comparison-of-vaginal-use-of-micronized-progesterone-for-the-luteal-support-randomized-study-comparison-of-utrogestan-and-crinone-8
#4
L Michnová, J Dostál, K Langová, T Rumpíková, M Kudela
OBJECTIVE: The study was focused on comparison of efficiency, safety and tolerance of vaginal use of micronized progesterone in preparations Utrogestan and Crinone 8%. DESIGN: Prospective randomized study. SETTING: Department of Gynecology and Obstetric, University Hospital, Olomouc, Faculty of Medicine and Dentistry, Palacky University, Olomouc. MATERIAL AND METHODOLOGY: Into a prospective randomized study was, after calculation of 80% of the power of the study, α = 0,05, included 111 women in age between 18-40 with a basal value FSH < 10 IU/l and a normal finding in uteral cavity...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28094198/late-side-effects-and-cosmetic-results-of-accelerated-partial-breast-irradiation-with-interstitial-brachytherapy-versus-whole-breast-irradiation-after-breast-conserving-surgery-for-low-risk-invasive-and-in-situ-carcinoma-of-the-female-breast-5-year-results
#5
Csaba Polgár, Oliver J Ott, Guido Hildebrandt, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Lyczek, José Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, Bülent Polat, György Kovács, Arnt-René Fischedick, Rainer Fietkau, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Richard Pötter, Christine Gall, Wolfgang Uter, Vratislav Strnad
BACKGROUND: We previously confirmed the non-inferiority of accelerated partial breast irradiation (APBI) with interstitial brachytherapy in terms of local control and overall survival compared with whole-breast irradiation for patients with early-stage breast cancer who underwent breast-conserving surgery in a phase 3 randomised trial. Here, we present the 5-year late side-effects and cosmetic results of the trial. METHODS: We did this randomised, controlled, phase 3 trial at 16 centres in seven European countries...
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28032352/patch-testing-with-rubber-series-in-europe-a-critical-review-and-recommendation
#6
Katharine L Warburton, Wolfgang Uter, Johannes Geier, Radoslaw Spiewak, Vera Mahler, Marie-Noëlle Crépy, Marie-Louise Schuttelaar, Andrea Bauer, Mark Wilkinson
BACKGROUND: Rubber additives constitute an important group of contact allergens, particularly in certain occupations. OBJECTIVES: To collect information regarding the current practice of using a 'rubber series' in Europe, and discuss this against the background of evidence concerning the prevalence of allergy in order to derive a recommendation for a 'European rubber series'. METHODS: The following were performed: (i) a survey targeting all members of the COST action 'StanDerm' consortium, (ii) analysis of rubber contact allergy data in the database of the European Surveillance System on Contact Allergies, and (iii) a literature review...
December 28, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/28032337/the-epidemic-of-methylisothiazolinone-a-european-prospective-study
#7
Jakob F Schwensen, Wolfgang Uter, Magnus Bruze, Cecilia Svedman, An Goossens, Mark Wilkinson, Ana Giménez Arnau, Margarida Gonçalo, Klaus E Andersen, Evy Paulsen, Tove Agner, Caterina Foti, Kristiina Aalto-Korte, John McFadden, Ian White, Jeanne D Johansen
BACKGROUND: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required. OBJECTIVES: To describe demographics and MI exposures for European patients with MI contact allergy. METHODS: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000 ppm aq...
December 28, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27924708/has-dry-cold-weather-an-impact-on-the-skin-condition-of-cleanroom-workers
#8
Wobbeke Weistenhöfer, Wolfgang Uter, Hans Drexler
In previous epidemiological studies irritant skin changes were reported significantly more frequently under dry/cold ambient air conditions. The aim of this study was to assess whether a similar effect might be observed in cleanroom workers, occupationally exposed to strictly controlled ambient conditions. This investigation examined 690 employees of a semiconductor production company in Germany, one half in winter (n = 358) and the other half in spring (n = 332). In both waves, both cleanroom workers, who used occlusive gloves predominantly during the entire shift, and employees in the administration, serving as the control group, were included...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27917498/guidelines-for-the-presentation-of-contact-allergy-case-reports
#9
Wolfgang Uter, An Goossens, Margarida Gonçalo, Jeanne D Johansen
Case reports constitute a classic publication format that is being increasingly appreciated, for example because of its educational value. In the field of contact dermatitis research, case reports often serve as sentinel publications concerning new allergens, or new exposures to known allergens, or regarding other conditions leading to contact dermatitis. The CARE guideline published in 2013 addresses standardized and complete reporting of case reports in all fields of medicine. The present article takes up the CARE suggestions, and further specifies these in terms of application to case reports in the field of contact dermatitis...
February 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/27896884/contact-allergy-to-preservatives-essca-results-with-the-baseline-series-2009-2012
#10
Ana M Giménez-Arnau, Gustavo Deza, Andrea Bauer, Graham A Johnston, Vera Mahler, Marie-Louise Schuttelaar, Javier Sanchez-Perez, Juan Francisco Silvestre, Mark Wilkinson, Wolfgang Uter
BACKGROUND: Allergic contact dermatitis caused by biocides is common, and causes significant patient morbidity. OBJECTIVE: To describe the current frequency and pattern of patch test reactivity to biocide allergens included in the baselines series of most European countries. METHODS: Data collected by the European Surveillance System on Contact Allergies (ESSCA) network between 2009 and 2012 from 12 European countries were analysed. RESULTS: Methylisothiazolinone 0...
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27803959/accelerated-partial-breast-irradiation-with-external-beam-radiotherapy-first-results-of-the-german-phase%C3%A2-2-trial
#11
Oliver J Ott, Vratislav Strnad, Wilhelm Stillkrieg, Wolfgang Uter, Matthias W Beckmann, Rainer Fietkau
BACKGROUND AND PURPOSE: To evaluate the feasibility and efficacy of external beam three-dimensional (3D) conformal accelerated partial breast irradiation (APBI) for selected patients with early breast cancer. PATIENTS AND METHODS: Between 2011 and 2016, 72 patients were recruited for this prospective phase 2 trial. Patients were eligible for APBI if they had histologically confirmed breast cancer or pure ductal carcinoma in situ (DCIS), a tumor diameter ≤3 cm, clear resection margins ≥2 mm, no axillary lymph node involvement, no distant metastases, tumor bed clips, and were aged ≥50 years...
January 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27780882/sickness-absence-among-peer-supported-drivers-after-occupational-trauma
#12
A Clarner, W Uter, L Ruhmann, N Wrenger, A Martin, H Drexler
BACKGROUND: Psychological first aid is a common approach for providing support after potentially traumatic events (PTEs). In Germany, a peer support model is recommended by the German Statutory Accident Insurance (DGUV) to reduce sickness absence after occupational accidents, especially in public transportation. However, data on the effectiveness of peer support are very sparse. AIMS: To analyse whether peer support has an impact on sickness absence after work-related traumatic events in public transportation...
October 25, 2016: Occupational Medicine
https://www.readbyqxmd.com/read/27754448/protection-from-ultraviolet-radiation-during-childhood-the-parental-perspective-in-bavaria
#13
Olaf Gefeller, Wolfgang Uter, Annette B Pfahlberg
During childhood, parents play a vital role in sun protection of their children. Their guidance is essential for avoiding excessive exposure to ultraviolet (UV) radiation, a risk factor for developing skin cancer in later life. In a population-based cross-sectional study conducted between October 2011 and February 2012, we assessed how 3281 parents implemented sun protection for their three- to six-year-old children in practice. In particular, clothing, shade-seeking behavior, wearing of sunhats and sunglasses, use of sunscreens and the amount of time spent outdoors were ascertained in two settings (beach, garden/playground)...
October 14, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27649803/association-between-month-of-birth-and-melanoma-risk-fact-or-fiction
#14
Cornelia Fiessler, Annette B Pfahlberg, Andrea K Keller, Martin Radespiel-Tröger, Wolfgang Uter, Olaf Gefeller
BACKGROUND: Evidence on the effect of ultraviolet radiation (UVR) exposure in infancy on melanoma risk in later life is scarce. Three recent studies suggest that people born in spring carry a higher melanoma risk. Our study aimed at verifying whether such a seasonal pattern of melanoma risk actually exists. METHODS: Data from the population-based Cancer Registry Bavaria (CRB) on the birth months of 28 374 incident melanoma cases between 2002 and 2012 were analysed and compared with data from the Bavarian State Office for Statistics and Data Processing on the birth month distribution in the Bavarian population...
September 20, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27633650/comparative-sensitizing-potencies-of-fragrances-preservatives-and-hair-dyes
#15
REVIEW
Carola Lidén, Kerem Yazar, Jeanne D Johansen, Ann-Therese Karlberg, Wolfgang Uter, Ian R White
The local lymph node assay (LLNA) is used for assessing sensitizing potential in hazard identification and risk assessment for regulatory purposes. Sensitizing potency on the basis of the LLNA is categorized into extreme (EC3 value of ≤0.2%), strong (>0.2% to ≤2%), and moderate (>2%). To compare the sensitizing potencies of fragrance substances, preservatives, and hair dye substances, which are skin sensitizers that frequently come into contact with the skin of consumers and workers, LLNA results and EC3 values for 72 fragrance substances, 25 preservatives and 107 hair dye substances were obtained from two published compilations of LLNA data and opinions by the Scientific Committee on Consumer Safety and its predecessors...
November 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27622254/effectiveness-of-an-employee-skin-cancer-screening-program-for-secondary-prevention
#16
Ugur Uslu, Felix Hees, Eva Winnik, Wolfgang Uter, Michael Sticherling
Incidences of UV-induced skin cancer are continuously increasing. For this reason, early diagnosis is becoming more important. In this study, 783 employees of a technical company participated in an employee skin cancer screening program, which consisted of a physical examination for benign and malignant skin lesions and premalignant conditions. To ensure the quality of the examinations, screening was only performed by 5 trained dermatologists. Participants also were asked to complete a standardized questionnaire prior to examination...
August 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27577494/the-effect-of-exposure-to-ultraviolet-radiation-in-infancy-on-melanoma-risk
#17
Olaf Gefeller, Cornelia Fiessler, Martin Radespiel-Tröger, Wolfgang Uter, Annette B Pfahlberg
Evidence on the effect of ultraviolet radiation (UVR) exposure in infancy on melanoma risk in later life is scarce. Three recent studies suffering from methodological shortcomings suggested that people born in spring carry a higher melanoma risk. Data from the Bavarian population-based cancer registry on 28374 incident melanoma cases between 2002 and 2012 were analyzed to reexamine this finding. Crude and adjusted analyses - using negative binomial regression models - were performed addressing the relationship...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27464585/contact-allergy-to-ingredients-of-topical-medications-results-of-the-european-surveillance-system-on-contact-allergies-essca-2009-2012
#18
Wolfgang Uter, Radoslaw Spiewak, Susan M Cooper, Mark Wilkinson, Javier Sánchez Pérez, Axel Schnuch, Marie-Louise Schuttelaar
PURPOSE: The aim of this study was to give an overview of the prevalence of contact allergy to active ingredients and excipients of topical medications across Europe. METHODS: Retrospective analysis of data collected by the European Surveillance System on Contact Allergies (www.essca-dc.org) with substances applied to consecutively patch tested patients, 2009-2012, in 54 departments in 12 European countries. RESULTS: In view of the varying composition of the baseline series used in the previously mentioned departments and countries, between 58 833 (lanolin alcohols) and 16 498 patients (sodium metabisulfite) were patch tested with the topical agents covered in this study...
July 28, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27422584/gec-estro-multicenter-phase-3-trial-accelerated-partial-breast-irradiation-with-interstitial-multicatheter-brachytherapy-versus-external-beam-whole-breast-irradiation-early-toxicity-and-patient-compliance
#19
Oliver J Ott, Vratislav Strnad, Guido Hildebrandt, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Łyczek, José Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, Bülent Polat, György Kovács, Arnt-René Fischedick, Thomas G Wendt, Rainer Fietkau, Rolf-Dieter Kortmann, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Richard Pötter, Christine Gall, Martina Malzer, Wolfgang Uter, Csaba Polgár
BACKGROUND AND PURPOSE: To compare early side effects and patient compliance of accelerated partial breast irradiation (APBI) with multicatheter brachytherapy to external beam whole breast irradiation (WBI) in a low-risk group of patients with breast cancer. MATERIAL AND METHODS: Between April 2004 and July 2009, 1328 patients with UICC stage 0-IIA breast cancer were randomized to receive WBI with 50Gy and a boost of 10Gy or APBI with either 32.0Gy/8 fractions, or 30...
July 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27402420/patch-test-results-with-rubber-series-in-the-european-surveillance-system-on-contact-allergies-essca-2013-14
#20
Wolfgang Uter, Katharine Warburton, Elke Weisshaar, Dagmar Simon, Barbara Ballmer-Weber, Vera Mahler, Thomas Fuchs, Johannes Geier, Mark Wilkinson
BACKGROUND: Contact allergy to rubber additives is common, particularly in patients with occupational dermatitis. OBJECTIVES: To descriptively analyse and compare patch test reactions in patients patch tested both with the baseline series and with an additional 'rubber series' as used in the department. METHODS: Patch test data from those members of the European Surveillance System on Contact Allergies (ESSCA) network (www.essca-dc.org) who also contributed data on rubber series patch test results were retrospectively analysed...
December 2016: Contact Dermatitis
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