Raja Atreya, Tanja Kühbacher, Maximilian J Waldner, Simon Hirschmann, Oliver Drvarov, Raed Abu Hashem, Christian Maaser, Torsten Kucharzik, Johanna Dinter, Jessica Mertens, Christoph Schramm, Babett Holler, Joachim Mössner, Kenji Suzuki, Junji Yokoyama, Shuji Terai, Wolfgang Uter, Hiroyuki Yoneyama, Hitoshi Asakura, Toshifumi Hibi, Markus F Neurath
BACKGROUND AND AIMS: Carbohydrate sulfotransferase 15 (CHST15) biosynthesizes sulfated matrix glycosaminoglycans and is implicated in intestinal inflammation and fibrosis. Here, we evaluate efficacy and safety of the double-stranded RNA oligonucleotide GUT-1, a specific blocker of CHST15, as induction therapy in patients with ulcerative colitis (UC). METHODS: In this randomized, double-blind, placebo-controlled, phase 2a study, we enrolled endoscopic active UC patients, refractory to conventional therapy, in 5 hospital centers across Germany...
September 30, 2023: Journal of Crohn's & Colitis