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https://www.readbyqxmd.com/read/27922105/interplay-of-coupling-and-common-noise-at-the-transition-to-synchrony-in-oscillator-populations
#1
Anastasiya V Pimenova, Denis S Goldobin, Michael Rosenblum, Arkady Pikovsky
There are two ways to synchronize oscillators: by coupling and by common forcing, which can be pure noise. By virtue of the Ott-Antonsen ansatz for sine-coupled phase oscillators, we obtain analytically tractable equations for the case where both coupling and common noise are present. While noise always tends to synchronize the phase oscillators, the repulsive coupling can act against synchrony, and we focus on this nontrivial situation. For identical oscillators, the fully synchronous state remains stable for small repulsive coupling; moreover it is an absorbing state which always wins over the asynchronous regime...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921259/from-compact-to-string-the-role-of-secondary-and-tertiary-structure-in-charge-induced-unzipping-of-gas-phase-proteins
#2
Stephan Warnke, Waldemar Hoffmann, Jongcheol Seo, Erwin De Genst, Gert von Helden, Kevin Pagel
In the gas phase, protein ions can adopt a broad range of structures, which have been investigated extensively in the past using ion mobility-mass spectrometry (IM-MS)-based methods. Compact ions with low number of charges undergo a Coulomb-driven transition to partially folded species when the charge increases, and finally form extended structures with presumably little or no defined structure when the charge state is high. However, with respect to the secondary structure, IM-MS methods are essentially blind...
December 5, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27920024/biology-and-pathobiology-of-tdp-43-and-emergent-therapeutic-strategies
#3
Lin Guo, James Shorter
Cytoplasmic TDP-43 mislocalization and aggregation is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is an RNA-binding protein (RBP) with a prion-like domain (PrLD) that promotes TDP-43 misfolding. PrLDs possess compositional similarity to canonical prion domains of various yeast proteins, including Sup35. Strikingly, disease-causing TDP-43 mutations reside almost exclusively in the PrLD and can enhance TDP-43 misfolding and toxicity. Another ∼70 human RBPs harbor PrLDs, including FUS, TAF15, EWSR1, hnRNPA1, and hnRNPA2, which have surfaced in the etiology of neurodegenerative diseases...
December 5, 2016: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/27919786/increasing-in-cysteine-proteinase-b-expression-and-enzymatic-activity-during-in-vitro-differentiation-of-leishmania-viannia-braziliensis-first-evidence-of-modulation-during-morphological-transition
#4
Cinthia Bernardes Gomes, Franklin Souza da Silva, Karen Dos Santos Charret, Bernardo Acácio Santini Pereira, Léa Cysne Finkelstein, Raquel Santos de Souza, Luzia Monteiro de Castro Côrtes, Mirian Claudia Souza Pereira, Francisco Odêncio Rodrigues de Oliveira, Carlos Roberto Alves
Leishmania (Viannia) braziliensis presents adaptive protease-dependent mechanisms, as cysteine proteinases B (CPB). This work focuses on the expression of three cpb gene isoforms and CPB enzymatic activity during the parasite differentiation. Relative expression levels of LbrM.08.0810 gene was assessed, showing a higher quantity of transcripts in the logarithmic promastigotes phase than in the stationary promastigotes phase (> 1.5 times). The cbp gene tends to decrease during acid pH shock and increases when the temperature rises (> 1...
December 2, 2016: Biochimie
https://www.readbyqxmd.com/read/27918764/effect-of-fluorouracil-leucovorin-and-oxaliplatin-with-or-without-onartuzumab-in-her2-negative-met-positive-gastroesophageal-adenocarcinoma-the-metgastric-randomized-clinical-trial
#5
Manish A Shah, Yung-Jue Bang, Florian Lordick, Maria Alsina, Meng Chen, Stephen P Hack, Jean Marie Bruey, Dustin Smith, Ian McCaffery, David S Shames, See Phan, David Cunningham
Importance: Dysregulation of the mesenchymal-epithelial transition (MET) signaling pathway is associated with poor prognosis in gastroesophageal adenocarcinoma (GEC). We report results of METGastric, a phase 3 trial of the MET inhibitor onartuzumab plus standard first-line chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative, MET-positive, advanced GEC. Objective: To determine whether the addition of onartuzumab to first-line fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) improves efficacy compared with mFOLFOX6 plus placebo in HER2-negative, MET-positive GEC...
December 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27918718/randomized-double-blind-placebo-controlled-multicenter-phase-ii-study-of-onartuzumab-plus-bevacizumab-versus-placebo-plus-bevacizumab-in-patients-with-recurrent-glioblastoma-efficacy-safety-and-hepatocyte-growth-factor-and-o-6-methylguanine-dna-methyltransferase
#6
Timothy Cloughesy, Gaetano Finocchiaro, Cristóbal Belda-Iniesta, Lawrence Recht, Alba A Brandes, Estela Pineda, Tom Mikkelsen, Olivier L Chinot, Carmen Balana, David R Macdonald, Manfred Westphal, Kirsten Hopkins, Michael Weller, Carlos Bais, Thomas Sandmann, Jean-Marie Bruey, Hartmut Koeppen, Bo Liu, Wendy Verret, See-Chun Phan, David S Shames
Purpose Bevacizumab regimens are approved for the treatment of recurrent glioblastoma in many countries. Aberrant mesenchymal-epithelial transition factor (MET) expression has been reported in glioblastoma and may contribute to bevacizumab resistance. The phase II study GO27819 investigated the monovalent MET inhibitor onartuzumab plus bevacizumab (Ona + Bev) versus placebo plus bevacizumab (Pla + Bev) in recurrent glioblastoma. Methods At first recurrence after chemoradiation, bevacizumab-naïve patients with glioblastoma were randomly assigned 1:1 to receive Ona (15 mg/kg, once every 3 weeks) + Bev (15 mg/kg, once every 3 weeks) or Pla + Bev until disease progression...
December 5, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27918644/self-assembled-supramolecular-nanogels-as-a-safe-and-effective-drug-delivery-vector-for-cancer-therapy
#7
Chih-Chia Cheng, Mei-Chih Liang, Zhi-Sheng Liao, Jyun-Jie Huang, Duu-Jong Lee
Simple construction and manipulation of low-molecular-weight supramolecular nanogels, based on the introduction of multiple hydrogen bonding interactions, with the desired physical properties to achieve effective and safe delivery of drugs for cancer therapy remain highly challenging. Herein, a novel supramolecular oligomer cytosine (Cy)-polypropylene glycol containing self-complementary multiple hydrogen-bonded Cy moieties is developed, which undergoes spontaneous self-assembly to form nanosized particles in an aqueous environment...
December 5, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27918299/monoclinic-to-orthorhombic-phase-transition-of-the-hexamethylenetetramine-2-methylbenzoic-acid-1-2-cocrystal-with-temperature-dependent-dynamic-molecular-disorder
#8
Tze Shyang Chia, Ching Kheng Quah
As a function of temperature, the hexamethylenetetramine-2-methylbenzoic acid (1/2) cocrystal, C6H12N4·2C8H8O2, undergoes a reversible structural phase transition. The orthorhombic high-temperature phase in the space group Pccn has been studied in the temperature range between 165 and 300 K. At 164 K, a t2 phase transition to the monoclinic subgroup P21/c space group occurs; the resulting twinned low-temperature phase was investigated in the temperature range between 164 and 100 K. The domains in the pseudomerohedral twin are related by a twofold rotation corresponding to the matrix (100/0-10/00-1...
December 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/27918043/thermoresponsive-structured-emulsions-based-on-the-fibrillar-self-assembly-of-natural-saponin-glycyrrhizic-acid
#9
Zhili Wan, Yingen Sun, Lulu Ma, Jian Guo, Jinmei Wang, Shouwei Yin, Xiaoquan Yang
We report the novel use of the naturally occurring saponin, glycyrrhizic acid (GA) as a structuring material to transform liquid oil into a soft-solid structured emulsion system. The GA nanofibrils from the anisotropic self-assembly of GA molecules were first used as stabilizers to fabricate olive oil-in-water emulsions using a facile one-step emulsification at high temperature. Then, the obtained emulsions were further self-organized into the emulsion gel by applying a subsequent cooling to trigger the gel network formation, which is mostly due to the enhanced noncovalent interactions among GA fibrils in the continuous phase as well as at the droplet surface...
December 5, 2016: Food & Function
https://www.readbyqxmd.com/read/27917865/critical-exponents-and-scaling-invariance-in-the-absence-of-a-critical-point
#10
N Saratz, D A Zanin, U Ramsperger, S Cannas, D Pescia, A Vindigni
The paramagnetic-to-ferromagnetic phase transition is classified as a critical phenomenon due to the power-law behaviour shown by thermodynamic observables when the Curie point is approached. Here we report the observation of such a behaviour over extraordinarily many decades of suitable scaling variables in ultrathin Fe films, for certain ranges of temperature T and applied field B. This despite the fact that the underlying critical point is practically unreachable because protected by a phase with a modulated domain structure, induced by the dipole-dipole interaction...
December 5, 2016: Nature Communications
https://www.readbyqxmd.com/read/27917600/determination-of-hepatitis-b-phenotype-using-biochemical-and%C3%A2-serological-markers
#11
A M Di Bisceglie, M Lombardero, J Teckman, L Roberts, H L A Janssen, S H Belle, J H Hoofnagle
The aim of this study was to assess the validity of categorization of chronic hepatitis B viral infection into stages or phases based upon measures of disease activity and viral load, assuming these phenotypes will be useful for prognostication and determining the need for antiviral therapy. We assessed the phenotype of hepatitis B of 1,390 adult participants enrolled in the Hepatitis B Research Network Cohort Study, using a computer algorithm. Only 4% were immune tolerant, while 35% had chronic hepatitis B (18% e antigen positive and 17% e antigen negative) while 23% were inactive carriers...
December 5, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27917386/transmission-of-foot-and-mouth-disease-virus-during-the-incubation-period-in-pigs
#12
Carolina Stenfeldt, Juan M Pacheco, Barbara P Brito, Karla I Moreno-Torres, Matt A Branan, Amy H Delgado, Luis L Rodriguez, Jonathan Arzt
Understanding the quantitative characteristics of a pathogen's capability to transmit during distinct phases of infection is important to enable accurate predictions of the spread and impact of a disease outbreak. In the current investigation, the potential for transmission of foot-and-mouth disease virus (FMDV) during the incubation (preclinical) period of infection was investigated in seven groups of pigs that were sequentially exposed to a group of donor pigs that were infected by simulated-natural inoculation...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27917102/euler-lagrange-computational-fluid-dynamics-for-bio-reactor-scale-down-an-analysis-of-organism-lifelines
#13
Cees Haringa, Wenjun Tang, Amit T Deshmukh, Jianye Xia, Matthias Reuss, Joseph J Heijnen, Robert F Mudde, Henk J Noorman
The trajectories, referred to as lifelines, of individual microorganisms in an industrial scale fermentor under substrate limiting conditions were studied using an Euler-Lagrange computational fluid dynamics approach. The metabolic response to substrate concentration variations along these lifelines provides deep insight in the dynamic environment inside a large-scale fermentor, from the point of view of the microorganisms themselves. We present a novel methodology to evaluate this metabolic response, based on transitions between metabolic "regimes" that can provide a comprehensive statistical insight in the environmental fluctuations experienced by microorganisms inside an industrial bioreactor...
October 2016: Engineering in Life Sciences
https://www.readbyqxmd.com/read/27917024/efficient-light-induced-phase-transitions-in-halogen-bonded-liquid-crystals
#14
Francisco Fernandez-Palacio, Mikko Poutanen, Marco Saccone, Antti Siiskonen, Giancarlo Terraneo, Giuseppe Resnati, Olli Ikkala, Pierangelo Metrangolo, Arri Priimagi
Here, we present a new family of light-responsive, fluorinated supramolecular liquid crystals (LCs) showing efficient and reversible light-induced LC-to-isotropic phase transitions. Our materials design is based on fluorinated azobenzenes, where the fluorination serves to strengthen the noncovalent interaction with bond-accepting stilbazole molecules, and increase the lifetime of the cis-form of the azobenzene units. The halogen-bonded LCs were characterized by means of X-ray diffraction, hot-stage polarized optical microscopy, and differential scanning calorimetry...
November 22, 2016: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/27914326/molecular-interactions-in-high-conductive-gel-electrolytes-based-on-low-molecular-weight-gelator
#15
Michał Bielejewski, Andrzej Łapiński, Oleg Demchuk
Organic ionic gel (OIG) electrolytes, also known as gel electrolytes or ionogels are one example of modern functional materials with the potential to use in wide range of electrochemical applications. The functionality of OIGs arises from the thermally reversible solidification of electrolytes or ionic liquids and their superior ionic conductivity. To understand and to predict the properties of these systems it is important to get the knowledge about the interactions on molecular level between the solid gelator matrix and the electrolyte solution...
November 16, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27911881/low-energy-ne-ion-beam-induced-modifications-of-magnetic-properties-in-mnas-thin-films
#16
M Trassinelli, L Bernard Carlsson, S Cervera, M Eddrief, V H Etgens, E V Gafton, E Lacaze, E Lamour, A Lévy, S Macé, C Prigent, J-P Rozet, S Steydli, M Marangolo, D Vernhet
Investigations of the complex behavior of the magnetization of manganese arsenide thin films due to defects induced by irradiation of slow heavy ions are presented. In addition to the thermal hysteresis suppression already highlighted in Trassinelli et al (2014 Appl. Phys. Lett. 104 081906), we report here on new local magnetic features recorded by a magnetic force microscope at different temperatures close to the characteristic sample phase transition. Complementary measurements of the global magnetization in different conditions (applied magnetic field and temperatures) enable the film characterization to be completed...
December 2, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27911534/structural-transitions-in-densifying-networks
#17
R Lambiotte, P L Krapivsky, U Bhat, S Redner
We introduce a minimal generative model for densifying networks in which a new node attaches to a randomly selected target node and also to each of its neighbors with probability p. The networks that emerge from this copying mechanism are sparse for p<1/2 and dense (average degree increasing with number of nodes N) for p≥1/2. The behavior in the dense regime is especially rich; for example, individual network realizations that are built by copying are disparate and not self-averaging. Further, there is an infinite sequence of structural anomalies at p=2/3, 3/4, 4/5, etc...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27911517/universal-signatures-of-quantum-critical-points-from-finite-size-torus-spectra-a-window-into-the-operator-content-of-higher-dimensional-conformal-field-theories
#18
Michael Schuler, Seth Whitsitt, Louis-Paul Henry, Subir Sachdev, Andreas M Läuchli
The low-energy spectra of many body systems on a torus, of finite size L, are well understood in magnetically ordered and gapped topological phases. However, the spectra at quantum critical points separating such phases are largely unexplored for (2+1)D systems. Using a combination of analytical and numerical techniques, we accurately calculate and analyze the low-energy torus spectrum at an Ising critical point which provides a universal fingerprint of the underlying quantum field theory, with the energy levels given by universal numbers times 1/L...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27910973/multiphase-transition-of-supramolecular-metallogels-triggered-by-temperature
#19
Bo Jiang, Li-Jun Chen, Guang-Qiang Yin, Yu-Xuan Wang, Wei Zheng, Lin Xu, Hai-Bo Yang
We present a new family of supramolecular metallogels undergoing reversible multiphase transition triggered by temperature from amphiphilic alkynylplatinum(ii) complexes. Further investigation revealed that intermolecular PtPt and π-π stacking interactions facilitate such phase transitions upon increasing the temperature.
December 2, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27910841/incommensurate-density-modulation-in-a-na-rich-plagioclase-feldspar-z-contrast-imaging-and-single-crystal-x-ray-diffraction-study
#20
Huifang Xu, Shiyun Jin, Bruce C Noll
Plagioclase feldspars are the most abundant mineral in the Earth's crust. Intermediate plagioclase feldspars commonly display incommensurately modulated or aperiodic structures. Z-contrast images show both Ca-Na ordering and density modulation. The local structure of lamellae domains has I1-like symmetry. The neighboring lamellae domains are in an inversion twinning relationship. With a state-of-the-art X-ray diffraction unit, second-order satellite reflections (f-reflections) are observed for the first time in andesine (An45), a Na-rich e-plagioclase...
December 1, 2016: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
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