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https://www.readbyqxmd.com/read/27922734/population-pharmacokinetics-of-ceritinib-in-adult-patients-with-tumors-characterized-by-genetic-abnormalities-in-anaplastic-lymphoma-kinase
#1
Ying Hong, Vanessa Q Passos, Pai-Hsi Huang, Yvonne Y Lau
Ceritinib is a second-generation selective and potent oral anaplastic lymphoma kinase (ALK) inhibitor approved for ALK-positive advanced non-small cell lung cancer previously treated with crizotinib. Population pharmacokinetic (PK) analysis was performed to describe the PK of ceritinib and was used to evaluate the covariate effects on systemic exposure at its label dose (750 mg orally once daily). Ceritinib concentration-time data from 4 clinical studies were described by a 1-compartment model with delayed first-order absorption and time-dependent elimination...
December 6, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27906144/positive-regulation-of-biochemical-parameters-by-tea-polyphenol-encapsulated-solid-lipid-nanoparticles-at-in-vitro-and-in-vivo-conditions
#2
Karikalan Kulandaivelu, Abul Kalam Azad Mandal
Tea polyphenols (TPPs) comprise preventive and therapeutic potentials against cancer, cardiovascular and neurological disorders. Chemical instability of TPP which leads to low bioavailability is the major constrain to its use as therapeutic agent. The authors prepared TPP encapsulated solid lipid nanoparticles (TPP-SLNs) to increase its stability and bioefficacy. Comparison of Fourier transformed infrared spectra of unloaded SLN, free TPP and TPP-SLN indicated encapsulation of TPP. Sustained release of TPP from TP-SLN was observed...
December 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27906105/pancreatic-metastases-from-ocular-malignant-melanoma-the-use-of-endoscopic-ultrasound-guided-fine-needle-aspiration-to-establish-a-definitive-cytologic-diagnosis-a-case-report
#3
Diogo Turiani Hourneaux De Moura, Danielle Azevedo Chacon, Ryan Tanigawa, Martin Coronel, Spencer Cheng, Éverson L A Artifon, José Jukemura, Eduardo Guimarães Hourneaux De Moura
BACKGROUND: When encountering solid pancreatic lesions, nonpancreatic primary metastases are rare and differentiating a metastasis from a primary neoplastic lesion is challenging. The clinical presentation and radiologic features can be similar and the possibility of a pancreatic metastasis should be considered when the patient refers to a history of a different primary cancer. Endoscopic ultrasound offers a key anatomical advantage in accessing the pancreas and endoscopic ultrasound-guided fine-needle aspiration has become the gold standard method for diagnosing pancreatic lesions...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27898288/prospective-validation-of-objective-prognostic-score-for-advanced-cancer-inpatients-in-south-korea-a-multicenter-study
#4
Seok Joon Yoon, Sang-Yeon Suh, Yong Joo Lee, Jeanno Park, Sunwook Hwang, Sanghee Shiny Lee, Hong Yup Ahn, Su-Jin Koh, Keon Uk Park
BACKGROUND: Objective Prognostic Score (OPS) was developed as an easy and simple prognosticating tool in South Korea. It has been validated retrospectively in a single center in South Korea. OBJECTIVE: We aimed to validate the OPS prospectively for advanced cancer inpatients in South Korea using a multicenter study. DESIGN: This was a prospective cohort study. SETTING/SUBJECTS: We enrolled 243 advanced cancer patients admitted in five palliative care units in South Korea from May 2013 till March 2015...
November 29, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27832205/gallstones-a-worldwide-multifaceted-disease-and-its-correlations-with-gallbladder-carcinoma
#5
Raj Kumar Sharma, Kanchan Sonkar, Neeraj Sinha, Pradeep Rebala, Ahmad Ebrah Albani, Anu Behari, Duvvuri Nageshwar Reddy, Alvina Farooqui, Vinay Kumar Kapoor
BACKGROUND: Gallstones (GS) associated diseases are among the most recurrent and frequent diseases delineated in India and United Arab Emirates. Several reports suggest that the association of GS with gallbladder cancer (GBC) is very high in Northern part of India; however, its occurrence in UAE and Southern part of India is notably low. Therefore, in the present study, we aimed to perform compositional analysis of GS in three different geographical areas by Solid State Nuclear Magnetic Resonance and Fourier Transformed Infrared spectroscopy...
2016: PloS One
https://www.readbyqxmd.com/read/27813395/precise-hepatectomy-based-on-the-optimized-technique-of-hepatic-blood-flow-occlusion-combined-with-the-curettage-and-cut-technique-by-electrotome
#6
Bin Huang, Yu Yu, Shaoyong Zhao, Changsong Wang, Wenhao Zhou, Huashan Jiang, Min Chen, Xiaozhong Jiang, Youjiang Tao, Tao Lv, Hong Luo, Xiao Cui, Yi Zhang, Xiaoqin Guo
BACKGROUND: To evaluate the outcome of precise hepatectomy based on the optimized technique of hepatic blood flow occlusion combined with the curettage and cut technique by electrotome. METHODS: Hospitalized patients with primary liver cancer treated in our hospital were included in this study and all patients (n=61) were numbered according to the inclusion sequence and were randomized into group A and group B: (1) group A: precise liver resection by using simplified blocking combining with electrotome; (2) group B: precise liver resection by using half-hepatic occlusion + CUSA assisting liver parenchyma transection+ lower central venous pressure controlled by the anesthesiologist...
November 4, 2016: Minerva Chirurgica
https://www.readbyqxmd.com/read/27807846/borderline-operability-in-hepatectomy-patients-is-associated-with-higher-rates-of-failure-to-rescue-after-severe-complications
#7
Bradford J Kim, Ching-Wei D Tzeng, Amanda B Cooper, Jean-Nicolas Vauthey, Thomas A Aloia
BACKGROUND/OBJECTIVE: To understand the influence of age and comorbidities, this study analyzed the incidence and risk factors for post-hepatectomy morbidity/mortality in patients with "borderline" (BL) operability, defined by the preoperative factors: age ≥75 years, dependent function, lung disease, ascites/varices, myocardial infarction, stroke, steroids, weight loss >10%, and/or sepsis. METHODS: All elective hepatectomies were identified in the 2005-2013 ACS-NSQIP database...
November 3, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27805040/personalized-risk-assessment-in-never-light-and-heavy-smokers-in-a-prospective-cohort-in-taiwan
#8
Xifeng Wu, Chi Pang Wen, Yuanqing Ye, MinKwang Tsai, Christopher Wen, Jack A Roth, Xia Pu, Wong-Ho Chow, Chad Huff, Sonia Cunningham, Maosheng Huang, Shuanbei Wu, Chwen Keng Tsao, Jian Gu, Scott M Lippman
The objective of this study was to develop markedly improved risk prediction models for lung cancer using a prospective cohort of 395,875 participants in Taiwan. Discriminatory accuracy was measured by generation of receiver operator curves and estimation of area under the curve (AUC). In multivariate Cox regression analysis, age, gender, smoking pack-years, family history of lung cancer, personal cancer history, BMI, lung function test, and serum biomarkers such as carcinoembryonic antigen (CEA), bilirubin, alpha fetoprotein (AFP), and c-reactive protein (CRP) were identified and included in an integrative risk prediction model...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27777770/safety-and-efficacy-of-anti-pd-1-in-patients-with-baseline-cardiac-renal-or-hepatic-dysfunction
#9
Bridgette A Kanz, Megan H Pollack, Romany Johnpulle, Igor Puzanov, Leora Horn, Alicia Morgans, Jeffrey A Sosman, Suthee Rapisuwon, R Martin Conry, Zeynep Eroglu, Douglas B Johnson
BACKGROUND: Anti-PD-1 therapy is increasingly used in various advanced malignancies. Patients with baseline organ dysfunction are largely excluded from clinical trials. Therefore it is unclear whether anti-PD-1 therapy is safe or effective in this setting. Further, these patients are often not candidates for other anti-cancer therapies, highlighting their need for active treatment options. METHODS: We performed a retrospective analysis of patients from multiple centers with advanced solid tumors and baseline organ dysfunction who received anti-PD-1 therapy...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27743089/percutaneous-intraductal-radiofrequency-ablation-for-extrahepatic-distal-cholangiocarcinoma-a-method-for-prolonging-stent-patency-and-achieving-better-functional-status-and-quality-of-life
#10
Tian-Tian Wu, Wei-Min Li, Hu-Cheng Li, Guo-Kun Ao, Fang Zheng, Hu Lin
PURPOSE: The clinical efficacy of intraductal radiofrequency ablation (RFA) with Habib™ EndoHPB catheter, a newly developed intervention for malignant extrahepatic biliary obstruction, remains uncertain. The aim of this study was to investigate the clinical efficacy of intraductal RFA. METHODS: Data from 71 patients with extrahepatic distal cholangiocarcinoma were retrospectively analyzed. The study patients were divided into RFA and control groups. The RFA group had undergone percutaneous transhepatic intraductal RFA with a Habib™ EndoHPB catheter, followed by placement of covered or uncovered biliary self-expandable metallic stents (SEMs) whereas the control group had undergone percutaneous transhepatic covered or uncovered SEMs placement...
October 14, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27704083/fiber-enhanced-raman-spectroscopic-analysis-as-a-novel-method-for-diagnosis-and-monitoring-of-diseases-related-to-hyperbilirubinemia-and-hyperbiliverdinemia
#11
Di Yan, Christian Domes, Robert Domes, Timea Frosch, Jürgen Popp, Mathias W Pletz, Torsten Frosch
Fiber enhanced resonance Raman spectroscopy (FERS) is introduced for chemically selective and ultrasensitive analysis of the biomolecules hematin, hemoglobin, biliverdin, and bilirubin. The abilities for analyzing whole intact, oxygenated erythrocytes are proven, demonstrating the potential for the diagnosis of red blood cell related diseases, such as different types of anemia and hemolytic disorders. The optical fiber enables an efficient light-guiding within a miniaturized sample volume of only a few micro-liters and provides a tremendously improved analytical sensitivity (LODs of 0...
October 17, 2016: Analyst
https://www.readbyqxmd.com/read/27686541/-clinical-application-of-multi-electrode-synchronous-radiofrequency-ablation-via-switching-controller-for-treating-large-hepatocellular-carcinoma
#12
T Q Zhang, Y Y Zhang, Y K Gu, F Gao, Z M Huang, J H Huang
Objective: To explore the preliminary clinical efficacy and safety of multi-electrode synchronous radiofrequency ablation via switching controller for treating large hepatocellular carcinoma. Methods: A total of 20 patients with large hepatocellular carcinoma from minimally invasive Interventional department of Sun Yat-sen University Cancer Center were enrolled in this retrospective study from December 2013 to December 2014.The procedures were conducted with multi-electrode synchronous radiofrequency ablation via switching controller under CT guidance...
September 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27685612/a-phase-i-trial-of-gbs-01-for-advanced-pancreatic-cancer-refractory-to-gemcitabine
#13
Masafumi Ikeda, Akihiro Sato, Nobuo Mochizuki, Kayo Toyosaki, Chika Miyoshi, Rumi Fujioka, Shuichi Mitsunaga, Izumi Ohno, Yusuke Hashimoto, Hideaki Takahashi, Hiromi Hasegawa, Shogo Nomura, Ryuji Takahashi, Satoshi Yomoda, Katsuya Tsuchihara, Satoshi Kishino, Hiroyasu Esumi
GBS-01, an extract from the fruit of Arctium lappa Linné is an orally administered drug rich in arctigenin, which has been reported to exert antitumor activity by attenuating the tolerance of cancer cells to glucose deprivation. We investigated the maximum tolerated dose of GBS-01 based on the frequency of the dose-limiting toxicities (DLT) and pharmacokinetics in patients with advanced pancreatic cancer refractory to gemcitabine. Patients with advanced pancreatic adenocarcinoma who were refractory to gemcitabine were enrolled...
September 29, 2016: Cancer Science
https://www.readbyqxmd.com/read/27683047/elevated-nlr-in-gallbladder-cancer-and-cholangiocarcinoma-making-bad-cancers-even-worse-results-from-the-us-extrahepatic-biliary-malignancy-consortium
#14
Eliza W Beal, Lai Wei, Cecilia G Ethun, Sylvester M Black, Mary Dillhoff, Ahmed Salem, Sharon M Weber, Thuy Tran, George Poultsides, Andre Y Son, Ioannis Hatzaras, Linda Jin, Ryan C Fields, Stefan Buettner, Timothy M Pawlik, Charles Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Carl R Schmidt
BACKGROUND: Gallbladder and extrahepatic biliary malignancies are aggressive tumors with high risk of recurrence and death. We hypothesize that elevated preoperative Neutrophil-Lymphocyte Ratios (NLR) are associated with poor prognosis among patients undergoing resection of gallbladder or extrahepatic biliary cancers. METHODS: Patients who underwent complete surgical resection between 2000-2014 were identified from 10 academic centers (n=525). Overall (OS) and recurrence-free survival (RFS) were analyzed by stratifying patients with normal (<5) versus elevated (>5) NLR...
September 24, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27677714/the-albi-grade-provides-objective-hepatic-reserve-estimation-across-each-bclc-stage-of-hepatocellular-carcinoma
#15
David J Pinato, Rohini Sharma, Elias Allara, Clarence Yen, Tadaaki Arizumi, Keiichi Kubota, Dominik Bettinger, Jeong Won Jang, Carlo Smirne, Young Woon Kim, Masatoshi Kudo, Jessica Howell, Ramya Ramaswami, Michela E Burlone, Vito Guerra, Robert Thimme, Mitsuru Ishizuka, Justin Stebbing, Mario Pirisi, Brian I Carr
BACKGROUND & AIMS: Overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma due to the mutual influence of cirrhosis and active malignancy in dictating patient's mortality. The ALBI grade is a recently described index of liver dysfunction in HCC, based solely on albumin and bilirubin levels. Whilst accurate, this score lacks cross-validation, especially in intermediate-stage HCC, where OS is highly heterogeneous. METHODS: We evaluated the prognostic accuracy of the ALBI grade in estimating overall survival (OS) in a large, multi-center study including 2426 patients, including a large proportion of intermediate-stage patients treated with chemoembolization (n=1461) accrued from Europe, the United States and Asia...
September 24, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27670892/regorafenib-versus-trifluridine-tipiracil-for-refractory-metastatic-colorectal-cancer-a-retrospective-comparison
#16
Toshiki Masuishi, Hiroya Taniguchi, Satoshi Hamauchi, Azusa Komori, Yosuke Kito, Yukiya Narita, Takahiro Tsushima, Makoto Ishihara, Akiko Todaka, Tsutomu Tanaka, Tomoya Yokota, Shigenori Kadowaki, Nozomu Machida, Takashi Ura, Akira Fukutomi, Masashi Ando, Yusuke Onozawa, Masahiro Tajika, Hirofumi Yasui, Kei Muro, Keita Mori, Kentaro Yamazaki
BACKGROUND: Regorafenib and trifluridine/tipiracil (TAS-102) both prolong survival for patients with refractory metastatic colorectal cancer. However, it is unclear which drug should be administered first. MATERIALS AND METHODS: We retrospectively evaluated the data from patients who had received regorafenib or TAS-102 at 2 institutions from May 2013 to March 2015. The inclusion criteria were disease refractory or intolerant to fluoropyrimidines, oxaliplatin, irinotecan, anti-vascular endothelial growth factor antibodies, and anti-epidermal growth factor receptor (EGFR) antibodies (if KRAS exon 2 wild-type), and no previous treatment with regorafenib or TAS-102...
August 31, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27629944/risk-factors-for-post-endoscopic-retrograde-cholangiopancreatography-ercp-pancreatitis-and-stent-dysfunction-after-preoperative-biliary-drainage-in-patients-with-malignant-biliary-stricture
#17
Shinichi Hashimoto, Kei Ito, Shinsuke Koshida, Yoshihide Kanno, Takahisa Ogawa, Kaori Masu, Yuji Iwashita, Jun Horaguchi, Go Kobayashi, Yutaka Noda
Objective To retrospectively evaluate the risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and stent dysfunction after performing preoperative biliary drainage (BD) in patients with malignant biliary stricture. Methods Between January 2003 and February 2013, 105 consecutive patients who had undergone transpapillary BD before surgery were enrolled in this study. Procedure-related complications, stent dysfunction rates, and their respective risk factors were investigated...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27628556/-a-case-of-advanced-gastric-cancer-with-severe-jaundice-from-multiple-liver-metastases-that-was-significantly-improved-after-capecitabine-plus-oxaliplatin-treatment
#18
Hiroaki Takagi, Takayuki Ando, Ayumu Hosokawa, Takaaki Nishino, Hiroshi Mihara, Hiroki Yoshita, Naokatsu Nakada, Sohachi Nanjo, Yoshiaki Miura, Shinya Kajiura, Haruka Fujinami, Toshiro Sugiyama
A 74-year-old man with advanced gastric cancer was admitted to our hospital. His liver function was impaired(total bilirubin 1.6mg/dL)with multiple liver metastases. He was treated with chemotherapy of S-1 plus cisplatin but it was discon- tinued due to severe diarrhea(CTCAE Grade 3)on day 6 and his liver dysfunction progressed(total bilirubin 10.3mg/dL). After his diarrhea improved, he was treated with capecitabine plus oxaliplatin(capecitabine 3,600mg/day on day 1-14, oxaliplatin 130mg/m2 on day 1, q3 weeks)...
September 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27614340/t2-breast-cancer-presenting-with-diffuse-liver-metastases-and-hepatic-failure-following-fertility-treatment-cautionary-report
#19
Emmanuel A Sule
BACKGROUND: Diffuse hepatic metastases with hepatic failure as a presentation of a T2 breast cancer is rare. This is also remarkable seeing our case had been on fertility treatments before presentation. There are no documented reports of breast cancer patient on fertility treatment presenting with diffuse hepatic metastases and liver failure. CASE SUMMARY: A 41 year old Para 1 Nigerian woman being managed for secondary infertility with an extended use of clomiphene presented with a 3 months history of a left breast lump, nipple bleeding and later, yellowness of eyes, right hypochondrial pain malaise and drowsiness...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27593590/risk-factors-for-a-high-comprehensive-complication-index-score-after-major-hepatectomy-for-biliary-cancer-a-study-of-229-patients-at-a-single-institution
#20
Yoshitsugu Nakanishi, Takahiro Tsuchikawa, Keisuke Okamura, Toru Nakamura, Eiji Tamoto, Takehiro Noji, Toshimichi Asano, Toraji Amano, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: The Comprehensive Complication Index (CCI) is a new tool to evaluate the postoperative condition by calculating the sum of all complications weighted by their severity. The aim of this study was to identify independent risk factors for a high CCI score (≥40) in 229 patients after major hepatectomies with biliary reconstruction for biliary cancers. METHODS: The CCI was calculated online via www.assessurgery.com. Independent risk factors were identified by multivariable analysis...
September 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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