keyword
MENU ▼
Read by QxMD icon Read
search

Bilirubin, cancer

keyword
https://www.readbyqxmd.com/read/29142752/protective-effect-of-hydrogen-rich-water-on-liver-function-of-colorectal-cancer-patients-treated-with-mfolfox6-chemotherapy
#1
Qingxi Yang, Guangdong Ji, Rongtao Pan, Yinghui Zhao, Peng Yan
The present study was conducted to investigate the protective effect of hydrogen-rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single-blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February 2016, among whom 146 met the inclusion criteria. Subsequently, 144 patients were randomized into the treatment (n=80) and placebo (n=64) groups...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29138755/paraneoplastic-hepatopathy-associated-with-gastrointestinal-carcinoid
#2
Dhruv Mehta, Priyanka Chugh, Lavneet Chawla, Daniela Jodorkovsky
Paraneoplastic hepatopathy has been reported with various malignancies, most commonly with renal cell cancer. This non-metastatic hepatic dysfunction in such malignancies is known as Stauffer syndrome. We describe a 61-year-old man who presented with symptoms of bowel obstruction with marked cholestasis and high levels of alkaline phosphatase and bilirubin. Imaging revealed an unremarkable liver and a mass in the ileocecal valve with mesenteric lymphadenopathy. Biopsies were consistent with a carcinoid tumor...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29133751/shanghai-score-a-prognostic-and-adjuvant-treatment-evaluating-system-constructed-for-chinese-patients-with-hepatocellular-carcinoma-after-curative-resection
#3
Hui-Chuan Sun, Lu Xie, Xin-Rong Yang, Wei Li, Jian Yu, Xiao-Dong Zhu, Yong Xia, Ti Zhang, Yang Xu, Bo Hu, Li-Ping Du, Ling-Yao Zeng, Jian Ouyang, Wei Zhang, Tian-Qiang Song, Qiang Li, Ying-Hong Shi, Jian Zhou, Shuang-Jian Qiu, Qian Liu, Yi-Xue Li, Zhao-You Tang, Yu Shyr, Feng Shen, Jia Fan
BACKGROUND: For Chinese patients with hepatocellular carcinoma (HCC), surgical resection is the most important treatment to achieve long-term survival for patients with an early-stage tumor, and yet the prognosis after surgery is diverse. We aimed to construct a scoring system (Shanghai Score) for individualized prognosis estimation and adjuvant treatment evaluation. METHODS: A multivariate Cox proportional hazards model was constructed based on 4166 HCC patients undergoing resection during 2001-2008 at Zhongshan Hospital...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29130008/a-rare-association-of-autoimmune-hemolytic-anemia-with-gastric-adenocarcinoma
#4
Kavita Agrawal, Flores Alfonso
An 80-year-old male presented with dyspnea on exertion for at least two months. He also complained of progressive dysphagia and weight loss of 35 pounds over the last eight months. Initial blood tests showed hemoglobin of 6.1 g/dl, reticulocytes count of 19.7%, total bilirubin of 3.2 mg/dl, lactate dehydrogenase of 600 U/L, and haptoglobin of less than 8 mg/dl, and direct Coombs test was positive for warm immunoglobulin G. The impression was autoimmune hemolytic anemia (AIHA). The evaluation of dysphagia with esophagogastroduodenoscopy revealed a single irregular 4 cm malignant appearing ulcerated mass at the incisura angularis of the stomach...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29119292/population-pharmacokinetics-of-nintedanib-an-inhibitor-of-tyrosine-kinases-in-patients-with-non-small-cell-lung-cancer-or-idiopathic-pulmonary-fibrosis
#5
Ulrike Schmid, Karl-Heinz Liesenfeld, Angele Fleury, Claudia Dallinger, Matthias Freiwald
PURPOSE: A population pharmacokinetic model was developed for nintedanib in patients with non-small cell lung cancer (NSCLC) or idiopathic pulmonary fibrosis (IPF). The effects of intrinsic and extrinsic patient factors on exposure of nintedanib and its main metabolite BIBF 1202 were studied. METHODS: Data from 1191 patients with NSCLC (n = 849) or IPF (n = 342) treated with oral nintedanib (once- or twice-daily, dose range 50-250 mg) in 4 Phase II or III studies were combined...
November 8, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29116365/acute-biliary-obstruction-after-gastroduodenal-covered-self-expanding-metallic-stent-placement-in-patients-with-previous-biliary-stent-placement-for-periampullary-cancer-frequency-and-protective-factors
#6
Kun Yung Kim, Jiaywei Tsauo, Pyeong Hwa Kim, Jung-Hoon Park, Zhe Wang, Min Tae Kim, Ho-Young Song
PURPOSE: We aimed to evaluate the frequency and protective factors of acute biliary obstruction in patients with biliary stent placement followed by gastroduodenal covered self-expandable metallic stent (SEMS) placement owing to progression of periampullary cancer. MATERIALS AND METHODS: We retrospectively reviewed 58 patients. Total bilirubin and alkaline phosphatase (ALP) levels before and after gastroduodenal covered SEMS placement were evaluated. The incidence of acute biliary obstruction correlated to age, sex, biliary stent length and type, and longitudinal and axial locations of the lower end of the biliary stent was evaluated...
November 7, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29113384/subclinical-involvement-of-the-liver-is-associated-with-prognosis-in-treatment-na%C3%A3-ve-cancer-patients
#7
Noemi Pavo, Markus Raderer, Georg Goliasch, Raphael Wurm, Guido Strunk, Anna Cho, Johannes F Novak, Heinz Gisslinger, Günther G Steger, Michael Hejna, Wolfgang Köstler, Sabine Zöchbauer-Müller, Christine Marosi, Gabriela Kornek, Leo Auerbach, Sven Thorben Schneider, Bernhard Parschalk, Werner Scheithauer, Robert Pirker, Barbara Kiesewetter, Richard Pacher, Christoph Zielinski, Martin Hülsmann
Background: Routinely tested liver biomarkers as alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), butyryl-cholinesterase (BChE), albumin and bilirubin are altered in distinct malignancies and hepatic metastases. This study aimed to investigate whether all liver parameters have the ability to predict long-term mortality in treatment naïve cancer patients but without a malignant hepatic involvement. Methods: We prospectively enrolled 555 consecutive patients with primary diagnosis of cancer without prior anticancer therapy...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29095307/survival-benefit-of-radiofrequency-ablation-for-solitary-3-5%C3%A2-cm-hepatocellular-carcinoma-an-analysis-for-nationwide-cancer-registry
#8
COMPARATIVE STUDY
Seung Ho Lee, Young-Joo Jin, Jin-Woo Lee
We retrospectively compared overall survival (OS) and progression-free survival (PFS) of patients with single (3-5 cm) hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer (BCLC) stage A treated by surgical resection (SR), radiofrequency ablation (RFA), or transarterial chemoembolization (TACE).Of the 38,167 HCC patients registered between 2008 and 2010 at Korea Central Cancer Registry, National Cancer Center of South Korea, 13% patients were randomly abstracted, and 4596 patients could be analyzed...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093678/immune-related-adverse-events-associated-with-anti-pd-1-pd-l1-treatment-for-malignancies-a-meta-analysis
#9
Peng-Fei Wang, Yang Chen, Si-Ying Song, Ting-Jian Wang, Wen-Jun Ji, Shou-Wei Li, Ning Liu, Chang-Xiang Yan
Background: Treatment of cancers with programmed cell death protein 1 (PD-1) pathway inhibitors can lead to immune-related adverse events (irAEs), which could be serious and even fetal. Therefore, clinicians should be aware of the characteristics of irAEs associated with the use of such drugs. Methods: The MEDLINE, EMBASE, and Cochrane databases were searched to find potential studies using the following strategies: anti-PD-1/PD-L1 treatment; irAEs; and cancer. R© package Meta was used to pool incidence. Results: Forty-six studies representing 12,808 oncologic patients treated with anti-PD-1/PD-L1 agents were included in the meta-analysis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29092670/protective-effects-of-chrysin-on-sub-acute-diazinon-induced-biochemical-hematological-histopathological-alterations-and-genotoxicity-indices-in-male-balb-c-mice
#10
Majid Zeinali, Naser Tayebi Meybodi, Seyed Abdolrahim Rezaee, Houshang Rafatpanah, Hossein Hosseinzadeh
Chrysin (CH) is a natural flavone which possesses antioxidant, anti-cancer, and anti-inflammatory properties. The aim of the present study was to investigate the effects of CH on biochemical parameters, histopathological changes, and genotoxicity and hematological indices in diazinon (DZN)-induced toxicity in BALB/c mice. We induced sub-acute toxicity in mice using DZN (20 mg/kg/day) and treated them with CH at the 12.5, 25, and 50 mg/kg/day five times/week in 28 days. In our study, DZN increased lipid profile and liver function tests (LFTs) and creatinine (Cr) but decreased the red blood cell acetylcholinesterase (RBC-AChE) activity and glucose level...
November 2, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29076939/transarterial-chemoembolization-for-hepatocellular-carcinoma-development-and-external-validation-of-the-munich-tace-score
#11
Mark Op den Winkel, Dorothea Nagel, Philip Op den Winkel, Jörg Trojan, Philipp M Paprottka, Christian J Steib, Laura Schmidt, Markus Göller, Petra Stieber, Peter Göhring, Andreas Herbst, Markus Rentsch, Enrico N De Toni, Burkhard Göke, Alexander L Gerbes, Frank T Kolligs
BACKGROUND: Allocation of patients with hepatocellular carcinoma (HCC) to the adequate therapy is determined by both tumor burden and liver function. The Barcelona Clinic Liver Cancer (BCLC) staging system and therapeutic algorithm recommends transarterial chemoembolization (TACE) based on the best evidence available to patients with intermediate-stage HCC (BCLC-B). However, many centers also treat subgroups of patients outside these recommendations and with more advanced disease by TACE...
October 25, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29066730/neutrophil-lymphocyte-ratio-plus-prognostic-nutritional-index-predicts-the-outcomes-of-patients-with-unresectable-hepatocellular-carcinoma-after-transarterial-chemoembolization
#12
Chang Liu, Lei Li, Wu-Sheng Lu, Hua Du, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Guo-Jun Zeng, Li Jiang, Jian Yang
For many malignancies, inflammation-based scores correlate with survival. The neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are immunonutritional indices associated with postoperative outcomes in patients with hepatocellular carcinoma (HCC). We evaluated whether a combined preoperative NLR and PNI score was prognostically superior to either index alone in 793 patients with unresectable HCC after transarterial chemoembolization. Patient demographic, clinical, and pathological data were also collected and analysed...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29061025/-prognostic-factors-and-model-of-primary-liver-cancer-treated-with-transcatheter-arterial-chemoembolization-combined-with-radiofrequency-ablation
#13
J Li, W L Zhu, X X Kang, L Zheng, C Y Guo, P Yu, J C Xiao
Objective: To investigate the prognostic factors of primary liver cancer treated with transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA), and then to establish a prognostic model. Methods: Clinicopathological and follow-up data of 145 patients who underwent TACE combined with RFA from January 2010 to December 2012 were retrospectively analyzed. Univariate and multivariate survival analyses were performed using the Cox proportional hazards model, and the prognostic model was established...
October 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29050349/nomograms-incorporated-serum-direct-bilirubin-level-for-predicting-prognosis-in-stages-ii-and-iii-colorectal-cancer-after-radical-resection
#14
Qunfeng Zhang, Xiaowei Ma, Qunhuan Xu, Juanxiu Qin, Yanhua Wang, Qian Liu, Hua Wang, Min Li
An elevated serum bilirubin has been reported to be associated with a reduced risk of some cancer; however, the prognostic significance of serum bilirubin in colorectal cancer wasn't fully understood. The purpose of this study was to evaluate whether serum bilirubin could predict the prognosis of patients in stages II and III colorectal cancer. A retrospective cohort of 986 patients with colorectal cancer who received surgical resection between January 2005 and December 2010 was included in the study. Levels for serum bilirubin were obtained from medical records...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29042755/clinical-data-combined-with-radiological-imaging-improves-the-accuracy-of-tnm-staging-of-pancreatic-body-and-tail-adenocarcinoma
#15
Wei Xu, Bo Jiang, Xinmin Yin
PURPOSE: Pancreatic body and tail adenocarcinoma (PBTA) remains one of the deadliest cancers, and current radiological modalities still have limitations on the staging of PBTA. Improving PBTA staging will contribute to the management of this disease. PATIENTS AND METHODS: Clinicopathological characteristics of 91 surgically treated PBTA patients were retrospectively retrieved. Clinical data associated with postoperative tumor staging (pTNM) were assessed using ordinal logistic regression model...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29040999/hepatic-function-during-repeated-tace-procedures-and-prognosis-after-introducing-sorafenib-in-patients-with-unresectable-hepatocellular-carcinoma-multicenter-analysis
#16
Atsushi Hiraoka, Takashi Kumada, Masatoshi Kudo, Masashi Hirooka, Yohei Koizumi, Yoichi Hiasa, Kazuto Tajiri, Hidenori Toyoda, Toshifumi Tada, Hironori Ochi, Koji Joko, Noritomo Shimada, Akihiro Deguchi, Toru Ishikawa, Michitaka Imai, Kunihiko Tsuji, Kojiro Michitaka
BACKGROUND/AIM: We evaluated the relationship of hepatic function with repeated transarterial catheter chemoembolization (TACE) and prognosis after sorafenib treatment in various patient cohorts. METHODS: Study 1 comprised of 212 Barcelona clinic liver cancer stage-B (BCLC-B) HCC patients classified as Child-Pugh A (CP-A) and who had received repeated TACE treatments (r-TACE) (naïve:recurrence = 66:146). Study 2 comprised of 435 patients with unresectable HCC classified as CP-A in who sorafenib was introduced (naïve:recurrence = 37:398; CP score 5:6 = 282:153; macro-vessel invasion [MVI]+: extrahepatic metastasis [EHM]+ both negative = 124:226:143)...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29034998/the-albumin-bilirubin-grade-uncovers-the-prognostic-relationship-between-hepatic-reserve-and-immune-dysfunction-in-hiv-associated-hepatocellular-carcinoma
#17
D J Pinato, R Sharma, C Citti, H Platt, M Ventura-Cots, E Allara, T-Y Chen, A Dalla Pria, M Jain, B Mínguez, L Kikuchi, E Kaufman West, M Merli, D E Kaplan, H Hasson, K Marks, M Nelson, M Núñez, A Aytaman, M Bower, N Bräu
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of liver-related mortality in people living with HIV, where co-infection with hepatotropic viruses accelerates the course of chronic liver disease. AIM: To evaluate whether the albumin-bilirubin (ALBI) grade, a more accurate marker of liver dysfunction in HCC, might identify patients with progressive liver dysfunction in the context of HIV/hepatitis co-infection. METHODS: Using uni- and multi-variable analyses, we studied the albumin-bilirubin grade as a predictor of overall survival (OS) in a large, multi-center cohort of patients with HIV-associated HCC recruited from 44 centres in 9 countries within the Liver Cancer in HIV study group...
October 16, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29030683/preoperative-alkaline-phosphatase-elevation-was-associated-with-poor-survival-in-colorectal-cancer-patients
#18
Hsin-Yuan Hung, Jinn-Shiun Chen, Chien-YuhYeh, Reiping Tang, Pao-Shiu Hsieh, Wen-SyTasi, Yau-Tong You, Jeng-Fu You, Jy-Ming Chiang
PURPOSE: Purpose To assess preoperative serum alkaline phosphatase (ALP) levels in colon adenocarcinomapatients with various clinical features and determine its prognostic value. METHODS: Between 2000 and 2013, 10,800 stage I-IV colon cancer patients who underwent surgery wereretrospectively enrolled. The relationship between ALP level and variables, including age, gender,carcinoembryonic Antigen (CEA) levels, aspartate aminotransferase (AST) level, bilirubin level, tumor size,liver cirrhosis, hepatitis, albumin level, histological type, and TNM-stage, were evaluated...
December 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29019562/twelve-years-of-experience-using-cholecystojejunal-by-pass-for-palliative-treatment-of-advanced-pancreatic-cancer
#19
Marcos Belotto de Oliveira, Bruna do Nascimento Santos, André de Moricz, Adhemar Monteiro Pacheco-Junior, Rodrigo Altenfelder Silva, Renata D'Alpino Peixoto, Tércio De Campos
BACKGROUND: The cholecistojejunal bypass is an important resource to treat obstructive jaundice due to advanced pancreatic cancer. AIM: To assess the early morbidity and mortality of patients with pancreatic cancer who underwent cholecystojejunal derivation, and to assess the success of this procedure in relieving jaundice. METHOD: This retrospective study examined the medical records of patients who underwent surgery. They were categorized into early death and non-early death groups according to case outcome...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28987770/prognostic-scores-for-sorafenib-treated-hepatocellular-carcinoma-patients-a-new-application-for-the-hepatoma-arterial-embolisation-prognostic-score
#20
J Edeline, J-F Blanc, B Campillo-Gimenez, Y-T Ma, J King, O Faluyi, J Mathurin, S Ghazi, D H Palmer, T Meyer
BACKGROUND: No prognostic classification is currently used for patients treated with systemic therapies for Hepatocellular Carcinoma (HCC). METHODS: We retrospectively analysed data from patients treated with sorafenib for HCC from five centres in France and in the United Kingdom (UK). The training set comprised data from two centres and the validation set from three. Variables independently associated with Overall Survival (OS) in the training set were used to build the SAP (Sorafenib Advanced HCC Prognosis) score...
October 4, 2017: European Journal of Cancer
keyword
keyword
82232
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"