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https://www.readbyqxmd.com/read/29766683/star-shaped-intense-uptake-of-%C3%A2-%C3%A2-%C3%A2-i-on-whole-body-scans-can-reflect-good-therapeutic-effects-of-low-dose-radioactive-iodine-treatment-of-1-1-gbq
#1
Sung Hye Kong, Jung Ah Lim, Young Shin Song, Shinje Moon, Ye An Kim, Min Joo Kim, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
BACKGROUND: After initial radioactive iodine (RAI) treatment in differentiated thyroid cancer patients, we sometimes observe a star-shaped region of intense uptake of ¹³¹I on whole body scans (WBSs), called a 'star artifact.' We evaluated the clinical implications of star artifacts on the success rate of remnant ablation and long-term prognosis. METHODS: Total 636 patients who received ¹³¹I dose of 1.1 GBq for the initial RAI therapy and who did not show distant metastasis at the time of diagnosis were retrospectively evaluated...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766463/predictive-factors-for-the-outcomes-of-initial-i-131-low-dose-ablation-therapy-to-japanese-patients-with-differentiated-thyroid-cancer
#2
Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa
OBJECTIVE: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). PATIENTS AND METHODS: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks...
May 15, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29715279/free-living-and-laboratory-gait-characteristics-in-patients-with-multiple-sclerosis
#3
Fabio A Storm, K P S Nair, Alison J Clarke, Jill M Van der Meulen, Claudia Mazzà
BACKGROUND: Wearable sensors offer the potential to bring new knowledge to inform interventions in patients affected by multiple sclerosis (MS) by thoroughly quantifying gait characteristics and gait deficits from prolonged daily living measurements. The aim of this study was to characterise gait in both laboratory and daily life conditions for a group of patients with moderate to severe ambulatory impairment due to MS. To this purpose, algorithms to detect and characterise gait from wearable inertial sensors data were also validated...
2018: PloS One
https://www.readbyqxmd.com/read/29707123/undetectable-or-low-1-ng-ml-postsurgical-thyroglobulin-values-do-not-rule-out-metastases-in-early-stage-differentiated-thyroid-cancer-patients
#4
Alfredo Campennì, Luca Giovanella, Salvatore Antonio Pignata, Antonio Vento, Angela Alibrandi, Letterio Sturiale, Riccardo Laudicella, Alessio Danilo Comis, Rossella Filice, Giuseppe Giuffrida, Maria Elena Stipo, Salvatore Giovinazzo, Francesco Trimarchi, Rosaria Maddalena Ruggeri, Sergio Baldari
Background: Differentiated thyroid cancer (DTC) work-up is based on (near)total-thyroidectomy plus thyroid remnant ablation (TRA) with 131-radioiodine in many patients, and long-life follow-up. 131 I-post therapy whole body scan (pT-WBS) and serum thyroglobulin (Tg) are used in identifying metastatic patients. Some authors have evaluated the possibility of using post-surgical Tg (ps-Tg) values in deciding for or against TRA. The aim of our study was to verify the diagnostic accuracy of 131 I-pT-WBS and SPECT/CT imaging (post-therapeutic imaging) compared to serum Tg levels in detecting metastases in early stage of DTC patients...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681090/williams-beuren-syndrome-in-diverse-populations
#5
Paul Kruszka, Antonio R Porras, Deise Helena de Souza, Angélica Moresco, Victoria Huckstadt, Ashleigh D Gill, Alec P Boyle, Tommy Hu, Yonit A Addissie, Gary T K Mok, Cedrik Tekendo-Ngongang, Karen Fieggen, Eloise J Prijoles, Pranoot Tanpaiboon, Engela Honey, Ho-Ming Luk, Ivan F M Lo, Meow-Keong Thong, Premala Muthukumarasamy, Kelly L Jones, Khadija Belhassan, Karim Ouldim, Ihssane El Bouchikhi, Laila Bouguenouch, Anju Shukla, Katta M Girisha, Nirmala D Sirisena, Vajira H W Dissanayake, C Sampath Paththinige, Rupesh Mishra, Monisha S Kisling, Carlos R Ferreira, María Beatriz de Herreros, Ni-Chung Lee, Saumya S Jamuar, Angeline Lai, Ee Shien Tan, Jiin Ying Lim, Cham Breana Wen-Min, Neerja Gupta, Stephanie Lotz-Esquivel, Ramsés Badilla-Porras, Dalia Farouk Hussen, Mona O El Ruby, Engy A Ashaat, Siddaramappa J Patil, Leah Dowsett, Alison Eaton, A Micheil Innes, Vorasuk Shotelersuk, Ëben Badoe, Ambroise Wonkam, María Gabriela Obregon, Brian H Y Chung, Milana Trubnykova, Jorge La Serna, Bertha Elena Gallardo Jugo, Miguel Chávez Pastor, Hugo Hernán Abarca Barriga, Andre Megarbane, Beth A Kozel, Mieke M van Haelst, Roger E Stevenson, Marshall Summar, A Adebowale Adeyemo, Colleen A Morris, Danilo Moretti-Ferreira, Marius George Linguraru, Maximilian Muenke
Williams-Beuren syndrome (WBS) is a common microdeletion syndrome characterized by a 1.5Mb deletion in 7q11.23. The phenotype of WBS has been well described in populations of European descent with not as much attention given to other ethnicities. In this study, individuals with WBS from diverse populations were assessed clinically and by facial analysis technology. Clinical data and images from 137 individuals with WBS were found in 19 countries with an average age of 11 years and female gender of 45%. The most common clinical phenotype elements were periorbital fullness and intellectual disability which were present in greater than 90% of our cohort...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29643667/role-of-preablative-stimulated-thyroglobulin-in-prediction-of-nodal-and-distant-metastasis-on-iodine-whole-body-scan
#6
Meghana Prabhu, Sanju Samson, Avinash Reddy, Sunil Hejaji Venkataramanarao, Naveen Hedne Chandrasekhar, Vijay Pillai, Vivek Shetty, Moni Abraham Koriokose, Bushan Vaidhya, Subramanian Kannan
Background: Preablative stimulated thyroglobulin (ps-Tg) is an important investigation in the follow-up of patients with Differentiated thyroid cancer(DTC) after surgery. Levels of ps-Tg >2-10 ng/ml have been suggested to predict metastasis to cervical and extracervical sites. There is still debate on the need for routine iodine whole-body scan (131 I WBS) in the management of low-to-intermediate-risk DTC patients. Objective: We analyzed our data of patients with DTC who underwent total thyroidectomy to discuss the predictability of ps-Tg on metastatic disease on the 131 I WBS...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29568691/consistent-hypersocial-behavior-in-mice-carrying-a-deletion-of-gtf2i-but-no-evidence-of-hyposocial-behavior-with-gtf2i-duplication-implications-for-williams-beuren-syndrome-and-autism-spectrum-disorder
#7
Loren A Martin, Erica Iceberg, Gabriel Allaf
Introduction: Williams-Beuren syndrome (WBS) is a developmental disorder caused by hemizygous deletion of human chromosome 7q11.23. Hypersocial behavior is one symptom of WBS and contrasts with hyposociality observed in autism spectrum disorder (ASD). Interestingly, duplications of 7q11.23 have been associated with ASD. The social phenotype of WBS has been linked to GTF2I or general transcription factor IIi ( TFII-I ). Duplication of GTF2I has also been associated with ASD. Methods: We compared mice having either a deletion ( Gtf2i +/- ) or duplication ( Gtf2i +/dup ) of Gtf2i to wild-type ( Gtf2i +/+ ) littermate controls in a series of behavioral tasks including open-field activity monitoring, olfactory probes, a social choice task, social transmission of food preference, habituation-dishabituation, and operant social motivation paradigms...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29559552/diagnostic-performance-of-pet-in-thyroid-cancer-with-elevated-anti-tg-ab
#8
Seong-Jang Kim, Sang-Woo Lee, Kyoungjune Pak, Sung Ryul Shim
We aimed to explore the role of the diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for the detection of recurrent and/or metastatic diseases in differentiated thyroid cancer (DTC) patients with progressively and/or persistently elevated TgAb levels and negative radioactive iodine whole body scan (RI-WBS) through a systematic review and meta-analysis. The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through June 30, 2017, were searched for studies evaluating the diagnostic performance of F-18 FDG PET/CT for the detection of recurrent and/or metastatic diseases in DTC patients with progressively and/or persistently elevated TgAb levels and negative RI-WBS...
March 20, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29554110/epigallocatechin-3-gallate-improves-cardiac-hypertrophy-and-short-term-memory-deficits-in-a-williams-beuren-syndrome-mouse-model
#9
Paula Ortiz-Romero, Cristina Borralleras, Mònica Bosch-Morató, Biuse Guivernau, Guillermo Albericio, Francisco J Muñoz, Luis A Pérez-Jurado, Victoria Campuzano
Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes at chromosome band 7q11.23. The complete deletion (CD) mouse model mimics the most common deletion found in WBS patients and recapitulates most neurologic features of the disorder along with some cardiovascular manifestations leading to significant cardiac hypertrophy with increased cardiomyocytes' size. Epigallocatechin-3-gallate (EGCG), the most abundant catechin found in green tea, has been associated with potential health benefits, both on cognition and cardiovascular phenotypes, through several mechanisms...
2018: PloS One
https://www.readbyqxmd.com/read/29550843/-18-f-fdg-pet-ct-and-ultrasonogrpahy-in-differentiated-thyroid-carcinoma-patients-with-elevated-serum-levels-of-antithyroglobulin-antibody-negative-tg-and-whole-body-131-i-scan
#10
Jiao Liu, Baoping Liu, Yanxia Yu, Fangfang Chao, Yan Liu, Xingmin Han
OBJECTIVE: In the follow-up of patients with differentiated thyroid cancer (DTC), several patients had elevated serum levels of antithyroglobulin antibody (TgAb), undetectable serum thyroglobulin (Tg), and negative radioiodine whole body scan (131 I-WBS). We describe the use of neck ultrasonography (US) and fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) imaging in these patients to investigate this clinically challenging problem and propose treating...
January 2018: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29550276/a-novel-dntp-limited-pcr-and-hrm-assay-to-detect-williams-beuren-syndrome
#11
Lichen Zhang, Xiaoqing Zhang, Guoling You, Yongguo Yu, Qihua Fu
BACKGROUND: Williams-Beuren syndrome (WBS) is caused by a microdeletion of chromosome arm 7q11.23. A rapid and inexpensive genotyping method to detect microdeletion on 7q11.23 needs to be developed for the diagnosis of WBS. This study describes the development of a new type of molecular diagnosis method to detect microdeletion on 7q11.23 based upon high-resolution melting (HRM). METHODS: Four genes on 7q11.23 were selected as the target genes for the deletion genotyping...
March 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29549631/combined-braf-v600e-analysis-and-99m-tc-mibi-scintigraphy-can-be-a-useful-diagnostic-tool-in-differentiated-thyroid-cancer-patients-with-incomplete-bio-chemical-response-to-first-radioiodine-therapy-rait-a-pilot-investigation
#12
A Campennì, R M Ruggeri, M Siracusa, S A Pignata, F Di Mauro, A Vento, F Trimarchi, S Baldari
PURPOSE: The aim of the present study was to evaluate the possible diagnostic role of the combined performance of BRAF mutation analysis and MIBI scintigraphy in papillary thyroid cancer (PTC) patients with incomplete bio-chemical response to first radioiodine therapy (RAIT) performed for thyroid remnant ablation. METHODS: The records of 15 PTC patients with bio-chemical incomplete response to first RAIT were retrospectively analyzed. BRAFV600E analysis on primary tumor samples was obtained in all cases along with neck ultrasonography and 99m Tc-MIBI scintigraphy of the neck-thorax regions at first follow-up...
March 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29496990/the-role-of-diagnostic-131-i-spect-tc-in-patients-with-papillary-thyroid-microcarcinoma-in-long-term-follow-up
#13
Angela Spanu, Susanna Nuvoli, Ilaria Gelo, Luciana Mele, Bastiana Piras, Giuseppe Madeddu
Papillary thyroid microcarcinoma (PTMC) usually presents favourable prognosis, but it can also be aggressive with neck and distant metastases. We evaluated the diagnostic role of 131 I-single photon emission computed tomography/computed tomography (SPECT/CT) in detecting metastases in PTMC patients in long-term follow-up and whether the procedure may be included in the current diagnostic protocol. Methods: We retrospectively studied 351 consecutive PTMC patients already submitted to thyroidectomy and radioiodine therapy; 21/351 patients were at high risk (H), 94 at low risk (L) and 236 at very low risk (VL)...
March 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29485411/response-of-retinoic-acid-in-patients-with-radioactive-iodine-refractory-thyroid-cancer-a-meta-analysis
#14
Kyoungjune Pak, Seunghyeon Shin, Seong-Jang Kim, In-Joo Kim, Samuel Chang, Phillip Koo, Jennifer Kwak, Jae-Ho Kim
PURPOSE: The purpose of this study was to evaluate the response of retinoic acid (RA) in radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). METHODS: Systematic searches of MEDLINE (from inception to December 2016) and of EMBASE (from inception to December 2016) were performed for English-language publications on thyroid cancer treated with RA. Studies were classified according to the response criteria used: (1) 123I or 131I whole body scintigraphy (WBS), (2) serum thyroglobulin (Tg) level, (3) the response evaluation criteria in solid tumors (RECIST) version 1...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29481451/dynamic-balance-evaluation-reliability-and-validity-of-a-computerized-wobble-board
#15
Andrea Fusco, Giuseppe Francesco Giancotti, Philip X Fuchs, Herbert Wagner, Carlo Varalda, Laura Capranica, Cristina Cortis
Computerized Wobble Boards (WB) are inexpensive, transportable and user-friendly devices to objectively quantify the dynamic balance performances out of laboratory settings, although it has not been established if they are reliable and valid tools. Therefore, the purpose of this study was to determine the reliability and validity of a computerized WB. Thirty-nine (18 female, 21 male) young adults (age: 23.3±2.1years; body mass: 65.9±1.8kg; height: 168.2±8.8cm; leg length: 78.8±5.7cm; BMI: 23.2±2.1kg·m) participated in the study...
February 22, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29469915/blood-pressure-lowering-efficacy-of-winged-bean-seed-hydrolysate-in-spontaneously-hypertensive-rats-peptide-characterization-and-a-toxicity-study-in-sprague-dawley-rats
#16
Shyan Yea Chay, Annas Salleh, Nor Fazila Sulaiman, Najib Zainal Abidin, Mohamad Ariff Hanafi, Mohammad Zarei, Nazamid Saari
Winged bean seed (WBS) is an underutilized tropical crop. The current study evaluates its potential to reduce blood pressure (BP) in spontaneously hypertensive rats and finds that it reduces BP significantly, in a dose-dependent manner. Five peptides with the sequences, RGVFPCLK, TQLDLPTQ, EPALVP, MRSVVT and DMKP, have been characterized in terms of their stability against ACE via in vitro and in silico modelling. All peptides exhibited IC50 values between 0.019 and 6.885 mM and various inhibitory modes, including substrate, prodrug and true inhibitor modes...
March 1, 2018: Food & Function
https://www.readbyqxmd.com/read/29465605/a-false-positive-i-131-finding-of-duodenum-diverticulum-in-thyroid-cancer-evaluation-by-spect-ct-a-case-report
#17
Rang Wang, Ke Zhou, Qiuping Fan, Haotian Chen, Chengzhong Fan
RATIONALE: Iodine-131 (I-131) is a sensitive marker for the detection of differentiated thyroid cancer (DTC). I-131 whole-body scintigraphy (WBS) has been used widely in evaluation of DTC patient. However, I-131 WBS exists many false-positive uptake of I-131 because radioiodine uptake can also be seen in healthy tissue or in a variety of benign and malignant non-thyroidal tumors. PATIENT CONCERNS: A 44-year-old woman with a papillary thyroid carcinoma for the purpose of ablation therapy after a total thyroidectomy...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29349347/pain-measurement-in-oral-and-maxillofacial-surgery
#18
REVIEW
Nattapong Sirintawat, Kamonpun Sawang, Teeranut Chaiyasamut, Natthamet Wongsirichat
Regardless of whether it is acute or chronic, the assessment of pain should be simple and practical. Since the intensity of pain is thought to be one of the primary factors that determine its effect on a human's overall function and sense, there are many scales to assess pain. The aim of the current article was to review pain intensity scales that are commonly used in dental and oral and maxillofacial surgery (OMFS). Previous studies demonstrated that multidimensional scales, such as the McGill Pain Questionnaire, Short form of the McGill Pain Questionnaire, and Wisconsin Brief Pain Questionnaire were suitable for assessing chronic pain, while unidimensional scales, like the Visual Analogue Scales (VAS), Verbal descriptor scale, Verbal rating scale, Numerical rating Scale, Faces Pain Scale, Wong-Baker Faces Pain Rating Scale (WBS), and Full Cup Test, were used to evaluate acute pain...
December 2017: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29343651/determining-patient-selection-tool-and-response-predictor-for-outpatient-30-mci-radioiodine-ablation-dose-in-non-metastatic-differentiated-thyroid-carcinoma-a-japanese-perspective
#19
Tetsuya Higuchi, Arifudin Achmad, Duong Duc Binh, Anu Bhattarai, Yoshito Tsushima
The lack of isolation ward throughout Japan has long been limiting the 131I radioactive iodine (RAI) ablation for differentiated thyroid cancer (DTC) cases. The 30 mCi RAI ablation was only recently permitted for outpatient basis. However, no patient selection tool nor response predictor has been proposed. This study evaluated factors to find response predictor and determinant for the suitable patients. The retrospective study reviewed 47 eligible non-metastatic papillary DTC patients whose had first 30 mCi RAI ablation after total thyroidectomy...
January 16, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#20
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
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