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Shalaka Dhat, Swati Pund, Chandrakant Kokare, Pankaj Sharma, Birendra Shrivastava
Rapidly evolving technical and regulatory landscapes of the pharmaceutical product development necessitates risk management with application of multivariate analysis using Process Analytical Technology (PAT) and Quality by Design (QbD). Poorly soluble, high dose drug, Satranidazole was optimally nanoprecipitated (SAT-NP) employing principles of Formulation by Design (FbD). The potential risk factors influencing the critical quality attributes (CQA) of SAT-NP were identified using Ishikawa diagram. Plackett-Burman screening design was adopted to screen the eight critical formulation and process parameters influencing the mean particle size, zeta potential and dissolution efficiency at 30min in pH7...
September 28, 2016: European Journal of Pharmaceutical Sciences
Bo Long, Junwei Lucas Bao, Donald G Truhlar
Criegee intermediates are produced in the ozonolysis of unsaturated hydrocarbons in the troposphere, and understanding their fate is a prerequisite to modeling climate-controlling atmospheric aerosol formation. Although some experimental and theoretical rate data are available, they are incomplete and partially inconsistent, and they do not cover the tropospheric temperature range. Here we report quantum chemical rate constants for the reactions of formaldehyde oxide (CH2OO) and acetaldehyde oxide (syn-CH3CHOO and anti-CH3CHOO) with H2O and for their unimolecular reactions...
September 29, 2016: Journal of the American Chemical Society
Sathya Prakash, Pratap Sharan, Mamta Sood
BACKGROUND: "Dhat syndrome" is believed to be a culture-bound syndrome of the Indian subcontinent. Although many studies have been performed, many have methodological limitations and there is a lack of agreement in many areas. AIMS: The aim is to study the phenomenology of "Dhat syndrome" in men and to explore the possibility of subtypes within this entity. SETTINGS AND DESIGN: It is a cross-sectional descriptive study conducted at a sex and marriage counseling clinic of a tertiary care teaching hospital in Northern India...
April 2016: Indian Journal of Psychiatry
Michael E Pyne, Stanislav Sokolenko, Xuejia Liu, Kajan Srirangan, Mark R Bruder, Marc G Aucoin, Murray Moo-Young, Duane A Chung, C Perry Chou
UNLABELLED: Crude glycerol, the major by-product of biodiesel production, is an attractive bioprocessing feedstock owing to its abundance, low cost, and high degree of reduction. In line with the advent of the biodiesel industry, Clostridium pasteurianum has gained prominence as a result of its unique capacity to convert waste glycerol into n-butanol, a high-energy biofuel. However, no efforts have been directed at abolishing the production of 1,3-propanediol (1,3-PDO), the chief competing product of C...
September 1, 2016: Applied and Environmental Microbiology
Sandeep Grover, Ajit Avasthi, Sunil Gupta, Nandita Hazari, Nidhi Malhotra
AIM: The aim of this study was to evaluate the concept of female Dhat syndrome characterized by the complaint of nonpathological vaginal discharge in association with somatic, anxiety, and depressive symptoms. MATERIALS AND METHODS: A total of 26 female subjects with nonpathological vaginal discharge along with depressive and somatic complaints were assessed on a self-rated questionnaire modified from Comprehensive Questionnaire for Assessment of Dhat Syndrome designed for males...
January 2016: Indian Journal of Psychiatry
Sandeep Grover, Sunil Gupta, Ajit Avasthi
AIM: The aim of this study was to evaluate the treatment pattern and satisfaction with treatment provided to patients with Dhat syndrome. It was also aimed to study the follow-up rates and reasons for dropping out of treatment in patients with Dhat syndrome. MATERIALS AND METHODS: Sixty-four subjects diagnosed with Dhat syndrome were prospectively contacted to evaluate treatment satisfaction and reason for dropout after 6 months of baseline evaluation. Sociodemographic, clinical details were recorded at initial intake and Sex Knowledge and Attitude Questionnaire was applied...
January 2016: Indian Journal of Psychiatry
Wei Jiang, Shizhen Wang, Yuanpeng Wang, Baishan Fang
Biodiesel can replace petroleum diesel as it is produced from animal fats and vegetable oils, and it produces about 10 % (w/w) glycerol, which is a promising new industrial microbial carbon, as a major by-product. One of the most potential applications of glycerol is its biotransformation to high value chemicals such as 1,3-propanediol (1,3-PD), dihydroxyacetone (DHA), succinic acid, etc., through microbial fermentation. Glycerol dehydratase, 1,3-propanediol dehydrogenase (1,3-propanediol-oxydoreductase), and glycerol dehydrogenase, which were encoded, respectively, by dhaB, dhaT, and dhaD and with DHA kinase are encompassed by the dha regulon, are the three key enzymes in glycerol bioconversion into 1,3-PD and DHA, and these are discussed in this review article...
2016: Biotechnology for Biofuels
Xianghui Qi, Junhua Yun, Yilin Qi, Huanhuan Zhang, Fei Wang, Qi Guo, Zheng Cao
1,3-Propanediol dehydrogenase (PDOR) is important in the biosynthesis of 1,3-propanediol. In the present study, the dhaT gene encoding PDOR was cloned from Lactobacillus brevis 6239 and expressed in Escherichia coli for the first time. Sequence analysis revealed that PDOR containing two Fe(2+)-binding motifs and a cofactor motif belongs to the type III alcohol dehydrogenase. The purified recombinant PDOR exhibited a single band of 42 kDa according to SDS-PAGE. Optimal temperatures and pH values of this dehydrogenase are 37 °C, 7...
July 2016: Applied Biochemistry and Biotechnology
Shalaka Dhat, Swati Pund, Chandrakant Kokare, Pankaj Sharma, Birendra Shrivastava
The designing of surface engineered nanocrystals for improved stability and bioavailability is a multivariate process depending on several critical formulation and process variables. The present investigation deals with formulation of stable nanocrystals of poorly soluble satranidazole (SAT) for improving dissolution rate and pharmacokinetic profiling. SAT has low polar surface area, high dose and dosing frequency. Based on goniometric and stability studies of formulations prepared with various stabilizers, a unique combination of Span 20 and HPMC E-5 was selected for detailed investigation...
March 2016: European Journal of Pharmaceutics and Biopharmaceutics
Sandeep Grover, Sunil Gupta, Ajit Avasthi
AIM: The aim of this study was to examine psychological factors in the form of somatosensory amplification, alexithymia and hypochondriasis in patients with Dhat syndrome. Secondary aims of the study were: (1) To evaluate the influence of psychiatric comorbidity on the psychological correlates; (2) to compare the prevalence of psychological correlates in those with Dhat syndrome and in those with depression and somatoform disorders. MATERIALS AND METHODS: A total of 106 subjects diagnosed with Dhat syndrome as per International Classification of Diseases-10 (ICD-10) criteria were assessed on Toronto Alexithymia Scale (TAS-20), Somatosensory Amplification Scale (SSAS) and Whitely Index (WI)...
July 2015: Indian Journal of Psychiatry
Sujita Kumar Kar, Siddharth Sarkar
Dhat syndrome has often been construed as a culture-bound sexual neurosis of the Indian subcontinent. Symptoms similar to that of Dhat syndrome has been described in other cultures across different time periods. The present paper looks at the evolution of the concept of Dhat syndrome in India. The review also takes an overview of the current understanding of this syndrome in terms of nosological status as a distinct entity and its "culture-bound" status. The narrative finally attempts to discuss the integrated approach for the treatment of this disorder...
July 2015: Journal of Human Reproductive Sciences
Moideen Sameer, Vikas Menon, Ramamurthy Chandrasekaran
BACKGROUND: Very little is known about the long term diagnostic stability of Dhat (semen loss) syndrome owing to a dearth of follow up studies on this condition. AIM: The aim of the study was to assess the diagnostic stability and naturalistic long term outcomes in a group of pure Dhat syndrome cases. MATERIALS AND METHODS: The study was carried out in the outpatient psychiatry department of a tertiary care hospital in South India, using a retrospective cohort design...
August 2015: Journal of Clinical and Diagnostic Research: JCDR
Hanna Przystałowska, Joanna Zeyland, Alicja Kośmider, Marlena Szalata, Ryszard Słomski, Daniel Lipiński
Compared with chemical synthesis, fermentation has the advantage of mass production at low cost, and has been used in the production of various industrial chemicals. As a valuable organic compound, 1,3-propanediol (1,3-PDO) has numerous applications in the production of polymers, lubricants, cosmetics and medicines. Here, conversion of glycerol (a renewable substrate and waste from biodiesel production) to 1,3-PDO by E. coli bacterial strain carrying altered glycerol metabolic pathway was investigated. Two gene constructs containing the 1,3-PDO operon from Citrobacter freundii (pCF1 and pCF2) were used to transform the bacteria...
2015: Acta Biochimica Polonica
Antonio Ventriglio, Oyedeji Ayonrinde, Dinesh Bhugra
Culture-bound syndromes were first described over 60 years ago. The underlying premise was that certain psychiatric syndromes are confined to specific cultures. There is no doubt that cultures influence how symptoms are perceived, explained and from where help is sought. Cultures determine what idioms of distress are employed to express distress. Rapid globalization and industrialization have made the world a smaller place and cultures are being more influenced by other cultures. This has led to social and economic changes in parts of the world where such syndromes were seen more frequently...
January 2016: Psychiatry and Clinical Neurosciences
Sandeep Grover, Sunil Gupta, Aseem Mehra, Ajit Avasthi
This study aimed to assess the knowledge about sex, attitude towards sex, prevalence of psychiatric comorbidity and relationship of the comorbidity with onset of symptoms of Dhat syndrome. Treatment records of 264 patients diagnosed with Dhat syndrome were reviewed for clinical profile including psychiatric comorbidity and sexual dysfunction and information on sexual knowledge and attitude using Sex Knowledge and Attitude Questionnaire (SKAQ-II). None of the patients gave all the correct responses on the SKAQ-II...
October 2015: Asian Journal of Psychiatry
Sandeep Grover, Ajit Avasthi, Sunil Gupta, Amitava Dan, Rajarshi Neogi, Prakash B Behere, Bhavesh Lakdawala, Adarsh Tripathi, Kaustav Chakraborty, Vishal Sinha, Manjeet Singh Bhatia, Amrit Patjoshi, T S S Rao, Abhijit Rozatkar
AIM: To assess the phenomenology and associated beliefs in patients with Dhat syndrome. METHODS: A total of 780 male patients aged more than 16 years were recruited from 15 centers spread across the country and were assessed on Dhat Syndrome Questionnaire. RESULTS: The most commonly reported reasons for passage of Dhat were excessive masturbation (55.1%), sexual dreams (47.3%), excessive sexual desire (42.8%) and consumption of high energy foods (36...
February 2016: International Journal of Social Psychiatry
Sandeep Grover, Ajit Avasthi, Sunil Gupta, Amitava Dan, Rajarshi Neogi, Prakash B Behere, Bhavesh Lakdawala, Adarsh Tripathi, Kaustav Chakraborty, Vishal Sinha, Manjeet Singh Bhatia, Amrit Pattojoshi, T S S Rao, Abhijit Rozatkar
INTRODUCTION: There are limited numbers of studies on Dhat syndrome. Major limitations of the existing literature are heterogeneous assessment methods used to describe the comorbidity and small sample size from isolated centers. AIM: To assess comorbidity with a common methodology in patients with Dhat syndrome from multiple centers across India. METHODS: Using a cross-sectional design, this multicentric study involved assessment of 780 male patients, aged more than 16 years, across 15 study centers...
June 2015: Journal of Sexual Medicine
Shunsuke Sato, Björn Andreeßen, Alexander Steinbüchel
Poly(3-hydroxybytyrate-co-3-hydroxypropionate), poly(3HB-co-3HP), is a possible alternative to synthetic polymers such as polypropylene, polystyrene and polyethylene due to its low crystallinity and fragility. We already reported that recombinant strains of Shimwellia blattae expressing 1,3-propanediol dehydrogenase DhaT as well as aldehyde dehydrogenase AldD of Pseudomonas putida KT2442, propionate-CoA transferase Pct of Clostridium propionicum X2 and PHA synthase PhaC1 of Ralstonia eutropha H16 are able to accumulate up to 14...
2015: AMB Express
Suravi Patra, Ajeet Sidana, Nitin Gupta
No abstract text is available yet for this article.
July 2014: Industrial Psychiatry Journal
Sathya Prakash, Piyali Mandal
No abstract text is available yet for this article.
January 2015: Indian Journal of Psychological Medicine
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