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https://www.readbyqxmd.com/read/29125885/mir-376c-inhibits-osteoblastogenesis-by-targeting-wnt3-and-arf-gef-1-facilitated-augmentation-of-beta-catenin-transactivation
#1
Jyoti Kureel, Aijaz A John, Ravi Prakash, Divya Singh
Wnt signaling pathway plays important role in all aspects of skeletal development which include chondrogenesis, osteoblastogenesis, and osteoclastogenesis. Induction of the Wnt signaling pathway promotes bone formation while inactivation of the pathway leads to bone related disorders like osteoporosis. Wnt signaling thus has become a desired target to treat osteogenic disorders. MicroRNAs (miRNAs) represent an important category of elements that interact with Wnt signaling molecules to regulate osteogenesis...
November 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29113300/deletion-of-tumor-suppressors-adenomatous-polyposis-coli-and-smad4-in-murine-luminal-epithelial-cells-causes-invasive-prostate-cancer-and-loss-of-androgen-receptor-expression
#2
Kenneth C Valkenburg, Angelo M De Marzo, Bart O Williams
Prostate cancer is the most diagnosed non-skin cancer in the US and kills approximately 27,000 men per year in the US. Additional genetic mouse models are needed that recapitulate the heterogeneous nature of human prostate cancer. The Wnt/beta-catenin signaling pathway is important for human prostate tumorigenesis and metastasis, and also drives tumorigenesis in mouse models. Loss of Smad4 has also been found in human prostate cancer and drives tumorigenesis and metastasis when coupled with other genetic aberrations in mouse models...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108267/beta-catenin-represses-protein-kinase-d1-gene-expression-by-non-canonical-pathway-through-myc-max-transcription-complex-in-prostate-cancer
#3
Bita Nickkholgh, Sivanandane Sittadjody, Michael B Rothberg, Xiaolan Fang, Kunzhao Li, Jeff W Chou, Gregory A Hawkins, K C Balaji
Down regulation of Protein Kinase D1 (PrKD1), a novel serine threonine kinase, in prostate, gastric, breast and colon cancers in humans leads to disease progression. While the down regulation of PrKD1 by DNA methylation in gastric cancer and by nuclear beta-catenin in colon cancer has been shown, the regulatory mechanisms in other cancers are unknown. Because we had demonstrated that PrKD1 is the only known kinase to phosphorylate threonine 120 (T120) of beta-catenin in prostate cancer resulting in increased nuclear beta-catenin, we explored the role of beta-catenin in gene regulation of PrKD1...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107899/role-of-micrornas-in-senescence-and-its-contribution-to-peripheral-neuropathy-in-the-arsenic-exposed-population-of-west-bengal-india
#4
Debmita Chatterjee, Apurba Bandyopadhyay, Nilendu Sarma, Santanu Basu, Tarit Roychowdhury, Sib Sankar Roy, Ashok K Giri
Arsenic induced senescence (AIS) has been identified in the population of West Bengal, India very recently. Also there is a high incidence of arsenic induced peripheral neuropathy (PN) throughout India. However, the epigenetic regulation of AIS and its contribution in arsenic induced PN remains unexplored. We recruited seventy two arsenic exposed and forty unexposed individuals from West Bengal to evaluate the role of senescence associated miRNAs (SA-miRs) in AIS and their involvement if any, in PN. The downstream molecules of the miRNA associated with the disease outcome, was also checked by immuoblotting...
November 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29106686/the-identification-of-pivotal-transcriptional-factors-mediating-cell-responses-to-drugs-with-drug-induced-liver-injury-liabilities
#5
Falgun Shah, Alex Medvedev, Anne Mai Wassermann, Marian Brodney, Liying Zhang, Sergei Makarov, Robert V Stanton
Drug-induced liver injury (DILI) is a leading cause of drug attrition during drug development and a common reason for drug withdrawal from the market. The poor predictability of conventional animal-based approaches (Olson et al. 2000) necessitates the development of alternative testing approaches. Body of evidence associates DILI with the induction of stress-response genes in the liver cells (Yuan and Kaplowitz 2013). Here, we set out to identify signal transduction pathways predominantly involved in the regulation of gene transcription by DILI drugs...
November 2, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29103082/mir-324-3p-promotes-gastric-cancer-development-by-activating-smad4-mediated-wnt-beta-catenin-signaling-pathway
#6
Guang-Li Sun, Zheng Li, Wei-Zhi Wang, Zheng Chen, Lei Zhang, Qing Li, Song Wei, Bo-Wen Li, Jiang-Hao Xu, Liang Chen, Zhong-Yuan He, Kai Ying, Xuan Zhang, Hao Xu, Dian-Cai Zhang, Ze-Kuan Xu
BACKGROUND: Emerging evidence suggested that miRNAs can function as oncogenes or tumor suppressors by regulating downstream target genes. miR-324-3p has been reported to function in several carcinomas, but its role in gastric cancer (GC) is still unknown. This study aims to explore the effects of miR-324-3p on the development of GC. METHODS: Expression of miR-324-3p was examined in GC cells and tissues by qRT-PCR. Effects of miR-324-3p on GC cells were evaluated by cell vitality assay, colony formation assay, cell migration assay, and flow cytometric assay...
November 4, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29102711/pleomorphic-lobular-carcinoma-in-situ-diagnosed-by-breast-core-biopsy-clinicopathologic-features-and-correlation-with-subsequent-excision
#7
Tianhua Guo, Yihong Wang, Nella Shapiro, Susan Fineberg
INTRODUCTION: Pleomorphic lobular carcinoma in situ (PLCIS) is a variant of LCIS with high-grade morphologic features. The number of case series studying PLCIS is limited, and clinical management of patients with PLCIS is controversial. We report a breast core biopsy (BCBx) series of PLCIS. MATERIALS AND METHODS: We reviewed 37 cases of PLCIS with or without microinvasion diagnosed by BCBx. PLCIS was defined as dyscohesive cells showing acinar expansion and loss of immunohistochemical membranous expression of e-cadherin or beta-catenin with nuclear pleomorphism with at least 2- to 3-fold variation in nuclear size, membrane irregularities, and variably prominent nucleoli...
October 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29102319/wnt-signaling-pathway-correlates-with-ossification-of-the-spinal-ligament-a-microrna-array-and-immunohistochemical-study
#8
Takafumi Yayama, Kanji Mori, Noriaki Okumura, Kazuya Nishizawa, Kosuke Kumagai, Akira Nakamura, Shinji Imai
BACKGROUND: Ossification of the posterior longitudinal ligament or the ligamentum flavum parallels endochondral ossification. Cell differentiation at the ossification front is known to be important during this process, although the factors regulating its initiation and progression are still unclear. The purpose of this study was to identify factors important for the regulation of chondrocyte/osteoblast differentiation during spinal ossification. METHODS: Ligamentum flavum tissue was isolated from 25 patients who underwent decompressive surgery for cervical ossification of the posterior longitudinal ligament...
October 25, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29099279/mtor-signaling-is-essential-for-the-development-of-thymic-epithelial-cells-and-the-induction-of-central-immune-tolerance
#9
Zhanfeng Liang, Lianjun Zhang, Huiting Su, Rong Luan, Ning Na, Lina Sun, Yang Zhao, Xiaodong Zhang, Qian Zhang, Juan Li, Lianfeng Zhang, Yong Zhao
Thymic epithelial cells (TECs) are critical for the establishment and maintenance of appropriate microenvironment for the positive and negative selection of thymocytes and the induction of central immune tolerance. Yet, little about the molecular regulatory network on TEC development and function is understood. Here, we demonstrate that MTOR (mechanistic target of rapamycin [serine/threonine kinase]) is essential for proper development and functional maturation of TECs. Pharmacological inhibition of MTOR activity by rapamycin (RPM) causes severe thymic atrophy and reduction of TECs...
November 3, 2017: Autophagy
https://www.readbyqxmd.com/read/29079516/pharmacological-blockade-of-the-wnt-beta-catenin-signaling-a-possible-first-in-kind-dmoad
#10
EDITORIAL
F Dell'Accio, F Cailotto
No abstract text is available yet for this article.
October 25, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29076875/ovarian-microcystic-stromal-tumors-are-characterized-by-alterations-in-the-beta-catenin-apc-pathway-and-may-be-an-extracolonic-manifestation-of-familial-adenomatous-polyposis
#11
(no author information available yet)
No abstract text is available yet for this article.
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29065434/unanswered-questions-in-the-genetic-basis-of-primary-aldosteronism
#12
Ute I Scholl
Over the past six years, the genetic basis of a significant fraction of primary aldosteronism (PA) cases has been solved. Breakthrough discoveries include the role of somatic variants in the KCNJ5, CACNA1D, ATP1A1, and ATP2B3 genes as causes of aldosterone-producing adenomas (APAs), and the recognition of three novel hyperaldosteronism syndromes with germline variants in the KCNJ5, CACNA1D, and CACNA1H genes. The description of somatic variants in CACNA1D and ATP1A1 in aldosterone-producing cell clusters (APCCs) suggests that these clusters are precursors of some aldosterone-producing adenomas...
October 24, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29057980/rock-inhibition-with-fasudil-induces-beta-catenin-nuclear-translocation-and-inhibits-cell-migration-of-mda-mb-231-human-breast-cancer-cells
#13
Fabiana Sélos Guerra, Ramon Guerra de Oliveira, Carlos Alberto Manssour Fraga, Claudia Dos Santos Mermelstein, Patricia Dias Fernandes
Tumor aggressiveness is usually associated with metastasis. MDA-MB 231, a triple-negative breast cancer (TNBC), is an aggressive type of breast cancer and associated with early metastasis. The Rho/ROCK pathway is a key regulator of cell motility involving cytoskeleton regulation through stabilization of actin filaments and stress fiber formation. In this study we show that Fasudil, a ROCK inhibitor, inhibited the migration of MDA-MB 231 and A549 cells, without altering the viability of these cells at the concentration of 10 μM, modified tumor cell morphology, with disorganization of stress fibers and promotes activation of the canonical-Wnt/beta-catenin pathway...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050516/human-bone-marrow-mesenchymal-stromal-cell-derived-osteoblasts-promote-the-expansion-of-hematopoietic-progenitors-through-beta-catenin-and-notch-signaling-pathways
#14
Matthew Michalicka, Gavin Boisjoli, Suria Jahan, Owen Hovey, Emily Doxtator, Ahmad Abu-Khader, Roya Pasha, Nicolas Pineault
Coculture of hematopoietic stem cells (HSC) with primary stromal cells from HSC niches supports the maintenance and expansion of HSC and progenitors ex vivo. However, a major drawback is the availability of primary human samples for research and clinical applications. We investigated the use of in vitro derived osteoblasts as a new source of feeder cells and characterized the molecular pathways that mediate their growth promoting activities. First, we compared the growth and differentiation modulating activities of mesenchymal stromal cells (MSC)-derived osteoblasts (M-OST) to that of their undifferentiated precursor on umbilical cord blood (UCB) progenitors...
October 19, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29050300/tfcp2-activates-beta-catenin-tcf-signaling-in-the-progression-of-pancreatic-cancer
#15
Dai Yuedi, Cai Yuankun, Zhao Jiaying, Liu Han, Wang Yueqi, Liu Houbao, Zhang Dexiang
Aberrant activation of beta-catenin/TCF (T-cell factor) signaling is frequently observed in the pancreatic cancer. However, the regulation of nuclear beta-catenin/TCF transcription machinery remains largely unknown. In this study, TFCP2 (transcriptional factor CP2) expression in pancreatic cancer was detected by qPCR, immunohistochemistry and western blot. Western blot, colony formation assay, migration and invasion experiment were performed to investigate the effects of TFCP2 on the growth and migration of pancreatic cancer cells...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029464/mir-324-3p-promotes-tumor-growth-through-targeting-dact1-and-activation-of-wnt-%C3%AE-catenin-pathway-in-hepatocellular-carcinoma
#16
Hang Tuo, Yufeng Wang, Liang Wang, Bowen Yao, Qing Li, Cong Wang, Zhikui Liu, Shaoshan Han, Guozhi Yin, Kangsheng Tu, Qingguang Liu
Recently, it has been reported that miR-324-3p participates in regulation of the carcinogenesis and tumor progression in various cancers. However, the expression and function of miR-324-3p in hepatocellular carcinoma (HCC) remain unclear. In the current study, miR-324-3p expression was significantly up-regulated in HCC tissues and cell lines. HCC patients with high miR-324-3p level showed poor prognostic features and shorter overall survival and disease-free survival. And in vitro and in vivo experiments revealed that miR-324-3p promoted cell viability, colony formation, proliferation and cell cycle progression of HCC cells...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29018044/rnf43
#17
REVIEW
Stefano Serra, Runjan Chetty
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation. Loss of function of RNF43 results in decrease/lack of degradation of Frizzled with enhancement of Wnt/β-catenin signaling pathway. Mutations of RNF43 have been reported in different cancers...
October 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28993399/myc-cooperates-with-beta-catenin-to-drive-gene-expression-in-the-nephron-progenitor-cells
#18
Xinchao Pan, Courtney M Karner, Thomas J Carroll
For organs to achieve their proper size, the processes of stem cell renewal and differentiation must be tightly regulated. We previously showed that in the developing kidney, Wnt9b regulates distinct beta-catenin-dependent transcriptional programs in the renewing and differentiating populations of the nephron progenitor cells. How beta-catenin stimulated these two distinct programs was unclear. Here, we show that beta-catenin cooperates with the transcription factor Myc to activate the progenitor renewal program...
October 9, 2017: Development
https://www.readbyqxmd.com/read/28977937/overexpression-of-mir-135b-5p-promotes-unfavorable-clinical-characteristics-and-poor-prognosis-via-the-repression-of-sfrp4-in-pancreatic-cancer
#19
Xu Han, Hexige Saiyin, Junjie Zhao, Yuan Fang, Yefei Rong, Chenye Shi, Wenhui Lou, Tiantao Kuang
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and malignant neoplasm. The aberrant expression of miR-135b-5p and secreted frizzled-related protein 4 (SFRP4) has been revealed to be involved in various cancers. However, the clinical significance of miR-135b-5p and that of its potential target SFRP4 in PDAC remain to be elucidated. Here, we found that miR-135b-5p was markedly upregulated in pancreatic cancer tissue compared with corresponding adjacent normal tissue, whereas SFRP4 was significantly downregulated...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976000/wnt10a-gene-is-the-second-molecular-candidate-in-a-cohort-of-young-italian-subjects-with-ectodermal-derivative-impairment-edi
#20
L Guazzarotti, G Tadini, G E Mancini, I Sani, S Pisanelli, F Galderisi, E D'Auria, R Secondi, A Bottero, G V Zuccotti
Ectodermal dysplasias are a group of genetic disorders defined by ectodermal derivative impairment (EDI). To test the impact of the Wnt/beta-catenin pathway in the genetic screening of EDI, we performed a molecular gene study of WNT10A in 60 subjects from a population of 133 young Italian patients referred for the impairment of at least one major ectodermal-derived structure and who had a previous negative molecular screen for ectodysplasin signaling pathway genes ED1, EDAR, and EDARADD. Fourteen WNT10A mutations were identified in 33 subjects (24...
October 4, 2017: Clinical Genetics
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