keyword
https://read.qxmd.com/read/37703992/rho-family-small-gtpase-rif-regulates-wnt5a-ror1-dvl2-signaling-and-promotes-lung-adenocarcinoma-progression
#21
JOURNAL ARTICLE
Michiru Nishita, Koki Kamizaki, Kyoka Hoshi, Kana Aruga, Ikumi Nishikaku, Hiroshi Shibuya, Kunio Matsumoto, Yasuhiro Minami
Rif, a member of the Rho family of small GTPases, induces filopodia formation primarily on the dorsal surface of cells; however, its function remains largely unclear. Here, we show that Rif interacts with Ror1, a receptor for Wnt5a that can also induce dorsal filopodia. Our immunohistochemical analysis revealed a high frequency of coexpression of Ror1 and Rif in lung adenocarcinoma. Lung adenocarcinoma cells cultured on Matrigel established front-rear polarity with massive filopodia on their front surfaces, where Ror1 and Rif accumulated...
September 11, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/37638287/prognostic-value-of-the-expression-of-receptor-tyrosine-kinase-like-orphan-receptor-1-ror-1-in-chronic-lymphocytic-leukemia
#22
JOURNAL ARTICLE
Aysun Şentürk Yikilmaz, Şule Mine Bakanay, Duygu Nurdan Avcı, Sema Akinci, Mesude Falay, Gülsüm Özet, İmdat Dilek
Background: The transmembrane receptor tyrosine kinase-like orphan receptor 1 (ROR1) has acted on the causation and sustentation of mature B-cell lymphomagenesis for chronic lymphocytic leukemia (CLL) cells. The study attempted to show whether there is a relationship between the level of ROR1 surface expression in CLL cells and disease findings. Materials and Methods: The level of ROR1 cell surface expression was determined in accordance with the flow cytometric analysis of CLL patients at the first diagnosis time...
January 1, 2023: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/37628927/cancer-stem-cell-markers-clinical-relevance-and-prognostic-value-in-high-grade-serous-ovarian-cancer-hgsoc-based-on-the-cancer-genome-atlas-analysis
#23
JOURNAL ARTICLE
Natalia Iżycka, Mikołaj Piotr Zaborowski, Łukasz Ciecierski, Kamila Jaz, Sebastian Szubert, Cezary Miedziarek, Marta Rezler, Kinga Piątek-Bajan, Aneta Synakiewicz, Anna Jankowska, Marek Figlerowicz, Karolina Sterzyńska, Ewa Nowak-Markwitz
Cancer stem cells (CSCs) may contribute to an increased risk of recurrence in ovarian cancer (OC). Further research is needed to identify associations between CSC markers and OC patients' clinical outcomes with greater certainty. If they prove to be correct, in the future, the CSC markers can be used to help predict survival and indicate new therapeutic targets. This study aimed to determine the CSC markers at mRNA and protein levels and their association with clinical presentation, outcome, and risk of recurrence in HGSOC (High-Grade Serous Ovarian Cancer)...
August 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37616519/current-treatments-in-mantle-cell-lymphoma
#24
JOURNAL ARTICLE
Avyakta Kallam Md, Julie M Vose
Mantle cell lymphoma (MCL) is characterized by heterogeneous biology and varied clinical presentations. Historically, it has been associated with a poor prognosis when compared with other non-Hodgkin lymphomas. With a better understanding of the disease biology, molecular pathogenesis, and new treatments, the outcomes have been gradually improving. Identification of high-risk mutations has resulted in better prognostication and paved the way for risk-adapted treatment approaches. Although chemoimmunotherapy remains the mainstay frontline treatment, combination therapies incorporating novel agents such as Bruton tyrosine kinase inhibitors, B-cell lymphoma inhibitors, and immunomodulatory agents are being studied, with promising results...
August 8, 2023: Oncology (Williston Park, NY)
https://read.qxmd.com/read/37610317/genome-wide-association-analysis-of-neck-ring-traits-in-nonghua-ma-male-ducks
#25
JOURNAL ARTICLE
H Wang, C Yang, J Wang, Y Xi, J Qi, J Hu, L Bai, L Li, A Mustafa, H Liu
Male NongHua ma ducks have more colourful feathers than females, especially considering that the former have a distinctive neck ring that is different from that of females. This ring development might be influenced by sex selection, the environment, genetics and other elements.Genome-wide association analysis (GWAS) was used to locate candidate genes that affect the neck ring formation of male ducks to investigate the genetic basis of this phenomenon.In this study, the neck ring area and width of 180 male ducks were assessed at ages 80, 90, 100, 110 and 120 d...
August 23, 2023: British Poultry Science
https://read.qxmd.com/read/37543028/from-the-archives-of-md-anderson-cancer-center-sporadic-burkitt-lymphoma-with-a-complex-karyotype-and-sox11-expression
#26
REVIEW
Saima Haleem Siddiqui, Beenu Thakral, Fnu Aakash, Chi Young Ok, Zhenya Tang, L Jeffrey Medeiros
Burkitt lymphoma (BL) is a mature B-cell neoplasm arising from germinal center B-cells. There are three epidemiological variants of which the sporadic variant is most prevalent in developed countries representing 1-2 % of all lymphomas in adults. Patients usually present with bulky abdominal masses and ~ 30 % have bone marrow involvement. BL is characterized by a germinal center B-cell immunophenotype and usually has a simple karyotype. Here we report an unusual case of sporadic BL in a 44-year-old man and we use this case to review sporadic BL in adults...
July 21, 2023: Annals of Diagnostic Pathology
https://read.qxmd.com/read/37499397/antitumor-activity-of-a-ror1-%C3%A3-cd3-bispecific-antibody-in-non-small-cell-lung-cancer
#27
JOURNAL ARTICLE
Yi Wang, Yuxi Zhang, Haoyi Sun, Jilan Chen, Hui Yang, Zhanqiong Zhong, Xiaoqian Xiao, Yanping Li, Yibei Tang, Haolan Lu, Xinzhi Tang, Mengyang Zhang, Wenjun Wu, Shiyi Zhou, Jiahui Yang
Over the last decade, immuno-oncologic drugs especially CD3-engaging bispecific antibodies (biAbs) are experiencing fast-paced evolution, but big challenges still exist in the clinical development of biAbs in solid tumors, especially non-small cell lung cancer (NSCLC). In this study, we choose a ROR1 × CD3 biAb in scFv-Fc format, named R11 × v9 biAb, to investigate its tumor-inhibiting role in NSCLC. Notably, the ROR1-engaging arm binds both human and mouse ROR1. We found that R11 × v9 biAb specifically binds T cells and tumor cells simultaneously, and dose-dependent cytotoxicity was detected for various ROR1+ NSCLC cell lines...
July 25, 2023: International Immunopharmacology
https://read.qxmd.com/read/37481855/evaluation-of-the-prognostic-significance-of-receptor-tyrosine-kinase-like-orphan-receptor-1-ror1-in-lung-carcinoma-and-its-relation-to-lymphangiogenesis-and-epithelial-mesenchymal-transition
#28
JOURNAL ARTICLE
Nehal Abd El-Ghaffar Heabah, Sara A Darwish, Asmaa Mustafa Eid
Exploring the carcinogenic mechanisms of lung carcinoma helps to discover novel prognostic biomarkers and develop new therapeutic options to improve patient's survival. Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1), a transmembrane protein, contributes to cancer progression and metastasis; via stimulation of epithelial mesenchymal transition (EMT) and promotion of angiogenesis. This makes ROR1 an important target for tumor therapy. This study aimed to evaluate expression of ROR1, E-cadherin (a marker of EMT), and D2-40 (a marker of lymphangiogenesis) in lung carcinoma and associate their expressions with the available clinicopathological parameters and patients' survival...
July 20, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/37430307/extracellular-vesicle-associated-tyrosine-kinase-like-orphan-receptors-ror1-and-ror2-promote-breast-cancer-progression
#29
JOURNAL ARTICLE
Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann, Kerstin Menck
BACKGROUND: Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment. So far, EV uptake and cargo delivery into target cells have been regarded as the main mechanisms for the pro-tumoral function of EVs. To test this hypothesis, we investigated the fate of the oncogenic transmembrane Wnt tyrosine kinase-like orphan receptor 1 and 2 (ROR1, ROR2) delivered via distinct EV subpopulations to breast cancer cells and aimed to unravel their impact on tumor progression...
July 10, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/37400436/ror1-stat3-signaling-contributes-to-ovarian-cancer-intra-tumor-heterogeneity
#30
JOURNAL ARTICLE
Emilia Piki, Alice Dini, Juuli Raivola, Kari Salokas, Kaiyang Zhang, Markku Varjosalo, Teijo Pellinen, Katja Välimäki, Kristina Tabor Veskimäe, Synnöve Staff, Sampsa Hautaniemi, Astrid Murumägi, Daniela Ungureanu
Wnt pathway dysregulation through genetic and non-genetic alterations occurs in multiple cancers, including ovarian cancer (OC). The aberrant expression of the non-canonical Wnt signaling receptor ROR1 is thought to contribute to OC progression and drug resistance. However, the key molecular events mediated by ROR1 that are involved in OC tumorigenesis are not fully understood. Here, we show that ROR1 expression is enhanced by neoadjuvant chemotherapy, and Wnt5a binding to ROR1 can induce oncogenic signaling via AKT/ERK/STAT3 activation in OC cells...
July 3, 2023: Cell Death Discovery
https://read.qxmd.com/read/37343369/ror1-stat3-positive-feedback-loop-facilitates-cartilage-degeneration-in-osteoarthritis-through-activation-of-nf-%C3%AE%C2%BAb-signaling-pathway
#31
JOURNAL ARTICLE
Wei Huang, Hao Tang, Yang Liu, WenWei Li, Ajmeri Sultana Shimu, BoFeng Li, Chen Zhu
BACKGROUND: Osteoarthritis (OA) is a chronic joint disorder with a serious impact on society. The main pathological change in OA is articular cartilage degeneration, which is directly associated with imbalance of anabolic and catabolic activities in chondrocytes. OBJECTIVE: To evaluate the expression and biological effects of ROR1 in OA cartilage and determine whether knockdown of ROR1 attenuates cartilage degeneration. METHODS: ROR1 expression in OA clinical specimens was evaluated by western blotting and immunohistochemistry...
June 19, 2023: International Immunopharmacology
https://read.qxmd.com/read/37312634/a-novel-emperor-of-pancreatic-malignancy
#32
JOURNAL ARTICLE
Irene Peñuelas-Haro, Elisa Espinet
How pancreatic cancer cells acquire tumor initiating capacities remains poorly understood. A recent study by Yamazaki et al (2023) uncovers a crucial, targetable role of tyrosine kinase-like orphan receptor (ROR1) in PDAC tumor formation and progression.
June 14, 2023: EMBO Journal
https://read.qxmd.com/read/37301125/the-onco-embryonic-antigen-ror1-is-a-target-of-chimeric-antigen-t-cells-for-colorectal-cancer
#33
JOURNAL ARTICLE
Shangsen Meng, Ming Li, Le Qin, Jiang Lv, Di Wu, Diwei Zheng, Heng Jia, Dongmei Chen, Qiting Wu, Youguo Long, Zhaoyang Tang, Yanlai Tang, Lihua Yang, Yao Yao, Xuequn Luo, Peng Li
Colorectal cancer is globally ranked second in both incidence and mortality rate. It usually develops during the middle or late stages of diagnosis, and is characterized by easy metastasis, poor prognosis, and a significant decline in postoperative quality of life. ROR1 is an excellent oncoembryonic antigen in numerous immunotherapy treatments for tumors. Additionally, it is overexpressed in colorectal cancer. To fill the void in CRC treatment with ROR1 as a target of CAR-T immunotherapy, we designed and prepared antiROR1-CART...
August 2023: International Immunopharmacology
https://read.qxmd.com/read/37269061/comprehensive-analyses-of-brain-cell-communications-based-on-multiple-scrna-seq-and-snrna-seq-datasets-for-revealing-novel-mechanism-in-neurodegenerative-diseases
#34
REVIEW
Chunlong Zhang, Guiyuan Tan, Yuxi Zhang, Xiaoling Zhong, Ziyan Zhao, Yunyi Peng, Qian Cheng, Ke Xue, Yanjun Xu, Xia Li, Feng Li, Yunpeng Zhang
AIMS: Complex cellular communications between glial cells and neurons are critical for brain normal function and disorders, and single-cell level RNA-sequencing datasets display more advantages for analyzing cell communications. Therefore, it is necessary to systematically explore brain cell communications when considering factors such as sex and brain region. METHODS: We extracted a total of 1,039,459 cells derived from 28 brain single-cell RNA-sequencing (scRNA-seq) or single-nucleus RNA-sequencing (snRNA-seq) datasets from the GEO database, including 12 human and 16 mouse datasets...
June 2, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37241228/the-role-of-ror1-in-chemoresistance-and-emt-in-endometrial-cancer-cells
#35
JOURNAL ARTICLE
Kyung-Jun Lee, Nam-Hyeok Kim, Hyeong Su Kim, Youngmi Kim, Jae-Jun Lee, Jung Han Kim, Hye-Yon Cho, Soo Young Jeong, Sung Taek Park
Background and Objectives : Receptor tyrosine kinase-like orphan receptor type 1 (ROR1) plays a critical role in embryogenesis and is overexpressed in many malignant cells. These characteristics allow ROR1 to be a potential new target for cancer treatment. The aim of this study was to investigate the role of ROR1 through in vitro experiments in endometrial cancer cell lines. Materials and Methods : ROR1 expression was identified in endometrial cancer cell lines using Western blot and RT-qPCR. The effects of ROR1 on cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) markers were analyzed in two endometrial cancer cell lines (HEC-1 and SNU-539) using either ROR1 silencing or overexpression...
May 21, 2023: Medicina
https://read.qxmd.com/read/37238084/genome-wide-signal-selection-analysis-revealing-genes-potentially-related-to-sheep-milk-production-traits
#36
JOURNAL ARTICLE
Ruonan Li, Yuhetian Zhao, Benmeng Liang, Yabin Pu, Lin Jiang, Yuehui Ma
Natural selection and domestication have shaped modern sheep populations into a vast range of phenotypically diverse breeds. Among these breeds, dairy sheep have a smaller population than meat sheep and wool sheep, and less research is performed on them, but the lactation mechanism in dairy sheep is critically important for improving animal-production methods. In this study, whole-genome sequences were generated from 10 sheep breeds, including 57 high-milk-yield sheep and 44 low-milk-yield sheep, to investigate the genetic signatures of milk production in dairy sheep, and 59,864,820 valid SNPs (Single Nucleotide Polymorphisms) were kept after quality control to perform population-genetic-structure analyses, gene-detection analyses, and gene-function-validation analyses...
May 16, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37111634/a-small-molecule-targeting-the-intracellular-tyrosine-kinase-domain-of-ror1-kan0441571c-induced-significant-apoptosis-of-non-small-cell-lung-cancer-nsclc-cells
#37
JOURNAL ARTICLE
Amineh Ghaderi, Mohammad-Ali Okhovat, Jemina Lehto, Luigi De Petris, Ehsan Manouchehri Doulabi, Parviz Kokhaei, Wen Zhong, Georgios Z Rassidakis, Elias Drakos, Ali Moshfegh, Johan Schultz, Thomas Olin, Anders Österborg, Håkan Mellstedt, Mohammad Hojjat-Farsangi
The ROR1 receptor tyrosine kinase is expressed in embryonic tissues but is absent in normal adult tissues. ROR1 is of importance in oncogenesis and is overexpressed in several cancers, such as NSCLC. In this study, we evaluated ROR1 expression in NSCLC patients (N = 287) and the cytotoxic effects of a small molecule ROR1 inhibitor (KAN0441571C) in NSCLC cell lines. ROR1 expression in tumor cells was more frequent in non-squamous (87%) than in squamous (57%) carcinomas patients, while 21% of neuroendocrine tumors expressed ROR1 ( p = 0...
April 5, 2023: Pharmaceutics
https://read.qxmd.com/read/37096681/yap-brd4-controlled-ror1-promotes-tumor-initiating-cells-and-hyperproliferation-in-pancreatic-cancer
#38
JOURNAL ARTICLE
Masaya Yamazaki, Shinjiro Hino, Shingo Usuki, Yoshihiro Miyazaki, Tatsuya Oda, Mitsuyoshi Nakao, Takaaki Ito, Kazuya Yamagata
Tumor-initiating cells are major drivers of chemoresistance and attractive targets for cancer therapy, however, their identity in human pancreatic ductal adenocarcinoma (PDAC) and the key molecules underlying their traits remain poorly understood. Here, we show that a cellular subpopulation with partial epithelial-mesenchymal transition (EMT)-like signature marked by high expression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) is the origin of heterogeneous tumor cells in PDAC. We demonstrate that ROR1 depletion suppresses tumor growth, recurrence after chemotherapy, and metastasis...
April 25, 2023: EMBO Journal
https://read.qxmd.com/read/37068700/targeting-ror1-inhibits-glucocorticoid-induced-gastric-cancer-metastasis
#39
JOURNAL ARTICLE
Wang Rui, Guo Quanquan, Ma Meimei, Shi Xiaohong
Glucocorticoids are commonly used in clinic but are also a double-edged sword. While treating tumors, they are reported to promote tumor growth and metastasis. To explore the role and elucidate the mechanism of dexamethasone in promoting tumor growth and metastasis, we detected the levels of cortisol and adrenocorticotropic hormone (ACTH) in peripheral blood of patients with gastric cancer, and immunohistochemical staining was used to detect the expression of GR and ROR1 in the surgically resected gastric cancer samples...
April 15, 2023: Steroids
https://read.qxmd.com/read/37056860/mir-379-5p-regulates-the-proliferation-cell-cycle-and-cisplatin-resistance-of-oral-squamous-cell-carcinoma-cells-by-targeting-ror1
#40
JOURNAL ARTICLE
Lei Meng, Yanlin Du, Banglian Deng, Yinzhong Duan
OBJECTIVE: To analyze the regulatory mechanism microRNA miR-379-5p in oral squamous cell carcinoma (OSCC). METHODS: We collected serum samples from patients with OSCC and examined the expression of miR-379-5p and receptor tyrosine kinase-like orphan receptor 1 (ROR1) by real-time polymerase chain reaction and western blot. OSCC cells were purchased for molecular research, cell multiplication was tested using the BrdU assay, cell cycle was tested using flow cytometry, and resistance to cisplatin (DDP) was assessed using the MTT assay...
2023: American Journal of Translational Research
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