Jianying Song, Aiai Liu, Bo Liu, Wei Huang, Zongzhe Jiang, Xue Bai, Lixin Hu, Silin Zheng, Shengming Guo, Jianming Wu, Qi Chen
Difficult or even non-healing diabetic foot ulcers (DFU) are a global medical challenge. Although current treatments such as debridement, offloading, and infection control have resulted in partial improvement in DFU, the incidence, amputation, and mortality rates of DFU remain high. Therefore, there is an urgent need to find new or more effective drugs. Numerous studies have shown that oxidative stress plays an important role in the pathophysiology of DFU. The nuclear factor erythroid 2-related factor (Nrf2) signaling pathway and the advanced glycated end products (AGEs)-receptor for advanced glycation endproducts (RAGE), protein kinase C (PKC), polyol and hexosamine biochemical pathways play critical roles in the regulation of oxidative stress in the body...
October 19, 2022: Frontiers in Bioscience (Landmark Edition)