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https://www.readbyqxmd.com/read/28087633/the-abl-pathway-bifurcates-to-balance-enabled-and-rac-signaling-in-axon-patterning-in-drosophila
#1
Ramakrishnan Kannan, Jeong-Kuen Song, Tatiana Karpova, Akanni Clarke, Madhuri Shivalkar, Benjamin Wang, Lyudmila Kotlyanskaya, Irina Kuzina, Qun Gu, Edward Giniger
The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. While individual components are known, the relationships among them remain mysterious. We now use FRET measurements of pathway activity, analysis of protein localization and genetic epistasis to dissect the structure of this network in Drosophila We find that the adaptor protein Disabled stimulates Abl kinase activity. Abl suppresses the actin regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase: Abl gates the activity of the spectrin repeats of Trio, allowing them to relieve intramolecular repression of Trio GEF activity by the Trio N-terminal domain...
January 13, 2017: Development
https://www.readbyqxmd.com/read/28087184/clinical-characteristics-of-ruptured-distal-middle-cerebral-artery-aneurysms-review-of-the-literature
#2
REVIEW
Keiji Tsutsumi, Tetsuyoshi Horiuchi, Alhusain Nagm, Yasuyuki Toba, Kazuhiro Hongo
Middle cerebral artery (MCA) aneurysms usually arise at the primary MCA bifurcation or trifurcation. Distal MCA aneurysms are rarely considered as sources of aneurysmal subarachnoid hemorrhage (SAH). It has been reported that ruptured distal MCA aneurysms are associated with head trauma, neoplastic emboli, arterial dissection, or bacterial infection. We experienced five cases of ruptured distal MCA aneurysms and evaluated their clinical characteristics. Retrospective analysis of aneurysmal SAH at Kobayashi Neurosurgical Neurological Hospital was performed from January, 2004 to December, 2014...
January 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28081099/high-order-external-cavity-modes-and-restabilization-of-a-laser-diode-subject-to-a-phase-conjugate-feedback
#3
Émeric Mercier, Lionel Weicker, Delphine Wolfersberger, Deborah M Kane, Marc Sciamanna
We experimentally report the sequence of bifurcations destabilizing and restabilizing a laser diode with phase-conjugate feedback when the feedback rate is increased. Specifically, we successively observe the initial steady state, undamped relaxation oscillations, quasi-periodicity, chaos, and oscillating solutions at harmonics up to 13 times the external cavity frequency but also the restabilization to a steady state. The experimental results are qualitatively well reproduced by a model that accounts for the time the light takes to penetrate the phase-conjugate mirror...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28079613/centripetal-movement-of-the-capillaries-in-the-central-macular-region-after-internal-limiting-membrane-peeling
#4
Kazuyuki Kumagai, Masanori Hangai, Mariko Furukawa, Tetsuyuki Suetsugu, Nobuchika Ogino
PURPOSE: To report a case that showed centripetal movements of the capillaries in the central macular region after vitrectomy with internal limiting membrane peeling. METHODS: A 57-year-old pseudophakic woman underwent successful vitrectomy with internal limiting membrane peeling and air tamponade for a vitreomacular traction. Optical coherence tomography angiographic images of the 3 mm × 3 mm inner retinal vascular plexus were examined preoperatively and at 3 months postoperatively...
January 11, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28077003/influence-of-extrinsic-inputs-and-synaptic-gains-on-dynamics-of-wendling-s-neural-mass-model-a-bifurcation-analysis
#5
Shujuan Geng, Weidong Zhou
We analyze the neurodynamics attributed by a model proposed by Wendling and co-workers (2002) [Wendling, F., Bartolomei, F., Bellanger, J.J. & Chauvel, P. (2002) Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition. Eur. J. Neurosci., 15, 1499.] to explain several different types of electroencephalographic activities. We could find three principal types of steady states when the system parameters change slowly: (i) the model produce a constant output when it is under a state of stable equilibrium point with a constant input...
January 11, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28076961/total-arch-replacement-through-a-median-sternotomy-for-kommerell-s-diverticulum
#6
Yoshihiro Goto, Yutaka Koyama, Soh Hosoba, Shinji Ogawa, Shunsuke Fukaya, Yasuhide Okawa
Kommerell's diverticulum with a right aortic arch and aberrant left subclavian artery is a rare anomaly, and the optimal operative strategy has not yet been established. In particular, the approach to the diverticulum is controversial, with the greatest concern being whether or not to add a right thoracotomy to the median sternotomy for distal anastomosis. We successfully performed total arch replacement through a median sternotomy only, by referring to preoperative computed tomography. We think that if the aneurysm is in a shallow position from the tracheal bifurcation, total arch replacement is possible with a midline incision only...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28074030/working-model-of-the-deep-relationships-of-diverse-modern-human-genetic-lineages-outside-of-africa
#7
Mark Lipson, David Reich
A major topic of interest in human prehistory is how the large-scale genetic structure of modern populations outside of Africa was established. Demographic models have been developed that capture the relationships among small numbers of populations or within particular geographical regions, but constructing a phylogenetic tree with gene flow events for a wide diversity of non-Africans remains a difficult problem. Here, we report a model that provides a good statistical fit to allele-frequency correlation patterns among East Asians, Australasians, Native Americans, and ancient western and northern Eurasians, together with archaic human groups...
January 10, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28072714/optical-coherence-tomography-assessment-of-a-complex-bifurcation-lesion-treated-with-double-kissing-crush-technique-a-case-report
#8
Jin-Zan Cai, Yao-Jun Zhang, Tian Xu, Yong-Xiang Zhu, Chen-Yu Mao, Christos V Bourantas, Tom Crake, Shao-Liang Chen
The DEFINITION (Impact of the complexity of bifurcation lesions treated with drug-eluting stents) study has provided a novel classification to evaluate the complexity of coronary bifurcation lesion according to coronary angiography, but angiographic imaging due to its low resolution and inherited limitation may result in an inaccurate adjudication.We used optical coherence tomography (OCT) to further evaluate the coronary characteristics in a patient with "simple" bifurcation lesion which was classified by the DEFINITION criteria...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071947/presacral-abscess-as-a-rare-complication-of-sacral-nerve-stimulator-implantation
#9
A Gumber, S Ayyar, H Varia, S Pettit
A 50-year-old man with intractable anal pain attributed to proctalgia fugax underwent insertion of a sacral nerve stimulator via the right S3 vertebral foramen for pain control with good symptomatic relief. Thirteen months later, he presented with signs of sepsis. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large presacral abscess. MRI demonstrated increased enhancement along the pathway of the stimulator electrode, indicating that the abscess was caused by infection introduced at the time of sacral nerve stimulator placement...
January 10, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28070902/a-modified-lvad-technique-to-augment-caval-and-pulmonary-arterial-blood-flow-in-the-failing-fontan-circulation
#10
Michael F Swartz, Louis DiVincenti, Karen Smith, Robin Westcott, Kevin Belmont, William Harris, Francisco Gensini, George M Alfieris
BACKGROUND: There are minimal circulatory support options for patients with a failing Fontan. The Heartmate II (HMII) left ventricular assist device (Thoratec, Bedford, MA) in its packaged state cannot augment caval/pulmonary arterial blood flow. AIM: We hypothesized that a modified HMII pump could augment caval and pulmonary arterial blood flow. METHODS: A bifurcated ringed Gore-Tex graft (W. L. Gore & Associates, Flagstaff, AZ) was sewn to the HMII inflow, and the outflow graft transected and tapered from 16 mm to 8 mm in diameter...
January 9, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28067200/quantitative-angiography-methods-for-bifurcation-lesions-a-consensus-statement-update-from-the-european-bifurcation-group
#11
Carlos Collet, Yoshinobu Onuma, Rafael Cavalcante, Maik Grundeken, Philippe Généreux, Jeffrey Popma, Ricardo Costa, Goran Stankovic, Shengxian Tu, Johan H C Reiber, Jean-Paul Aben, Jens Flensted Lassen, Yves Louvard, Alexandra Lansky, Patrick W Serruys
Bifurcation lesions represent one of the most challenging lesions subset in interventional cardiology. The European Bifurcation Club (EBC) is an academic consortium whose goal has been to assess and recommend the appropriate strategies to manage bifurcation lesions. The quantitative coronary angiography (QCA) methods for the evaluation of bifurcation lesions has been subject to extensive research. Single vessel quantitative coronary angiography (QCA) has shown to be inaccurate to assess bifurcation lesions dimensions...
January 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28065691/difference-in-vascular-response-between-sirolimus-eluting-and-everolimus-eluting-stents-in-ostial-left-circumflex-artery-after-unprotected-left-main-as-observed-by-optical-coherence-tomography
#12
Yusuke Fujino, Guilherme F Attizzani, Satoko Tahara, Toru Naganuma, Kensuke Takagi, Hiroto Yabushita, Wei Wang, Kentaro Tanaka, Takahiro Matsumoto, Hiroyoshi Kawamoto, Yuya Yamada, Shinnosuke Amano, Yusuke Watanabe, Takayuki Warisawa, Tomohiko Sato, Satoru Mitomo, Naoyuki Kurita, Hisaaki Ishiguro, Koji Hozawa, Takahiro Tsukahara, Masahiro Motosuke, Hiram G Bezerra, Shotaro Nakamura, Sunao Nakamura
BACKGROUND: Kissing-balloon technique (KBT) is commonly performed during percutaneous coronary intervention of distal unprotected left main coronary artery (ULM) aiming at obtaining optimal opening of the side branch (left circumflex artery; LCX) ostium. Nonetheless, detailed evaluation of vascular response to stents in LCX ostium is lacking. We therefore evaluated the vascular response to different drug-eluting stents (DES) in ostial LCX after ULM by means of optical coherence tomography (OCT)...
December 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28063427/hydrogen-bond-breaking-dynamics-in-the-water-pentamer-terahertz-vrt-spectroscopy-of-a-20-%C3%AE-m-libration
#13
William T S Cole, Raymond S Fellers, Mark R Viant, Richard J Saykally
Hydrogen bonds in solid and liquid water are formed and broken via librational vibrations, hence characterizing the details of these motions is vital to understanding these important dynamics. Here we report the measurement and assignment of 875 transitions comprising 6 subbands originating from out-of-plane librational transitions of the water pentamer-d10 near 512 cm(-1). The precisely measured (ca. 1 ppm) transitions reveal bifurcation splittings of ∼1884 MHz, a ∼4000× enhancement over ground state splittings and 100× greater than predicted by theory...
January 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28062986/the-psilostomidae-looss-1900-sensu-stricto-digenea-echinostomatoidea-description-of-three-new-genera-and-a-key-to-the-genera-of-the-family
#14
Olena Kudlai, Aneta Kostadinova, Eric E Pulis, Vasyl V Tkach
Three new psilostomid genera, Byrdtrema n. g., Longisaccus n. g. and Macracetabulum n. g., each with a single species, are described from ducks, Aix sponsa (L.) and Bucephala albeola (L.) in North America. Byrdtrema n. g. and Macracetabulum n. g. possess a bipartite seminal vesicle and share this character with four psilostomid genera, Grysoma Byrd, Bogitsh & Maples, 1961, Neopsilotrema Kudlai, Pulis, Kostadinova & Tkach, 2016, Psilostomum Looss, 1899 and Psilotornus Byrd & Prestwood, 1969. Byrdtrema n. g. differs from Macracetabulum n...
January 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28062892/a-bifurcation-theorem-for-evolutionary-matrix-models-with-multiple-traits
#15
J M Cushing, F Martins, A A Pinto, Amy Veprauskas
One fundamental question in biology is population extinction and persistence, i.e., stability/instability of the extinction equilibrium and of non-extinction equilibria. In the case of nonlinear matrix models for structured populations, a bifurcation theorem answers this question when the projection matrix is primitive by showing the existence of a continuum of positive equilibria that bifurcates from the extinction equilibrium as the inherent population growth rate passes through 1. This theorem also characterizes the stability properties of the bifurcating equilibria by relating them to the direction of bifurcation, which is forward (backward) if, near the bifurcation point, the positive equilibria exist for inherent growth rates greater (less) than 1...
January 6, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28061486/superficial-temporal-artery-sparing-mini-pterional-approach-for-cerebral-aneurysm-surgery
#16
Jun-Young Ahn, Sung-Tae Kim, Ki-Chang Yi, Won-Hee Lee, Sung Hwa Paeng, Young-Gyun Jeong
OBJECTIVE: The purposes of this study were to introduce a superficial temporal artery (STA)-sparing mini-pterional approach for the treatment of cerebral aneurysms and review the surgical results of this approach. METHODS: Between June 2010 and December 2015, we performed the STA-sparing mini-pterional approach for 117 patients with 141 unruptured intracranial aneurysms. We analyzed demographic, radiologic, and clinical variables including age, sex, craniotomy size, aneurysm location, height of STA bifurcation, and postoperative complications...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28060923/comparative-postembryonic-skeletal-ontogeny-in-two-sister-lineages-of-old-world-tree-frogs-rhacophoridae-taruga-polypedates
#17
Gayani Senevirathne, Ryan Kerney, Madhava Meegaskumbura
Rhacophoridae, a family of morphologically cryptic frogs, with many genetically distinct evolutionary lineages, is understudied with respect to skeletal morphology, life history traits and skeletal ontogeny. Here we analyze two species each from two sister lineages, Taruga and Polypedates, and compare their postembryonic skeletal ontogeny, larval chondrocrania and adult osteology in the context of a well-resolved phylogeny. We further compare these ontogenetic traits with the direct-developing Pseudophilautus silus...
2017: PloS One
https://www.readbyqxmd.com/read/28059656/midterm-results-of-t-stent-assisted-coiling-of-wide-necked-and-complex-intracranial-bifurcation-aneurysms-using-low-profile-stents
#18
Kubilay Aydin, Serra Sencer, Mehmet Barburoglu, Mynzhylky Berdikhojayev, Yavuz Aras, Altay Sencer, Nail İzgi
OBJECTIVE Coiling of wide-necked and complex bifurcation aneurysms frequently requires implantation of double stents in various configurations. T-stent-assisted coiling involves the nonoverlapping implantation of 2 stents to protect the daughter vessels of bifurcation and is followed by coiling of the aneurysm. The authors studied the feasibility, efficacy, and safety of the T-stent-assisted coiling procedure as well as the midterm angiographic/clinical outcomes of patients with wide-necked bifurcation intracranial aneurysms treated using this technique...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28059129/dynamics-of-ferrofluidic-flow-in-the-taylor-couette-system-with-a-small-aspect-ratio
#19
Sebastian Altmeyer, Younghae Do, Ying-Cheng Lai
We investigate fundamental nonlinear dynamics of ferrofluidic Taylor-Couette flow - flow confined be-tween two concentric independently rotating cylinders - consider small aspect ratio by solving the ferro-hydrodynamical equations, carrying out systematic bifurcation analysis. Without magnetic field, we find steady flow patterns, previously observed with a simple fluid, such as those containing normal one- or two vortex cells, as well as anomalous one-cell and twin-cell flow states. However, when a symmetry-breaking transverse magnetic field is present, all flow states exhibit stimulated, finite two-fold mode...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057816/the-microscale-distribution-and-dynamic-surface-tension-of-pulmonary-surfactant-normalizes-the-recruitment-of-asymmetric-bifurcating-airways
#20
Eiichiro Yamaguchi, Liam P Nolan, Donald P Gaver
We investigate the influence of bifurcation geometry, asymmetry of daughter airways, surfactant distribution and physicochemical properties on the uniformity of airway recruitment of asymmetric bifurcating airways. To do so, we developed micro-fluidic idealized in vitro models of bifurcating airways, through which we can independently evaluate the impact of carina location, and the daughter airway width and length. We explore the uniformity of recruitment and its relationship to the dynamic surface tension of the lining fluid, and relate this behavior to the hydraulic and capillary pressure drops (PHyd and PCap, respectively)...
January 5, 2017: Journal of Applied Physiology
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