Deep Pandya, Shannon Tomita, Maria Padron Rhenals, Sabina Swierczek, Katherine Reid, Olga Camacho-Vanegas, Catalina Camacho, Kelsey Engelman, Stephanie Polukort, Jordan RoseFigura, Linus Chuang, Vaagn Andikyan, Samantha Cohen, Paul Fiedler, Steven Sieber, Ie-Ming Shih, Jean-Noël Billaud, Robert Sebra, Boris Reva, Peter Dottino, John A Martignetti
OBJECTIVE: Endometrial cancer (EndoCA) is the most common gynecologic cancer and incidence and mortality rate continue to increase. Despite well-characterized knowledge of EndoCA-defining mutations, no effective diagnostic or screening tests exist. To lay the foundation for testing development, our study focused on defining the prevalence of somatic mutations present in non-cancerous uterine tissue. METHODS: We obtained ≥8 uterine samplings, including separate endometrial and myometrial layers, from each of 22 women undergoing hysterectomy for non-cancer conditions...
March 6, 2024: Gynecologic Oncology