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https://www.readbyqxmd.com/read/28730678/prognosis-following-cancer-surgery-during-holiday-periods
#1
Jesper Lagergren, Fredrik Mattsson, Pernilla Lagergren
Surgery is the mainstay curative treatment in most cancer. We aimed to test the new hypothesis that cancer surgery performed during holiday periods is associated with worse long-term prognosis than for non-holiday periods. This nationwide Swedish population-based cohort study included 228,927 patients during 1997-2014 who underwent elective resectional surgery for a cancer where the annual number of resections was over 100. The 16 eligible cancer sites were grouped into 10 cancer groups. The exposure, holiday periods, was classified as wide (14-weeks) or narrow (7-weeks)...
July 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28727127/the-assessment-of-overall-survival-os-after-adjuvant-chemotherapy-for-patients-with-malignant-endometrial-cancer-in-poland
#2
Zbigniew Teter, Andrzej Śliwczyński, Melania Brzozowska, Marcin Świerkowski, Andrzej Jacyna, Jarosław Pinkas, Aleksandra Sierocka, Michał Marczak, Anna Dańska-Bidzińska, Mariusz Bidziński, Waldemar Wierzba
OBJECTIVES: In 2013 malignant endometrial cancers have amounted to 7.3% of all cancers diagnosed among women in the report by the Polish National Cancer Registry Raw prevalence rate amounted to 28.7, whereas standardised prevalence rate 15.6 per 100 000 population. Among the causes of death, these cancers amounted to 3% and were ranked ninth on the list of the most common causes of oncologic mortality of women. In the year 2013 a total of 1243 women died of malignant endometrial cancers...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28725636/epithelial-to-mesenchymal-transition-in-the-female-reproductive-tract-from-normal-functioning-to-disease-pathology
#3
REVIEW
Olena Bilyk, Mackenzie Coatham, Michael Jewer, Lynne-Marie Postovit
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28721180/adenomyosis-back-to-the-future
#4
Z Ferraz, N Nogueira-Martins, F Nogueira-Martins
Adenomyosis is a benign invasion of endometrium into the myometrium. It produces a diffusely enlarged uterus and predominantly affects women in the late reproductive age. It has recently been associated with a negative impact on female fertility. Diagnosis is challenging because nonspecific symptoms can be present. However, it is asymptomatic in the majority of women. Medical treatment with GnRH agonist seems to be promising, particularly in subfertile women. A retrospective study was performed (182 patients) by examination of histopathological results with "adenomyosis" between January/2013 and September/2016...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28720378/a-novel-technique-carbon-dioxide-gas-assisted-total-peritonectomy-diaphragm-and-intestinal-meso-stripping-in-open-surgery-for-advanced-ovarian-cancer-%C3%A3-ukurova-technique
#5
Ghanim Khatib, Ahmet Baris Guzel, Umran Kucukgoz Gulec, Mehmet Ali Vardar
OBJECTIVE: Most of the ovarian cancers are diagnosed at advanced stages. As peritoneal carcinomatosis increases, especially when it extends to the diaphragm and intestinal mesos, probability of obtaining complete cytoreduction is reduced. Complete cytoreduction (residue zero: R0) is one of the main factors affecting survival [1-3]. Here we present a novel technique of stripping the peritoneal surfaces as a part of cytoreductive surgery in such cases. METHODS: A 55year-old woman diagnosed with peritoneal carcinomatosis was considered appropriate for primary cytoreduction after assessment of her thorax-abdominopelvic tomography, which revealed resectable intra-abdominal disease...
July 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28698536/metformin-use-associated-with-lower-risk-of-cancer-in-patients-with-diabetes-mellitus-type-2
#6
Jasna Kusturica, Aida Kulo Ćesić, Edis Gušić, Sanita Maleškić, Maida Rakanović-Todić, Damir Šečić
Aim In order to increase the database related to the antineoplastic potential of metformin, association between the use of metformin and risk of cancer occurence in patients with diabetes mellitus type 2 (DM2) was investigated. Methods In this cross-sectional study, medical records of patients with DM2 were reviewed for cancer occurence. Data on age, body mass index (BMI), alcohol and nicotine consumption, glucose and HbA1c levels, duration of DM2, medication used in the treatment of DM2 and cancer occurence were collected and analyzed...
August 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28697913/uterine-transposition-technique-and-a-case-report
#7
Reitan Ribeiro, Juliano Camargo Rebolho, Fernanda Keiko Tsumanuma, Giovana Gugelmin Brandalize, Carlos Henrique Trippia, Karam Abou Saab
OBJECTIVE: To report the first uterine transposition for fertility preservation in a patient with rectal cancer. DESIGN: Case report. SETTING: Community hospital. PATIENT(S): A 26-year-old patient with stage cT3N1M0 rectal adenocarcinoma located 5 cm from the anal margin. INTERVENTION(S): Laparoscopic transposition of the uterus to the upper abdomen, outside of the scope of radiation, was performed to preserve fertility...
July 8, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28691261/hyperphosphatasemia-in-leiomyosarcoma-of-the-uterus-two-case-reports-and-a-literature-review
#8
Mariko Jitsumori, Anna Umeda, Ayako Hosoi, Kazuya Miyanishi, Satoru Munakata, Toshiya Yamamoto
Some tumors are known to produce alkaline phosphatase (ALP). Seven cases of uterine leiomyosarcoma were identified from the clinical records of Sakai City Medical Center from January 2006 to December 2014. Patients' ages ranged from 47 to 75 years (median: 58). Clinical stages were IB, IIB, IIIA, and IVB in four, one, one, and one cases, respectively. Of these, two were found to have hyperphosphatasemia before surgery, and the elevated ALP level decreased after surgery, and increased with disease recurrence...
July 10, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28678605/the-early-pregnancy-placenta-foreshadows-dna-methylation-alterations-of-solid-tumors
#9
Akpéli V Nordor, Djamel Nehar-Belaid, Sophie Richon, David Klatzmann, Dominique Bellet, Virginie Dangles-Marie, Thierry Fournier, Martin J Aryee
The placenta relies on phenotypes that are characteristic of cancer to successfully implant the embryo in the uterus during early pregnancy. Notably, it has to invade its host tissues, promote angiogenesis-while surviving hypoxia-, and escape the immune system. Similarities in DNA methylation patterns between the placenta and cancers suggest that common epigenetic mechanisms may be involved in regulating these behaviors. We show here that megabase-scale patterns of hypomethylation distinguish first from third trimester chorionic villi in the placenta, and that these patterns mirror those that distinguish many tumors from corresponding normal tissues...
July 5, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28677024/evolution-of-socioeconomic-inequalities-in-site-specific-cancer-mortality-among-belgian-women-between-1991-and-2008-using-a-fundamental-cause-approach
#10
Katrien Vanthomme, Hadewijch Vandenheede, Paulien Hagedoorn, Sylvie Gadeyne
PURPOSE: According to the "fundamental cause theory", emerging knowledge on health-enhancing behaviours and technologies results in persisting and even widening health disparities, favouring the higher socioeconomic groups. This study aims to assess (trends in) socioeconomic inequalities in site-specific cancer mortality in Belgian women. METHODS: Data were derived from record linkage between the Belgian census and register data on mortality for 1991-1997 and 2001-2008 for all Belgian female inhabitants aged 50-79 years...
July 4, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28663148/oral-reproductive-and-developmental-toxicity-of-lignosus-rhinocerotis-mycelium-in-rat
#11
Bo-Yi Jhou, Hsiao-Hui Liu, Shu-Hsing Yeh, Chin-Chu Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Lignosus rhinocerotis (L. rhinocerotis), also known as the tiger milk mushroom, is widely used as traditional medicine and as soup ingredient in Malaysia and Hong Kong. It is edible and is used traditionally for the treatment of fever, cough, asthma, wounds, chronic hepatitis, gastric ulcers and cancers. In view of its safety profile, little information is found in scientific literature. The objective of this study is to investigate developmental toxicity of L...
June 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28657664/conditional-abrogation-of-transforming-growth-factor-beta-receptor-1-in-pten-inactivated-endometrium-promotes-endometrial-cancer-progression-in-mice
#12
Yang Gao, Pengfei Lin, John P Lydon, Qinglei Li
Although a putative role for TGF beta (TGFB) signaling in the pathogenesis of human endometrial cancer has long been proposed, the precise function of TGFB signaling in the development and progression of endometrial cancer remains elusive. Depletion of PTEN in the mouse uterus causes endometrial cancer. To identify the potential role of TGFB signaling in endometrial cancer, we simultaneously deleted TGFB receptor 1 (Tgfbr1) and Pten in the mouse uterus using Cre-recombinase driven by the progesterone receptor (termed Pten(d/d) ; Tgfbr1(d/d) )...
June 28, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28656251/identification-of-a-gene-expression-profile-associated-with-the-regulation-of-angiogenesis-in-endometrial-cancer
#13
Marcin Opławski, Mateusz Michalski, Andrzej Witek, Bogdan Michalski, Nikola Zmarzły, Agnieszka Jęda-Golonka, Maria Styblińska, Joanna Gola, Małgorzata Kasprzyk-Żyszczyńska, Urszula Mazurek, Andrzej Plewka
The publication of the human genome sequence provided direction in the search for novel diagnostic and therapeutic methods for the treatment of human diseases. The aim of the present study was to investigate the hypothesis that the expression profile of genes involved in the regulation of angiogenesis may be a marker in endometrial cancer that facilitates the diagnosis and prognosis of patients, as well as the identification of novel therapeutic targets. The current study included 36 patients with grade (G) 1 to 3 endometrial cancer, and a control group of patients consisting of females that qualified for the removal of the uterus...
June 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28648614/the-effects-of-retinoic-acid-on-mmp-2-production-proliferation-and-ultrastructural-morphology-in-rat-uterus
#14
Tuğba Kotil, Şengül Şentürk, Türkan Sarioğlu, Leyla Tapul
AIMS: Retinoic acid (RA) has a vital importance in order to ensure continuity and morphology in many tissues. Matrix metalloproteinases (MMPs) have significant roles in proliferation, the formation of cancers, and metastasis. In this study the effects of RA on MMP-2 production in cells of rat uterus were investigated. METHODS: Twenty-four adult Spraque Dawley rats were divided into two groups, the experimental group was treated with 40mg/kg/day 13-cis RA for 5days by gavage...
June 22, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28600055/recurrent-female-adnexal-tumor-of-probably-wolffian-origin-a-case-report
#15
Tian Qiu, Yincheng Teng, Jianqian Tong, Wenqi Tao, Liang Xu
OBJECTIVE: Wolffian adnexal tumors (WATs) are rare, and metastasis is uncommon. We present the case of a 53-year-old female with a recurrent WAT. CASE REPORT: The patient presented with abdominal distension, and ultrasound revealed heterogeneous echoes (130 × 93 × 116 mm(3)) around the uterus and ascites. Her cancer antigen 125 (CA125) and CA19-9 levels were elevated. Hysterectomy, bilateral oophorectomy, and tumor resection were performed. The histopathological diagnosis was a WAT...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28599153/effects-of-repeated-biaxial-loads-on-the-creep-properties-of-cardinal-ligaments
#16
Adwoa Baah-Dwomoh, Raffaella De Vita
The cardinal ligament (CL) is one of the major pelvic ligaments providing structural support to the vagina/cervix/uterus complex. This ligament has been studied mainly with regards to its important function in the treatment of different diseases such as surgical repair for pelvic organ prolapse and radical hysterectomy for cervical cancer. However, the mechanical properties of the CL have not been fully determined, despite the important in vivo supportive role of this ligament within the pelvic floor. To advance our limited knowledge about the elastic and viscoelastic properties of the CL, we conducted three consecutive planar equi-biaxial tests on CL specimens isolated from swine...
May 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28595311/evaluation-of-rectum-and-bladder-dose-accumulation-from-external-beam-radiotherapy-and-brachytherapy-for-cervical-cancer-using-two-different-deformable-image-registration-techniques
#17
Noriyuki Kadoya, YuYa Miyasaka, Takaya Yamamoto, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Yujiro Nakajima, Noriyoshi Takahashi, Masaki Kubozono, Rei Umezawa, Suguru Dobashi, Ken Takeda, Keiichi Jingu
We evaluated dose-volume histogram (DVH) parameters based on deformable image registration (DIR) between brachytherapy (BT) and external beam radiotherapy (EBRT) that included a center-shielded (CS) plan. Eleven cervical cancer patients were treated with BT, and their pelvic and CS EBRT were studied. Planning CT images for EBRT and BT (except for the first BT, used as the reference image) were deformed with DIR to reference image. We used two DIR parameter settings: intensity-based and hybrid. Mean Dice similarity coefficients (DSCs) comparing EBRT with the reference for the uterus, rectum and bladder were 0...
June 8, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28594773/all-cause-mortality-after-fertility-sparing-surgery-for-stage-i-epithelial-ovarian-cancer
#18
Alexander Melamed, Anthony E Rizzo, Roni Nitecki, Allison A Gockley, Amy J Bregar, John O Schorge, Marcela G Del Carmen, J Alejandro Rauh-Hain
OBJECTIVE: To compare all-cause mortality between women who underwent fertility-sparing surgery with those who underwent conventional surgery for stage I ovarian cancer. METHODS: In a cohort study using the National Cancer Database, we identified women younger than 40 years diagnosed with stage IA and unilateral IC epithelial ovarian cancer between 2004 and 2012. Fertility-sparing surgery was defined as conservation of one ovary and the uterus. The primary outcome was time from diagnosis to death...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28585847/-uterine-inversion
#19
L Mužná, R Pilka
AIM: Summarize the literature on the inversion of the uterus. DESIGN: A review article. SETTING: Department of Obstetrics and Gynecology, SZZ Krnov, Department of Obstetrics and Gynecology, University Hospital, Palacky University, Olomouc. METHOD: Literature review was conducted using the following key words. There were included articles published in English since 1980, from which relevant data were obtained. RESULTS: In the literature the general occurrence is broad, ranging from 1:27 000 in the UK to 1:1739 in the US, where it varies greatly according to geographic location...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28585779/the-impact-of-initial-cancer-stage-on-the-incidence-of-venous-thromboembolism-the-scandinavian-thrombosis-and-cancer-stac-cohort
#20
I L Gade, S K Braekkan, I A Naess, J-B Hansenx, S C Cannegieter, K Overvad, H Jensvoll, J Hammerstrøm, K Blix, A Tjønneland, S R Kristensen, M T Severinsen
BACKGROUND: Absolute measures of the impact of cancer stage on the incidence of venous thromboembolism (VTE) in distinct cancer types have not been investigated in a large population based cohort study. OBJECTIVES: To investigate differences in incidence rates of objectively confirmed VTE according to development of cancer in a large population based cohort study. Cancer type and stage at the time of diagnosis was taken into account. PATIENTS AND METHODS: The Scandinavian Thrombosis and Cancer cohort includes data regarding cancer types, stages and objectively confirmed VTE diagnoses among 144,952 participants followed from 1993 through 2012...
June 6, 2017: Journal of Thrombosis and Haemostasis: JTH
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