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Corpus cavernosum

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https://www.readbyqxmd.com/read/29198509/testosterone-deficiency-causes-endothelial-dysfunction-via-elevation-of-asymmetric-dimethylarginine-and-oxidative-stress-in-castrated-rats
#1
Tomoya Kataoka, Yuji Hotta, Yasuhiro Maeda, Kazunori Kimura
BACKGROUND: Testosterone is believed to mediate the penile erectile response by producing adequate nitric oxide; therefore, testosterone deficiency results in erectile dysfunction through decreased nitric oxide bioavailability. However, the mechanisms underlying endothelial dysfunction in testosterone deficiency remain unclear. AIM: To investigate the mechanism of endothelial dysfunction in a rat model of testosterone deficiency. METHODS: Rats were distributed into 3 groups: castrated (Cast), castrated and supplemented with testosterone (Cast + T), and sham (Sham)...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29191197/in-vitro-and-in-vivo-aphrodisiac-properties-of-the-seed-extract-from-allium-tuberosum-on-corpus-cavernosum-smooth-muscle-relaxation-and-sexual-behavior-parameters-in-male-wistar-rats
#2
Xingli Tang, Opeyemi J Olatunji, Yifeng Zhou, Xilin Hou
BACKGROUND: Allium tuberosum is a well-known spice as well as a herb in traditional Chinese medicine, used for increasing libido and treating erectile dysfunction. However, not many studies have been done to evaluate the sexual enhancing properties of A. tuberosum. The aim of this study was to evaluate the aphrodisiac and vasorelaxant properties of A. tuberosum on corpus cavernosum smooth muscle (CCSM) as well as checking the effect on enhancing male rat sexual behavior, libido, potency as well as its spermatogenic properties...
December 1, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29174980/pdgf-mediated-pi3k-akt-%C3%AE-catenin-signaling-regulates-gap-junctions-in-corpus-cavernosum-smooth-muscle-cells
#3
Xiang Zhang, Fan Zhao, Jian-Feng Zhao, Hui-Ying Fu, Xiao-Jun Huang, Bo-Dong Lv
Erectile dysfunction (ED) is the most common sexual disorder that men report to healthcare providers. Gap junctions (GJs) are thought to be responsible for synchronous shrinkage of corpus cavernosum smooth muscle cells (CCSMCs), and play thus an important role in the maintenance of an erection. Hypoxia has been suggested as a pathological mechanism underlying ED. Here we demonstrate that hypoxia increased the expression of platelet-derived growth factor (PDGF) and the main GJ component connexin (Cx)43 in CCSMCs...
November 22, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29170014/-treatment-by-stem-cell-therapy-of-erectile-dysfunction-of-diabetic-origin-state-of-the-art
#4
R El Osta, V Decot, D Bensoussan, J F Stoltz, P Eschwege, J Hubert
PURPOSE: Review of various publications on stem cell therapy to treat erectile dysfunction of diabetic origin. MATERIAL AND METHODS: Bibliographic search in PUBMED performed using the keywords cell therapy strain/erectile dysfunction associated with diabetes. Among the 51 articles obtained from the PUBMED research, we selected 16 articles for their specificity of studying erectile dysfunction (DE) related to diabetes. RESULTS: Different types of stem cells have been studied: adipose derived mesenchymal stem cells/bone marrow derived mesenchymal stem cells as well as progenitor endothelial cells...
November 20, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29164835/penile-erection-induced-by-scoparone-from-artemisia-capillaris-through-the-nitric-oxide-cyclic-guanosine-monophosphate-signaling-pathway
#5
Bo Ram Choi, Hye Kyung Kim, Jong Kwan Park
PURPOSE: The objective of this study was to evaluate the relaxant effect of scoparone from Artemisia capillaris on rabbit penile corpus cavernosum smooth muscle (PCCSM) and to elucidate the mechanism of action of scoparone for the treatment of erectile dysfunction (ED). MATERIALS AND METHODS: PCCSM that had been precontracted with phenylephrine was treated with 3 Artemisia herbs (A. princeps, A. capillaris, and A. iwayomogi) and 3 fractions (n-hexane, ethyl acetate, and n-butanol) with different concentrations (0...
November 21, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29164834/effects-of-next-generation-low-energy-extracorporeal-shockwave-therapy-on-erectile-dysfunction-in-an-animal-model-of-diabetes
#6
Hyun Cheol Jeong, Seung Hwan Jeon, Zhu Guan Qun, Kang Sup Kim, Sae Woong Choi, Fahad Bashraheel, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, U Syn Ha, Sung Hoo Hong, Ji Youl Lee, Du Geon Moon, Sae Woong Kim
PURPOSE: Gene therapy, stem cell therapy, and low-energy extracorporeal shockwave therapy (ESWT) have been investigated as treatments for refractory erectile dysfunction (ED), but inconclusive evidence has been obtained. We investigated the effect of a next-generation electromagnetic cylinder ESWT device on an animal model of ED. MATERIALS AND METHODS: Diabetes mellitus (DM)-induced rats were divided into 3 groups: group 1, control; group 2, DM; and group 3, DM+ESWT...
November 20, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29151107/repeated-micro-trauma-of-the-penile-tunica-albuginea-a-new-animal-model-of-peyronie-s-disease
#7
Hesong Jiang, Qingqiang Gao, Xiaoyan Che, Leilei Zhu, Zheng Zhang, Yun Chen, Yutian Dai
OBJECTIVES: To compare effects of repairing injured tunica albuginea (PTA) of rat penis by single or repeated local injections of chlorhexidine ethanol (ChE) into the PTA and to establish a new animal model of Peyronie's disease (PD). MATERIALS AND METHODS: Forty-two rats were divided into 7 groups. Rats either served as the normal control group with 1-5 injections of 0.9% saline or they received a single injection, 2, 3, 4, or 5 injections of ChE (0.1% chlorhexidine gluconate plus 15% ethanol dissolved in saline); rats in the positive control group were injected with TGF-β1...
November 18, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29133940/stimulators-and-activators-of-soluble-guanylate-cyclase-for-urogenital-disorders
#8
REVIEW
Fabiola Z Mónica, Edson Antunes
Lower urinary tract symptoms (LUTS), comprising storage (such as urinary incontinence and urinary frequency), voiding, and postmicturition symptoms, are highly prevalent conditions that affect millions of people worldwide. LUTS have a profound effect on quality of life and are a considerable cost to health care systems. In men specifically, BPH commonly leads to LUTS. Clinical studies also show an association of LUTS with erectile dysfunction (ED). Nitric oxide (NO) has long been recognized as an important nonadrenergic, noncholinergic (NANC) transmitter in bladder, urethra, prostate, and corpus cavernosum smooth muscle...
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29123449/fracture-with-urethral-injury-evaluation-by-retrograde-urethrogram
#9
Abdulkadir Kandemir, Mehmet Balasar, Necdet Poyraz, Mehmet Mesut Piskin
Penile fracture is a rare condition. It primarily involves the rupture of the corpus cavernosum during erection, which may also affect the corpus spongiosum and urethra. We describe the case of a 35-year-old man who presented with acute penile pain, penile swelling, and a hematuria after a blunt trauma during sexual intercourse. The emergency retrograde urethrogram revealed a rare condition, extravasation of the opaque material from the penile urethra into the cavernous structure. The partial rupture of the corpus cavernosum with urethral disruption was repaired surgically...
October 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29098193/double-intracavernous-breakage-of-sachse-s-knife-blade-management-of-a-rare-complication-performing-direct-vision-internal-urethrotomy
#10
Alfonso Benincasa, Alberto Saita, Angelo Pinto, Carmine Pilerci, Lamberti Francesco, Aniello Russo, Giuseppe Benincasa
Background: Although the breakage of a Sachse's knife blade is already a rare event while performing optical internal urethrotomy, a double failure appears to be at the same time a unique and a challenging complication to manage since no reference has emerged from literature review. Case Presentation: A male patient, 80 years of age, underwent retreatment of recurrent urethral stricture that occurred after transurethral resection of the prostate. The latter was complicated by severe intraoperative urethrorrhagia; this is the reason he was transferred from another institution where at first a suprapubic cystostomy was carried out, followed by urethral recanalization through internal urethrotomy and finally he underwent intracavernous Sachse's knife blade discharge...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29064545/the-morphological-characters-of-the-male-external-genitalia-of-the-european-hedgehog-erinaceus-europaeus
#11
Ghasem Akbari, Mohammad Babaei, Nader Goodarzi
This study was conducted to depict anatomical characteristics of the penis in hedgehog. Seven sexually mature male European hedgehogs were used. Following anesthesia, the animals were scarified with chloroform inhalation. Gross penile characteristics such as length and diameter were thoroughly explored and measured using digital calipers. Tissue samples stained with Hematoxylin - Eosin and Masson's trichrome for microscopic analysis. The penis of the European hedgehog was composed of a pair of corpus cavernosum penis and the glans penis without corpus spongiosum penis...
October 24, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29057541/transplantation-of-adipose-tissue-derived-stem-cell-derived-exosomes-ameliorates-erectile-function-in-diabetic-rats
#12
L L Zhu, X Huang, W Yu, H Chen, Y Chen, Y T Dai
Mesenchymal stem cells (MSCs) have been considered as an attractive tool for the therapy of diseases. Accumulating evidence indicates that the healing effects of MSCs are mainly related to paracrine action rather than transdifferentiation. Exosomes excreted from MSCs have emerged as physiologically relevant and powerful components of the MSC secretome. However, whether MSC-derived exosomes can improve erectile function of streptozotocin-induced diabetic rats and its mechanism remains unknown. Our previous work showed that adipose tissue-derived stem cells (ADSCs) transplantation could increase endothelial and smooth muscle contents and improve erectile function of diabetic rats...
October 23, 2017: Andrologia
https://www.readbyqxmd.com/read/29051003/spontaneous-regeneration-of-nerve-fiber-and-irreversibility-of-corporal-smooth-muscle-fibrosis-after-cavernous-nerve-crush-injury-evidence-from-serial-transmission-electron-microscopy-and-intracavernous-pressure
#13
Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao, Han-Sun Chiang
OBJECTIVES: To determine the pathophysiological progresses following bilateral cavernous nerve crushing (BCNC) injury, as an index for a treatment point and establishment of adequate treatment strategies for neurogenic erectile dysfunction (ED). METHODS: Thirty-six rats were assigned to 1 of 6 groups, and BCNC or sham surgery was performed. Functional testing and ultrastructural analyses were performed immediately and at 7, 14, 21, and 28 d after the cavernous nerve (CN) injury (n = 6)...
October 16, 2017: Urology
https://www.readbyqxmd.com/read/29041845/relationship-between-oxidative-stress-and-erectile-function
#14
Thierry Roumeguère, Pierre Van Antwerpen, Henda Fathi, Alexandre Rousseau, Luc Vanhamme, Thierry Franck, Carla Costa, Annamaria Morelli, Christophe Lelubre, Claude Hauzeur, Martine Raes, Didier Serteyn, Eric Wespes, Michel Vanhaeverbeek, Karim Zouaoui Boudjeltia
The aim of this study was to investigate markers of inflammation and oxidative stress in the corpus cavernosum (CC) and to compare levels of inflammatory markers recorded in CC to venous blood from the arm to examine the potential impact of inflammatory parameters on erectile function and endothelial dysfunction in vitro. Ninety-seven patients with no complaint of erectile dysfunction (ED) at inclusion were prospectively included and completed the Erectile Function domain of the IIEF questionnaire. Several parameters, including lipids, MPO-dependent oxidized LDL (Mox-LDL), IL-8, IL-18, were measured...
October 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29032115/toll-like-receptor-4-tlr4-impairs-nitric-oxide-contributing-to-angiotensin-ii-induced-cavernosal-dysfunction
#15
Kenia P Nunes, Gisele F Bomfim, Haroldo A Toque, Theodora Szasz, R Clinton Webb
AIM: Angiotensin II (AngII), a corpus cavernosum (CC) constrictor peptide, modulates Toll like receptor (TLR) expression, a key element of the innate immune system, contributing to impaired vascular function in pathological conditions. However, it is unknown whether TLR4 is involved in AngII-induced erectile dysfunction. In this study, we investigated whether TLR4 plays a role in cavernosal dysfunction caused by AngII upregulation. MATERIAL AND METHODS: Cavernosal smooth muscle cells (CSMC) from C57/BL6 mice were treated with AngII (0...
October 12, 2017: Life Sciences
https://www.readbyqxmd.com/read/29022780/primary-urethral-reconstruction-results-in-penile-fracture
#16
R Barros, Mis Silva, V Antonucci, L Schulze, L Koifman, L A Favorito
Objective This study assessed primary urethral reconstruction results in patients with a penile fracture. Materials and methods Between January 2005 and April 2016, patients who underwent primary urethral reconstruction due to penile fracture were called for a follow-up. Epidemiological and clinical presentation data and operative findings were reviewed retrospectively. Partial urethral lesions were primarily treated with interrupted absorbable sutures over urethral catheter. In cases of complete urethral lesion, tension-free end-to-end anastomosis was performed...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28993731/small-and-intermediate-calcium-activated-potassium-channel-openers-improve-rat-endothelial-and-erectile-function
#17
Simon G Comerma-Steffensen, Ingrid Carvacho, Elise R Hedegaard, Ulf Simonsen
Modulation of endothelial calcium-activated potassium (KCa) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of KCa channels with small (KCa2.x) and intermediate (KCa3.1) conductance, NS309 and NS4591, improve endothelium-dependent relaxation and erectile function. Rat corpus cavernosum (CC) strips were mounted for isometric tension recording and processed for immunoblotting. Mean arterial pressure (MAP), intracavernosal pressure (ICP), and electrocardiographic (ECG) measurements were conducted in anesthetized rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28979612/-rupture-of-the-albuginea-of-the-corpora-cavernosa
#18
Hamza Dergamoun, Zayd El Boukili El Makhoukhi
The fractures of the penis are rare in our context and are most often secondary to false penile fracture. A more common cause has been described in the countries of the Middle East where people interrupt the erection due to a violent bending of their penis called "Taqaandan". We here report the case of a 21-year old patient with no particular previous history, presenting to the emergency department at the Medical Center Avicenna with pain and deformation of the penis following "Taqaandan" manoeuvre. After having heard a click the patient felt pain and had violent detumescence without associated urinary problems, thus excluding urethral involvement...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28970082/identification-and-functional-verification-of-micrornas-in-the-obese-rat-with-erectile-dysfunction
#19
Yunlong Bai, Liangshuan Zhang, Yanan Jiang, Jiaming Ju, Guiyang Li, Juan Xu, Xing Jiang, Peng Zhang, Linchuan Lang, Olga Sadkovaya, Peter V Glybochko, Wei Zhang, Baofeng Yang
INTRODUCTION: Obesity is a potential risk factor for erectile dysfunction (ED). MicroRNAs (miRNAs) regulate the expression of genes involved in various pathophysiologic processes. AIM: To identify the miRNA profile in the corpus cavernosum (CC) of obese rats with ED and elucidate the potential function of miRNA in the pathogenesis of ED. METHODS: Obesity was induced in rats by a high-fat diet. After the erectile function test, experimental animals were divided into two groups: obese rats with ED and obese rats with normal erectile function...
December 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28918294/potassium-channels-modulate-the-action-but-not-the-synthesis-of-hydrogen-sulfide-in-rat-corpus-cavernosum
#20
H Abd Elmoneim, F Sharabi, M Mohy El Din, L Louedec, X Norel, A Senbel
AIM: Hydrogen sulfide (H2S) is a newly-introduced gasotransmitter in penile tissues. However, its exact mechanism of action in mediating penile erection is not fully elucidated. The major aim of this study was to examine the role of different K(+) channels in mediating the responses to H2S in the corpus cavernosum. MAIN METHODS: Tension studies using isolated rat corpus cavernosum strips were conducted. Endogenous H2S production was measured using polarographic technique...
November 15, 2017: Life Sciences
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