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Corpus cavernosum

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https://www.readbyqxmd.com/read/28316938/accidental-non-masturbatory-non-intercourse-related-self-inflicted-penile-fracture-case-report-and-review-of-literature
#1
Christopher Bastianpillai, Aijing Wang, Jeevan Kumaradevan, Sudhanshu Chitale
Penile fracture is a relatively rare condition arising from a rupture of the corpus cavernosum. In the western world, it is most commonly associated with sexual intercourse. We hereby, report a rare case of accidental, non-masturbatory, self-inflicted penile fracture. It was diagnosed promptly based on clinical assessment, confirmed radiologically and managed surgically, resulting in a good long-term clinical outcome. Our case highlights the importance of maintaining a high index of suspicion to diagnose this rare condition, even in the absence of a typical mechanism of injury, in order to ensure that such an injury is not missed...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28299329/angiotensin-1-7-downregulates-diabetes-induced-cgmp-phosphodiesterase-activation-in-rat-corpus-cavernosum
#2
Gursev S Dhaunsi, Mariam Yousif, Batoul Makki, Saghir Akhtar, Ibrahim F Benter
Molecular mechanisms of the beneficial effects of angiotensin-(1-7), Ang-(1-7), in diabetes-related complications, including erectile dysfunction, remain unclear. We examined the effect of diabetes and/or Ang-(1-7) treatment on vascular reactivity and cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE) in corpus cavernosum. Male Wistar rats were grouped as (1) control, (2) diabetic (streptozotocin, STZ, treated), (3) control + Ang-(1-7), and (4) diabetic + Ang-(1-7). Following 3 weeks of Ang-(1-7) treatment subsequent to induction of diabetes, rats were sacrificed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28296277/effect-of-icariin-in-combination-with-daily-sildenafil-on-penile-atrophy-and-erectile-dysfunction-in-a-rat-model-of-bilateral-cavernous-nerves-injury
#3
Y Xu, H Xin, Y Wu, R Guan, H Lei, X Fu, Z Xin, Y Yang
The commonly utilized phosphodiesterase type 5 inhibitors do not lead to satisfactory penile erection after radical prostatectomy mainly because of insufficient nitric oxide drive from the damaged cavernous nerves. The aim of this study was to assess the efficacy and mechanisms of icariin in combination with daily sildenafil on neurogenic erectile dysfunction and penile atrophy in a rat model of bilateral cavernous nerves injury. Sixty male Sprague-Dawley rats injected with 5-ethynyl-2-deoxyuridine (50 mg/kg) at postnatal day 1 for the purpose of tracking endogenous stem cells in penis...
March 10, 2017: Andrology
https://www.readbyqxmd.com/read/28288470/circulating-concentrations-of-adipocytokines-and-their-receptors-in-the-isolated-corpus-cavernosum-and-femoral-artery-from-trained-rats-on-a-high-fat-diet
#4
Amanda C S Sponton, Fábio H Silva, Hygor N Araujo, Carmem P Valgas da Silva, Camila de Moraes, Edson Antunes, Angelina Zanesco, Maria A Delbin
BACKGROUND: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS: Functional experiments were performed in control sedentary and trained rats, and sedentary (h-SD) and trained male Wistar rats on a high-fat diet (h-TR)...
March 14, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28271049/intracorporeal-dilatation-plus-al-ghorab-corporoglandular-shunt-for-salvage-management-of-prolonged-ischemic-priapism
#5
Andika Afriansyah, Prahara Yuri, Yonas Immanuel Hutasoit
Ischemic priapism (IP) is a urological emergency that requires early intervention in order to prevent irreversible structural and functional changes. The purpose of penile shunt surgery is to passage out ischemic blood in the corpus cavernosum (CC), restoring the normal circulation within these structures. Here, we present our first experience using modification of Al-Ghorab shunt procedure to treat severe and prolonged IP. The Al-Ghorab shunt procedure was modified by the retrograde insertion of a 7/8 Hegar dilator into the opening of the distal cavernous tissue via the original Al-Ghorab incision...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28267524/the-value-of-shear-wave-elastography-in-the-quantification-of-corpus-cavernosum-penis-rigidity-and-its-alteration-with-age
#6
Ercan Inci, Rustu Turkay, Mustafa Orhan Nalbant, Mustafa Gurkan Yenice, Volkan Tugcu
OBJECTIVE: The goal of this study was to measure corpus cavernosum (CC) penis rigidity with shear wave elastography (SWE) in healthy volunteers and to evaluate the change of rigidity with age. METHODS: SWE was performed in 60 healthy volunteers (age range 20-71, mean 47±12,83 years). Volunteers were divided into 2 groups by age (Group 1 age <50, group 2 age ≥50). We assessed SWE in 3 parts of penis (proximal, middle and glans penis) on both sides of CC. All values of SWE (in kilo Pascal) were noted along with volunteers' ages...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28245285/the-platelet-derived-growth-factor-receptor-stat3-signaling-pathway-regulates-the-phenotypic-transition-of-corpus-cavernosum-smooth-muscle-in-rats
#7
Jun-Feng Yan, Wen-Jie Huang, Jian-Feng Zhao, Hui-Ying Fu, Gao-Yue Zhang, Xiao-Jun Huang, Bo-Dong Lv
Erectile dysfunction (ED) is a common clinical disease that is difficult to treat. We previously found that hypoxia modulates the phenotype of primary corpus cavernosum smooth muscle cells (CCSMCs) in rats, but the underlying molecular mechanism is still unknown. Platelet-derived growth factor receptor (PDGFR)-related signaling pathways are correlated with cell phenotypic transition, but research has been focused more on vascular smooth muscle and tracheal smooth muscle and less on CCSMCs. Here, we investigated the role of PDGFR-related signaling pathways in penile CCSMCs, which were successfully isolated from rats and cultured in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28226311/effects-of-root-extracts-of-eurycoma-longifolia-jack-on-corpus-cavernosum-of-rat
#8
Bae Huey Tee, See Ziau Hoe, Swee Hung Cheah, Sau Kuen Lam
OBJECTIVE: This study was conducted to investigate the mechanisms of action of Eurycoma longifolia in rat corpus cavernosum. MATERIALS AND METHODS: Tincture of the roots was concentrated to dryness by evaporating the ethanol in vacuo. This ethanolic extract was partitioned into five fractions sequentially with hexane, dichloromethane, ethyl acetate, butanol and water. The corpus cavernosum relaxant activity of each fraction was investigated. Dichloromethanic (DCM) fraction which showed the highest potency in relaxing phenylephrine-precontracted corpora cavernosa was purified by column chromatography...
February 22, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28225916/expression-profiles-of-enos-inos-and-microrna-27b-in-the-corpus-cavernosum-of-rats-submitted-to-chronic-alcoholism-and-diabetes-mellitus
#9
Joao Paulo da Cunha, Fermino Sanches Lizarte, Paulo Cezar Novais, Daniela Gattas, Camila Albuquerque Mello de Carvalho, Daniela Pretti da Cunha Tirapelli, Carlos Augusto Fernandes Molina, Luis Fernando Tirapelli, Silvio Tucci
Purpose: To evaluate the expression of endothelial and inducible NOS in addition to the miRNA-27b in the corpus cavernosum and peripheral blood of healthy rats, diabetic rats, alcoholic rats and rats with both pathologies. Methods: Forty eight Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D) and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study protein expressions of eNOS and iNOS by immunohistochemistry and expression of miRNA-27b in the corpus cavernosum and peripheral blood...
January 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28214569/effect-of-testosterone-on-the-phenotypic-modulation-of-corpus-cavernosum-smooth-muscle-cells-in-a-castrated-rat-model
#10
Luhao Liu, Ermao Li, Futian Li, Lianmin Luo, Shankun Zhao, Ran Kang, Jintai Luo, Zhigang Zhao
OBJECTIVE: To investigate the effect of testosterone (T) on the phenotypic modulation of corpus cavernosum smooth muscle (CCSM) cells in a castrated rat model. METHODS: Thirty male Sprague-Dawley rats were randomly divided into three groups: control group, castration group, and castration with testosterone supplementation (castration+T) group. Erectile function, histological change and biochemical markers were assessed for phenotypic modulation of CCSM cells in corporal tissue...
February 15, 2017: Urology
https://www.readbyqxmd.com/read/28208559/re-mirabegron-causes-relaxation-of-human-and-rat-corpus-cavernosum-could-it-be-a-potential-therapy-for-erectile-dysfunction
#11
Allen D Seftel
No abstract text is available yet for this article.
March 2017: Journal of Urology
https://www.readbyqxmd.com/read/28176530/effects-of-castration-on-penile-extracellular-matrix-morphology-in-domestic-cats
#12
Nathalia Cs Borges, Marco A Pereira-Sampaio, Vivian Alves Pereira, Marcelo Abidu-Figueiredo, Maurício Alves Chagas
Objectives This study was undertaken to verify the possible modifications caused by hormonal deprivation in the extracellular matrix in the penises of neutered cats. Methods Twenty-seven penises from domestic shorthair cats were collected: 14 samples from intact cats and 13 from neutered cats. Sections were stained with Weigert's resorcin-fuchsin, hematoxylin and eosin, and picrosirius red. Histomorphometric analysis was performed using light microscopy and image analysis software. The following parameters were analyzed: density of the elastic fibers and collagen fibers in the corpus spongiosum; density of the elastic fibers in the tunica albuginea of the corpus cavernosum and the tunica albuginea of the corpus spongiosum; luminal area of the urethra; area of the corpus spongiosum; area of the corpus cavernosum; and thickness of the urethral epithelium...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28106289/the-involvement-of-corin-in-the-progression-of-diabetic-erectile-dysfunction-in-a-rat-model-by-down-regulating-anp-no-cgmp-signal-pathway
#13
Jian Wang, Yuanyuan Mi, Fenglai Yuan, Sheng Wu, Xiaoming You, Feng Dai, Yi Huang, Jia Cao, Jin Zhu, Boxin Xue, Lijie Zhu
This study was aimed to analyze the potential role of Corin in the procession of diabetic ED and to explore the underlying mechanism. Diabetic ED rat model was constructed and the characteristics of diabetic ED and control rats were recorded at 4, 8, 12 and 16 weeks. qRT-PCR and Western bloting were used to detected the mRNA and protein levels. Intracellular cGMP detection was accomplished using a commercial radioimmunoassay method. Vascular endothelial cell from rat corpus cavernosum spiral artery was isolated and transfected with si- Corin to analyzed the potential role of Corin...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28103290/involvement-of-ddah-adma-nos-cgmp-and-cox-2-ptgis-camp-pathways-in-human-tissue-kallikrein-1-protecting-erectile-function-in-aged-rats
#14
Kai Cui, Yang Luan, Zhe Tang, Ke Rao, Tao Wang, Zhong Chen, Shaogang Wang, Jihong Liu, Daowen Wang
Our previous studies had reported that Human Tissue Kallikrein 1 (hKLK1) preserved erectile function in aged transgenic rats, while the detailed mechanism of hKLK1 protecting erectile function in aged rats through activation of cGMP and cAMP was not mentioned. To explore the latent mechanism, male wild-type Sprague-Dawley rats (WTR) and transgenic rats harboring the hKLK1 gene (TGR) were fed to 4 and 18 months old and divided into four groups: young WTR (yWTR) as the control, aged WTR (aWTR), aged TGR (aTGR) and aged TGRs with HOE140 (aTGRH)...
2017: PloS One
https://www.readbyqxmd.com/read/28093890/long-term-follow-up-for-treatment-of-erectile-dysfunction-post-radical-prostatectomy-using-nerve-grafts-and-end-to-side-somatic-autonomic-neurorraphy-a-new-technique
#15
José Carlos Souza Trindade, Fausto Viterbo, André Petean Trindade, Wagner José Fávaro, José Carlos Souza Trindade Filho
Radical prostatectomy (RP) for prostate cancer treatment, although effective, can lead to severe erectile dysfunction. This study describes a new technique, which aims to reestablish the nerve stimulus in penile erection by two sural nerve graft bridges bilaterally, using the end to side neurorraphy. The first bridge is between femoral nerve and dorsal nerve of penis and the second, is between the femoral nerve and the interior of the corpus cavernosum. In this neurorraphy the endings of the newly formed fibres, generated by the femoral nerve, release acetylcholine inside the cavernous bodies, beginning the erection mechanism...
January 17, 2017: BJU International
https://www.readbyqxmd.com/read/28064474/the-effect-of-alcohol-administration-on-the-corpus-cavernosum
#16
See Min Choi, Deok Ha Seo, Sin Woo Lee, Chunwoo Lee, Seong Uk Jeh, Sung Chul Kam, Jeong Seok Hwa, Ky Hyun Chung, Jae Seog Hyun
PURPOSE: We studied the effects of alcohol administration on the corpus cavernosum (CC) using an animal model. MATERIALS AND METHODS: CC sections and the aortic ring of rabbits were used in an organ bath study. After acute alcohol administration, changes in blood alcohol concentration and electrical stimulation induced intracavernosal pressure/mean arterial pressure (ICP/MAP) percentage were compared in rats. Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) levels in the CC were measured using immunoassays...
December 22, 2016: World Journal of Men's Health
https://www.readbyqxmd.com/read/27999920/bilateral-arterial%C3%A2-embolization-of-the-prostate-through-a-single-prostatic-artery-a-case-series
#17
Gregory Amouyal, Olivier Pellerin, Costantino Del Giudice, Carole Déan, Nicolas Thiounn, Marc Sapoval
Peri-prostatic shunts are frequent during PAE, carrying the risk of non-target embolization of penis/corpus cavernosum or rectum but also the potential advantage to irrigate the contralateral lobe. Sometimes, bilateral embolization is impossible, carrying the risk of limited clinical success. The possibility to reach contralateral prostatic territory from the ipsilateral prostatic artery (PA) and embolize it via peri/intra-prostatic anastomoses could be of interest in this situation. We describe a series of three consecutive patients (among 89 consecutive patients treated by PAE for symptomatic BPH) who underwent successful embolization of both prostatic lobes through catheterization of a PA on only one side...
December 20, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27935981/sympathetic-hyperactivity-increased-tyrosine-hydroxylase-and-exaggerated-corpus-cavernosum-relaxations-associated-with-oxidative-stress-plays-a-major-role-in-the-penis-dysfunction-in-townes-sickle-cell-mouse
#18
Fábio H Silva, Mário A Claudino, Fabiano B Calmasini, Eduardo C Alexandre, Carla Franco-Penteado, Arthur L Burnett, Edson Antunes, Fernando F Costa
BACKGROUND: Sickle cell disease patients display priapism that may progress to erectile dysfunction. However, little is known about the pathophysiological alterations of corpus cavernosum in sickle cell disease. OBJECTIVE: Thus, this study aimed to evaluate the functional and molecular alterations of sympathetic machinery and nitric oxide-cyclic guanosine monophosphate signaling pathway in Townes transgenic sickle cell disease mice. METHODS: Concentration-response curves to contractile (phenylephrine) and relaxant agents (acetylcholine and sodium nitroprusside) were obtained in corpus cavernosum strips from sickle and C57BL/6 (control) mice...
2016: PloS One
https://www.readbyqxmd.com/read/27920989/dartos-fascia-interposition-flap-for-penetrating-cavernosal-and-urethral-trauma
#19
Hailiu Yang, Robert D Brown, John Chovanes, Allen D Seftel
We present an unusual case of a single gunshot to the genitalia in which the bullet trajectory injured the urethra, corpus cavernosum, and both testicles. All injuries were successfully repaired during initial exploration. Our report serves as a reminder to clinicians to have a high index of suspicion in this circumstance and consider immediate exploration of all the injured areas. We also demonstrate the use of a dartos fascia interposition flap to cover and separate the concomitant urethral and corporal sutures lines...
January 2017: Urology Case Reports
https://www.readbyqxmd.com/read/27904147/penile-constitutive-nitric-oxide-synthase-expression-in-rats-exposed-to-unpredictable-chronic-mild-stress-role-of-inflammation
#20
T D Şahin, Y Yazır, T Utkan, S S Göçmez, D Bayramgürler
Chronic psychological stress cause erectile dysfunction (ED). Considering recent evidence that tumor necrosis factor-α (TNF-α) levels are increased in serum of patients with ED, the present study investigated the effects of infliximab (a TNF-α blocker) on endothelial nitric oxide synthase (eNOS) and neuronal NOS (nNOS) immunoreactivity of rat penile corpus cavernosum in unpredictable chronic mild stress (UCMS). Male adult rats were randomly divided into three groups (n=8 per group): Control, UCMS and UCMS+infliximab...
March 2017: International Journal of Impotence Research
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