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JOURNAL ARTICLE
Sheikh Jamal Hossain, Syed Moshfiqur Rahman, Jane Fisher, Anisur Rahman, Fahmida Tofail, Jena Derakhshani Hamadani
BACKGROUND: Although sustainable development goals mandate for quality early childhood development (ECD) interventions for children <8 years, little occurs for children <3 years, especially in urban settings in low-and-middle-income countries (LMICs). Our primary objective was to measure the effect of an ECD-focused parenting and nutrition education on children's development through home visits using a social safety net platform of urban Bangladesh. METHODS: A cluster randomized controlled trial was conducted with mothers of children aged 6-16 months in 20 clusters across the Rangpur city, Bangladesh...
June 2024: Lancet Reg Health Southeast Asia
#22
Monique A M de Jong, Eleonora P M Corssmit, Jeroen C Jansen, Thomas P Potjer, Jean-Pierre L Bayley, Erik F Hensen
Head and neck paragangliomas are slow growing and highly vascular neuroendocrine tumors. It is currently assumed that SDHAF2 variants exclusively cause benign and often multicentric head and neck paragangliomas. Here, we present a patient diagnosed with multiple SDHAF2 -linked head and neck paragangliomas who in addition developed paraganglioma metastases to the lung and spine and a primary or metastatic paraganglioma in the head of the pancreas. During the course of the disease, a range of management strategies were deployed for the different head and neck tumors, including total resections, partial resections, and active surveillance...
2024: Case Reports in Otolaryngology
#23
JOURNAL ARTICLE
Santiago Allende, Louise Mahoney, Jasmin M Francisco, Korrine Fitz, Audrey Keaney, Kelly Parker-Bridges, Heidi Mahoney, Booil Jo, Jason Greenberg, Peter J Bayley
BACKGROUND: Chronic musculoskeletal pain is common in patients with Alzheimer's disease (AD), and there is growing awareness that chronic pain has an impact on the progression of dementia. Yoga has shown promise in treating chronic pain. However, attending in-person yoga can be difficult for AD patients. OBJECTIVE: To assess the feasibility, acceptability and preliminary efficacy of an online yoga (teleyoga) protocol suitable for AD patients with chronic pain, and their caregivers...
2024: Glob Adv Integr Med Health
#24
JOURNAL ARTICLE
Fu-Tsuen Lee, Liqun Sun, Joshua F P van Amerom, Sharon Portnoy, Davide Marini, Amandeep Saini, Natasha Milligan, Jessie Mei Lim, Brahmdeep Saini, Thiviya Selvanathan, Vanna Kazazian, Renee Sananes, Edgar Jaeggi, John C Kingdom, Christopher K Macgowan, Linh Ly, Vann Chau, Steven P Miller, Mike Seed
BACKGROUND: Fetuses with cyanotic congenital heart disease (CHD) exhibit profound fetal circulatory disturbances that may affect early outcomes. OBJECTIVES: This study sought to investigate the relationship between fetal hemodynamics and early survival and neurodevelopmental (ND) outcomes in patients with cyanotic CHD. METHODS: In this longitudinal observational study, fetuses with cyanotic CHD underwent late gestational fetal cardiovascular magnetic resonance (CMR) to measure vessel blood flow and oxygen content...
April 2, 2024: Journal of the American College of Cardiology
#25
JOURNAL ARTICLE
Danielle R Heller, Bayley Axelrod, Varadan Sevilimedu, Monica Morrow, Babak J Mehrara, Andrea V Barrio
IMPORTANCE: Higher lymphedema rates after axillary lymph node dissection (ALND) have been found in Black and Hispanic women; however, there is poor correlation between subjective symptoms, quality of life (QOL), and measured lymphedema. Additionally, racial and ethnic differences in QOL have been understudied. OBJECTIVE: To evaluate the association of race and ethnicity with long-term QOL in patients with breast cancer treated with ALND. DESIGN, SETTING, AND PARTICIPANTS: This cohort study enrolled women aged 18 years and older with breast cancer who underwent unilateral ALND at a tertiary cancer center between November 2016 and March 2020...
March 27, 2024: JAMA Surgery
#26
JOURNAL ARTICLE
Zonghua Bo, Zhong Hui Lim, Fernanda Duarte, Hagan Bayley, Yujia Qing
We previously reported a molecular hopper, which makes sub-nanometer steps by thiol-disulfide interchange along a track with cysteine footholds within a protein nanopore. Here we optimize the hopping rate (ca. 0.1 s-1 in the previous work) with a view towards rapid enzymeless biopolymer characterization during translocation within nanopores. We first took a single-molecule approach to obtain the reactivity profiles of individual footholds. The p K a values of cysteine thiols within a pore ranged from 9...
May 15, 2023: Angewandte Chemie
#27
JOURNAL ARTICLE
Thiviya Selvanathan, Ting Guo, Steven Ufkes, Vann Chau, Helen Branson, Anne Synnes, Linh G Ly, Edmond N Kelly, Ruth E Grunau, Steven P Miller
BACKGROUND AND OBJECTIVES: We examined associations of white matter injury (WMI) and periventricular hemorrhagic infarction (PVHI) volume and location with 18-month neurodevelopment in very preterm infants. METHODS: A total of 254 infants born <32 weeks' gestational age were prospectively recruited across 3 tertiary neonatal intensive care units (NICUs). Infants underwent early-life (median 33.1 weeks) and/or term-equivalent-age (median 41.9 weeks) MRI. WMI and PVHI were manually segmented for quantification in 92 infants...
April 23, 2024: Neurology
#28
JOURNAL ARTICLE
Mijna Hadders-Algra, Uta Tacke, Joachim Pietz, André Rupp, Heike Philippi
AIM: To compare the predictive values of the General Movements Assessment (GMA) and the Standardized Infant NeuroDevelopmental Assessment (SINDA) neurological scale for atypical neurodevelopmental outcome in 3-month-old at-risk infants. METHOD: A total of 109 infants (gestational age 30 weeks; range: 24-41; 52 males) attending a non-academic outpatient clinic were assessed with the GMA and the SINDA at 3 (2-4) months corrected age. The GMA pays attention to the complexity of general movements and presence of fidgety movements...
March 24, 2024: Developmental Medicine and Child Neurology
#29
JOURNAL ARTICLE
Catherine J Wedderburn, Shunmay Yeung, Sivenesi Subramoney, Jean-Paul Fouche, Shantanu H Joshi, Katherine L Narr, Andrea M Rehman, Annerine Roos, Diana M Gibb, Heather J Zar, Dan J Stein, Kirsten A Donald
BACKGROUND: There is a growing population of children with in utero HIV exposure who are at risk of poor neurodevelopmental outcomes despite avoiding HIV infection. However, the underlying neurobiological pathways are not understood and neuroimaging studies are lacking. We aimed to investigate the cortical brain structure of children who are HIV-exposed and uninfected (HEU) compared to HIV-unexposed (HU) children and to examine the relationship with neurodevelopment. METHODS: The Drakenstein Child Health birth cohort study enrolled pregnant women from a high HIV prevalence area in South Africa with longitudinal follow-up of mother-child pairs...
March 22, 2024: BMC Medicine
#30
JOURNAL ARTICLE
Adriana S Morell, Sarah E Monsell, Marie-Coralie Cornet, Jessica L Wisnowski, Robert C McKinstry, Amit M Mathur, Yi Li, Hannah C Glass, Fernando F Gonzalez, Dennis E Mayock, Kristen L Benninger, Krisa P Van Meurs, Andrea L Lampland, Tai-Wei Wu, David Riley, Ulrike Mietzsch, Lina Chalak, John Flibotte, Joern-Hendrick Weitkamp, Kaashif A Ahmad, Toby D Yanowitz, Mariana Baserga, Stephanie Merhar, Rakesh Rao, Gregory M Sokol, Bryan A Comstock, Patrick J Heagerty, Sandra E Juul, Yvonne W Wu
BACKGROUND: Infants with hypoxic ischemic encephalopathy (HIE) may have underlying conditions predisposing them to hypoxic-ischemic injury during labor and delivery. It is unclear how genetic and congenital anomalies impact outcomes of HIE. METHODS: Infants with HIE enrolled in a phase III trial underwent genetic testing when clinically indicated. Infants with known genetic or congenital anomalies were excluded. The primary outcome, i.e., death or neurodevelopmental impairment (NDI), was determined at age two years by a standardized neurological examination, Bayley Scales of Infant Development, Third Edition (BSID-III), and the Gross Motor Function Classification Scales...
February 20, 2024: Pediatric Neurology
#31
JOURNAL ARTICLE
Rebecca Baril, Ari R Joffe, John C Andersen, Sara Khademioureh, Irina A Dinu, Charlene M T Robertson
To address the research hypothesis that the Alberta Infant Motor Scale (AIMS) completed following complex cardiac surgery (CCS) is a useful outcomes measure this study determined: (1) AIMS scores at age 8 months after CCS; (2) predictive validity of AIMS at 8 months for Bayley Scales of Infant and Toddler Development-III Gross Motor-scaled scores (GMSS) and diagnosis of cerebral palsy (CP) at 21 months; and (3) predictive demographic and surgical variables of AIMS scores. A prospective cohort study of 250/271 (92...
March 21, 2024: Pediatric Cardiology
#32
JOURNAL ARTICLE
Yan Liu, Nuo-Xuan Liu
OBJECTIVE: To evaluate the variations in serum levels of microRNA-21 (miR-21) and S-100B protein in neonates with hypoxic-ischemic encephalopathy (HIE) after receiving hypothermia therapy and explore the correlation of these biomarkers with the neurodevelopmental prognosis of the infants. METHODS: This retrospective analysis included 90 neonatal HIE patients diagnosed and treated between January 2019 and December 2022. Real-time quantitative PCR and enzyme-linked immunosorbent assay (ELISA) methods were used to measure miR-21 and S-100B protein levels...
March 21, 2024: International Journal of Neuroscience
#33
JOURNAL ARTICLE
Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Ram K Chandyo, Antoine Guedeney, Hanne C Braarud, Mari Hysing, Tor A Strand
BACKGROUND: Social withdrawal in infants may be a signal of distress and a precursor for non-optimal development. OBJECTIVE: To examine the relationship between infant social withdrawal and neurodevelopment up to 4 years in Nepalese children. METHODS: A total of 597 Nepalese infants 6-11 months old were assessed with the modified Alarm Distress Baby Scale (m-ADBB), and of these, 527 with the Bayley Scales of Infant and Toddler Development 3rd edition (Bayley-III) during early childhood, and the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) and NEPSY-II subtests at 4 years...
March 18, 2024: BMC Pediatrics
#34
JOURNAL ARTICLE
Basic Environmental Supports for Positive Brain and Cognitive Development in the First Year of Life.
Joan L Luby, Max P Herzberg, Caroline Hoyniak, Rebecca Tillman, Rachel E Lean, Rebecca Brady, Regina Triplett, Dimitrios Alexopoulos, David Loseille, Tara Smyser, Cynthia E Rogers, Barbara Warner, Christopher D Smyser, Deanna M Barch
IMPORTANCE: Defining basic psychosocial resources to facilitate thriving in the first year of life could tangibly inform policy and enhance child development worldwide. OBJECTIVE: To determine if key environmental supports measured as a thrive factor (T-factor) in the first year of life positively impact brain, cognitive, and socioemotional outcomes through age 3. DESIGN, SETTING, AND PARTICIPANTS: This prospective longitudinal cohort study took place at a Midwestern academic medical center from 2017 through 2022...
March 18, 2024: JAMA Pediatrics
#35
COMMENT
Tarah T Colaizy, Brenda B Poindexter, Scott A McDonald, Edward F Bell, Waldemar A Carlo, Susan J Carlson, Sara B DeMauro, Kathleen A Kennedy, Leif D Nelin, Pablo J Sánchez, Betty R Vohr, Karen J Johnson, Dianne E Herron, Abhik Das, Margaret M Crawford, Michele C Walsh, Rosemary D Higgins, Barbara J Stoll, Namisavayam Ambalavanan, Myra H Wyckoff, Carl T D'Angio, George W Bugg, Robin K Ohls, Anne Marie Reynolds, Gregory M Sokol, Abbot R Laptook, Steven L Olsen, Jessica R White, Sudarshan R Jadcherla, Monika Bajaj, Prabhu S Parimi, Barbara Schmidt, Matthew M Laughon, John Barks, Kimberley A Fisher, Anna Maria Hibbs, Myriam Peralta-Carcelen, Noah Cook, Roy J Heyne, Brenna Cavanaugh, Ira Adams-Chapman, Janell Fuller, Michelle E Hartley-McAndrew, Heidi M Harmon, Andrea F Duncan, Abbey C Hines, Howard W Kilbride, Laurie A Richards, Nathalie L Maitre, Girija Natarajan, Andrea N Trembath, Martha D Carlson, William F Malcolm, Deanne E Wilson-Costello
IMPORTANCE: Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared with preterm formula. For infants receiving no or minimal maternal milk, it is unknown whether donor human milk conveys similar neurodevelopmental advantages vs preterm formula. OBJECTIVE: To determine if nutrient-fortified, pasteurized donor human milk improves neurodevelopmental outcomes at 22 to 26 months' corrected age compared with preterm infant formula among extremely preterm infants who received minimal maternal milk...
February 20, 2024: JAMA
#36
REVIEW
Khoa L Nguyen, Dominic A Fitzgerald, Annabel Webb, Barbara Bajuk, Himanshu Popat
OBJECTIVE: To investigate the neurodevelopmental outcomes for preterm infants born < 29 weeks gestation with/without bronchopulmonary dysplasia (BPD). STUDY DESIGN: Preterm infants < 29 weeks' gestation born 2007-2018 in New South Wales and the Australian Capital Territory, Australia, were included. Infants who died < 36 weeks' postmenstrual age and those with major congenital anomalies were excluded. Subjects were assessed at 18-42 months corrected age using the Bayley Scales of Infant Development, 3rd edition...
March 1, 2024: Paediatric Respiratory Reviews
#37
JOURNAL ARTICLE
Catherine Forward, Zana Bayley, Liz Walker, Justine Krygier, Caroline White, Kasonde Mwaba, Helene Elliott-Button, Paul Taylor, Miriam J Johnson
BACKGROUND: Social homecare workers provide essential care to those living at home at the end of life. In the context of a service experiencing difficulties in attracting and retaining staff, we have limited knowledge about the training, support needs and experiences of this group. AIM: To gain a timely understanding from the international literature of the experience, training and support needs of homecare workers providing end-of-life care. METHODS: We conducted a rapid review and narrative synthesis using the recommendations of the Cochrane Rapid Reviews Methods Group...
March 15, 2024: BMJ Supportive & Palliative Care
#38
JOURNAL ARTICLE
Adam Mutsaers, Ahmed Abugharib, Ian Poon, Joshua Loblaw, Andrew Bayley, Liying Zhang, Lee Chin, Madette Galapin, Darby Erler, Arjun Sahgal, Kevin Higgins, Danny Enepekides, Antoine Eskander, Irene Karam
PURPOSE: To report clinical outcomes for patients with metastatic disease to the head and neck (HN) treated with stereotactic body radiation therapy (SBRT). METHODS: A retrospective review of patients treated with SBRT to HN sites from 2012 to 2020 was conducted. Treatment indications included the following: oligometastases, oligoprogression, and control a dominant area of progression (DAP). Kaplan-Meier method was used to estimate local control (LC), regional control (RC), overall survival (OS), and progression-free survival (PFS)...
March 15, 2024: Supportive Care in Cancer
#39
JOURNAL ARTICLE
Thiviya Selvanathan, Steven Ufkes, Ting Guo, Vann Chau, Helen M Branson, George M Ibrahim, Linh G Ly, Edmond N Kelly, Ruth E Grunau, Steven P Miller
IMPORTANCE: Early-life exposure to painful procedures has been associated with altered brain maturation and neurodevelopmental outcomes in preterm infants, although sex-specific differences are largely unknown. OBJECTIVE: To examine sex-specific associations among early-life pain exposure, alterations in neonatal structural connectivity, and 18-month neurodevelopment in preterm infants. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study recruited 193 very preterm infants from April 1, 2015, to April 1, 2019, across 2 tertiary neonatal intensive care units in Toronto, Canada...
March 4, 2024: JAMA Network Open
#40
JOURNAL ARTICLE
Cainá Corrêa do Amaral, Fernanda Nedel, Camila Perelló Ferrúa, Tiago Fernandez Garcia, Geovanna Peter Corrêa, Roberta Giorgi, Aline Longoni Dos Santos, Adriano Martimbianco de Assis, Luciana de Avila Quevedo, Gabriele Cordenonzi Ghisleni, Mariana Bonati de Matos, Karen Amaral Tavares Pinheiro, Jéssica Puchalski Trettim, Ricardo Tavares Pinheiro
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth...
2024: Frontiers in Human Neuroscience
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